公开(公告)号：US11884002B2

公开(公告)日：2024-01-30

申请号：US17049934

申请日：2019-04-05

Applicant: Lawrence Livermore National Security, LLC ,  Virginia Polytechnic Institute and State University

Inventor： Marcus A. Worsley ,  Xiaoyu Zheng ,  Patrick G. Campbell ,  Eric Duoss ,  James Oakdale ,  Christopher Spadaccini ,  Ryan Hensleigh

IPC: B01J13/00 ,  B29C64/124 ,  B33Y10/00 ,  B33Y70/00 ,  C08K3/04 ,  C01B32/194 ,  C01B32/198 ,  B29C64/30 ,  B33Y40/20 ,  C08F283/06 ,  C08J9/28 ,  B29K105/00

CPC classification number: B29C64/124 ,  B01J13/0091 ,  B29C64/30 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/00 ,  C01B32/194 ,  C01B32/198 ,  C08F283/065 ,  C08J9/286 ,  C08K3/042 ,  B29K2105/0061 ,  C01B2204/22 ,  C01B2204/26 ,  C01B2204/32 ,  C01P2002/82 ,  C01P2004/03 ,  C01P2006/10 ,  C08J2205/026 ,  C08J2333/08

Abstract: Disclosed here is a method for making a three-dimensional micro-architected aerogel, comprising: (a) curing a reaction mixture comprising a co-sol-gel material (e.g., graphene oxide (GO)) and at least one catalyst to obtain a crosslinked co-sol-gel (e.g., GO hydrogel); (b) providing a photoresin comprising a solvent, a photoinitiator, a crosslinkable polymer precursor, and a dispersion of the crosslinked co-sol-gel (e.g., GO hydrogel); (c) curing the photoresin using projection microstereolithography layer-by-layer to produce a wet gel having a pre-designed three-dimensional structure; (d) drying the wet gel to produce a dry gel; and (e) pyrolyzing the dry gel to produce a three-dimensional micro-architected aerogel (e.g., graphene aerogel). Also disclosed is a photoresin for projection microstereolithography, comprising a solvent, a photoinitiator, a crosslinkable polymer precursor, and a dispersion of a crosslinked co-sol-gel.

公开(公告)号：US20230310609A1

公开(公告)日：2023-10-05

申请号：US18021637

申请日：2021-08-21

Applicant: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Zerin Mahzabin Khan ,  Scott S. Verbridge ,  Timothy E. Long ,  Eli Vlaisavlijevich

IPC: A61K41/00 ,  A61K9/00 ,  A61K9/06 ,  A61P35/00 ,  A61K47/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/26

CPC classification number: A61K41/0033 ,  A61K9/0024 ,  A61K9/06 ,  A61P35/00 ,  A61K47/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/26 ,  A61L2400/06 ,  A61B2017/320069

Abstract: Described in several embodiments herein are injectable hydrogels that are capable of attracting one or more cells, in situ. In some embodiments, the cells are cancer cells, such as cancer stem cells. Also described herein are methods of using the injectable hydrogels to fill a cavity in a subject. Also described herein are methods of treating a cancer by injecting an injectable hydrogel in a cavity in a subject formed from resecting a tumor and applying an external stimulus to the injected injectable hydrogel or area proximate to the injected injectable hydrogel.

公开(公告)号：US20230205955A1

公开(公告)日：2023-06-29

申请号：US18108964

申请日：2023-02-13

Applicant: Lawrence Livermore National Security, LLC ,  Virginia Polytechnic Institute and State University

Inventor： Xiao Chen ,  Can Huang ,  Liang Min ,  Charanraj Thimmisetty ,  Charles Tong ,  Yijun Xu ,  Lamine Mili

