公开(公告)号：US20100332246A1

公开(公告)日：2010-12-30

申请号：US12377578

申请日：2007-08-15

申请人： Ludwik Fedorko ,  Joseph Fisher ,  Bryan Drew Miller ,  Bryan Kowalchuk

发明人： Ludwik Fedorko ,  Joseph Fisher ,  Bryan Drew Miller ,  Bryan Kowalchuk

IPC分类号： G06Q50/00 ,  G09F3/00 ,  A61M5/31

CPC分类号： A61J1/2003 ,  A61J1/14 ,  A61J2205/10 ,  A61J2205/20 ,  A61J2205/30 ,  A61J2205/70 ,  A61M2205/6072 ,  A61M2205/6081 ,  G06F19/3456 ,  G06Q10/00 ,  G06Q10/06 ,  G06Q10/08 ,  G06Q10/0875 ,  G06Q50/22 ,  G16H40/20

摘要： The invention relates to a system and method for tracking drugs during a transfer and administering process to reduce labeling errors that can occur during that process. The system includes a storage container reader that is configured to read a set of one or more storage-container-associated machine-readable indicia positioned on a container containing a drug. The set of one or more storage-container-associated machine-readable indicia identifies the drug. The system further includes an indicia-generating device that is configured to generate a drug-delivery-container-associated indicia identifying the drug based on the storage-container-associated machine-readable indicia. The set of one or more drug-delivery-container-associated indicia includes a set of one or more drug-delivery-container-associated machine-readable indicia. Optionally the system further includes a drug delivery container reader, wherein the drug delivery container reader is configured to read the set of one or more drug-delivery-container-associated machine-readable indicia. Optionally the system further includes a processing unit that generates an output signal corresponding to the drug based on the set of one or more drug-delivery-container-associated machine-readable indicia. Optionally the system further includes an output device that outputs a user-comprehensible output identifying the drug based on the output signal from the processing unit.

摘要翻译： 本发明涉及用于在转移和施用过程中跟踪药物以减少在该过程中可能发生的标记错误的系统和方法。 该系统包括存储容器读取器，其被配置为读取位于容纳药物的容器上的一组或多个存储容器相关联的机器可读标记的集合。 一个或多个存储容器相关联的机器可读标记的集合识别该药物。 该系统还包括标记产生装置，其被配置为基于与存储容器相关联的机器可读标记来生成识别药物的药物递送 - 容器相关标记。 一组或多个药物递送 - 容器相关标记包括一组一个或多个药物递送 - 容器相关联的机器可读标记。 任选地，系统还包括药物递送容器读取器，其中药物递送容器读取器被配置为读取一组或多个药物递送 - 容器相关联的机器可读标记。 可选地，系统还包括处理单元，其基于一个或多个药物递送 - 容器相关联的机器可读标记的集合生成与药物相对应的输出信号。 可选地，系统还包括输出装置，其基于来自处理单元的输出信号输出识别药物的用户可理解的输出。

公开(公告)号：US20100060568A1

公开(公告)日：2010-03-11

申请号：US12205770

申请日：2008-09-05

申请人： Joseph Fisher ,  Erturk Kocalar

发明人： Joseph Fisher ,  Erturk Kocalar

IPC分类号： G09G5/08 ,  G09G5/00

CPC分类号： G06F3/03547 ,  H03K17/9622 ,  H03K2217/96031 ,  H03K2217/96066 ,  H03K2217/960725 ,  H03K2217/960755

摘要： A curved surface input device with normalized capacitive sensing is disclosed. The input device can normalize capacitive sensing through an overlay having a varying thickness, such as an overlay with a curved surface. The capacitive sensing normalization can be implemented in software, hardware or a combination of software and hardware. A software implementation for normalizing capacitive sensing can comprise adjusting the sensitivity of a sensing operation associated with different sensor elements of the input device. A hardware implementation for normalizing capacitive sensing can comprise adjusting a hardware configuration of the input device associated with one or more physical parameters that can influence the capacitive sensitivity of the sensor elements, such as an area of the sensor elements, a distance between the sensor elements and other conductive input device elements (such as a ground plane), and a dielectric constant associated with the overlay.

