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21.
公开(公告)号:US20090131434A1
公开(公告)日:2009-05-21
申请号:US12355909
申请日:2009-01-19
申请人: Michael E. Brune , Peer B. Jacobson , James T. Link , Jyoti R. Patel , Jeffrey J. Rohde , Qi Shuai , Martin Winn , Vince S. Yeh , Hong Yong
发明人: Michael E. Brune , Peer B. Jacobson , James T. Link , Jyoti R. Patel , Jeffrey J. Rohde , Qi Shuai , Martin Winn , Vince S. Yeh , Hong Yong
IPC分类号: A61K31/5377 , C07C233/01 , C07D413/02 , A61P3/10 , A61K31/16
CPC分类号: C07C233/23 , C07C235/14 , C07C237/24 , C07C255/31 , C07C255/47 , C07C259/16 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/30 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/48 , C07D213/64 , C07D233/64 , C07D257/04 , C07D261/08
摘要: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病,胰岛素抵抗,肥胖症,脂质障碍,代谢综合征和其他介导的疾病和病症的用途 由过度的糖皮质激素作用。
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公开(公告)号:US20090054426A1
公开(公告)日:2009-02-26
申请号:US12195937
申请日:2008-08-21
申请人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong
发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong
IPC分类号: A61K31/496 , A61P25/00 , A61K31/5375 , A61K31/445 , A61K31/16
CPC分类号: C07D403/12 , A61K31/44 , A61K31/495 , C07D207/267 , C07D401/12 , C07D401/14
摘要: A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.
摘要翻译: 一种治疗患有与老化和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者的方法,包括注意力缺陷障碍,注意力缺陷多动障碍(ADHD),阿尔茨海默病(AD),轻度认知障碍 老年性痴呆,艾滋病痴呆,神经变性,抑郁和精神分裂症,包括向需要这种治疗的患者施用有效量的11-β-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。
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公开(公告)号:US07365093B2
公开(公告)日:2008-04-29
申请号:US11063476
申请日:2005-02-23
申请人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号: A01N43/36 , C07D405/00
CPC分类号: C07D207/16 , C07D405/04 , C07D405/14 , C07D413/14
摘要: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐,以及其制备方法和中间体,以及拮抗内皮素的方法。
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公开(公告)号:US07208517B1
公开(公告)日:2007-04-24
申请号:US09653563
申请日:2000-08-31
申请人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King , Todd J. Janus , Robert J. Padley
发明人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King , Todd J. Janus , Robert J. Padley
IPC分类号: A61K31/40
CPC分类号: A61K31/40
摘要: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, a method of antagonizing endothelin, methods for the inhibition of bone metastases, methods for the prevention of growth of new metastases, methods for the inhibition of bone turnover, and methods for the prevention of bone loss in patients, including cancer patients, using an endothelin ET-A receptor antagonist.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐,以及其制备方法和中间体,拮抗内皮素的方法,抑制骨转移的方法,预防生长的方法 的新转移,抑制骨转换的方法,以及使用内皮素ET-A受体拮抗剂预防患者(包括癌症患者)的骨丢失的方法。
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公开(公告)号:US06946481B1
公开(公告)日:2005-09-20
申请号:US10266270
申请日:2002-10-08
申请人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号: A61K31/40 , C07D207/00 , C07D405/04
CPC分类号: C07D405/04
摘要: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐,以及其制备方法和中间体,以及拮抗内皮素的方法。
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公开(公告)号:US6162927A
公开(公告)日:2000-12-19
申请号:US905913
申请日:1997-08-04
申请人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号: C07D207/16 , C07D207/26 , C07D207/27 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59 , C07D405/02 , C07D405/06 , A61K41/30 , A61N9/06 , A61N9/10
CPC分类号: C07D207/27 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59
摘要: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐,以及其制备方法和中间体,以及拮抗内皮素的方法。
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公开(公告)号:US20060229280A1
公开(公告)日:2006-10-12
申请号:US11063476
申请日:2005-02-23
申请人: Martin Winn , Steven Boyd , Charles Hutchins , Hwan-Soo Jae , Andrew Tasker , Thomas von Geldern , Jeffrey Kester , Bryan Sorensen , Bruce Szczepankiewicz , Kenneth Henry , Gang Liu , Steven Wittenberger , Steven King
发明人: Martin Winn , Steven Boyd , Charles Hutchins , Hwan-Soo Jae , Andrew Tasker , Thomas von Geldern , Jeffrey Kester , Bryan Sorensen , Bruce Szczepankiewicz , Kenneth Henry , Gang Liu , Steven Wittenberger , Steven King
IPC分类号: A61K31/675 , A61K31/454 , C07D413/02 , C07D43/02
CPC分类号: C07D207/16 , C07D405/04 , C07D405/14 , C07D413/14
摘要: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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公开(公告)号:US06462194B1
公开(公告)日:2002-10-08
申请号:US09572493
申请日:2000-05-15
申请人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号: C07D26530
CPC分类号: C07D207/27 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59
摘要: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐,以及其制备方法和中间体,以及拮抗内皮素的方法。
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公开(公告)号:US06380241B1
公开(公告)日:2002-04-30
申请号:US09714934
申请日:2000-11-17
申请人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号: C07D40502
CPC分类号: C07D207/27 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59
摘要: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐,以及其制备方法和中间体,以及拮抗内皮素的方法。
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公开(公告)号:US5767144A
公开(公告)日:1998-06-16
申请号:US442575
申请日:1995-05-30
申请人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
发明人: Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
IPC分类号: C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59 , A61K31/40 , C07D207/08
CPC分类号: C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
摘要: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译: 公开了式(I)的化合物:其中(I)或其药学上可接受的盐,以及其制备方法和中间体,以及拮抗内皮素的方法。
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