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公开(公告)号：US20230073186A1
公开(公告)日：2023-03-09
申请号：US17943064
申请日：2022-09-12
Applicant: 10X GENOMICS, INC.
Inventor： Xinying ZHENG , Serge SAXONOV , Michael SCHNALL-LEVIN , Kevin NESS , Rajiv BHARADWAJ
IPC: C12Q1/6809 , C12Q1/6806 , C12Q1/6834 , C12Q1/6869
Abstract: The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information.
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公开(公告)号：US20220106641A1
公开(公告)日：2022-04-07
申请号：US17473760
申请日：2021-09-13
Applicant: 10X Genomics, Inc.
Inventor： Phillip BELGRADER , Zachary BENT , Rajiv BHARADWAJ , Vijay Kumar Sreenivasa GOPALAN , Josephine HARADA , Christopher HINDSON , Mohammad Rahimi LENJI , Michael Ybarra LUCERO , Geoffrey McDERMOTT , Elliott MEER , Tarjei Sigurd MIKKELSEN , Christopher Joachim O'KEEFFE , Katherine PFEIFFER , Andrew D. PRICE , Paul RYVKIN , Serge SAXONOV , John R. STUELPNAGEL , Jessica Michele TERRY , Tobias Daniel WHEELER , Indira WU , Solongo Batjargal ZIRALDO , Stephane Claude BOUTET , Sarah TAYLOR , Niranjan SRINIVAS
IPC: C12Q1/6874 , C12Q1/6806 , C12Q1/683
Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.
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公开(公告)号：US20220080424A1
公开(公告)日：2022-03-17
申请号：US17357617
申请日：2021-06-24
Applicant: 10X Genomics, Inc.
Inventor： Ivan AKHREMICHEV , Rajiv BHARADWAJ , Lynna CHEN , Francis CUI , Rachel GERVER , Mohammad Rahimi LENJI , Bill Kengli LIN , Anthony MAKAREWICZ , Martin SAUZADE , Astha TANNA , Fernandino VALDECANAS , Tobias Daniel WHEELER , Yiran ZHANG , Alireza SALMANZADEH
Abstract: Disclosed are devices, systems, kits, and methods for controlling liquid flow and, e.g., in particular, for forming droplet having substantially uniform droplet-to-droplet content. The devices, systems, and kits may include a first channel including a funnel or may include a first channel and a first-side channel, the first channel being in fluid communication with a droplet formation region. The devices, systems, and kits may further include a second channel fluidically connected to the first channel or the first side-channel. Funnels and/or side-channels may be used to enhance the control over particle spacing in the channels, thereby providing superior control over the number of particles of the same kind in formed droplets. The devices, systems, and kits of the invention may further include a mixer downstream of a channel intersection. Mixers can be used to reduce localized pockets of high concentration of dissolved ingredients.
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公开(公告)号：US20210053063A1
公开(公告)日：2021-02-25
申请号：US16998648
申请日：2020-08-20
Applicant: 10X Genomics, Inc.
Inventor： Mohammad Rahimi LENJI , Rajiv BHARADWAJ
Abstract: The invention provides kits, devices, methods, and systems for forming droplets or particles and methods of their use. The devices may be used to form droplets of a size suitable for utilization as microscale chemical reactors, e.g., for genetic sequencing. In general, droplets are formed in a device by flowing a first liquid through a channel and into a droplet formation region including a second liquid, i.e., the continuous phase. The invention allows for more efficient recovery of droplets or processed droplets.
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公开(公告)号：US20200290048A1
公开(公告)日：2020-09-17
申请号：US16797727
申请日：2020-02-21
Applicant: 10X Genomics, Inc.
Inventor： Rajiv BHARADWAJ , Anthony MAKAREWICZ , Bill Kengli LIN
Abstract: Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.
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Patent Agency Ranking
公开(公告)号：US20240369471A1
公开(公告)日：2024-11-07
申请号：US18775876
申请日：2024-07-17
Applicant: 10x Genomics, Inc.
Inventor： David HOFFMAN , Denis PRISTINSKI , Rajiv BHARADWAJ , Yiran ZHANG
Abstract: Disclosed are assemblies, systems, and methods for transilluminating a sample disposed within a device. An assembly includes a first optically transparent substrate configured to receive a biological sample, a second optically transparent substrate having a top surface, a bottom surface, and a plurality of sides. The first substrate contacts the top surface of the second substrate. The assembly includes at least one light source configured to illuminate at least one of the plurality of sides of the second substrate and a light scattering layer on the bottom surface of the second substrate. The light scattering layer is configured to scatter light from the light source. The assembly includes a thermal control module coupled to the second substrate and configured to control the temperature of the second substrate.
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公开(公告)号：US20240167079A1
公开(公告)日：2024-05-23
申请号：US18520514
申请日：2023-11-27
Applicant: 10X GENOMICS, INC.
Inventor： Xinying ZHENG , Serge SAXONOV , Michael SCHNALL-LEVIN , Kevin NESS , Rajiv BHARADWAJ
IPC: C12Q1/6809 , C12Q1/6806 , C12Q1/6834 , C12Q1/6869
CPC classification number: C12Q1/6809 , C12Q1/6806 , C12Q1/6834 , C12Q1/6869
Abstract: The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information.
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公开(公告)号：US20220097045A1
公开(公告)日：2022-03-31
申请号：US17471603
申请日：2021-09-10
Applicant: 10x Genomics, Inc.
Inventor： Donald A. MASQUELIER , Benjamin HINDSON , Kevin NESS , Rajiv BHARADWAJ
IPC: B01L3/00 , F16K99/00 , B01L9/00 , C12Q1/6874
Abstract: An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.
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公开(公告)号：US20210387195A1
公开(公告)日：2021-12-16
申请号：US17458757
申请日：2021-08-27
Applicant: 10x Genomics, Inc.
Inventor： Ivan AKHREMICHEV , Rajiv BHARADWAJ , Lynna CHEN , Mohammad Rahimi LENJI , Alireza SALMANZADEH , Martin SAUZADE , Tobias Daniel WHEELER , Yiran ZHANG
Abstract: Devices, systems, and their methods of use, for generating and collecting droplets are provided. The device includes a collection region comprising a side wall canted at an angle. The invention further provides multiplex devices that increase droplet formation.
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公开(公告)号：US20210293693A1
公开(公告)日：2021-09-23
申请号：US17343281
申请日：2021-06-09
Applicant: 10X Genomics, Inc.
Inventor： Rajiv BHARADWAJ , Jianying CAO , Mohammad Rahimi LENJI , Anthony MAKAREWICZ , Alireza SALMANZADEH
Abstract: Devices, systems, and their methods of use, for detecting and/or sorting droplets or particles are provided. One or more sorters can be selected to sort droplets or particles of a desired and predictable property or droplet size. The invention involves detection of droplets or particles from a droplet or particle source through a detection region.
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