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30 条记录 (耗时 0.05 秒)

    Method for preparing substituted pyrimidines
    24.
    发明授权
    Method for preparing substituted pyrimidines 有权
    制备取代嘧啶的方法

    公开(公告)号：US08013155B2

    公开(公告)日：2011-09-06

    申请号：US11886653

    申请日：2006-05-12

    申请人： Gary David Annis

    发明人： Gary David Annis

    IPC分类号： C07D239/46 ,  C07D239/48

    CPC分类号： C07D239/42 ,  C07D239/30 ,  C07D239/36

    摘要： Disclosed a method for preparing a compound of Formula 1, wherein R1 is cyclopropyl, 4-chlorophenyl or 4-bromophenyl; and R2 is C1-C14 alkyl; comprising contacting a compound of Formula 2 with a persulfate oxidant in the presence of a strong sulfur- or phosphorus-containing mineral acid and an oxidation resistant solvent. Also disclosed are methods for preparing the compound of Formula 2 from a compound of Formula 5 as well as compounds of Formula 6 and salts thereof, wherein R is NH2, Cl or OH; X is H or Cl; R1 is cyclopropyl, 4-chlorophenyl or 4-bromophenyl; and R2 is C1-C14 alkyl; provided that when R is NH2 or Cl, then X is Cl; which are useful a process intermediates.

    摘要翻译： 公开了制备式1化合物的方法，其中R 1是环丙基，4-氯苯基或4-溴苯基; R2为C1-C14烷基; 包括在强硫或磷的无机酸和抗氧化溶剂的存在下使式2的化合物与过硫酸盐氧化剂接触。 还公开了从式5化合物制备式2化合物的方法以及式6化合物及其盐，其中R是NH 2，Cl或OH; X是H或Cl; R1是环丙基，4-氯苯基或4-溴苯基; R2为C1-C14烷基; 条件是当R为NH 2或Cl时，则X为Cl; 这是一个有用的过程中间体。

    Substituted 1H-dihydropyrazoles, their preparation and use
    25.
    发明授权
    Substituted 1H-dihydropyrazoles, their preparation and use 失效
    取代的1H-二氢吡唑，其制备和用途

    公开(公告)号：US07932395B2

    公开(公告)日：2011-04-26

    申请号：US12578227

    申请日：2009-10-13

    申请人： Gary David Annis

    发明人： Gary David Annis

    IPC分类号： C07D213/02

    CPC分类号： C07D213/77 ,  A01N43/56 ,  C07C251/76 ,  C07C255/66 ,  C07D231/08 ,  C07D231/14 ,  C07D231/16 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14

    摘要： This invention provides compounds of Formula I, methods for their preparation and use for preparing compounds of Formula II wherein R1, R2, R3, R5, R6, X and n are as defined in the disclosure. This invention also discloses preparation of compounds of Formula III wherein R1, R2, R7, R8, R9 and n are as defined in the disclosure. This invention also pertains to certain compounds of Formula 4 and 6 used to prepare compounds of Formula I. wherein R1, R2, R5, X and n are as defined in the disclosure.

    摘要翻译： 本发明提供式I化合物，其制备方法和用于制备式II化合物的方法，其中R 1，R 2，R 3，R 5，R 6，X和n如本公开所定义。 本发明还公开了式III化合物的制备，其中R 1，R 2，R 7，R 8，R 9和n如本公开所定义。 本发明还涉及用于制备式I化合物的式4和6的某些化合物，其中R 1，R 2，R 5，X和n如本公开所定义。

    METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES
    26.
    发明申请
    METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES 有权
    制备3-三氟甲基吡咯烷酮的方法

    公开(公告)号：US20110009638A1

    公开(公告)日：2011-01-13

    申请号：US12933493

    申请日：2009-04-08

    申请人： Gary David Annis

    发明人： Gary David Annis

    IPC分类号： C07D213/56 ,  C07D249/08 ,  C07D231/14 ,  C07D231/12 ,  C07D261/04 ,  C07C51/347 ,  C07C231/12 ,  C07D277/30 ,  C07C67/327 ,  C07C45/74 ,  C07C303/30 ,  C07C209/68 ,  C07C253/30 ,  C07C45/68 ,  C07C49/80 ,  C07C25/13

    CPC分类号： C07D261/04 ,  C07C17/35 ,  C07C25/13 ,  C07C45/455 ,  C07C45/70 ,  C07C49/80 ,  C07C49/813 ,  C07C67/343 ,  C07C205/45 ,  C07C209/74 ,  C07C231/12 ,  C07C231/14 ,  C07C235/84 ,  C07D213/40 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D249/08 ,  C07D249/10 ,  C07D277/28 ,  C07C69/94 ,  C07C69/76 ,  C07C211/56

    摘要： Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.

