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公开(公告)号：US20120059355A1
公开(公告)日：2012-03-08
申请号：US12877820
申请日：2010-09-08
Applicant: Shubhayu Basu , Randolf von Oepen , Eugene Michal , Florian Ludwig
Inventor： Shubhayu Basu , Randolf von Oepen , Eugene Michal , Florian Ludwig
CPC classification number: A61M25/1011 , A61B17/12045 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B17/3478 , A61B2017/00243 , A61B2017/00495 , A61M25/003 , A61M2025/0092 , A61M2025/1052
Abstract: A reinforcement region is formed within the myocardium by introducing a delivery device through a vessel wall to a treatment site within a myocardium. A biomaterial is then delivered to the treatment site as the delivery device is withdrawn from the treatment site to form the reinforcement regions. Formation of the reinforcement region may further include introducing a delivery device through a vessel wall to a region within a myocardium such that the delivery device is positioned within the myocardium substantially parallel to a wall of the myocardium. A biomaterial may be delivered into a space formed within the region by the delivery device. The reinforcement region may be formed around an infarct tissue region of a myocardium to reinforce the damaged tissue.
Abstract translation: 通过将输送装置通过血管壁引导到心肌内的治疗部位，在心肌内形成增强区域。 然后当从处理部位取出输送装置以形成加强区域时，将生物材料输送到处理部位。 加强区域的形成可以进一步包括将输送装置通过血管壁引入心肌内的区域，使得输送装置位于基本上平行于心肌壁的心肌内。 生物材料可以通过输送装置输送到在该区域内形成的空间中。 加强区域可以围绕心肌的梗塞组织区域形成以加强受损组织。
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公开(公告)号：US20090022817A1
公开(公告)日：2009-01-22
申请号：US12016180
申请日：2008-01-17
Applicant: Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
Inventor： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
CPC classification number: A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
Abstract translation: 可以在足以引起心肌梗死扩张速率衰减的后心肌梗死区域中形成生物支架。 在心肌梗死后区域可进一步形成生物支架，引起左后壁壁厚度增加。 凝胶或生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。 例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分） 的至少两种不同的双组分凝胶化体系以形成第二混合物。
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23.发明申请Modified two-component gelation systems, methods of use and methods of manufacture 失效改进的双组分凝胶化系统，使用方法和制造方法公开(公告)号：US20080025943A1
公开(公告)日：2008-01-31
申请号：US11496824
申请日：2006-07-31
Applicant: Eugene Michal , Olof Mikael Trollsas , Shubhayu Basu
Inventor： Eugene Michal , Olof Mikael Trollsas , Shubhayu Basu
CPC classification number: A61K47/34 , A61K9/0024 , A61K9/06 , A61K35/12 , A61K38/00 , A61L27/26 , A61L27/38 , A61L27/50 , A61K2300/00
Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.
Abstract translation: 本文公开了组合物，制造方法和心肌梗死后治疗方法。 在一些实施方案中，组合物包含至少两种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物和具有在约6.5的pH下在第一缓冲液中组合的至少一个细胞粘附位点的物质。 第二组分可以包括pH在约7.5和9.0之间的第二缓冲液。 第二官能化聚合物可以包括在第一或第二组分中。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，本发明的组合物可以通过双孔注射装置递送到治疗区域，例如心肌梗死后区域。
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24.发明申请公开(公告)号：US20070218118A1
公开(公告)日：2007-09-20
申请号：US11447340
申请日：2006-06-05
Applicant: Eugene Michal , Shubhayu Basu , Hai-Chien Kuo
Inventor： Eugene Michal , Shubhayu Basu , Hai-Chien Kuo
IPC: A61K38/22 , A61K38/20 , A61K38/19 , A61K38/18 , A61K31/4439 , A61K31/56 , A61K31/557 , A61K9/70 , A61K9/127 , A61K9/50
CPC classification number: A61K9/0024 , A61K31/4439 , A61K31/557 , A61K31/56 , A61K38/195 , A61K38/27 , A61K38/30 , A61K47/36 , A61L27/26 , A61L27/52 , C08L5/08 , C08L89/06
Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
Abstract translation: 本文公开了治疗心肌梗死后损伤的方法和组合物。 在一些实施方案中，可以制造具有处理剂的载体。 载体可以由生物可蚀塑的缓释物质配制。 然后将所得负载载体悬浮在双组分基质系统的至少一个组分中，用于同时递送至心肌梗死后治疗区域。
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公开(公告)号：US20150017265A9
公开(公告)日：2015-01-15
申请号：US12016180
申请日：2008-01-17
Applicant: Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
Inventor： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
CPC classification number: A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
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Patent Agency Ranking
26.发明授权Modified two-component gelation systems, methods of use and methods of manufacture 有权改进的双组分凝胶化系统，使用方法和制造方法公开(公告)号：US08741326B2
公开(公告)日：2014-06-03
申请号：US11561328
申请日：2006-11-17
Applicant: Gene Michal , Shubhayu Basu
Inventor： Gene Michal , Shubhayu Basu
CPC classification number: A61K35/28 , A61K33/14 , A61K33/20 , A61K38/1858 , A61K38/363 , A61K38/4833 , A61L27/26 , A61L27/3873 , A61L27/52 , C12Y304/21005 , A61K2300/00 , A61K38/00
Abstract: A bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture. A treatment agent, such as a cell type or a growth factor, can be added to either the first mixture or the second mixture. In some embodiments, the treatment agent is not added to either mixture. The first mixture can be co-injected with the second mixture to form a bioscaffolding in an infarct region for treatment thereof.
