公开(公告)号：US20130324732A1

公开(公告)日：2013-12-05

申请号：US13906960

申请日：2013-05-31

申请人： BASF SE

发明人： Roland Bou Chedid ,  Johann-Peter Melder ,  Ulrich Abel ,  Roman Dostalek ,  Bernd Stein

IPC分类号： C07D295/088 ,  B01J23/835 ,  C07D295/03

CPC分类号： C07D295/088 ,  B01J23/835 ,  C07D295/03

摘要： Process for the preparation of a mono-N-alkylpiperazine of the formula I in which R1 is C1- to C5-alkyl or 2-(2-hydroxyethoxy)ethyl, by reacting diethanolamine (DEOA) of the formula II with a primary amine of the formula H2N—R1 (III) in the presence of hydrogen and a supported, metal-containing catalyst, where the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and, in the range from 0.2 to 5.0% by weight, oxygen-containing compounds of tin, calculated as SnO, and the reaction is carried out in the liquid phase at an absolute pressure in the range from 95 to 145 bar.

摘要翻译： 通过使式II的二乙醇胺（DEOA）与式Ⅰ的伯胺反应制备其中R 1为C 1 -C 5 - 烷基或2-（2-羟基乙氧基）乙基的式I的单-N-烷基哌嗪的方法 在氢气和负载的含金属催化剂存在下，式H2N-R1（III），其中催化剂的催化活性物质在用氢还原之前包含含铝的铝，铜，镍和 钴，并且在0.2至5.0重量％的范围内，以SnO计算的含锡化合物的锡和反应在液相中以95至145巴的绝对压力进行。

公开(公告)号：US20130324731A1

公开(公告)日：2013-12-05

申请号：US13906931

申请日：2013-05-31

申请人： BASF SE

发明人： Roland Bou Chedid ,  Johann-Peter Melder ,  Ulrich Abel ,  Roman Dostalek ,  Bernd Stein

IPC分类号： C07D295/088 ,  C07D295/03 ,  B01J23/83

CPC分类号： C07D295/088 ,  B01J23/83 ,  B01J35/023 ,  B01J37/0009 ,  B01J37/031 ,  B01J37/08 ,  B01J37/18 ,  B01J2523/00 ,  C07D295/03 ,  B01J2523/17 ,  B01J2523/31 ,  B01J2523/3706

摘要： Process for the preparation of a mono-N-alkylpiperazine of the formula I in which R1 is C1- to C5-alkyl or 2-(2-hydroxyethoxy)ethyl, by reacting diethanolamine (DEOA) of the formula II with a primary amine of the formula H2N—R1 (III) in the presence of hydrogen and a catalyst molding, where the reaction is carried out in the liquid phase at an absolute pressure in the range from 150 to 250 bar and the amination is carried out by means of a catalyst molding, the precursor of which can be prepared according to a process in which (i) an oxidic material comprising copper oxide, aluminum oxide and lanthanum oxide is provided, (ii) pulverulent metallic copper and/or copper flakes and optionally graphite is added to the oxidic material, (iii) the mixture resulting from step ii is shaped to give a molding, where the oxidic material is obtainable by simultaneous or successive precipitation of the component copper oxide, of the component aluminum oxide and of the component lanthanum oxide and subsequent drying and calcination and, after the shaping according to step iii, the catalyst molding is calcined again.

摘要翻译： 通过使式II的二乙醇胺（DEOA）与式Ⅰ的伯胺反应制备其中R 1为C 1 -C 5 - 烷基或2-（2-羟基乙氧基）乙基的式I的单-N-烷基哌嗪的方法 在氢气和催化剂模塑的存在下，式H2N-R1（III），其中反应在150-250巴的绝对压力下在液相中进行，并且胺化通过 催化剂成型，其前体可以根据其中（i）包含氧化铜，氧化铝和氧化镧的氧化物质的方法制备，（ii）加入粉末状金属铜和/或铜片以及任选的石墨 （iii）由步骤ii得到的混合物成型为得到模制品，其中氧化材料可通过组分氧化铜，组分氧化铝和组分氧化镧同时或连续沉淀获得，以及 苏 随后干燥和煅烧，并且在根据步骤iii成形之后，再次煅烧催化剂成型。

公开(公告)号：US11518749B2

公开(公告)日：2022-12-06

申请号：US16971650

申请日：2019-02-11

申请人： BASF SE

发明人： Oliver Bussmann ,  Eva Koch ,  Manfred Heilig ,  Joachim Pfeffinger ,  Joerg Pastre ,  Johann-Peter Melder

IPC分类号： C07C217/08 ,  C07C41/42 ,  C07C213/02 ,  C07C213/10 ,  C07D295/03 ,  C07D295/023

摘要： A process for the continuous distillative separation of mixtures comprising morpholine (MO), monoaminodiglycol (ADG), ammonia, water and methoxyethanol (MOE), obtained by reacting diethylene glycol (DEG) with ammonia, wherein ammonia, water, ADG and DEG are removed by distillation and the resulting stream comprising MO and MOE is supplied to a distillation column K40 in which at a top pressure of from 20 to 2000 mbar MO, MOE and organic products having a boiling point 128° C. (1.013 bar) are removed via the bottom and organic products having a boiling point 128° C. are removed overhead, and also MO is removed via a side draw, where K40 is equipped with an evaporator for heating the bottoms, into which is fed heating vapor having a pressure of from 1 to 10 bar.