    摘要翻译： 公开了一种制备式1化合物的方法，其中Q和Z如本公开中所定义，包括从包含式2化合物，式3化合物，包含至少一种选自 由式4的碱土金属氢氧化物组成的组，其中M是Ca，Sr或Ba，式4a的碱金属碳酸盐，其中M1是Li，Na或K，1,5-二氮杂双环[4.3.0]壬-5-烯和 1,8-二氮杂双环[5.4.0]十一碳-7-烯，以及能够与水形成低沸点共沸物的非质子传递溶剂。 还公开了制备式2化合物的方法，其包括（1）形成反应混合物，该反应混合物包含衍生自在存在下使式5的化合物（其中X为Cl，Br或I）与镁金属或烷基卤化镁接触的格利雅试剂 的醚溶剂，然后（2）使反应混合物与式6化合物（其中Y是OR 11或NR 12 R 13）和R 11，R 12和R 13如本公开所定义。 进一步公开的是制备式7化合物的方法，其中Q和Z如本公开所定义，使用式1的化合物，其特征在于通过上述方法制备式1化合物或使用制备的式1化合物 通过上述方法。

    Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates
    27.
    发明授权
    Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates 有权
    2-取代-5-氧代-3-吡唑烷羧酸酯的制备和用途

    公开(公告)号：US07834186B2

    公开(公告)日：2010-11-16

    申请号：US12234063

    申请日：2008-09-19

    申请人： Gary David Annis

    发明人： Gary David Annis

    IPC分类号： C07D401/04 ,  C07D231/04

    CPC分类号： C07D231/06 ,  C07D409/04

    摘要： A method is disclosed for preparing a 2-substituted-5-oxo-3-pyrazolidinecarboxylate compound of Formula I The method comprises contacting a succinic acid derivative of the formula R1OC(O)C(H)(X)C(R2a)(R2b)C(O)Y (i.e. Formula II) wherein X and Y are leaving groups and L, R1, R2a and R2b are as defined in the disclosure, with a substituted hydrazine of the formula LNHNH2 (i.e. Formula III) in the presence of a suitable acid scavenger and solvent. Also disclosed is the preparation of compounds of Formula IV wherein X1, R6, R7, R8a, R8b, R9, and n are as defined in the disclosure. Also disclosed is a composition comprising on a weight basis about 20 to 99% of the compound of Formula II wherein R1, R2a, R2b, R3, R4 and R5 are as defined in the disclosure; X is Cl, Br or I; and Y is F, Cl, Br or I; provided that when R2a and R2b are each H, and X and Y are each Cl then R1 is other than benzyl and when R2a and R2b are each phenyl, and X and Y are each Cl, then R1 is other than methyl or ethyl. Also disclosed is a crystalline composition comprising at least about 90% by weight of the compound of the formula R1OC(O)C(H)(X)C(R2a)(R2b)CO2H (i.e. Formula VI) wherein R2a and R2b are H, X is Br and R1 is methyl.

    摘要翻译： 公开了制备式I的2-取代-5-氧代-3-吡唑烷羧酸酯化合物的方法。该方法包括使式R 1 OC（O）C（H）（X）C（R 2a）（R 2b） ）C（O）Y（即式II）其中X和Y是离去基团，L，R 1，R 2a和R 2b如本公开所定义，与式LNHNH 2（即式III）的取代肼在 合适的酸清除剂和溶剂。 还公开了式IV化合物的制备，其中X1，R6，R7，R8a，R8b，R9和n如本公开所定义。 还公开了一种组合物，其包含基于重量计约20至99％的式II化合物，其中R 1，R 2a，R 2b，R 3，R 4和R 5如本公开中所定义; X是Cl，Br或I; Y为F，Cl，Br或I; 条件是当R 2a和R 2b各自为H，且X和Y各自为Cl时，R 1不是苄基，并且当R 2a和R 2b各自为苯基时，X和Y各自为Cl，则R 1不是甲基或乙基。 还公开了包含至少约90重量％的式R 1 OC（O）C（H）（X）C（R 2a）（R 2b）CO 2 H（即式VI）的化合物的至少约90重量％，其中R 2a和R 2b是H ，X是Br，R 1是甲基。