Abstract translation: 生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。 例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分） 的至少两种不同的双组分凝胶化体系以形成第二混合物。 可以将第一混合物或第二混合物中的处理剂如细胞类型或生长因子加入。 在一些实施方案中，处理剂不加入任何混合物中。 可以将第一混合物与第二混合物共注射以在梗塞区域中形成生物支架，用于治疗它们。
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公开(公告)号：US08377033B2
公开(公告)日：2013-02-19
申请号：US12877820
申请日：2010-09-08
Applicant: Shubhayu Basu , Randolf von Oepen , Eugene Michal , Florian Ludwig
Inventor： Shubhayu Basu , Randolf von Oepen , Eugene Michal , Florian Ludwig
IPC: A61M25/00
CPC classification number: A61M25/1011 , A61B17/12045 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B17/3478 , A61B2017/00243 , A61B2017/00495 , A61M25/003 , A61M2025/0092 , A61M2025/1052
Abstract: A reinforcement region is formed within the myocardium by introducing a delivery device through a vessel wall to a treatment site within a myocardium. A biomaterial is then delivered to the treatment site as the delivery device is withdrawn from the treatment site to form the reinforcement regions. Formation of the reinforcement region may further include introducing a delivery device through a vessel wall to a region within a myocardium such that the delivery device is positioned within the myocardium substantially parallel to a wall of the myocardium. A biomaterial may be delivered into a space formed within the region by the delivery device. The reinforcement region may be formed around an infarct tissue region of a myocardium to reinforce the damaged tissue.
Abstract translation: 通过将输送装置通过血管壁引导到心肌内的治疗部位，在心肌内形成增强区域。 然后当从处理部位取出输送装置以形成加强区域时，将生物材料输送到处理部位。 加强区域的形成可以进一步包括将输送装置通过血管壁引入心肌内的区域，使得输送装置位于基本上平行于心肌壁的心肌内。 生物材料可以通过输送装置输送到在该区域内形成的空间中。 加强区域可以围绕心肌的梗塞组织区域形成以加强受损组织。
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公开(公告)号：US08221744B2
公开(公告)日：2012-07-17
申请号：US11857878
申请日：2007-09-19
Applicant: Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
Inventor： Shubhayu Basu , Gene Michal , Florian Ludwig , Jinping Wan , John Stankus
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
Abstract translation: 本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。
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公开(公告)号：US20110077618A1
公开(公告)日：2011-03-31
申请号：US12963397
申请日：2010-12-08
Applicant: Shubhayu Basu , Greg W. Chan
Inventor： Shubhayu Basu , Greg W. Chan
CPC classification number: A61M25/003 , A61M25/00 , A61M25/0032 , A61M25/0084 , A61M25/10
Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
Abstract translation: 本文公开了治疗心肌梗死后损伤的方法和组合物。 在一些实施方案中，可以制造具有处理剂的载体。 载体可以由生物可蚀塑的缓释物质配制。 然后将所得负载载体悬浮在双组分基质系统的至少一个组分中，用于同时递送至心肌梗死后治疗区域。
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30.发明申请公开(公告)号：US20080125745A1
公开(公告)日：2008-05-29
申请号：US11978986
申请日：2007-10-29
Applicant: Shubhayu Basu , Greg W. Chan
Inventor： Shubhayu Basu , Greg W. Chan
IPC: A61M25/00
CPC classification number: A61M25/003 , A61M25/00 , A61M25/0032 , A61M25/0084 , A61M25/10
Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
Abstract translation: 本文公开了治疗心肌梗死后损伤的方法和组合物。 在一些实施方案中，可以制造具有处理剂的载体。 载体可以由生物可蚀塑的缓释物质配制。 然后将所得负载载体悬浮在双组分基质系统的至少一个组分中，用于同时递送至心肌梗死后治疗区域。
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