摘要翻译： 公开了一种具有归一化电容感测的曲面输入装置。 输入设备可以通过具有变化厚度的覆盖层（例如具有弯曲表面的覆盖层）来对电容感测进行归一化。 电容感测归一化可以在软件，硬件或软件和硬件的组合中实现。 用于规范化电容感测的软件实现可以包括调整与输入设备的不同传感器元件相关联的感测操作的灵敏度。 用于规范化电容感测的硬件实现可以包括调整与一个或多个物理参数相关联的输入设备的硬件配置，该物理参数可以影响传感器元件的电容灵敏度，例如传感器元件的区域，传感器元件之间的距离 和其它导电输入设备元件（例如接地平面）以及与覆盖层相关联的介电常数。

公开(公告)号：US20180311454A1

公开(公告)日：2018-11-01

申请号：US15904235

申请日：2018-02-23

申请人： Michael Klein ,  Joseph Fisher ,  James Duffin ,  Marat Slessarev ,  Cathie Kessler ,  Shoji Ito ,  Olivia Sobczyk ,  Anne Battisti-Charbonney ,  Daniel Michael Mandell

发明人： Michael Klein ,  Joseph Fisher ,  James Duffin ,  Marat Slessarev ,  Cathie Kessler ,  Shoji Ito ,  Olivia Sobczyk ,  Anne Battisti-Charbonney ,  Daniel Michael Mandell

IPC分类号： A61M16/00 ,  A61M16/12 ,  A61M16/10 ,  A61B5/091 ,  A61B5/08

CPC分类号： A61M16/0066 ,  A61B5/082 ,  A61B5/091 ,  A61M16/0045 ,  A61M16/026 ,  A61M16/1005 ,  A61M16/12 ,  A61M16/122 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2016/1025 ,  A61M2016/103 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/04 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/208 ,  A61M2230/432 ,  A61M2230/435

摘要： An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: obtaining input of a series of logistically attainable PetX values for a series of respective breaths: determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.

公开(公告)号：US20170224230A1

公开(公告)日：2017-08-10

申请号：US15438503

申请日：2017-02-21

申请人： Joseph Fisher ,  Michael Klein ,  James Duffin

发明人： Joseph Fisher ,  Michael Klein ,  James Duffin

IPC分类号： A61B5/0205 ,  A61B5/00

CPC分类号： A61B5/0205 ,  A61B5/026 ,  A61B5/029 ,  A61B5/0813 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/7225 ,  A61B5/7278 ,  A61M16/0057 ,  A61M16/12

摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non-invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a test criterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.

公开(公告)号：US20150083121A1

公开(公告)日：2015-03-26

申请号：US12513322

申请日：2007-11-07

申请人： Joseph Fisher ,  Bryan Kowalchuk ,  Bryan Drew Miller ,  Kevin Ramkhelawan ,  Kevin Kowalchuk ,  Cliff Ansel ,  David Dunn ,  Ludwik Fredorko

发明人： Joseph Fisher ,  Bryan Kowalchuk ,  Bryan Drew Miller ,  Kevin Ramkhelawan ,  Kevin Kowalchuk ,  Cliff Ansel ,  David Dunn ,  Ludwik Fredorko

IPC分类号： A61M16/10 ,  A61M16/04 ,  A61M16/22 ,  A61M16/08 ,  A61M16/20 ,  A61M16/00 ,  A61M16/06

CPC分类号： A61M16/1005 ,  A61G1/04 ,  A61M16/0003 ,  A61M16/0009 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/0066 ,  A61M16/0069 ,  A61M16/0075 ,  A61M16/024 ,  A61M16/0465 ,  A61M16/0666 ,  A61M16/0816 ,  A61M16/0833 ,  A61M16/0841 ,  A61M16/085 ,  A61M16/0875 ,  A61M16/101 ,  A61M16/106 ,  A61M16/1065 ,  A61M16/107 ,  A61M16/12 ,  A61M16/125 ,  A61M16/202 ,  A61M16/208 ,  A61M16/209 ,  A61M16/22 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2016/1025 ,  A61M2016/103 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2205/14 ,  A61M2205/18 ,  A61M2205/3334 ,  A61M2205/502 ,  A61M2205/8212 ,  A61M2209/082 ,  A61M2230/04 ,  A61M2230/06 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/432 ,  B01D53/0407 ,  B01D53/047 ,  B01D2256/12 ,  B01D2257/102 ,  B01D2259/40009 ,  B01D2259/4533 ,  B01D2259/4541

