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公开(公告)号：US11873350B2
公开(公告)日：2024-01-16
申请号：US17233694
申请日：2021-04-19
Applicant: Covidien LP
Inventor： Valentino J. Tramontano , Joshua Kennedy , Philip D. Blaskovich , Rachit Ohri , Daniel S. Costa , Sajida Farooqi
IPC: C08B16/00 , C08K3/16 , C08K5/20 , C08K5/3415 , C08J3/09 , C08B15/02 , C08J3/12 , C08L1/04 , A61K9/16
CPC classification number: C08B16/00 , C08B15/02 , C08J3/091 , C08J3/096 , C08J3/12 , C08K3/16 , C08K5/20 , C08K5/3415 , C08L1/04 , A61K9/1652 , C08J2301/02 , C08J2301/04 , C08L1/04 , C08K3/16 , C08K5/3415 , C08L1/04 , C08K3/16 , C08K5/20 , C08K3/06 , C08L1/04 , C08K5/3415 , C08L1/04 , C08K5/20 , C08L1/04
Abstract: A process for dissolving modified cellulose is disclosed. The process includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose.
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2.发明授权公开(公告)号：US11053323B2
公开(公告)日：2021-07-06
申请号：US15344633
申请日：2016-11-07
Applicant: Covidien LP
Inventor： Phillip Blaskovich , Valentino Tramontano , Rachit Ohri , Joshua Kennedy , Christopher M. Henry
Abstract: A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.
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公开(公告)号：US10040871B2
公开(公告)日：2018-08-07
申请号：US13927311
申请日：2013-06-26
Applicant: Confluent Surgical, Inc. , Covidien LP
Inventor： Valentino Tramontano , Phillip Blaskovich , Rachit Ohri , Joshua Kennedy , Sajida Farooqi
Abstract: A process for dissolving modified cellulose includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose. The dissolved modified cellulose is used to form at least one of a predictably degrading coating, film, or a fiber.
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4.发明授权Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations 有权通过与多价阳离子交联，氧化纤维素和颗粒制剂的溶解公开(公告)号：US09499636B2
公开(公告)日：2016-11-22
申请号：US13927316
申请日：2013-06-26
Applicant: Confluent Surgical, Inc. , Covidien LP
Inventor： Phillip Blaskovich , Valentino Tramontano , Rachit Ohri , Daniel S. Costa , Joshua Kennedy , Sajida Farooqi
CPC classification number: C08B1/003 , C08B15/00 , C08B15/005 , C08B15/02 , C08J3/075 , C08J3/096 , C08J3/14 , C08J2301/04 , C08L1/04
Abstract: A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.
Abstract translation: 溶解改性纤维素的方法包括将改性纤维素溶液与至少一种多价阳离子接触以形成多个改性纤维素颗粒。
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公开(公告)号：US10584184B2
公开(公告)日：2020-03-10
申请号：US16022772
申请日：2018-06-29
Applicant: Covidien LP
Inventor： Valentino Tramontano , Phillip Blaskovich , Rachit Ohri , Joshua Kennedy , Sajida Farooqi
Abstract: A process for dissolving modified cellulose includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose. The dissolved modified cellulose is used to form at least one of a predictably degrading coating, film, or a fiber.
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Patent Agency Ranking
公开(公告)号：US09687450B2
公开(公告)日：2017-06-27
申请号：US15054479
申请日：2016-02-26
Applicant: Covidien LP
Inventor： Phillip Blaskovich , Valentino Tramontano , Joshua Kennedy , Rachit Ohri
IPC: A61K9/16 , A61K31/714 , A61K31/445 , A61K33/24 , B01J13/12 , A61L15/28 , A61L27/20
CPC classification number: A61K9/1682 , A61K9/1652 , A61K9/1694 , A61K31/445 , A61K31/714 , A61K33/24 , A61L15/28 , A61L27/20 , B01J13/12 , B01J13/125
Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
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公开(公告)号：US20170066846A1
公开(公告)日：2017-03-09
申请号：US15353997
申请日：2016-11-17
Applicant: Covidien LP
Inventor： Valentino J. Tramontano , Joshua Kennedy , Sajida Farooqi , Phillip D. Blaskovich , Rachit Ohri , Daniel S. Costa
CPC classification number: C08B16/00 , A61K9/1652 , C08B15/02 , C08J3/091 , C08J3/096 , C08J3/12 , C08J2301/02 , C08J2301/04 , C08K3/16 , C08K5/20 , C08K5/3415 , C08L1/04
Abstract: A process for dissolving modified cellulose is disclosed. The process includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose.
