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21.发明申请Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunoglobulin folds, BGS2, 3 and 4 and variants thereof 失效编码具有富含亮氨酸重复序列和免疫球蛋白折叠的三种新型人细胞表面蛋白的多核苷酸，BGS2,3和4及其变体公开(公告)号：US20070178088A1
公开(公告)日：2007-08-02
申请号：US11726220
申请日：2007-03-21
申请人： Shujian Wu , Stanley Krystek , Liana Lee , John Feder , Janet Cheng
发明人： Shujian Wu , Stanley Krystek , Liana Lee , John Feder , Janet Cheng
IPC分类号： A61K39/395 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28 , A61K38/17
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-2,3和4多肽，其片段和同系物的新型多核苷酸。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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22.发明申请Polynucleotides encoding a novel human Kupffer cell receptor protein, BGS-18 审中-公开编码新型人类枯否细胞受体蛋白BGS-18的多核苷酸公开(公告)号：US20060003367A1
公开(公告)日：2006-01-05
申请号：US11152697
申请日：2005-06-14
申请人： Shujian Wu , John Feder , Thomas Nelson
发明人： Shujian Wu , John Feder , Thomas Nelson
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding BGS-18 polypeptide, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-18 polypeptide to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码BGS-18多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-18多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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23.发明授权公开(公告)号：US07705133B2
公开(公告)日：2010-04-27
申请号：US12220155
申请日：2008-07-22
申请人： Ning Lee , Jian Chen , Shujian Wu , Michael A. Blanar , Paul C. Levesque , Lucy Sun
发明人： Ning Lee , Jian Chen , Shujian Wu , Michael A. Blanar , Paul C. Levesque , Lucy Sun
IPC分类号： C07K16/28 , C07K16/18 , A61K39/395
CPC分类号： C07K14/705 , C07H21/04 , C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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24.发明申请Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权编码新型睾丸特异性微管蛋白酪氨酸连接酶样蛋白的多核苷酸BGS42公开(公告)号：US20080026401A1
公开(公告)日：2008-01-31
申请号：US11900344
申请日：2007-09-10
申请人： John Feder , Shujian Wu , Thomas Nelson , Liana Lee
发明人： John Feder , Shujian Wu , Thomas Nelson , Liana Lee
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07034134B2
公开(公告)日：2006-04-25
申请号：US10133797
申请日：2002-04-26
申请人： Shujian Wu , Jian Chen
发明人： Shujian Wu , Jian Chen
CPC分类号： C12N9/6489
摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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公开(公告)号：US6020161A
公开(公告)日：2000-02-01
申请号：US955937
申请日：1997-10-22
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P17/00 , A61P29/00 , A61P37/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/12 , C12P21/02 , C12R1/91 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/70503 , A61K38/00
摘要： PIGR-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGR-1 polypeptides and polynucleotides in the design of protocols for the treatment of rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), among others and diagnostic assays for such conditions.
摘要翻译： 公开了PIGR-1多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗类风湿性关节炎（RA），多发性硬化症（MS），牛皮癣，系统性红斑狼疮（SLE）和炎症性肠病（IBD））的方案中使用PIGR-1多肽和多核苷酸的方法，其中 其他和诊断测定这些条件。
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27.发明申请BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO MICORTUBULE-STABILIZING AGENTS 审中-公开用于确定微生物稳定剂敏感性的生物标志物和方法公开(公告)号：US20110104664A1
公开(公告)日：2011-05-05
申请号：US12225776
申请日：2007-03-30
申请人： Hyerim Lee , Edwin A. Clark , Shujian Wu , Li-An Xu
发明人： Hyerim Lee , Edwin A. Clark , Shujian Wu , Li-An Xu
CPC分类号： G01N33/57415 , G01N33/57484 , G01N33/57496 , G01N2800/52
摘要： Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone.
摘要翻译： 可用于鉴定将对治疗癌症的治疗方法进行治疗或反应的哺乳动物有用的生物标志物，其包括施用微管稳定剂。 一方面，癌症是乳腺癌，并且微管稳定剂是埃坡霉素或其类似物或衍生物，或ixabepilone。
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28.发明申请BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 MODULATORS 审中-公开生物标志物和确定血管内皮生长因子受体-2调节因子灵敏度的方法公开(公告)号：US20100035259A1
公开(公告)日：2010-02-11
申请号：US12450122
申请日：2008-03-12
申请人： Shujian Wu , Mark David Ayers , Xia Han , Suganthy Yoganathan , Joseph Fargnoli
发明人： Shujian Wu , Mark David Ayers , Xia Han , Suganthy Yoganathan , Joseph Fargnoli
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： VEGFR-2 biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an VEGFR-2 modulator, wherein the method comprises (a) exposing the mammal to the VEGFR-2 modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the VEGFR-2 modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a VEGFR-2 modulator indicates that the mammal has responded therapeutically to the method of treating cancer
摘要翻译： 可用于鉴定和监测将对治疗癌症治疗的治疗反应的哺乳动物的方法中的VEGFR-2生物标志物，其包括施用VEGFR-2调节剂，其中所述方法包括（a）将哺乳动物暴露于VEGFR-2调节剂和（ b）在哺乳动物中测量至少一种生物标志物的水平，其中在（b）中测量的至少一种生物标志物水平的差异与未暴露于VEGFR的哺乳动物中的生物标志物的水平相比较 -2调节剂表明哺乳动物将对治疗癌症的方法进行治疗反应，（c）其中在暴露于VEGFR-2调节剂之后哺乳动物中生物标志物的水平表明哺乳动物对治疗癌症的方法有治疗反应
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公开(公告)号：US20080221305A1
公开(公告)日：2008-09-11
申请号：US12148669
申请日：2008-04-21
申请人： Jian Chen , Shujian Wu , Ning Lee , Dong Cheng
发明人： Jian Chen , Shujian Wu , Ning Lee , Dong Cheng
IPC分类号： C07K14/00
CPC分类号： C07K14/72
摘要： The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽，其片段及其同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新的人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽应用于诊断，治疗和/或治疗的诊断和治疗方法。 预防与这些多肽相关的各种疾病和/或病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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30.发明申请Polynucelotides encoding novel variants of the TRP channel family member, LTRPC3 有权Polynucelotides编码TRP通道家族成员LTRPC3的新型变体公开(公告)号：US20080118952A1
公开(公告)日：2008-05-22
申请号：US11985981
申请日：2007-11-19
申请人： Ning Lee , Jian Chen , John Feder , Shujian Wu , Michael Blanar , David Bol , Paul Levesque , Lucy Sun
发明人： Ning Lee , Jian Chen , John Feder , Shujian Wu , Michael Blanar , David Bol , Paul Levesque , Lucy Sun
CPC分类号： C07K14/705 , C07H21/04 , C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC3l多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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