摘要： A portable life support apparatus (1102) and particularly a respiratory support apparatus adapted to be easily mounted to a stretcher is disclosed. Prior devices that attach onto a stretcher are heavy and cumbersome and obstruct access to the patient. Accordingly, there is a great need for a portable emergency support device that overcomes the weight, size, positioning, and other portability disadvantages. One aspect relates to a portable life support device including at least one ambient gas inlet (14); a conditioned gas outlet (30); an oxygen concentrator (26,28) fluidly connected between the at least one gas inlet and the gas outlet, and a ventilator (44) fluidly connected downstream from the oxygen concentrator. A further aspect is directed to a portable life support apparatus in the form of a portable respiratory support apparatus (1102) capable of exploiting both ambient air and expired gas as oxygen sources, wherein the oxygen generator (20) and ventilator (10) are arranged end to end to provide a longitudinal profile that can thus be compactly secured to a stretcher or other similar emergency transport vehicle.

摘要翻译： 公开了一种便携式生命支持设备（1102），特别是适于容易地安装在担架上的呼吸支持设备。 附着在担架上的现有装置是沉重和繁琐的并阻碍对患者的进入。 因此，非常需要一种克服重量，尺寸，定位和其他便携性缺点的便携式应急支持装置。 一个方面涉及包括至少一个环境气体入口（14）的便携式生命支持装置。 调节气体出口（30）; 流体连接在至少一个气体入口和气体出口之间的氧气浓缩器（26,28）和与氧气浓缩器下游流体连接的通气机（44）。 另一方面涉及一种便携式生命支持装置，其形式为能够利用环境空气和呼出气体作为氧源的便携式呼吸支持装置（1102），其中氧气发生器（20）和呼吸机（10）被布置 从而提供纵向轮廓，从而可以紧凑地固定到担架或其他类似的紧急运输车辆。

公开(公告)号：US20140311491A1

公开(公告)日：2014-10-23

申请号：US14363259

申请日：2012-12-05

申请人： Michael KLEIN ,  Joseph FISHER ,  James DUFFIN ,  Marat SLESSAREV ,  Cathie KESSLER ,  Shoji ITO

发明人： Michael Klein ,  Joseph Fisher ,  James Duffin ,  Marat Slessarev ,  Cathie Kessler ,  Shoji Ito

IPC分类号： A61M16/00 ,  A61M16/12 ,  A61B5/00 ,  A61M16/10 ,  A61M16/08 ,  A61B5/083

CPC分类号： A61M16/0051 ,  A61B5/083 ,  A61B5/0833 ,  A61B5/0836 ,  A61B5/4836 ,  A61M16/0003 ,  A61M16/0069 ,  A61M16/026 ,  A61M16/085 ,  A61M16/0883 ,  A61M16/1005 ,  A61M16/12 ,  A61M16/122 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/102 ,  A61M2016/1025 ,  A61M2016/103 ,  A61M2205/502 ,  A61M2230/43 ,  A61M2230/432 ,  A61M2230/435

摘要： A processor obtains input of a logistically attainable end tidal partial pressure of gas X (PetX[i]T) for one or more respective breaths [i] and input of a prospective computation of an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX[i]T for a respective breath [i] using inputs required to utilize a mass balance relationship, wherein one or more values required to control the amount of gas X in a volume of gas delivered to the subject is output from an expression of the mass balance relationship. The mass balance relationship is expressed in a form which takes into account (prospectively), for a respective breath [i], the amount of gas X in the capillaries surrounding the alveoli and the amount of gas X in the alveoli, optionally based on a model of the lung which accounts for those sub-volumes of gas in the lung which substantially affect the alveolar gas X concentration affecting mass transfer.

