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    Methods of regulating cytokine signalling
    21.
    发明申请
    Methods of regulating cytokine signalling 审中-公开
    调节细胞因子信号传导的方法

    公开(公告)号：US20080057517A1

    公开(公告)日：2008-03-06

    申请号：US11818589

    申请日：2007-06-15

    申请人： Sandra Nicholson ,  Manuel Baca ,  Nicos Nicola ,  Douglas Hilton ,  Jian Zhang ,  Louis Fabri ,  Andrew Nash

    发明人： Sandra Nicholson ,  Manuel Baca ,  Nicos Nicola ,  Douglas Hilton ,  Jian Zhang ,  Louis Fabri ,  Andrew Nash

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6863

    摘要： The present invention relates generally to a method for regulating cytokine signalling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signalling (SOCS) interaction in controlling cytokine signalling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signalling. Control of cytokine signalling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.

    摘要翻译： 本发明一般涉及用于调节细胞因子信号传导的方法和可用于其的试剂。 本发明的方法部分地基于在控制细胞因子信号传导中识别细胞因子信号传导抑制剂（SOCS）相互作用的分子靶标。 分子靶标的鉴定允许开发测定以筛选可用于调节细胞因子功能的一系列激动剂和拮抗剂。 因此，本发明进一步提供用于SOCS-受体相互作用的激动剂和拮抗剂的筛选测定和更特别的高通量筛选测定。 这样的激动剂和拮抗剂可用于制备用于控制细胞因子信号传导的药物。 细胞因子信号传导的控制对于治疗一系列病症（包括癌症，炎性病症，免疫学障碍和涉及信号转导异常的任何其他病症）是重要的。

    Method of modulating cell survival and reagents useful for same
    24.
    发明申请
    Method of modulating cell survival and reagents useful for same 有权
    调节细胞存活的方法和对其有用的试剂

    公开(公告)号：US20050090442A1

    公开(公告)日：2005-04-28

    申请号：US10921065

    申请日：2004-08-18

    申请人： Perry Bartlett ,  Elizabeth Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    发明人： Perry Bartlett ,  Elizabeth Coulson ,  Katrina Fieldew ,  Manuel Baca ,  Trevor Kilpatrick ,  Cheema Surindar

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  A61K38/17 ,  C12N5/00

    CPC分类号： C07K14/70571 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins s well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.

    摘要翻译： 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75 NTR）鉴定的区域介导。 本发明进一步提供编码p75 NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑重组肽，多肽和蛋白质以及其包含p75 NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75 NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75 NTR介导的细胞死亡。