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公开(公告)号：US5652264A
公开(公告)日：1997-07-29
申请号：US624779
申请日：1996-03-27
申请人： Klaus Urbahns , Hans-Georg Heine , Bodo Junge , Rudolf Schohe-Loop , Hartmund Wollweber , Henning Sommermeyer , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor De Vry
发明人： Klaus Urbahns , Hans-Georg Heine , Bodo Junge , Rudolf Schohe-Loop , Hartmund Wollweber , Henning Sommermeyer , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor De Vry
IPC分类号： A61K31/195 , A61K31/215 , A61K31/245 , A61P7/06 , A61P25/16 , A61P25/28 , C07C227/04 , C07C227/06 , C07C227/08 , C07C227/34 , C07C229/46 , C07C229/48 , C07C255/58 , A61K31/235 , A61K31/24 , A61K31/44
CPC分类号： C07C229/48 , C07C2101/16
摘要： The cyclohexadiene derivatives are prepared by reaction of cyclohexanones with amines and subsequent dehydration. The compounds are effective in the treatment of depression on account of their property of being selective modulators of calcium channel-dependent potassium channels.
摘要翻译： 环己二烯衍生物通过环己酮与胺反应并随后脱水制备。 这些化合物由于其作为钙通道依赖性钾通道的选择性调节剂的性质而有效治疗抑郁症。
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公开(公告)号：US5328931A
公开(公告)日：1994-07-12
申请号：US917565
申请日：1992-07-21
IPC分类号： A61K31/435 , A61K31/44 , A61P25/18 , A61P25/28 , C07D211/90 , C07D213/55 , A61K31/455
CPC分类号： C07D211/90
摘要： N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be prepared either by reaction of aldehydes with acetoacetic esters and amines, optionally with isolation of the corresponding ylidene compounds, or by reaction of aminocrotonic acid esters with ylidene compounds and subsequent alkylation of the NH function. The N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be employed as active compounds in medicaments, in particular as cerebral therapeutics.
摘要翻译： N-烷基化的1,4-二氢吡啶二羧酸酯可以通过醛与乙酰乙酸酯和胺的反应制备，任选地分离相应的亚基化合物，或通过氨基巴豆酸酯与亚基化合物的反应和随后NH官能团的烷基化 。 N-烷基化的1,4-二氢吡啶二羧酸酯可以用作药物中的活性化合物，特别是作为脑治疗剂。
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公开(公告)号：US4935409A
公开(公告)日：1990-06-19
申请号：US186522
申请日：1988-04-27
IPC分类号： A23K20/111 , A23K20/116 , A23K50/30 , C07C67/00 , C07C213/00 , C07C215/68 , C07C219/32 , C07C313/00 , C07C323/36 , C07C323/62 , C07D263/04 , C07D263/06 , C07D263/20 , C07D263/22 , C07D263/24 , C07D305/06 , C07D307/14 , C07D309/04 , C07D413/06 , C07F7/18
CPC分类号： C07D263/04 , A23K20/111 , A23K20/116 , A23K50/30 , C07D263/20 , C07D305/06 , C07D307/14 , C07D309/04 , C07D413/06 , C07F7/1852
摘要： Animal growth promoters of the formula ##STR1## The intermediates of the formula ##STR2## are also new.
摘要翻译： 式（Ⅰ）的化合物生长促进剂（Ⅰ）（Ia）或（Ⅰa）式（Ⅰb）式（IMA）的中间体也是新的。
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公开(公告)号：US4904679A
公开(公告)日：1990-02-27
申请号：US185177
申请日：1988-04-22
IPC分类号： C07D207/06 , A61K31/40 , A61K31/4025 , A61P15/00 , C07D207/32 , C07D207/325 , C07D207/33 , C07D207/34 , C07D401/12 , C07D405/10 , C07D413/10
CPC分类号： C07D207/325 , C07D207/33 , C07D207/34 , C07D401/12 , C07D413/10
摘要： Pyrrolophenylalkanolamines of the formula ##STR1## R.sup.1 and R.sup.2 represent hydrogen or various radicals, R.sup.3 represents hydrogen, acyl or trialkylsilyl,R.sup.4 represents hydrogen or alkyl,R.sup.5 represents hydrogen, or, together with R.sup.3, represents ##STR2## wherein R.sup.7 represents hydrogen or alkyl, andR.sup.6 represents branched or cyfclic alkyl, which is optionally substituted,and salts thereof promote the yield of animals. Many new intermediates are also shown.
摘要翻译： 下式的吡咯基苯基烷醇胺R1和R2代表氢或各种基团，R3代表氢，酰基或三烷基甲硅烷基，R4代表氢或烷基，R5代表氢，或与R3一起代表其中R7代表氢或烷基 ，R 6表示任选被取代的支链或环状烷基，其盐可促进动物的产量。 还显示了许多新的中间体。
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25.发明授权
公开(公告)号：US4088780A
公开(公告)日：1978-05-09
申请号：US690073
申请日：1976-05-26
IPC分类号： A61K31/155 , C07C129/12
CPC分类号： A61K31/155
摘要： N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.