Abstract translation: 公开了一种溶解改性纤维素的方法。 该方法包括使改性纤维素与溶剂在混合物中接触以形成溶胀的改性纤维素，然后使该混合物与盐接触以溶解溶胀的改性纤维素。
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8.发明申请Crosslinked Polymers with the Crosslinker as Therapeutic for Sustained Release 有权交联聚合物与交联剂作为持续释放的治疗剂公开(公告)号：US20130225857A1
公开(公告)日：2013-08-29
申请号：US13862500
申请日：2013-04-15
Applicant: Confluent Surgical, Inc. , Covidien LP
Inventor： Rachit Ohri , Phillip Blaskovich , Joshua Kennedy , Steven L. Bennett , Arthur Driscoll
IPC: C07C231/02 , C08G65/00
CPC classification number: C07C231/02 , A61K47/30 , A61K47/60 , A61K47/6903 , C07D207/46 , C08G65/00 , Y10T428/31551
Abstract: Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
Abstract translation: 描述了交联聚合物，其制备和使用方法，其中交联聚合物由至少两种聚合物前体形成，其中一种聚合物前体在交联聚合物降解时被设计为以其原始的未改性的方式释放第二聚合物前体 化学形式。
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公开(公告)号：US09271937B2
公开(公告)日：2016-03-01
申请号：US13903297
申请日：2013-05-28
Applicant: Covidien LP
Inventor： Phillip Blaskovich , Valentino Tramontano , Joshua Kennedy , Rachit Ohri
IPC: A61K9/16 , A61K31/714 , A61K31/445 , A61K33/24 , B01J13/12
CPC classification number: A61K9/1682 , A61K9/1652 , A61K9/1694 , A61K31/445 , A61K31/714 , A61K33/24 , A61L15/28 , A61L27/20 , B01J13/12 , B01J13/125
Abstract: A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
Abstract translation: 公开了一种形成微球的方法。 该方法包括使溶剂与改性纤维素接触以形成溶液; 使改性纤维素溶液与至少一种生物活性剂接触以形成不连续相液体; 使不连续相液体与连续相液体接触以形成乳液; 并将乳液与第三相液体接触以从乳液中提取溶剂，从而形成多个改性的纤维素微球。
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10.发明授权Crosslinked polymers with the crosslinker as therapeutic for sustained release 有权具有交联剂的交联聚合物作为持续释放的治疗剂公开(公告)号：US08889889B2
公开(公告)日：2014-11-18
申请号：US13862500
申请日：2013-04-15
Applicant: Confluent Surgical, Inc. , Covidien LP
Inventor： Rachit Ohri , Phillip Blaskovich , Joshua Kennedy , Steven L. Bennett , Arthur Driscoll
IPC: C07D207/46 , A61K47/30 , C07C231/02 , A61K47/48 , C08G65/00
CPC classification number: C07C231/02 , A61K47/30 , A61K47/60 , A61K47/6903 , C07D207/46 , C08G65/00 , Y10T428/31551
Abstract: Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
Abstract translation: 描述了交联聚合物，其制备和使用方法，其中交联聚合物由至少两种聚合物前体形成，其中一种聚合物前体在交联聚合物降解时被设计为以其原始的未改性的方式释放第二聚合物前体 化学形式。
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