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公开(公告)号：US09790229B2
公开(公告)日：2017-10-17
申请号：US15006061
申请日：2016-01-25
Applicant: Biogen MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D487/14 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04 , A61K31/519
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
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公开(公告)号：US09771326B2
公开(公告)日：2017-09-26
申请号：US14443944
申请日：2013-11-20
Applicant: BIOGEN MA INC.
Inventor： Hairuo Peng , Zhili Xin , Lihong Sun , Timothy Chan , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: C07D211/62 , C07D401/10 , C07D237/14 , C07D215/14 , C07D401/04 , C07D239/34 , C07D417/04 , C07D417/06 , C07C229/14 , C07D249/06 , C07C229/48 , C07C229/50 , C07D487/04 , C07D205/04 , C07D207/16 , C07D277/28 , C07D209/44 , C07D211/34 , C07D211/46 , C07D213/38 , C07D213/65 , A61K31/196 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/427 , A61K31/445 , A61K31/4545 , A61K31/50 , A61K31/505 , A61K45/06
CPC classification number: C07D211/62 , A61K31/196 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/427 , A61K31/445 , A61K31/4545 , A61K31/50 , A61K31/505 , A61K45/06 , C07B2200/07 , C07C229/14 , C07C229/48 , C07C229/50 , C07C2601/14 , C07C2602/44 , C07D205/04 , C07D207/16 , C07D209/44 , C07D211/34 , C07D211/46 , C07D213/38 , C07D213/65 , C07D215/14 , C07D237/14 , C07D239/34 , C07D249/06 , C07D277/28 , C07D401/04 , C07D401/10 , C07D417/04 , C07D417/06 , C07D487/04
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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公开(公告)号：US20170239280A1
公开(公告)日：2017-08-24
申请号：US15397421
申请日：2017-01-03
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/18 , A61K31/223 , A61K31/222 , A61K31/397 , A61K31/401 , A61K31/445 , A61K31/235 , A61K31/197 , A61K31/198 , A61K31/683 , A61K31/662 , A61K31/277 , A61K31/137 , A61K31/41 , A61K31/165 , A61K31/185 , A61K31/337 , A61K45/06
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US20170204093A1
公开(公告)日：2017-07-20
申请号：US15326740
申请日：2015-07-17
Applicant: BIOGEN MA INC.
Inventor： Timothy Chan , Kevin Guckian , Tracy Jenkins , Jermaine Thomas , Jeffery Vessels , Gnanasambandam Kumaravel , Robert Meissner , Joseph Lyssikatos , Brian Lucas , Irina Leaf , Jeremy Duffield
IPC: C07D471/04 , C07D401/12 , C07D405/14 , C07D413/14 , C07B59/00 , C07D401/14 , C07D417/14
CPC classification number: C07D471/04 , A61K31/416 , A61P13/12 , C07B59/002 , C07B2200/05 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号：US09708353B2
公开(公告)日：2017-07-18
申请号：US14620700
申请日：2015-02-12
Applicant: BIOGEN MA INC.
Inventor： Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: C07D263/24 , C07F9/6512 , C07C233/47 , C07C229/36 , C07C217/58 , C07D215/20 , C07F9/60 , C07D239/80
CPC classification number: C07F9/6512 , C07C217/58 , C07C217/74 , C07C229/36 , C07C233/47 , C07C2602/10 , C07D215/06 , C07D215/20 , C07D215/227 , C07D233/32 , C07D239/74 , C07D239/80 , C07D263/24 , C07D277/64 , C07D401/04 , C07F9/091 , C07F9/60 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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Patent Agency Ranking
公开(公告)号：US20170174710A1
公开(公告)日：2017-06-22
申请号：US15368454
申请日：2016-12-02
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Zhili Xin , Lei Zhang
IPC: C07F7/08 , C07C229/50 , A61K31/196 , C07D215/12 , A61K31/47 , C07D401/04 , A61K31/4545 , A61K31/506 , C07D295/096 , A61K31/495 , C07D213/74 , A61K31/496 , A61K31/551 , C07D239/42 , C07D241/20 , A61K31/497 , C07D211/14 , A61K31/451 , C07D205/04 , A61K31/397 , C07D401/06 , A61K31/4709 , C07D491/107 , C07D209/52 , A61K31/403 , C07D451/02 , A61K31/439 , A61K31/695 , C07C233/60 , C07D215/38 , C07D451/14 , A61K45/06
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).
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公开(公告)号：US09572824B2
公开(公告)日：2017-02-21
申请号：US14874600
申请日：2015-10-05
Applicant: Biogen MA Inc.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , A61K31/11 , A61K31/18 , A61K31/216 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/683 , A61K31/662 , A61K31/47 , A61K31/277 , A61K31/41 , A61K31/4709 , A61K31/472 , A61K31/337 , A61K31/517 , A61K31/428 , A61K31/404 , A61K45/06 , A61K31/085 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C309/14 , C07C311/51 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D217/24 , C07D257/04 , C07D305/08 , C07D403/06 , C07D417/06 , C07F9/38 , C07F9/40 , C07C43/247 , C07C47/575 , C07C255/54 , C07D215/227 , C07D217/04 , C07D239/74 , C07D277/64 , C07D401/06 , C07F7/08
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是肌氨酸 - 甙类似物，磷酸化后，可以作为S1P受体的激动剂。
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公开(公告)号：US09555050B2
公开(公告)日：2017-01-31
申请号：US14417353
申请日：2013-07-26
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: C07D215/20 , A61K31/662 , A61K45/06 , C07D401/04 , C07D401/06 , C07C229/48 , C07D265/30 , C07D211/34 , C07D211/62 , C07D213/79 , C07D223/06 , C07C233/47 , C07D205/04 , C07D207/08 , C07D207/16 , C07C229/46 , C07F9/38 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , C07D213/80
CPC classification number: A61K31/662 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C229/46 , C07C229/48 , C07C233/47 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/26 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07D213/79 , C07D213/80 , C07D215/20 , C07D223/06 , C07D265/30 , C07D401/04 , C07D401/06 , C07F9/38 , C07F9/3808
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可调节自分泌素（ATX）的活性。
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公开(公告)号：US20160376281A1
公开(公告)日：2016-12-29
申请号：US15006061
申请日：2016-01-25
Applicant: Biogen MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D487/14 , C07D413/14 , C07D417/14 , C07D401/14 , C07D401/04 , C07D473/34
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US09522889B2
公开(公告)日：2016-12-20
申请号：US14417300
申请日：2013-07-26
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: A61K31/015 , A61K31/44 , A61K31/4375 , C07D295/096 , C07D223/06 , A61K45/06 , C07D217/22 , C07D471/08 , C07D211/34 , C07D211/62 , C07C255/59 , C07C229/46 , C07C229/48 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/5375 , A61K31/55 , C07C217/22 , C07D209/52 , C07D221/22
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
Abstract translation: 公开了式（I）的双环芳基化合物，其可以调节自分泌素（ATX）酶的活性。 本发明还涉及作为ATX抑制剂的化合物，以及制备和使用这些化合物治疗由于损伤或疾病引起的脱髓鞘以及治疗增殖性疾病如癌症的方法。
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