公开(公告)号：US20140274945A1

公开(公告)日：2014-09-18

申请号：US14210873

申请日：2014-03-14

Applicant: Covidien LP

Inventor： Phillip Blaskovich ,  Rachit Ohri ,  Olga Cherniavsky

IPC: A61K31/717 ,  A61K31/43 ,  A61K31/545 ,  A61K31/738

CPC classification number: A61K31/717 ,  A61L24/06 ,  A61L2430/36 ,  C08L1/04

Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.

Abstract translation: 公开了一种在血管内形成栓塞的方法。 该方法包括：将多个氧化的纤维素微球体注入血管的内腔，以至少部分阻断内腔。

公开(公告)号：US20140274944A1

公开(公告)日：2014-09-18

申请号：US14197634

申请日：2014-03-05

Applicant: Covidien LP

Inventor： Rachit Ohri ,  Phillip Blaskovich ,  Stephen Wu

IPC: A61K31/717 ,  A61M11/00

CPC classification number: A61K31/717 ,  A61L26/0014 ,  A61L26/0023 ,  A61L26/0076 ,  A61L2400/04 ,  A61M11/001 ,  C08B15/005 ,  C08B15/10 ,  C08L1/02 ,  C08L5/08 ,  C08L33/04

Abstract: An applicator for forming a film is disclosed. The applicator includes: a first extension tube coupled to a source of a modified cellulose solution; a shaft coupled to the first extension tube at a proximal end thereof, the shaft defining a first lumen in fluid communication with the first extension tube for transmission of the modified cellulose solution through the shaft; and an atomizer disposed at a distal end of the and configured to atomize the modified cellulose solution into a plurality of particles.

Abstract translation: 公开了一种用于形成薄膜的涂布器。 施用器包括：连接到改性纤维素溶液源的第一延伸管; 轴在其近端处联接到所述第一延伸管，所述轴限定与所述第一延伸管流体连通的第一腔，用于通过所述轴传播所述改性纤维素溶液; 以及设置在所述雾化器的远端并且被配置成将所述改性纤维素溶液雾化成多个颗粒的雾化器。

公开(公告)号：US20140228559A1

公开(公告)日：2014-08-14

申请号：US14129187

申请日：2012-06-28

Applicant: COVIDIEN LP

Inventor： Valentino J. Tramontano ,  Joshua Kennedy ,  Sajida Farooqi ,  Phillip D. Blaskovich ,  Rachit Ohri ,  Daniel S. Costa

IPC: C08B15/02

CPC classification number: C08B16/00 ,  A61K9/1652 ,  C08B15/02 ,  C08J3/091 ,  C08J3/096 ,  C08J3/12 ,  C08J2301/02 ,  C08J2301/04 ,  C08K3/16 ,  C08K5/20 ,  C08K5/3415 ,  C08L1/04

Abstract: A process for dissolving modified cellulose is disclosed. The process includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose.

Abstract translation: 公开了一种溶解改性纤维素的方法。 该方法包括使改性纤维素与溶剂在混合物中接触以形成溶胀的改性纤维素，然后使该混合物与盐接触以溶解溶胀的改性纤维素。

公开(公告)号：US20140005376A1

公开(公告)日：2014-01-02

申请号：US13927313

申请日：2013-06-26

Applicant: Covidien LP ,  Confluent Surgical, Inc.

Inventor： Valentino Tramontano ,  Phillip Blaskovich ,  Rachit Ohri ,  Daniel S. Costa ,  Joshua Kennedy ,  Sajida Farooqi

IPC: C08B15/00 ,  C08B15/02

CPC classification number: C08B1/003 ,  C08B15/00 ,  C08B15/005 ,  C08B15/02 ,  C08J3/096 ,  C08J3/14 ,  C08J2301/04

Abstract: A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one non-solvent to form a plurality of modified cellulose particles.

Abstract translation: 用于溶解改性纤维素的方法包括使改性纤维素溶液与至少一种非溶剂接触以形成多个改性的纤维素颗粒。

公开(公告)号：US20200016081A1

公开(公告)日：2020-01-16

申请号：US16581817

申请日：2019-09-25

Applicant: Covidien LP

Inventor： Rachit Ohri ,  Gary R. Strichartz ,  Phillip Blaskovich

IPC: A61K9/16 ,  A61K31/445

Abstract: A microsphere is disclosed. The microsphere includes at least one biodegradable polymer and at least one local anesthetic, wherein about 75% of the at least one local anesthetic is released by about 72 hours and from about 80% to about 90% of the at least one local anesthetic is released by about 120 hours, thereby relieving chronic pain for at least 28 days.