公开(公告)号：US10941092B2

公开(公告)日：2021-03-09

申请号：US16621050

申请日：2018-06-06

申请人： BASF SE

发明人： Marek Pazicky ,  Martin Ernst ,  Nicolas Marion ,  Rocco Paciello ,  Johann-Peter Melder ,  Hermann Luyken

IPC分类号： C07C29/141 ,  C07D317/26 ,  B01J31/18 ,  C07C31/20

摘要： The present invention relates to a two-stage hydroformylation process for producing pound of the formula (I) and to a process for producing a compound of the formula (V) comprising the two-stage hydroformylation process for producing a compound of the formula (I) followed by hydrogenation of the compound of the formula (I).

公开(公告)号：USRE46374E1

公开(公告)日：2017-04-25

申请号：US15051391

申请日：2016-02-23

申请人： BASF SE

发明人： Thomas Schaub ,  Boris Buschhaus ,  Marion Kristina Da Silva ,  Mathias Schelwies ,  Rocco Paciello ,  Johann-Peter Melder ,  Martin Merger

IPC分类号： C07C213/02 ,  C07D307/52 ,  C07C209/16 ,  C07C211/10 ,  C07C217/08 ,  C07C215/08 ,  C07C211/09 ,  C07C211/18 ,  C07C215/20 ,  C07C211/12 ,  C07D223/04 ,  C07D205/04 ,  C07D207/02 ,  C07D207/20 ,  C07D211/06 ,  C07D295/027

CPC分类号： C07C213/02 ,  C07C209/16 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/02 ,  C07D207/20 ,  C07D211/06 ,  C07D223/04 ,  C07D295/027 ,  C07D307/52 ,  C07C217/08 ,  C07C215/08 ,  C07C211/09 ,  C07C211/10 ,  C07C211/18 ,  C07C215/20 ,  C07C211/12

摘要： Process for preparing primary amines which have at least one functional group of the formula (—CH2—NH2) and at least one further primary amino group by alcohol amination of starting materials having at least one functional group of the formula (—CH2—OH) and at least one further functional group (—X), where (—X) is selected from among hydroxyl groups and primary amino groups, by means of ammonia with elimination of water, wherein the reaction is carried out homogeneously catalyzed in the presence of at least one complex catalyst comprising at least one element selected from groups 8, 9 and 10 of the Periodic Table and also at least one donor ligand.

公开(公告)号：US08981093B2

公开(公告)日：2015-03-17

申请号：US13910554

申请日：2013-06-05

申请人： BASF SE

发明人： Roland Bou Chedid ,  Johann-Peter Melder ,  Ulrich Abel ,  Roman Dostalek ,  Nina Challand ,  Bernd Stein ,  Michael Jödecke

IPC分类号： C07D295/023 ,  C07D241/04 ,  C07C209/28 ,  C07C213/04 ,  C07D295/027

CPC分类号： C07D241/04 ,  C07C209/28 ,  C07C213/04 ,  C07D295/023 ,  C07D295/027

摘要： Process for preparing piperazine of the formula I by reacting diethanolamine (DEOA) of the formula II with ammonia in the presence of hydrogen and a supported, metal-containing catalyst has been found, wherein the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and in the range from 0.2 to 5.0% by weight of oxygen-containing compounds of tin, calculated as SnO, and the reaction is carried out in the liquid phase at an absolute pressure in the range from 160 to 220 bar, a temperature in the range from 180 to 220° C., using ammonia in a molar ratio to DEOA used of from 5 to 25 and in the presence of 0.2 to 9.0% by weight of hydrogen, based on the total amount of DEOA used and ammonia.

