公开(公告)号：US20090041627A1

公开(公告)日：2009-02-12

申请号：US12205949

申请日：2008-09-08

Applicant: Michael J. Pugia ,  James A. Profitt ,  Ronald G. Sommer ,  Sung-Kwon Jung

Inventor： Michael J. Pugia ,  James A. Profitt ,  Ronald G. Sommer ,  Sung-Kwon Jung

IPC: B01J19/00 ,  B32B37/12 ,  B01L3/00

CPC classification number: B01L3/502707 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/0672 ,  B01L2400/0406 ,  B01L2400/0677 ,  B01L2400/0683 ,  B29K2509/08

Abstract: A microfluidic device containing liquid reagents having an extended shelf life contains the liquid reagents in micro-reservoirs that limit the escape of moisture to less than 10% over the shelf life of the device. The micro-reservoir preferably is made of polypropylene and covered with a metallized plastic film.

Abstract translation: 包含具有延长的保存期限的液体试剂的微流体装置包含微储存器中的液体试剂，其在装置的保存期限内将水分逸出限制在小于10％。 微型储存器优选由聚丙烯制成并用金属化塑料膜覆盖。

公开(公告)号：US5140027A

公开(公告)日：1992-08-18

申请号：US522932

申请日：1990-05-14

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D313/14

CPC classification number: C07D313/14

Abstract: Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.

Abstract translation: 公开了新的氨基烷基硫代二氧化硫蛋白，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽医制剂以及通过施用方法进行治疗。 这些化合物可用作镇痛药，抗抑郁药和抗惊厥药。 还公开了一种通过碱金属在低级烷醇中选择性还原烯烃的方法。

公开(公告)号：US4672138A

公开(公告)日：1987-06-09

申请号：US825725

申请日：1986-02-03

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07C45/63 ,  C07C333/02 ,  C07D333/52 ,  C07D333/54 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76 ,  C07C155/02

CPC classification number: C07D333/54 ,  C07C309/00 ,  C07C323/00 ,  C07C45/63 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76

Abstract: Novel benzo[b]thiophenes, compositions containing same, process for the preparation thereof and methods of reducing blood pressure and producing diuresis by administration of the compounds and compositions are disclosed.

Abstract translation: 公开了新的苯并[b]噻吩，含有它们的组合物，其制备方法和通过施用化合物和组合物降低血压和产生利尿的方法。

公开(公告)号：US4537976A

公开(公告)日：1985-08-27

申请号：US558074

申请日：1983-12-05

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07C45/63 ,  C07D333/54 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76

CPC classification number: C07D333/54 ,  C07C309/00 ,  C07C323/00 ,  C07C45/63 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76

Abstract: Novel benzo[b]thiophenes, compositions containing same, process for the preparation thereof and methods of reducing blood pressure and producing diuresis by administration of the compounds and compositions are disclosed.

Abstract translation: 公开了新的苯并[b]噻吩，含有它们的组合物，其制备方法和通过施用化合物和组合物降低血压和产生利尿的方法。

公开(公告)号：US4307235A

公开(公告)日：1981-12-22

申请号：US121824

申请日：1980-02-15

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07D211/64 ,  C07D471/10

CPC classification number: C07D471/10 ,  C07D211/64

Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.

Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。

公开(公告)号：US4198418A

公开(公告)日：1980-04-15

申请号：US2348

申请日：1979-01-10

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: A61K31/435 ,  A61P25/04 ,  A61P25/20 ,  C07C43/225 ,  C07C43/23 ,  C07D211/64 ,  C07D491/10 ,  C07D491/107 ,  A61K31/44 ,  A61K31/55

CPC classification number: C07D491/10 ,  C07C43/225 ,  C07C43/23 ,  C07D211/64

Abstract: Novel spiro[dibenz(b,f)oxepin-piperidine]s and methods of preparing same are described. These compounds are useful as analgetics, tranquilizers and anticonvulsants.