    Method for preparing 3-halo-4,5-dihydro-1H-pyrazoles
    28.
    发明授权
    Method for preparing 3-halo-4,5-dihydro-1H-pyrazoles 有权
    制备3-卤代-4,5-二氢-1H-吡唑的方法

    公开(公告)号：US07705160B2

    公开(公告)日：2010-04-27

    申请号：US12004902

    申请日：2007-12-21

    申请人： Gary David Annis

    发明人： Gary David Annis

    IPC分类号： C07D231/08

    CPC分类号： C07D231/08 ,  C07D231/06 ,  C07D401/04

    摘要： This invention relates to a method for preparing a 3-halo-4,5-dihydro-1H-pyrazole compound of Formula I comprising contacting with HX1 a different 4,5-dihydro-1H-pyrazole compound of Formula II wherein X1 is halogen and L, R, k and X2 are as defined in the disclosure. This invention also discloses preparation of compounds of Formula III wherein X1, R3, R6, R7, R8a, R8b and n are as defined in the disclosure.

    摘要翻译： 本发明涉及一种制备式I的3-卤代-4,5-二氢-1H-吡唑化合物的方法，包括使HX1与不同的式II的4,5-二氢-1H-吡唑化合物（其中X 1为卤素和 L，R，k和X2如本公开中所定义。 本发明还公开了式III化合物的制备，其中X1，R3，R6，R7，R8a，R8b和n如本公开所定义。

    Heterocyclic diamide invertebrate pest control agents
    29.
    发明授权
    Heterocyclic diamide invertebrate pest control agents 失效
    杂环二酰胺无脊椎害虫防治剂

    公开(公告)号：US07560564B2

    公开(公告)日：2009-07-14

    申请号：US11158200

    申请日：2005-06-21

    申请人： Gary David Annis ,  Bruce Lawrence Finkelstein

    发明人： Gary David Annis ,  Bruce Lawrence Finkelstein

    IPC分类号： C07D401/00 ,  A61K31/50 ,  A61K31/44

    CPC分类号： C07D213/81 ,  A01N43/10 ,  A01N43/40 ,  A01N43/54 ,  A01N43/80 ,  C07D213/82 ,  C07D231/40 ,  C07D333/38

    摘要： This invention provides compounds of Formula (I), N-oxides and suitable salts thereof, wherein A and B are independently O or S; each J is independently a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system wherein each ring or ring system is optionally substituted with 1 to 4 R5; K is, together with the two contiguous linking carbon atoms, a 5- or 6-membered heteroaromatic ring optionally substituted with 1 to 3 R4; and R1 R2, R3, R4, R5 and n are as defined in the disclosure. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents.

    摘要翻译： 本发明提供式（I）的化合物，其N-氧化物及其合适的盐，其中A和B独立地为O或S; 每个J独立地是苯基环，萘基环系，5或6元杂芳环或芳族8-，9-或10-元稠合杂双环系统，其中每个环或环系统任选被1至 4 R5; K与两个相邻的连接碳原子连接，任选被1至3个R 4取代的5或6元杂芳环; 并且R1R2，R3，R4，R5和n如本公开所定义。 还公开了用于控制无脊椎害虫的方法，包括使无脊椎害虫或其环境与生物有效量的式（I）化合物，其N-氧化物或该化合物的合适盐（例如，作为所述的组合物）接触 这里）。 本发明还涉及用于控制无脊椎害虫的组合物，其包含生物有效量的式（I）化合物，其N-氧化物或该化合物的合适的盐和至少一种选自以下的另外的组分： 表面活性剂，固体稀释剂和液体稀释剂。