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21.发明申请Methods and Devices for Forming Biomedical Coatings Using Variable Mixing Ratios of Multi-Part Compositions 审中-公开使用多部件组合物的可变混合比形成生物医学涂层的方法和装置公开(公告)号：US20150250463A1
公开(公告)日：2015-09-10
申请号：US14199173
申请日：2014-03-06
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , An-Min Jason Sung , Leo B. Kriksunov
CPC classification number: A61B17/00491 , A61B2017/00495 , A61B2017/00522 , A61M5/16827 , A61M5/19 , A61M5/3129 , A61M11/00 , A61M2005/31598 , B05B11/3059 , B05B11/3083 , B05B11/3084
Abstract: The present invention relates devices capable of continuous and simultaneous expression of components of a multi-part biomedical composition with variable mixing ratios. The device has at least two syringes that contain the inter-reactive components of the multi-part biomedical composition. At least the barrel of the first syringe has a first retention compartment having a cross-sectional area dimension that is larger than the cross-sectional area of a second retention compartment. The first piston has a cross-sectional dimension that matches the inside cross-sectional dimension of the small dimensioned retention compartment, while a ring-shaped gasket is located within the large dimensioned retention compartment and has an outside cross-sectional dimension that matches an interior dimension of the large dimension retention compartment.
Abstract translation: 本发明涉及能够以可变混合比连续并同时表达多部分生物医学组合物的组分的装置。 该装置具有至少两个注射器，其包含多部分生物医学组合物的反应活性成分。 至少第一注射器的筒体具有第一保留隔室，其具有比第二保留隔室的横截面面积大的横截面积尺寸。 第一活塞具有与小尺寸的保持隔室的内部横截面尺寸相匹配的横截面尺寸，而环形垫圈位于大尺寸的保持隔室内并且具有与内部相匹配的外部横截面尺寸 尺寸大的保留隔间。
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22.发明申请Absorbable Bimodal Polymeric Blend Compositions, Processing Methods, and Medical Devices 有权可吸收双峰聚合物混合组合物，加工方法和医疗器械公开(公告)号：US20150159011A1
公开(公告)日：2015-06-11
申请号：US14533274
申请日：2014-11-05
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Sasa Andjelic , Brian M. Kelly , Christopher DeFelice
CPC classification number: C08L67/04 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61B2017/00831 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/148 , C08G63/664 , C08L2201/06 , C08L2203/02 , C08L2205/02 , C08L2205/025
Abstract: Novel absorbable polymeric blends having bimodal molecular weight distribution are disclosed. The bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a bimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of unimodal or bimodal molecular weight distribution. Alternately, the bimodal blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide having a unimodal molecular weight distribution, and a second component that is a poly(p-dioxanone) polymer of bimodal molecular weight distribution. The novel polymeric bimodal molecular weight blends provide medical devices having improved dimensional stability. Also disclosed are novel absorbable medical devices made from these novel bimodal polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了具有双峰分子量分布的新型可吸收聚合物共混物。 双峰共混物具有第一组分，其是聚丙交酯聚合物或具有双峰分子量分布的丙交酯和乙交酯的共聚物，以及作为单峰或双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 或者，双峰共混物具有第一组分，其是具有单峰分子量分布的聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及作为双峰分子量分布的聚（对二恶烷酮）聚合物的第二组分。 新型聚合双峰分子量共混物提供具有改进的尺寸稳定性的医疗装置。 还公开了由这些新型双峰聚合物共混物制成的新型可吸收医疗装置，以及新颖的制造方法。
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23.发明申请公开(公告)号：US20130315963A1
公开(公告)日：2013-11-28
申请号：US13833690
申请日：2013-03-15
Applicant: ETHICON, INC.
Inventor： Modesto Erneta , Daniel Steiger , Dennis D. Jamiolkowski
Abstract: Novel absorbable polymer blends are disclosed. The blends are useful for manufacturing medical devices having engineered degradation and breaking strength retention in vivo. The blends consist of a first absorbable polymeric component and a second absorbable polymeric component. The weight average molecular weight of the first polymeric component is higher than the weight average molecular weight of the second polymeric component. At least at least one of said components is at least partially end-capped by a carboxylic acid group. Further aspects are medical devices made therefrom.