Abstract translation: 描述了新的螺[二苯并（b，f）氧杂七环素 - 哌啶]和其制备方法。 这些化合物可用作止痛药，止痛药和抗惊厥药。

公开(公告)号：US20110223673A1

公开(公告)日：2011-09-15

申请号：US13129937

申请日：2009-11-16

Applicant: James A. Profitt

Inventor： James A. Profitt

IPC: G01N21/00

CPC classification number: G01N21/78 ,  G01N21/21 ,  G01N21/8483 ,  G01N2021/8488 ,  Y10T436/10

Abstract: A readhead for a photometric diagnostic instrument includes a holder configured for receiving reagent sample media therein. The sample media has a plurality of test areas configured to react with, and change color, according to an amount of an analyte in a sample. The holder is sized and shaped for forming an indexed fit with the sample media. One or more light sources are configured to emit light onto the test areas. First and second polarized light filters are respectively disposed between the light sources and the test areas, and between the test areas and one or more light detectors, so that the light detectors receive diffuse, non-specular reflections of the light from the test areas, while substantially preventing the light detectors from receiving specular reflections of the light.

Abstract translation: 用于光度测量诊断仪的读取头包括配置用于在其中接收试剂样品介质的保持器。 样品介质具有多个测试区域，其被配置为根据样品中分析物的量反应并改变颜色。 支架的尺寸和形状用于与样品介质形成索引配合。 一个或多个光源被配置为将光发射到测试区域。 第一和第二偏振光滤光器分别设置在光源和测试区域之间以及测试区域和一个或多个光检测器之间，使得光检测器接收来自测试区域的光的漫反射，非镜面反射， 同时基本上防止光检测器接收光的镜面反射。

公开(公告)号：US20080257754A1

公开(公告)日：2008-10-23

申请号：US12102631

申请日：2008-04-14

Applicant: Michael J. Pugia ,  James A. Profitt ,  Gert Blankenstein ,  Ralf-Peter Peters

Inventor： Michael J. Pugia ,  James A. Profitt ,  Gert Blankenstein ,  Ralf-Peter Peters

IPC: G01N27/26

CPC classification number: B01L3/50273 ,  B01L3/5025 ,  B01L3/502723 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/086

Abstract: A microfluidic device for analyzing biological samples is provided with a sample inlet section including an inlet port, a capillary passageway communication with the inlet port and with an inlet chamber. The inlet chamber includes means for uniformly distributing the sample liquid across the inlet chamber and purging the air initially contained therein.

Abstract translation: 用于分析生物样品的微流体装置设置有样品入口部分，其包括入口端口，与入口端口的毛细通道连通和入口室。 入口室包括用于均匀地分布样品液体穿过入口室并净化最初容纳在其中的空气的装置。

公开(公告)号：US5401466A

公开(公告)日：1995-03-28

申请号：US69420

申请日：1993-06-01

Applicant: Mary M. Foltz ,  Chen-Jung Hsu ,  Robert C. Payne ,  James A. Profitt

Inventor： Mary M. Foltz ,  Chen-Jung Hsu ,  Robert C. Payne ,  James A. Profitt

IPC: G01N33/48 ,  B01D15/08 ,  G01N33/52 ,  G01N33/92 ,  G01N31/02

CPC classification number: B01D15/362 ,  B01D15/00 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28083 ,  G01N33/526 ,  G01N33/92 ,  G01N2800/044 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: A dry phase device separates high density lipoprotein (HDL) from a blood (serum or plasma) sample. The device contains a fluid permeable material having dispersed therein finely divided, porous silica or silicate particles as selective absorbant for HDL. By combining the device with a second layer designed to remove very low density lipoproteins/chylomicrons from the blood, and a third layer containing means for quantitative cholesterol detection, there is provided a test device for the direct determination of low density lipoproteins cholesterol.

Abstract translation: 干相装置将高密度脂蛋白（HDL）与血液（血清或血浆）样品分离。 该装置包含流体可渗透的材料，其中分散有细碎的多孔二氧化硅或硅酸盐颗粒作为HDL的选择性吸收剂。 通过将该装置与设计用于从血液中除去非常低密度脂蛋白/乳糜微粒的第二层和含有用于定量胆固醇检测的装置的第三层组合，提供了用于直接测定低密度脂蛋白胆固醇的测试装置。

公开(公告)号：US5216178A

公开(公告)日：1993-06-01

申请号：US745623

申请日：1991-08-15

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D313/14

CPC classification number: C07D313/14

Abstract: Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.

Abstract translation: 公开了新的氨基烷基硫代二氧化硫蛋白，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽医制剂以及通过施用方法进行治疗。 这些化合物可用作镇痛药，抗抑郁药和抗惊厥药。 还公开了一种通过碱金属在低级烷醇中选择性还原烯烃的方法。