公开(公告)号：US10449152B2

公开(公告)日：2019-10-22

申请号：US14848385

申请日：2015-09-09

Applicant: Covidien LP

Inventor： Rachit Ohri ,  Gary R. Strichartz ,  Phillip Blaskovich

IPC: A61K9/16 ,  A61K31/445 ,  A61K9/00

Abstract: A microsphere is claimed which includes at least one biodegradable polymer and at least one local anesthetic, wherein about 75% of the at least one local anesthetic is released by about 72 hours and from about 80% to about 90% of the at least one local anesthetic is released by about 120 hours, thereby relieving chronic pain for at least 28 days.

公开(公告)号：US10328095B2

公开(公告)日：2019-06-25

申请号：US14210873

申请日：2014-03-14

Applicant: Covidien LP

Inventor： Phillip Blaskovich ,  Rachit Ohri ,  Olga Cherniavsky

IPC: A61K31/717 ,  A61L24/06

Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting a plurality of oxidized cellulose microspheres into a lumen of a blood vessel to at least partially block the lumen.

公开(公告)号：US10188608B2

公开(公告)日：2019-01-29

申请号：US15593871

申请日：2017-05-12

Applicant: Covidien LP

Inventor： Phillip Blaskovich ,  Rachit Ohri ,  Lan Pham

IPC: A61L15/28 ,  A61K9/16 ,  A61K31/714 ,  A61K31/445 ,  A61K33/24 ,  B01J13/12 ,  A61L27/20

Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.

公开(公告)号：US09814844B2

公开(公告)日：2017-11-14

申请号：US14011414

申请日：2013-08-27

Applicant: COVIDIEN LP

Inventor： Rachit Ohri ,  Lan Pham ,  Phillip D. Blaskovich ,  Les Hull ,  Rupal Ayer ,  Stephen H. Wu ,  Clifford J. Herman ,  William H. Nau, Jr. ,  Francesca Rossetto ,  Allison Waller ,  Wenxing Huang ,  Paul DiCarlo ,  Mantao Xu ,  Xingyan Lu ,  Jiagui Li ,  Qinlin Gu ,  Harold M. Martins

IPC: A61M5/32 ,  A61B17/34 ,  A61B18/14 ,  A61M25/00 ,  A61B18/00

CPC classification number: A61M5/329 ,  A61B17/3421 ,  A61B17/3478 ,  A61B18/1477 ,  A61B18/1487 ,  A61B2017/3447 ,  A61B2018/00577 ,  A61B2018/143 ,  A61B2218/002 ,  A61M25/00 ,  A61M25/0097 ,  A61M2025/0037 ,  A61M2202/0007

Abstract: A drug-delivery cannula assembly includes a cannula housing adapted for receiving at least one obturator shaft of an obturator assembly therethrough, one or more cannulae, and a supply line coupled to the cannula housing. The cannula housing is adapted for receiving one or more obturator shafts of an obturator assembly therethrough. The one or more cannulae define a longitudinal axis and a passageway aligned with the longitudinal axis. The one or more cannulae each include a proximal end coupled to the cannula housing. The cannula housing is configured to fluidly-couple the one or more cannulae to a source of a drug delivery supply for supplying drugs via the supply line to the one or more cannulae.

公开(公告)号：US09271937B2

公开(公告)日：2016-03-01

申请号：US13903297

申请日：2013-05-28

Applicant: Covidien LP

Inventor： Phillip Blaskovich ,  Valentino Tramontano ,  Joshua Kennedy ,  Rachit Ohri

IPC: A61K9/16 ,  A61K31/714 ,  A61K31/445 ,  A61K33/24 ,  B01J13/12

CPC classification number: A61K9/1682 ,  A61K9/1652 ,  A61K9/1694 ,  A61K31/445 ,  A61K31/714 ,  A61K33/24 ,  A61L15/28 ,  A61L27/20 ,  B01J13/12 ,  B01J13/125

Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.

Abstract translation: 公开了一种形成微球的方法。 该方法包括使溶剂与改性纤维素接触以形成溶液; 使改性纤维素溶液与至少一种生物活性剂接触以形成不连续相液体; 使不连续相液体与连续相液体接触以形成乳液; 并将乳液与第三相液体接触以从乳液中提取溶剂，从而形成多个改性的纤维素微球。