IPC: G06F30/27 ,  G06N20/00 ,  G06N7/01

CPC classification number: G06F30/27 ,  G06N20/00 ,  G06N7/01 ,  G06F2111/10

Abstract: Techniques, systems, and devices are described for providing a computational frame for estimating high-dimensional stochastic behaviors. In one exemplary aspect, a method for performing numerical estimation includes receiving a set of measurements of a stochastic behavior. The set of correlated measurements follows a non-standard probability distribution and is non-linearly correlated. Also, a non-linear relationship exists between a set of system variables that describes the stochastic behavior and a corresponding set of measurements. The method includes determining, based on the set of measurements, a numerical model of the stochastic behavior. The numerical model comprises a feature space comprising non-correlated features corresponding to the stochastic behavior. The non-correlated features have a dimensionality of M and the set of measurements has a dimensionality of N, M being smaller than N. The method includes generating a set of approximated system variables corresponding to the set of measurements based on the numerical model.

公开(公告)号：US20220372509A1

公开(公告)日：2022-11-24

申请号：US17637627

申请日：2020-08-21

Applicant: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Dorothea THOLL ,  JASON LANCASTER

IPC: C12N15/82 ,  C12N9/88 ,  C12N9/02 ,  C12N9/90

Abstract: Described herein are engineered polynucleotides and vectors capable of encoding one or more engineered harlequin and/or brown marmorated stink bug pheromone synthesis enzymes. Also described herein are engineered harlequin and/or brown marmorated stink bug pheromone synthesis enzymes. Also described herein are methods of making modified plants capable of expressing one or more harlequin and/or brown marmorated stink bug pheromone synthesis enzymes.

公开(公告)号：US20220119794A1

公开(公告)日：2022-04-21

申请号：US17419274

申请日：2019-12-23

Applicant: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Liwu LI ,  Shuo GENG ,  Yao ZHANG

IPC: C12N15/01 ,  C12N15/85 ,  A61K35/15 ,  A61K31/192 ,  A61P29/00 ,  A61P9/10

Abstract: Described herein are embodiments of chemically modified neutrophils and pharmaceutical formulations thereof. Also described herein are 4-phenylbutyrate pharmaceutical formulations. Also described herein are methods of chemically modifying neutrophils. Also described herein are treatments for non-resolving inflammation and/or related diseases or conditions, including but not limited to atherosclerosis, cardiovascular disease, stroke, myocardial infarction, neurological disease, and/or a symptom thereof in a subject in need thereof.

公开(公告)号：US20220074772A1

公开(公告)日：2022-03-10

申请号：US17017149

申请日：2020-09-10

Applicant: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Vasileios KYRITSIS ,  Kevin Todd LOWE ,  Maurice BRISTOW ,  Peter LOFTUS

IPC: G01F1/66 ,  G01K11/24 ,  G01M15/14

Abstract: A method of thermodynamic assessment of flow through a turbomachine having a compressor, comprising: receiving sensor readings from a plurality of acoustic sensors located about an intake for the turbomachine upstream of the compressor; and receiving pressure and stagnation temperature readings for the flow into the intake. A static temperature is determined for the flow into the intake and an average velocity of the flow over a flow area of the intake upstream of the compressor using the acoustic sensor readings. A mass flow rate of the flow through the intake is determined using the average velocity of the flow and the stagnation pressure.

公开(公告)号：US20170300657A1

公开(公告)日：2017-10-19

申请号：US15487929

申请日：2017-04-14

Applicant: Virginia Polytechnic Institute and State University

Inventor： Christopher L. Barrett ,  Madhav V. Marathe

IPC: G06F19/00 ,  G06F17/30

CPC classification number: G06F16/245 ,  G16H50/20 ,  G16H50/50 ,  Y02A90/24 ,  Y02A90/26

Abstract: Systems, methods, and computer-readable media for simulating the course of an event are provided. A processing unit can receive attributes of a synthetic population and select a synthetic-population graph from a data library based at least in part on the attributes. The processing unit can receive data of an intervention designed to affect the course of the event. The processing unit can then simulate the course of the event in the synthetic-population graph to produce an estimate of the event, based at least in part on the intervention. The event can include an epidemic, and the intervention can include vaccination, facility closures, or medication, in some examples. In some examples, the data library can include a social-contact graph determined at least in part by a broker software module.

