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    Taxane coatings for implantable medical devices
    23.
    发明申请
    Taxane coatings for implantable medical devices 有权
    可植入医疗器械的紫杉烷涂层

    公开(公告)号：US20070212394A1

    公开(公告)日：2007-09-13

    申请号：US11715975

    申请日：2007-03-08

    Applicant: Priscilla Reyes ,  William Moore ,  Patrick Ruane ,  Darin Schaeffer

    Inventor： Priscilla Reyes ,  William Moore ,  Patrick Ruane ,  Darin Schaeffer

    IPC: A61K31/337 ,  A61F2/02

    CPC classification number: A61L27/54 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61K31/337 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606

    Abstract: This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.

    Abstract translation: 本公开涉及涂覆有紫杉烷治疗剂（例如紫杉醇）的可植入医疗装置，其具有不同溶解速率的一种或多种固体形式。 特别优选的涂层包括紫杉烷治疗剂的无定形和/或溶剂化固体形式，其提供耐久性涂层，其在期望的时间段内释放紫杉烷，其可以在不存在聚合物的情况下变化，通过选择固体形式的类型和量 紫杉烷治疗剂在涂层中。 其它优选实施方案涉及涂覆医疗装置的方法和治疗方法。 涂层可以在体内容器内提供紫杉烷治疗剂的持续释放而不含聚合物以达到期望的紫杉醇洗脱速率。

    Self centering delivery catheter
    24.
    发明授权
    Self centering delivery catheter 有权
    自动定心输送导管

    公开(公告)号：US07232462B2

    公开(公告)日：2007-06-19

    申请号：US10814988

    申请日：2004-03-31

    Applicant: Darin Schaeffer

    Inventor： Darin Schaeffer

    IPC: A61F2/01 ,  A61M25/00 ,  A61M29/00

    CPC classification number: A61F2/01 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/005 ,  A61F2230/008

    Abstract: A self centering delivery catheter is provided for delivering a filter into a vessel in a centered manner which aids in the retrieval of the filter. The delivery catheter generally includes an outer sheath and a cannula disposed inside the outer sheath and axially translatable relative thereto. A set of centering legs are attached to the cannula. The centering legs are operable between a first retracted position and a second extended position, the centering legs moving radially away from the cannula as the centering legs move from the retracted position to the extended position. The relative position of the outer sheath and cannula control the operation of the centering legs. A control wire is disposed inside the cannula and is axially translatable relative thereto. Axial translation of the control wire operates a release mechanism to disengage the filter for delivering the filter into the vessel.

    Abstract translation: 提供自定心输送导管，用于以中心方式将过滤器输送到容器中，这有助于过滤器的回收。 输送导管通常包括外护套和设置在外护套内部并相对于其可轴向平移的套管。 一组中心腿连接到插管。 定心腿可在第一缩回位置和第二延伸位置之间操作，当定心腿从缩回位置移动到延伸位置时，定心腿从插管径向移动。 外护套和套管的相对位置控制定心腿的操作。 控制线设置在套管内部并且可相对于其轴向平移。 控制线的轴向平移操作释放机构以使过滤器脱离以将过滤器输送到容器中。

    Flexible tip
    25.
    发明申请
    Flexible tip 审中-公开
    弹性提示

    公开(公告)号：US20070135830A1

    公开(公告)日：2007-06-14

    申请号：US10591367

    申请日：2005-10-05

    Applicant: Darin Schaeffer

    Inventor： Darin Schaeffer

    IPC: A61M29/00

    CPC classification number: A61M25/0069 ,  A61M25/0043 ,  A61M25/0068 ,  A61M25/0074 ,  A61M25/008 ,  A61M25/10 ,  A61M2025/1093

    Abstract: An elongate flexible catheter tip is disclosed herein. This catheter tip may include a longitudinal axis extending between a proximal end and a distal end. It may further comprise a corrugated region located between the proximal end and the distal end. The elongate flexible catheter tip, as disclosed herein, may be employed with a large variety of dilation catheters.

    Abstract translation: 本文公开了一种细长的柔性导管尖端。 该导管尖端可以包括在近端和远端之间延伸的纵向轴线。 它还可以包括位于近端和远端之间的波纹区域。 如本文所公开的，细长的柔性导管末端可以与多种扩张导管一起使用。

    Coated implantable medical device
    26.
    发明申请
    Coated implantable medical device 有权
    涂层可植入医疗器械

    公开(公告)号：US20070050010A1

    公开(公告)日：2007-03-01

    申请号：US11515395

    申请日：2006-09-01

    Applicant: Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    Inventor： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    IPC: A61F2/86 ,  A61F2/06

    CPC classification number: A61F2/91 ,  A61F2/24 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61N5/1002 ,  C08L65/04

    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    Abstract translation: 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

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