公开(公告)号：US09365574B2

公开(公告)日：2016-06-14

申请号：US13699046

申请日：2011-05-24

申请人： Subharekha Raghavan ,  John E. Stelmach ,  Cameron J. Smith ,  Hong Li ,  Alan Whitehead ,  Sherman T. Waddell ,  Yi-Heng Chen ,  Shouwu Miao ,  Olga A. Ornoski ,  Joie Garfunkle ,  Xibin Liao ,  Jiang Chang ,  Xiaoqing Han ,  Jian Guo ,  Jonathan A. Groeper ,  Linda L. Brockunier ,  Keith Rosauer ,  Emma R. Parmee

发明人： Subharekha Raghavan ,  John E. Stelmach ,  Cameron J. Smith ,  Hong Li ,  Alan Whitehead ,  Sherman T. Waddell ,  Yi-Heng Chen ,  Shouwu Miao ,  Olga A. Ornoski ,  Joie Garfunkle ,  Xibin Liao ,  Jiang Chang ,  Xiaoqing Han ,  Jian Guo ,  Jonathan A. Groeper ,  Linda L. Brockunier ,  Keith Rosauer ,  Emma R. Parmee

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/519 ,  A61P29/00 ,  A61P9/12 ,  A61P3/10 ,  A61P9/10 ,  A61P11/06 ,  A61P15/10 ,  A61P9/04 ,  A61P13/12 ,  A61P1/16

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07D519/00

摘要： A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof.

摘要翻译： 式（I）的化合物或其药学上可接受的盐能够调节身体的环鸟苷酸（“cGMP”）的产生，并且通常适用于治疗和预防与受干扰的cGMP平衡相关的疾病 。 本发明还涉及用于制备式I化合物或其药学上可接受的盐的方法，用于治疗和预防上述疾病和用于制备用于该目的的药物以及包含式（III）化合物的药物制剂 I）或其药学上可接受的盐。

公开(公告)号：US07968589B2

公开(公告)日：2011-06-28

申请号：US12702358

申请日：2010-02-09

申请人： John E. Stelmach ,  Emma R. Parmee ,  James R. Tata ,  Keith G. Rosauer ,  Ronald M. Kim ,  Amy R. Bittner ,  Jiang Chang ,  Christopher Joseph Sinz

发明人： John E. Stelmach ,  Emma R. Parmee ,  James R. Tata ,  Keith G. Rosauer ,  Ronald M. Kim ,  Amy R. Bittner ,  Jiang Chang ,  Christopher Joseph Sinz

IPC分类号： A61K31/404 ,  C07D209/10

CPC分类号： C07D209/18

摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

公开(公告)号：US20110118282A1

公开(公告)日：2011-05-19

申请号：US12674795

申请日：2008-09-02

申请人： Amy R. Bittner ,  Christopher Joseph Sinz ,  Jiang Chang ,  Ronald M. Kim ,  J.W. Mirc ,  Emma R. Parmee ,  Qiang Tan

发明人： Amy R. Bittner ,  Christopher Joseph Sinz ,  Jiang Chang ,  Ronald M. Kim ,  J.W. Mirc ,  Emma R. Parmee ,  Qiang Tan

IPC分类号： A61K31/497 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  C07D409/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/427 ,  A61K31/506 ,  C12N9/88 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P15/10 ,  A61P11/06 ,  A61P13/12 ,  A61P3/10 ,  A61P1/16 ,  A61P9/08 ,  A61P7/10 ,  A61P3/06

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.