公开(公告)号：US08682828B2

公开(公告)日：2014-03-25

申请号：US13796284

申请日：2013-03-12

Applicant: Virginia Polytechnic Institute and State University

Inventor： Christopher L. Barrett ,  Madhav V. Marathe ,  Keith R. Bisset ,  Paula E. Stretz

IPC: G06F17/00

CPC classification number: G06N5/022 ,  G06F17/00 ,  G06N5/02 ,  G06Q10/00 ,  G06Q30/00

Abstract: Systems, methods, and computer-readable media for generating a data set are provided. One method includes generating a data set based on input data using a plurality of brokers. The method further includes receiving a request from a user and determining whether the request can be fulfilled using data currently in the data set. When the request can be fulfilled using data currently in the data set, the data is accessed using broker(s) configured to provide access to data within the data set. When the request cannot be fulfilled using data currently in the data set, at least one new broker is spawned using existing broker(s) and additional data needed to fulfill the request is added to the data set using the new broker. The method further includes generating a response to the request using one or more of the plurality of brokers.

Abstract translation: 提供了用于生成数据集的系统，方法和计算机可读介质。 一种方法包括使用多个经纪人基于输入数据生成数据集。 该方法还包括从用户接收请求，并使用数据集中的当前数据来确定请求是否可以被满足。 当使用当前在数据集中的数据可以满足请求时，使用被配置为提供对数据集内的数据的访问的代理访问数据。 当使用当前数据集中的数据不能满足请求时，使用现有代理产生至少一个新代理，并且使用新代理将满足请求所需的附加数据添加到数据集中。 所述方法还包括使用所述多个经纪人中的一个或多个来产生对所述请求的响应。

公开(公告)号：US20240226809A9

公开(公告)日：2024-07-11

申请号：US18547489

申请日：2022-02-23

Applicant: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Spencer MARSH ,  Kevin J. PRIDHAM ,  Linda Jane JOURDAN ,  Robert G. GOURDIE

IPC: B01D61/14

CPC classification number: B01D61/14 ,  B01D2311/2676 ,  B01D2315/10 ,  B01D2315/16

Abstract: Described in certain example embodiments herein are methods of isolating exosomes from a biological fluid, such as those containing caseins.

公开(公告)号：US11914937B2

公开(公告)日：2024-02-27

申请号：US18108964

申请日：2023-02-13

Applicant: Lawrence Livermore National Security, LLC ,  Virginia Polytechnic Institute and State University

Inventor： Xiao Chen ,  Can Huang ,  Liang Min ,  Charanraj Thimmisetty ,  Charles Tong ,  Yijun Xu ,  Lamine Mili

IPC: G06F30/27 ,  G06N20/00 ,  G06N7/01 ,  G06F111/10

CPC classification number: G06F30/27 ,  G06N7/01 ,  G06N20/00 ,  G06F2111/10

Abstract: Techniques, systems, and devices are described for providing a computational frame for estimating high-dimensional stochastic behaviors. In one exemplary aspect, a method for performing numerical estimation includes receiving a set of measurements of a stochastic behavior. The set of correlated measurements follows a non-standard probability distribution and is non-linearly correlated. Also, a non-linear relationship exists between a set of system variables that describes the stochastic behavior and a corresponding set of measurements. The method includes determining, based on the set of measurements, a numerical model of the stochastic behavior. The numerical model comprises a feature space comprising non-correlated features corresponding to the stochastic behavior. The non-correlated features have a dimensionality of M and the set of measurements has a dimensionality of N, M being smaller than N. The method includes generating a set of approximated system variables corresponding to the set of measurements based on the numerical model.