Abstract translation: 公开了新颖的可吸收聚合物共混物。 该混合物可用于制造具有工程化降解和体内断裂强度保留的医疗装置。 共混物由第一可吸收聚合物组分和第二可吸收聚合物组分组成。 第一聚合物组分的重均分子量高于第二聚合物组分的重均分子量。 所述组分中的至少一种至少部分被羧酸基部分封端。 其他方面是由其制成的医疗装置。
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24.发明申请Copolymers of E-Caprolactone and Glycolide for Melt Blown Nonwoven Applications 有权用于熔喷无纺布应用的ε-己内酯和乙交酯共聚物公开(公告)号：US20130029556A1
公开(公告)日：2013-01-31
申请号：US13630062
申请日：2012-09-28
Applicant: Ethicon, Inc
Inventor： Modesto Erneta , Dennis D. Jamiolkowski , Jianguo J. Zhou , Sasa Andjelic
IPC: D04H1/56
CPC classification number: C08G63/08 , B29C47/0014 , B29C47/385 , B29C47/6087 , B29C47/889 , B29C2947/92514 , B29C2947/9259 , B29C2947/92704 , B29C2947/92885 , B29C2947/92895 , B29C2947/92904 , D04H1/56 , D04H3/02 , D04H3/16 , Y10T442/68
Abstract: Copolymers exhibiting the following combinations of properties, including without limitation, ε-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.
Abstract translation: 表现出以下组合性能的共聚物，包括但不限于约12至约70摩尔％的量的ε-己内酯，其量为约30至约88摩尔％，约10至约88摩尔％的结晶度 通过WAXD测量为50％，通过DSC测量为约10至约50J / g，并且在25℃下以0.1g / dl HFIP溶液测量的特性粘度为约0.5至约1.45dL / g。 ; 本文描述了熔融吹制由此产生的共聚物和非织造构造物的方法。
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公开(公告)号：US11596709B2
公开(公告)日：2023-03-07
申请号：US17349535
申请日：2021-06-16
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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Patent Agency Ranking
26.发明申请公开(公告)号：US20180368824A1
公开(公告)日：2018-12-27
申请号：US16106278
申请日：2018-08-21
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , An-Min Jason Sung , Leo B. Kriksunov
CPC classification number: A61B17/00491 , A61B2017/00495 , A61B2017/00522 , A61M5/16827 , A61M5/19 , A61M5/3129 , A61M11/00 , A61M2005/31598 , B05B11/3059 , B05B11/3083 , B05B11/3084
Abstract: The present invention relates devices capable of continuous and simultaneous expression of components of a multi-part biomedical composition with variable mixing ratios. The device has at least two syringes that contain the inter-reactive components of the multi-part biomedical composition. At least the barrel of the first syringe has a first retention compartment having a cross-sectional area dimension that is larger than the cross-sectional area of a second retention compartment. The first piston has a cross-sectional dimension that matches the inside cross-sectional dimension of the small dimensioned retention compartment, while a ring-shaped gasket is located within the large dimensioned retention compartment and has an outside cross-sectional dimension that matches an interior dimension of the large dimension retention compartment.
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27.发明申请公开(公告)号：US20180333247A1
公开(公告)日：2018-11-22
申请号：US16049871
申请日：2018-07-31
Applicant: Ethicon, Inc.,
Inventor： Anthony Miksza , Robert Nering , MarK D. Kenyon , Omar J. Vakharia , Dennis D. Jamiolkowski
IPC: A61F2/00 , A61B17/068 , A61B17/064 , A61B50/20 , A61B17/062 , A61B50/30 , A61B17/00
CPC classification number: A61F2/0063 , A61B17/062 , A61B17/064 , A61B17/0682 , A61B50/20 , A61B50/30 , A61B2017/00424 , A61B2017/00477 , A61B2017/0688
Abstract: A surgical fastener for anchoring medical devices to tissue includes a first leg having a proximal end, a distal end, a first rib projecting from an outer wall of the first leg and extending between the proximal and distal ends of the first leg, and a first insertion tip at the distal end of the first leg. The surgical fastener includes a second leg having a proximal end, a distal end, a second rib projecting from an outer wall of the second leg and extending between the proximal and distal ends of the second leg, and a second insertion tip at the distal end of the second leg. A bridge connects the proximal ends of the first and second legs for forming a closed end of the surgical fastener. The first and second legs are curved between the bridge and the first and second insertion tips at the distal ends of the respective first and second legs, and the first and second ribs have curves that mirror the curvature of the respective first and second legs.
