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52 条记录 (耗时 0.023 秒)

    Secondary Amine Containing Nitric Oxide Releasing Polymer Composition
    22.
    发明申请
    Secondary Amine Containing Nitric Oxide Releasing Polymer Composition 审中-公开
    含有一氧化氮释放聚合物组合物的二级胺

    公开(公告)号：US20090222088A1

    公开(公告)日：2009-09-03

    申请号：US12040503

    申请日：2008-02-29

    申请人： Mingfei Chen ,  Peiwen Cheng

    发明人： Mingfei Chen ,  Peiwen Cheng

    IPC分类号： A61F2/02 ,  C08F20/06 ,  A61B17/08 ,  C07C211/22

    CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/114

    摘要： Disclosed herein are polymers used to coat or form implantable medical devices. The polymers comprise secondary amines useful in binding nitric oxide (NO). After diazeniumdiolation, the polymers can sustain controlled release of NO. In one embodiment, the secondary amines are linked to a functionalized dendrimer. In another embodiment, secondary amines are chelated with copper (II) which in turn serve as a catalyst for NO production.

    摘要翻译： 本文公开了用于涂覆或形成可植入医疗装置的聚合物。 聚合物包含可用于结合一氧化氮（NO）的仲胺。 在二氮烯硫醇化后，聚合物可以维持NO的控制释放。 在一个实施方案中，仲胺与官能化的树枝状聚合物连接。 在另一个实施方案中，仲胺与铜（II）螯合，其又用作NO生产的催化剂。

    Controlled Radical Polymerization-Derived Block Copolymer Compositions for Medical Device Coatings
    25.
    发明申请
    Controlled Radical Polymerization-Derived Block Copolymer Compositions for Medical Device Coatings 审中-公开
    用于医疗器械涂层的受控自由基聚合衍生的嵌段共聚物组合物

    公开(公告)号：US20080305143A1

    公开(公告)日：2008-12-11

    申请号：US12064110

    申请日：2006-08-09

    申请人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

    发明人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

    IPC分类号： A61F2/02 ,  A61L27/34

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  C08F293/005 ,  C08F2438/01 ,  C09D153/00

    摘要： Controlled radical polymerization-derived biocompatible block copolymer coatings for medical devices are disclosed. Specifically, block copolymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed. The present application also discloses providing vascular stents with drug-eluting controlled release block copolymer coatings and related methods for making these medical devices and coatings.

    摘要翻译： 公开了用于医​​疗装置的受控自由基聚合衍生的生物相容性嵌段共聚物涂层。 具体地，公开了设计用于控制体内从医疗器械释放生物活性剂的嵌段共聚物涂层。 本申请还公开了提供血管支架药物洗脱控制释放嵌段共聚物涂层和制备这些医疗装置和涂层的相关方法。

    Hydrogen sulfide generating polymers
    29.
    发明授权
    Hydrogen sulfide generating polymers 有权
    产生硫化氢的聚合物

    公开(公告)号：US08182830B2

    公开(公告)日：2012-05-22

    申请号：US12606346

    申请日：2010-01-05

    申请人： Mingfei Chen ,  Christopher Storment ,  David Shumaker

    发明人： Mingfei Chen ,  Christopher Storment ,  David Shumaker

    IPC分类号： C08F20/38 ,  A61F2/00

    CPC分类号： C08F20/38 ,  A61L27/14 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  C08F20/54 ,  C08L101/02

    摘要： Described herein are hydrogen sulfide (H2S) generating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H2S generating polymers comprising at least one thioamide group. The H2S generating polymers can provide controlled site-specific release of H2S once implanted at or within the target surgical site by hydrolysis of the thioamide group in physiological media. The H2S generating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system. Also described are methods of treating restenosis and inflammation and promoting vasodilation utilizing such medical devices.

    摘要翻译： 本文描述了产生适于涂覆或形成医疗装置的聚合物和聚合物系统的硫化氢（H 2 S）及其制备和使用方法。 更具体地，描述了包含至少一个硫代酰胺基团的H 2 S生成聚合物。 H 2 S生成聚合物可以通过在生理介质中水解硫代酰胺基团一次植入到目标手术部位内或内部，从而提供控制的位点特异性释放H 2 S. 产生H 2 S的聚合物可以涂覆在医疗装置上，形成医疗装置或与一种或多种其它聚合物组合以形成聚合物体系。 还描述了使用这种医疗装置治疗再狭窄和炎症并促进血管扩张的方法。

    Biocompatible controlled release coatings for medical devices and related methods
    30.
    发明授权
    Biocompatible controlled release coatings for medical devices and related methods 有权
    用于医疗器械和相关方法的生物相容性控释涂层

    公开(公告)号：US08088404B2

    公开(公告)日：2012-01-03

    申请号：US11005463

    申请日：2004-12-06

    申请人： Kishore Udipi ,  Peiwen Cheng ,  Mingfei Chen ,  Su-Ping Lyu

    发明人： Kishore Udipi ,  Peiwen Cheng ,  Mingfei Chen ,  Su-Ping Lyu

    IPC分类号： A61F2/04 ,  A61F2/00

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/602

    摘要： Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.

    摘要翻译： 公开了用于医​​疗装置的生物相容性涂层。 具体地，公开了设计用于在体内控制生物活性剂从医疗装置释放的聚合物涂层，其中聚合物和药物的溶解度参数与控制洗脱速率曲线紧密匹配。 本申请还公开了提供具有控制释放涂层的血管支架和用于制备这些涂层的相关方法。