摘要翻译： 具有用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，心绞痛，血栓形成，再狭窄，心肌梗塞，中风，心功能不全，肺性高血压，勃起功能障碍，哮喘支气管炎，慢性肾脏的结构的化合物 功能不全，糖尿病或人类或动物患者肝脏肝硬化。

公开(公告)号：US07853292B2

公开(公告)日：2010-12-14

申请号：US10840756

申请日：2004-05-06

申请人： Jiang Chang ,  Fang-Chen Cheng ,  Teck Hu ,  Jun Qiang Liu ,  Yifei Yuan

发明人： Jiang Chang ,  Fang-Chen Cheng ,  Teck Hu ,  Jun Qiang Liu ,  Yifei Yuan

IPC分类号： H04M1/00 ,  H04B1/38

CPC分类号： H04W28/18

摘要： The present invention provides methods for distributed resource management for enhanced dedicated channel. One method of communication with at least one base station includes determining at least one short-term entity associated with the at least one base station and providing the at least one short-term entity to a radio network controller. Another method includes receiving at least one short-term entity associated with the at least one base station and allocating at least one long-term resource based upon the at least one short-term entity.

摘要翻译： 本发明提供了用于增强专用信道的分布式资源管理方法。 与至少一个基站进行通信的一种方法包括确定与所述至少一个基站相关联的至少一个短期实体，并向无线电网络控制器提供所述至少一个短期实体。 另一种方法包括接收至少一个与所述至少一个基站相关联的短期实体，并且基于所述至少一个短期实体分配至少一个长期资源。

公开(公告)号：US07687534B2

公开(公告)日：2010-03-30

申请号：US11906374

申请日：2007-10-02

申请人： John E. Stelmach ,  Emma R. Parmee ,  James R. Tata ,  Keith G. Rosauer ,  Ronald M. Kim ,  Amy R. Bittner ,  Jiang Chang ,  Christopher Joseph Sinz

发明人： John E. Stelmach ,  Emma R. Parmee ,  James R. Tata ,  Keith G. Rosauer ,  Ronald M. Kim ,  Amy R. Bittner ,  Jiang Chang ,  Christopher Joseph Sinz

IPC分类号： A61K31/404 ,  C07D209/14

CPC分类号： C07D209/18

摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

摘要翻译： 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。

公开(公告)号：US20090209564A1

公开(公告)日：2009-08-20

申请号：US12225056

申请日：2007-03-19

申请人： Ronald M. Kim ,  Emma R. Parmee ,  Qiang Tan ,  Ashley Rouse Lins ,  Jiang Chang ,  Cangming Yang

发明人： Ronald M. Kim ,  Emma R. Parmee ,  Qiang Tan ,  Ashley Rouse Lins ,  Jiang Chang ,  Cangming Yang

IPC分类号： A61K31/505 ,  C07C233/78 ,  A61K31/192 ,  A61K31/47 ,  C07D215/06 ,  C07D239/34 ,  A61P3/10

CPC分类号： C07D215/06 ,  C07C229/52 ,  C07C233/83 ,  C07C235/42 ,  C07C255/57 ,  C07C309/65 ,  C07C309/66 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07D209/10 ,  C07D213/30 ,  C07D213/56 ,  C07D213/61 ,  C07D213/64 ,  C07D213/69 ,  C07D213/74 ,  C07D215/14 ,  C07D215/20 ,  C07D215/227 ,  C07D231/12 ,  C07D231/56 ,  C07D235/18 ,  C07D239/34 ,  C07D257/06 ,  C07D261/08 ,  C07D263/57 ,  C07D271/10 ,  C07D271/12 ,  C07D277/64 ,  C07D277/68 ,  C07D285/14 ,  C07D307/42 ,  C07D307/79 ,  C07D307/81 ,  C07D311/12 ,  C07D311/58 ,  C07D333/54 ,  C07D333/60 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/12 ,  C07D491/04

摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

摘要翻译： 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。

公开(公告)号：US20060142193A1

公开(公告)日：2006-06-29

申请号：US11270653

申请日：2005-11-09

申请人： Lei Wei ,  Robert Schwartz ,  Jiang Chang ,  Mark Entman

发明人： Lei Wei ,  Robert Schwartz ,  Jiang Chang ,  Mark Entman

IPC分类号： A61K38/17 ,  A61K48/00

CPC分类号： A61K38/45 ,  A01K67/0276 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0375 ,  A61K48/005 ,  A61K48/0058 ,  C07K14/4747 ,  C12N15/1137 ,  C12N15/86 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2710/10343 ,  C12N2830/002

摘要： The present invention is directed to the treatment and/or prevention of disease as it relates to Rho kinase. In specific embodiments, disease is treated and/or prevented through the administration of an agent that selectively inhibits ROCK1. In specific embodiments, it inhibits ROCK1 and not ROCK2. In other specific embodiments, the disease is cardiac disease.

