公开(公告)号：US06586572B2

公开(公告)日：2003-07-01

申请号：US09604287

申请日：2000-06-22

申请人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler

发明人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler

IPC分类号： C07K1100

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K2319/00 ,  Y10S977/907 ,  Y10S977/911 ,  Y10S977/912

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06528054B1

公开(公告)日：2003-03-04

申请号：US09620405

申请日：2000-07-20

申请人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler

发明人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler

IPC分类号： A61K39395

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/4748 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S977/924

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US08182823B2

公开(公告)日：2012-05-22

申请号：US12895274

申请日：2010-09-30

申请人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

发明人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

IPC分类号： A61K47/00 ,  A61K38/00 ,  C07K1/00 ,  C07H21/02

CPC分类号： C07K16/3015 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/4748 ,  C07K2317/34 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N2500/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。

公开(公告)号：US07033827B2

公开(公告)日：2006-04-25

申请号：US10144678

申请日：2002-05-09

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  John Hural ,  Patricia D. McNeill ,  Raymond L. Houghton ,  Carlota Vinals y de Bassols ,  Teresa M. Foy ,  Yoshihiro Watanabe ,  Madeleine Joy Meagher ,  Ta Deng

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  John Hural ,  Patricia D. McNeill ,  Raymond L. Houghton ,  Carlota Vinals y de Bassols ,  Teresa M. Foy ,  Yoshihiro Watanabe ,  Madeleine Joy Meagher ,  Ta Deng

IPC分类号： C12Q1/68 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C07H21/02

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2710/14143 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。

公开(公告)号：US06943236B2

公开(公告)日：2005-09-13

申请号：US10012896

申请日：2001-12-10

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson ,  John Hural ,  Patricia D. McNeill ,  Raymond L. Houghton ,  Carlota Vinals y de Bassols ,  Teresa M. Foy ,  Yoshihiro Watanabe ,  Madeleine Joy Meagher

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson ,  John Hural ,  Patricia D. McNeill ,  Raymond L. Houghton ,  Carlota Vinals y de Bassols ,  Teresa M. Foy ,  Yoshihiro Watanabe ,  Madeleine Joy Meagher

IPC分类号： A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/11 ,  C07K14/47 ,  C07K14/705 ,  C07K16/30 ,  C12N9/64 ,  C07K14/00 ,  C07H21/02 ,  C12Q1/68 ,  C12N1/20

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US06818751B1

公开(公告)日：2004-11-16

申请号：US09651236

申请日：2000-08-29

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C07H2104

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2710/14143 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US06759515B1

公开(公告)日：2004-07-06

申请号：US09679426

申请日：2000-10-02

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C07K1400

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。

公开(公告)号：US06756477B1

公开(公告)日：2004-06-29

申请号：US09590751

申请日：2000-06-08

申请人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker

发明人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker

IPC分类号： C07K1400

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/4748 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S530/806 ,  Y10S530/828

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US6034218A

公开(公告)日：2000-03-07

申请号：US946026

申请日：1997-10-07

申请人： Steven G. Reed ,  Davin C. Dillon ,  Daniel R. Twardzik ,  Jennifer L. Mitcham

发明人： Steven G. Reed ,  Davin C. Dillon ,  Daniel R. Twardzik ,  Jennifer L. Mitcham

IPC分类号： A61K39/00 ,  C07K14/705 ,  C07K14/82 ,  C07K14/00

CPC分类号： C07K14/705 ,  C07K14/82 ,  A61K39/00

摘要： Compounds and methods for treating and diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides or DNA molecules encoding such polypeptides are also provided. The inventive polypeptides may also be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.

摘要翻译： 提供了治疗和诊断前列腺癌的化合物和方法。 本发明化合物包括含有至少一部分前列腺蛋白质的多肽。 还提供了包含这样的多肽或编码这种多肽的DNA分子的前列腺癌的免疫治疗用疫苗和药物组合物。 本发明的多肽也可用于产生可用于诊断和监测前列腺癌的抗体。 还提供了用于制备探针，引物和多肽的核酸序列。

公开(公告)号：US20080226643A1

公开(公告)日：2008-09-18

申请号：US11929833

申请日：2007-10-30

申请人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon ,  Marc W. Retter ,  Susan L. Harlocker

发明人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon ,  Marc W. Retter ,  Susan L. Harlocker

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K9/00 ,  C07K14/00 ,  C12N15/64 ,  C12Q1/68 ,  C12N5/08 ,  C07K16/00 ,  G01N33/53 ,  C07K19/00 ,  A61P35/00

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/82 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2319/00 ,  C12Q1/6886

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.