摘要翻译： 在2-（取代的酰氨基）苯甲酸的4-或5-位上带有任选取代的苯氧基，苯硫基，苯基亚磺酰基或苯基磺酰基的N- [2-（取代的酰胺基）苯基] -N'，N“ - 双 - 羰基胍 - 苯基是驱肠剂。 其中N-（2-乙酰氨基-4-苯硫基苯基）-N'，N“ - 双 - 甲酯基胍的化合物是典型的例子，通过异硫脲-S-烷基醚和适当取代的2- 氨基苯胺。
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公开(公告)号：US4070494A
公开(公告)日：1978-01-24
申请号：US640581
申请日：1975-12-15
IPC分类号： A61K47/38 , A61K9/02 , A61K9/20 , A61K31/135 , A61K31/215 , A61K31/40 , A61K31/445 , A61K45/08 , A01N17/00 , G01N1/00 , G01N33/16
CPC分类号： A61K9/02 , A61K31/135 , A61K31/137 , A61K31/215 , A61K31/40 , A61K31/445 , A61K31/60 , A61K9/2054 , Y10S514/944 , Y10S514/96 , Y10S514/974
摘要： Enteral pharmaceutical compositions containing medicinal agents having parenteral abuse potential are rendered resistant to aqueous extraction through the incorporation of a sufficient amount of a nontoxic, water gelable material. Attempts to extract the medicinal agent for parenteral abuse are thus inhibited or prevented since the material gels in the presence of water leaving no filterable liquid.
摘要翻译： 含有具有非肠道滥用潜力的药物的肠内药物组合物通过加入足量的无毒的水可胶化材料使其耐水萃取。 因此，由于材料在水的存在下凝胶不会有可过滤的液体，所以尝试提取肠胃外滥用的药剂因此被抑制或防止。
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公开(公告)号：US4064270A
公开(公告)日：1977-12-20
申请号：US505745
申请日：1974-09-13
IPC分类号： A61K31/165 , A61K31/155 , A61K31/40 , A61K31/495 , A61K31/535 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C239/00 , C07C257/14 , C07C257/20 , C07D295/15 , C07D295/00
CPC分类号： C07D295/15 , Y02P20/55
摘要： A new class of N'-(aminoacylaminophenyl) acetamidines: ##STR1## in which R.sup.1 and R.sup.2 are the same or different and represent hydrogen, alkyl, aryl or the substituted derivatives thereof or, together with the nitrogen atom to which they are attached, an heterocyclic ring; and R.sup.3 is hydrogen, alkyl, aryl, aralkyl, or a heterocyclic moiety including the substituted derivatives thereof. The products have utility as anthelmintics.The products are obtained by treating a suitable amino-acid or a carbonyl-activated amino-acid, with the appropriate N'-(4-aminophenyl)-N,N-dimethylacetamidine. In addition, the products are obtained by treating a suitable N'-(haloacylaminophenylacetamidine with an appropriate amine.
摘要翻译： 一类新的N' - （氨基酰氨基苯基）乙酰胺：其中R1和R2相同或不同，代表氢，烷基，芳基或其取代的衍生物，或与它们所连接的氮原子一起， 杂环; 并且R 3是氢，烷基，芳基，芳烷基或包括其取代的衍生物的杂环部分。 该产品具有作为驱虫剂的功效。
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28.发明授权
公开(公告)号：US4024176A
公开(公告)日：1977-05-17
申请号：US690075
申请日：1976-05-26
IPC分类号： A61K31/155 , C07C149/40
CPC分类号： A61K31/155
摘要： N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.
摘要翻译： 在2-（取代的酰氨基）苯甲酸的4-或5-位上带有任选取代的苯氧基，苯硫基，苯基亚磺酰基或苯基磺酰基的N- [2-（取代的酰胺基）苯基] -N'，N“ - 双 - 羰基胍 - 苯基是驱肠剂。 其中N-（2-乙酰氨基-4-苯硫基苯基）-N'，N“ - 双 - 甲酯基胍的化合物是典型的例子，通过异硫脲-S-烷基醚和适当取代的2- 氨基苯胺。
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公开(公告)号：US3996247A
公开(公告)日：1976-12-07
申请号：US569923
申请日：1975-04-21
IPC分类号： C07D209/42 , C07D231/56 , C07D307/20 , C07D307/42 , C07D307/54 , C07D307/68 , C07D309/08
CPC分类号： C07D307/42 , C07D209/42 , C07D231/56 , C07D307/20 , C07D307/54 , C07D307/68
摘要： N-Phenylacetamidines bearing an acylamino group in the phenyl ring have anthelmintic activity and are effective against nematodes and cestodes. A representative embodiment is N-(4-carbophenoxyaminophenyl)-N',N'-dimethylacetamidine.
摘要翻译： 在苯环中带有酰氨基的N-苯基乙酰胺具有驱虫活性，对线虫和绦虫有效。 代表性的实施方案是N-（4-羰苯氧基氨基苯基）-N'，N'-二甲基乙脒。
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