摘要翻译： 本发明涉及与Rho激酶有关的疾病的治疗和/或预防。 在具体实施方案中，通过施用选择性抑制ROCK1的药剂来治疗和/或预防疾病。 在具体实施方案中，其抑制ROCK1而不是ROCK2。 在其它具体实施方案中，该疾病是心脏病。

公开(公告)号：US06511994B2

公开(公告)日：2003-01-28

申请号：US09973920

申请日：2001-10-10

申请人： Ronald M. Kim ,  Jiang Chang ,  Kevin T. Chapman ,  Sander G. Mills

发明人： Ronald M. Kim ,  Jiang Chang ,  Kevin T. Chapman ,  Sander G. Mills

IPC分类号： A61K31445

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Compounds of Formula I: (wherein R1, R2, R3, R4, Q, and X are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

摘要翻译： 描述式I化合物（其中R 1，R 2，R 3，R 4，Q和X在本文中定义）。 这些化合物是CCR5趋化因子受体活性的调节剂。 所述化合物可用于例如预防或治疗HIV感染和治疗AIDS，作为化合物或药学上可接受的盐，或作为药物组合物中的成分，任选地与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。

公开(公告)号：US10990342B2

公开(公告)日：2021-04-27

申请号：US16669804

申请日：2019-10-31

申请人： Jiang Chang

发明人： Jiang Chang

IPC分类号： G06F3/14 ,  H04N5/33 ,  G06F3/01 ,  H04N13/133 ,  H04N13/275 ,  H04N13/282 ,  H04N13/327 ,  G09G5/02 ,  H04N13/324 ,  G06F3/147

摘要： A method and system for a displaying content that makes LED real-time 3D displays possible. The 3D image formation includes multi-screen display color correction and multi-camera infrared positioning technology. The present invention presents the display effects of a simulation environment in a better way through switching and moving and ensures that while in movement, the display effects of LED screens taken by video cameras from different angles can be maintained the same, so as to create a vivid simulation environment for television programming and film shooting. The multi-viewpoint switched shooting system and method based on the infrared positioning system includes a multifaceted irregular screen, a video splicer, a 3D rendering server, an infrared positioning system, a motion-capture computer, a Network switch and a multichannel control server.

公开(公告)号：US20210072946A1

公开(公告)日：2021-03-11

申请号：US16950021

申请日：2020-11-17

申请人： Jiang Chang ,  Xingchen Liu

发明人： Jiang Chang ,  Xingchen Liu

IPC分类号： G06F3/14 ,  H04N5/33 ,  G06F3/01 ,  H04N13/133 ,  H04N13/275 ,  H04N13/282 ,  H04N13/327 ,  G09G5/02 ,  H04N13/324 ,  G06F3/147

摘要： A method and system for a displaying content that makes LED real-time 3D displays possible. The 3D image formation includes multi-screen display color correction and multi-camera infrared positioning technology. The present invention presents the display effects of a simulation environment in a better way through switching and moving and ensures that while in movement, the display effects of LED screens taken by video cameras from different angles can be maintained the same, so as to create a vivid simulation environment for television programming and film shooting. The system for maintaining accuracy in a 3D image formation includes a multi-screen display color correction system, a multi-screen display color correction system comprising a large-size screen server, a video camera and a large-size display screen wherein the large-size screen color correction server includes an image input module, a position data module, a comprehensive color correction server and an image output module.