摘要翻译： 已经发现通过使式II的二乙醇胺（DEOA）与氢气和负载的含金属的催化剂的氨反应制备式I的哌嗪的方法，其中催化剂的催化活性物质在其还原之前 与氢气一起包含铝，铜，镍和钴的含氧化合物，其含量为0.2至5.0重量％，以SnO计算的含氧化合物锡，反应在液相中进行 使用160-220巴的绝对压力，温度在180-220℃范围内，使用摩尔比为DEA的氨为5至25，在0.2至9.0重量％存在下 的氢气，基于使用的DEOA的总量和氨。

公开(公告)号：US08766009B2

公开(公告)日：2014-07-01

申请号：US13682059

申请日：2012-11-20

申请人： BASF SE

发明人： Norbert Asprion ,  Manfred Julius ,  Oliver Bey ,  Stefanie Werland ,  Frank Stein ,  Matthias Kummer ,  Wolfgang Mägerlein ,  Johann-Peter Melder ,  Kevin Huyghe ,  Maarten Moors

IPC分类号： C07C209/16

CPC分类号： C07C209/16 ,  C07C213/02 ,  C07C211/05 ,  C07C211/06

摘要： A process for preparing ethylamines and monoisopropylamine (MIPA), in which bioethanol is reacted with ammonia in the presence of hydrogen and of a heterogeneous catalyst to give ethylamines, said bioethanol having a content of sulfur and/or sulfur compounds of ≧0.1 ppm by weight (calculated S), and then isopropanol is reacted with ammonia in the presence of the same catalyst and in the presence of hydrogen to give MIPA.

摘要翻译： 一种制备乙胺和单异丙胺（MIPA）的方法，其中生物乙醇在氢气和非均相催化剂存在下与氨反应得到乙胺，所述生物乙醇具有≥0.1ppm重量的硫和/或硫化合物 （计算的S），然后异丙醇在相同催化剂存在下和在氢的存在下与氨反应，得到MIPA。

公开(公告)号：US20140018547A1

公开(公告)日：2014-01-16

申请号：US13940964

申请日：2013-07-12

申请人： BASF SE

发明人： Roland Bou Chedid ,  Johann-Peter Melder ,  Roman Dostalek ,  Jörg Pastre ,  Aik Meam Tan

IPC分类号： C07D295/027

CPC分类号： C07D295/027

摘要： Process for preparing pyrrolidine of the formula I by reacting 1,4-butanediol (BDO) of the formula II with ammonia in the presence of hydrogen and a supported, metal-containing catalyst, wherein the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and in the range from 0.2 to 5.0% by weight of oxygen-containing compounds of tin, calculated as SnO, and the reaction is carried out in the liquid phase at an absolute pressure in the range from 160 to 220 bar, a temperature in the range from 160 to 230° C., using ammonia in a molar ratio to BDO used of from 5 to 50 and in the presence of 1.0 to 4.5% by weight of hydrogen, based on the amount of BDO used.

摘要翻译： 通过使式II的1,4-丁二醇（BDO）与氨在负载的含金属催化剂的存在下与氨反应制备式I的吡咯烷的方法，其中催化剂的催化活性物质在其 用氢还原，包括铝，铜，镍和钴的含氧化合物，并且在0.2至5.0重量％的锡的含氧化合物的锡的范围内，以SnO计算，并且反应在液相中进行 在160-240巴范围内的绝对压力下，温度在160-230℃的范围内，使用与BDO的摩尔比为5至50的氨和在1.0至4.5％的存在下，通过 基于所用BDO的量，氢的重量。

公开(公告)号：US12129217B2

公开(公告)日：2024-10-29

申请号：US17922798

申请日：2021-04-26

申请人： BASF SE

发明人： Martin Ernst ,  Johann-Peter Melder ,  Tatjana Huber ,  Markus Dierker

IPC分类号： C07C1/22 ,  A61K8/31 ,  C07C1/20

CPC分类号： C07C1/22 ,  A61K8/31 ,  C07C1/20 ,  A61K2800/805 ,  C07C2521/08 ,  C07C2523/755

摘要： Continuous reductive dehydroxymethylation process for the preparation of alkanes from primary aliphatic alcohols, having 3 to 25 carbon atoms, in the presence of hydrogen and a catalyst in a reactor at a pressure of ≥2 bar, characterized in that the dehydroxymethylation takes place in the vapor phase.

公开(公告)号：US11274072B2

公开(公告)日：2022-03-15

申请号：US16768505

申请日：2018-11-19

申请人： BASF SE

发明人： Christian Eidamshaus ,  Johann-Peter Melder ,  Joerg Pastre ,  Hans-Juergen Pallasch

IPC分类号： C07C209/16 ,  B01D3/14 ,  B01J21/04 ,  B01J23/72 ,  B01J23/75 ,  B01J23/755 ,  C07C209/02 ,  C07C209/84 ,  C07C211/11 ,  C07C211/14

摘要： A process for the continuous preparation of 1,2-propylenediamine (1,2-PDA) and dimethyldiethylenetriamine (DMDETA) via reaction of monoisopropanolamine (MIPOA) with ammonia in the presence of hydrogen and a supported heterogeneous hydrogenation catalyst (catalyst), wherein the reaction is effected in the liquid phase at an absolute pressure in the range from 60 to 170 bar.