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公开(公告)号：US20190003940A1
公开(公告)日：2019-01-03
申请号：US15639511
申请日：2017-06-30
Applicant: General Electric Company , University of Akron
Inventor： Arunkumar Natarajan , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk , Wei Gao , Kwok Pong Chan , Lakshmi Sireesha Kaanumalle , Abraham Joy , Nicholas Nun
Abstract: A method includes providing a biological sample, providing a sample collection device, wherein the sample collection device includes a sample binding surface including a photodegradable polymer configured to bind the biological sample, contacting the biological sample with the sample binding surface of the sample collection device, and irradiating the sample binding surface and the bound biological sample using light emitted from a light source to initiate degradation of the photodegradable polymer of the sample binding surface to cause release of the biological sample.
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公开(公告)号：US20170302826A1
公开(公告)日：2017-10-19
申请号：US15130401
申请日：2016-04-15
Applicant: General Electric Company
Inventor： Ralf Lenigk , Mark Marshall Meyers , Victor Petrovich Ostroverkhov , Timothy Toepfer , Keith Michael Looney
CPC classification number: H04N5/04 , G01J3/2823 , G01J5/0896 , G01J5/10 , G01J2005/0077 , H04N5/33
Abstract: The present approach relates to the synchronization of frame acquisition by a camera with an external event or trigger despite the camera lacking external control or synchronization capabilities. For example, inexpensive and/or consumer grade camera typically lack a control interface to explicitly synchronize with an external trigger event or external device. The present approach allows synchronization of such a camera lacking external synchronization capabilities with an external event or device.
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公开(公告)号：US20170211982A1
公开(公告)日：2017-07-27
申请号：US15217493
申请日：2016-07-22
Applicant: GENERAL ELECTRIC COMPANY , TOKITAE LLC
Inventor： Ralf Lenigk , Mark Marshall Meyers , Victor Petrovich Ostroverkhov , Timothy Toepfer , Keith Michael Looney , Terry Lee Saunders , Kevin Paul Flood Nichols , Matthew P. Horning , Benjamin K. Wilson , Daniel Keith Connors , David Gasperino
IPC: G01J5/10 , G01J5/08 , G01N33/543
CPC classification number: G01N21/171 , G01N21/8483 , G01N25/00 , G01N33/49 , G01N2021/1714 , G01N2201/105 , G01N2201/126 , G02B26/101
Abstract: Disclosed is a low-cost, portable photo thermal spectroscopy (PTS) reader for use in detecting the presence of diseases in the bodily fluid of affected patients. The PTS reader is designed to be durable, easy to use and provide readings from the Lateral Flow Assay (LFA) with rapid results. Also provided are methods of use.
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公开(公告)号：US09714447B2
公开(公告)日：2017-07-25
申请号：US13970315
申请日：2013-08-19
Applicant: General Electric Company
Inventor： Erin Jean Finehout , Christopher Michael Puleo , Ralf Lenigk , Jason M. Nichols , John Nelson
IPC: C12Q1/68
CPC classification number: C12Q1/6844 , C12Q1/6816 , C12Q1/6851 , C12Q2565/137 , C12Q2565/625 , C12Q2527/113 , C12Q2565/133 , C12Q2545/114
Abstract: The present disclosure relates to characterization of biological samples by amplification detection in a porous substrate. By way of example, a porous substrate may include amplification reagents configured to provide a signal when released during amplification. When a sample is applied, amplification occurs as a wavefront from the application point, and the time that the wavefront reaches a distance on the porous substrate is related to an initial concentration of the sample applied. By detecting the distance traveled by the amplification products at one or more time points, an initial concentration of the sample may be estimated.
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公开(公告)号：US20250064349A1
公开(公告)日：2025-02-27
申请号：US18456193
申请日：2023-08-25
Applicant: General Electric Company
Inventor： Andrew Arthur Paul Burns , Azar Alizadeh , Ralf Lenigk
Abstract: A wearable interstitial fluid (ISF) sensing includes a first patch layer and an electronics module component layer. The electronics module component layer is laminated to the first patch layer to form a patch component and a plurality of microneedles extending from the patch component. The electronics module component layer includes a substrate and a sensor positioned on the substrate. Each microneedle of the plurality of microneedles includes a microneedle base extending from the patch component, a body extending from the microneedle base, and a tip extending from the body. The body defines a slot extending through the first patch layer of the body. The slot defines a first opening and a second opening. The at least one sensor is positioned over the second opening. The first opening, the slot, and the sensor define a channel exposed to the environment. The channel is configured to channel ISF to the sensor.
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Patent Agency Ranking
公开(公告)号：US11821891B2
公开(公告)日：2023-11-21
申请号：US17113527
申请日：2020-12-07
Applicant: General Electric Company
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
CPC classification number: G01N33/5002 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L3/502769 , C12Q1/24 , G01N33/491 , B01D2313/18 , B01D2313/50 , B01L2200/0647 , B01L2300/16 , G01N2001/4088
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US20210088503A1
公开(公告)日：2021-03-25
申请号：US17113527
申请日：2020-12-07
Applicant: General Electric Company
Inventor： Jessica Godin Karp , Xiaohui Chen , Kashan Ali Shaikh , Mengli Wang , Ralf Lenigk , Christine Lynne Surrette
Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.
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公开(公告)号：US10350592B2
公开(公告)日：2019-07-16
申请号：US15326412
申请日：2015-07-20
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
IPC: B01L3/00 , C12Q1/6806 , A61B5/15 , G01N1/14 , B01L3/02
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
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公开(公告)号：US10132743B2
公开(公告)日：2018-11-20
申请号：US15217493
申请日：2016-07-22
Applicant: GENERAL ELECTRIC COMPANY , TOKITAE LLC
Inventor： Ralf Lenigk , Mark Marshall Meyers , Victor Petrovich Ostroverkhov , Timothy Toepfer , Keith Michael Looney , Terry Lee Saunders , Kevin Paul Flood Nichols , Matthew P. Horning , Benjamin K. Wilson , Daniel Keith Connors , David Gasperino
Abstract: Disclosed is a low-cost, portable photo thermal spectroscopy (PTS) reader for use in detecting the presence of diseases in the bodily fluid of affected patients. The PTS reader is designed to be durable, easy to use and provide readings from the Lateral Flow Assay (LFA) with rapid results. Also provided are methods of use.
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公开(公告)号：US09999856B2
公开(公告)日：2018-06-19
申请号：US13951881
申请日：2013-07-26
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk , Nichole Lea Wood , Li Zhu , Craig Patrick Galligan
CPC classification number: B01D57/02 , C12N15/101
Abstract: A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.
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