-
21.发明授权Methods of making amidino compounds useful as nitric oxide synthase inhibitors 有权制备脒基化合物可用作一氧化氮合酶抑制剂的方法公开(公告)号：US07102013B2
公开(公告)日：2006-09-05
申请号：US10321969
申请日：2002-12-17
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： C07D233/40 , C07C271/00 , C07C323/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: where the substituents are described herein.
摘要翻译： 制备具有式32结构的α-氨基酸化合物的方法：包括在水解条件下处理具有结构式33的乙内酰脲化合物：其中取代基在本文中描述。
-
22.发明授权2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers 失效2 - [（咪唑并[1,2-a]吡啶-3-基甲基）亚磺酰基] -1H-苯并咪唑可用于治疗和预防溃疡
公开(公告)号：US4721718A
公开(公告)日：1988-01-26
申请号：US897687
申请日：1986-08-18
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： This invention relates to 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles that are useful in the treatment and prevention of ulcers.
摘要翻译： 本发明涉及可用于治疗和预防溃疡的2 - [（咪唑并[1,2-a]吡啶-3-基甲基）亚磺酰基] -1H-苯并咪唑。
-
23.发明授权2-[(Aminophenyl and amidophenyl)amino]-1-azacycloalkanes having antidiarrheal activity 失效2 - 具有止泻活性的[（氨基苯基和氨基苯基）氨基] -1-氮杂环烷烃
公开(公告)号：US4533739A
公开(公告)日：1985-08-06
申请号：US433922
申请日：1982-10-12
IPC分类号： A61K31/445 , A61K31/55 , A61P1/12 , C07C67/00 , C07C231/00 , C07C233/43 , C07D207/22 , C07D207/40 , C07D211/72 , C07D223/12 , C07D207/18
CPC分类号： C07D211/72 , C07D207/22 , C07D223/12 , Y10S514/867
摘要： This invention relates to the novel use of certain aromatic substituted amidines as antidiarrheals.
摘要翻译： 本发明涉及某些芳族取代的脒类作为止泻药的新用途。
-
24.发明授权6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade 失效可用于选择性抑制凝血级联的6元杂环化合物公开(公告)号：US06969715B2
公开(公告)日：2005-11-29
申请号：US10263637
申请日：2002-10-03
申请人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
发明人： Michael S. South , Ronald K. Webber , Horng-Chih Huang , Mihaly V. Toth , Alan E. Moormann , Jeffery S. Snyder , Jeffrey A. Scholten , Danny J. Garland , Melvin L. Rueppel , William L. Neumann , Scott Long , Wei Huang , John Trujillo , John J. Parlow , Darin E. Jones , Brenda Case , Michael J. Hayes
IPC分类号： C07D249/12 , A61K31/451 , A61K31/495 , A61K31/50 , A61K31/513 , A61K31/53 , A61K31/535 , A61K45/00 , A61P7/02 , A61P9/10 , A61P43/00 , C07C257/18 , C07D207/32 , C07D211/56 , C07D211/98 , C07D213/74 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
CPC分类号： C07D213/74 , C07C257/18 , C07C2601/04 , C07C2601/10 , C07D207/32 , C07D211/56 , C07D211/98 , C07D231/38 , C07D231/48 , C07D237/04 , C07D239/10 , C07D239/22 , C07D241/04 , C07D241/20 , C07D249/14 , C07D253/06 , C07D253/075 , C07D263/48 , C07D265/02 , C07D277/42 , C07D307/22 , C07D333/36 , C07D401/12 , C07D403/10 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
-
公开(公告)号：US06403830B2
公开(公告)日：2002-06-11
申请号：US09816577
申请日：2001-03-23
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey S. Snyder , Mahima Trivedi , Sofya Tsymbalov
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey S. Snyder , Mahima Trivedi , Sofya Tsymbalov
IPC分类号： C07C32358
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.
-
公开(公告)号：US5098915A
公开(公告)日：1992-03-24
申请号：US403205
申请日：1989-09-05
IPC分类号： C07D401/12 , C07D405/12
CPC分类号： C07D401/12 , C07D405/12
摘要： Substituted N-benzylpiperidine amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compunds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.
摘要翻译： 取代的N-苄基哌啶酰胺，其具有作为III类抗心律失常药物的活性，通过延长心脏动作电位复极化起作用。 本发明还提供了掺入其组合物及其使用方法的组合物，以及提供化合物的药学上可接受的盐。
-
公开(公告)号：US07196118B2
公开(公告)日：2007-03-27
申请号：US11032650
申请日：2005-01-10
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31/195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译： 本发明涉及脒基化合物及其盐和前药。 在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。 在另一个实施方案中，本发明提供了制备脒基化合物的方法。
-
公开(公告)号：US06586474B2
公开(公告)日：2003-07-01
申请号：US09816575
申请日：2001-03-23
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
-
![Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors](/abs-image/US/2003/04/22/US06552052B2/abs.jpg.150x150.jpg)
29.发明授权Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors 失效吡咯并[2,1-c] [1,2,4]噻二唑和Pyrollo [2,1-c] [1,12,4]恶二唑可用作一氧化氮合酶抑制剂公开(公告)号：US06552052B2
公开(公告)日：2003-04-22
申请号：US09818297
申请日：2001-03-26
申请人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
发明人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
IPC分类号： C07D27112
CPC分类号： C07D487/04 , C07D513/04 , C07D515/04 , C07F9/6561
摘要： Pyrrolo[2,1-c][1,2,4]thiadiazole or pyrollo[2,1-c][1,2,4]oxadiazoles having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein.
摘要翻译： 具有下式的吡咯并[2,1-c] [1,2,4]噻二唑或pyrollo [2,1-c] [1,2,4]恶二唑或其药学上可接受的盐，其可用作一氧化氮合酶抑制剂，其中 每个取代基在本文中定义。
-
公开(公告)号：US06495544B2
公开(公告)日：2002-12-17
申请号：US09920612
申请日：2001-08-01
申请人： Donald W. Hansen, Jr. , Jeffrey S. Snyder , Alan E. Moormann , Alok K. Awasthi , Ronald Keith Webber , Thaddeus S. Franczyk , Mahima Trivedi
发明人： Donald W. Hansen, Jr. , Jeffrey S. Snyder , Alan E. Moormann , Alok K. Awasthi , Ronald Keith Webber , Thaddeus S. Franczyk , Mahima Trivedi
IPC分类号： A61K3155
CPC分类号： C07D223/12 , C07D223/10
摘要： Homoiminopiperidinyl Hexanoic Acid derivatives and pharmaceutically acceptable salts thereof useful in the inhibition of the inducible isoform of nitric oxide synthase are disclosed.
-
-
-
-
-
-
-
-
-
搜索结果
37 条记录 (耗时 0.044 秒)