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公开(公告)号：US10058637B2
公开(公告)日：2018-08-28
申请号：US14548536
申请日：2014-11-20
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Brian M. Kelly , Christopher DeFelice , Sasa Andjelic , Modesto Erneta
IPC: A61L27/26 , A61L27/58 , C08L67/04 , A61L31/04 , A61L31/14 , A61B17/064 , A61L17/10 , A61B17/06 , A61B17/00
CPC classification number: A61L31/041 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/105 , A61L27/26 , A61L27/58 , A61L31/148 , C08L67/04 , C08L2205/03 , C08L2666/18
Abstract: Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
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29.发明授权Absorbable poly (p-dioxanone-co-glycolide) monofilament fibers possessing mid-term strength retention post-implantation 有权具有中期强度保留植入后的可吸收聚（对 - 二氧杂环己酮 - 共 - 乙交酯）单丝纤维公开(公告)号：US09296145B2
公开(公告)日：2016-03-29
申请号：US14068226
申请日：2013-10-31
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Kenneth Keilman , Dennis D. Jamiolkowski
IPC: A61B17/04 , B29C47/00 , D01D5/098 , A61B17/06 , A61L17/12 , B29C47/86 , B29C47/88 , B29K73/00 , B29L31/00
CPC classification number: B29C47/0014 , A61B17/04 , A61B17/06166 , A61L17/12 , B29C47/0004 , B29C47/0061 , B29C47/0064 , B29C47/0066 , B29C47/0088 , B29C47/862 , B29C47/8805 , B29C47/8895 , B29K2073/00 , B29K2995/0056 , B29K2995/006 , B29L2031/726 , B29L2031/731 , B29L2031/753 , D01D5/098
Abstract: Novel absorbable monofilament sutures and fibers having unique and improved properties are disclosed including mid-term strength retention post-implantation. Also disclosed is a novel method of manufacturing absorbable monofilament sutures and fibers. The sutures and fibers are extruded from poly(p-dioxanone-co-glycolide) copolymers.
Abstract translation: 公开了新颖的可吸收单丝缝合线和具有独特且改善的性质的纤维，包括植入后的中期强度保留。 还公开了制造可吸收的单丝缝合线和纤维的新方法。 缝合线和纤维从聚（对二恶烷酮 - 共 - 乙交酯）共聚物挤出。
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30.发明申请公开(公告)号：US20150174288A1
公开(公告)日：2015-06-25
申请号：US14635215
申请日：2015-03-02
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Modesto Erneta
CPC classification number: A61L17/12 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/005 , A61L27/26 , A61L27/54 , A61L2300/202 , A61L2300/404 , A61L2300/606 , A61L2430/00 , B29C45/00 , B29C47/00 , B29C49/00 , B29L2031/753 , C08J3/005 , C08J2367/04 , C08J2467/04 , C08L67/04 , Y10T442/10 , Y10T442/3976 , Y10T442/40 , Y10T442/696
Abstract: Novel absorbable polymer blends are disclosed. The blends are useful for manufacturing medical devices having engineered degradation and breaking strength retention in vivo. The blends consist of a first absorbable polymeric component and a second absorbable polymeric component. The weight average molecular weight of the first polymeric component is higher than the weight average molecular weight of the second polymeric component. At least at least one of said components is at least partially end-capped by a carboxylic acid group. Further aspects are medical devices made therefrom.
Abstract translation: 公开了新颖的可吸收聚合物共混物。 该混合物可用于制造具有工程化降解和体内断裂强度保留的医疗装置。 共混物由第一可吸收聚合物组分和第二可吸收聚合物组分组成。 第一聚合物组分的重均分子量高于第二聚合物组分的重均分子量。 所述组分中的至少一种至少部分被羧酸基部分封端。 其他方面是由其制成的医疗装置。
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