摘要翻译： 处理器获得用于一个或多个相应呼吸[i]的气体X（PetX [i] T）的逻辑可达到的末端潮气分压的输入，并且输入需要被受试者启发的气体X的量的预期计算 在一个启发的气体中，使用所需的输入来使用质量平衡关系的输入，使PetX [i] T针对相应的呼吸[i]，其中一个或多个值需要控制输送到 主体是从质量平衡关系的表达式输出的。 质量平衡关系以考虑（前瞻性）的形式表示，对于相应的呼吸[i]，肺泡周围的毛细血管中的气体量X和肺泡中的气体X的量，可选地基于 肺的模型，其占肺中气体的子体积，其基本上影响影响传质的肺泡气体X浓度。

公开(公告)号：US20110169667A1

公开(公告)日：2011-07-14

申请号：US13051691

申请日：2011-03-18

申请人： Fletcher ROTHKOPF ,  Jan Moolsintong ,  Joseph Fisher ,  Wendell Sander ,  Erturk Kocalar

发明人： Fletcher ROTHKOPF ,  Jan Moolsintong ,  Joseph Fisher ,  Wendell Sander ,  Erturk Kocalar

IPC分类号： H03M11/00

CPC分类号： H01H13/02 ,  G06F3/03547 ,  G06F3/044 ,  G06F3/0485 ,  G06F3/04883 ,  H01H13/7006 ,  H01H13/81 ,  H01H2003/0293 ,  H01H2207/004 ,  H01H2225/004 ,  H01H2225/03 ,  H01H2231/022 ,  H01H2231/032 ,  H01H2231/042 ,  H01H2239/006 ,  H01H2239/018 ,  H03K2217/96066

摘要： Compact input devices formed on flexible substrates are disclosed. The input devices may be formed using three or more conducting layers. By including three or more conducting layers, the diameter of the input device may be minimized. In addition, to improve the flexibility of portions of the input device mounted, some portions of the input device may be made to have fewer layers than other portions of the input device.

摘要翻译： 公开了形成在柔性基板上的紧凑型输入装置。 可以使用三个或更多个导电层来形成输入装置。 通过包括三个或更多个导电层，输入装置的直径可以最小化。 此外，为了提高安装的输入装置的部分的灵活性，可以使输入装置的一些部分具有比输入装置的其它部分更少的层。

公开(公告)号：US20070172818A1

公开(公告)日：2007-07-26

申请号：US11636405

申请日：2006-12-07

申请人： Joseph Fisher ,  James Lorens ,  Donald Payan ,  Alexander Rossi

发明人： Joseph Fisher ,  James Lorens ,  Donald Payan ,  Alexander Rossi

IPC分类号： C40B30/06 ,  C40B40/02 ,  C40B40/10

CPC分类号： G01N33/5008 ,  G01N15/147 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N2015/1477 ,  G01N2015/149

摘要： The invention relates to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.

摘要翻译： 本发明涉及检测细胞或细胞群体中细胞周期调节变化的新方法，并且通过使用多参数测定法和荧光激活细胞分选仪（FACS）机器筛选能够调节细胞周期调节的试剂。

公开(公告)号：US20060184508A1

公开(公告)日：2006-08-17

申请号：US09681574

申请日：2001-05-01

申请人： Christopher Fuselier ,  John Dougherty ,  Joseph Fisher ,  Thomas Digate ,  Richard Carpenter ,  Bernardo Anger

发明人： Christopher Fuselier ,  John Dougherty ,  Joseph Fisher ,  Thomas Digate ,  Richard Carpenter ,  Bernardo Anger

IPC分类号： G06F17/30

CPC分类号： G06Q10/06 ,  Y10S707/99933

摘要： A method and system are described for providing context sensitive data to a system user. The method includes the steps of identifying the user and querying databases to create a user context. Information is aggregated from the network databases and filtered using the user context. Providing the correct data needed by the user for that particular time, location and job function.

公开(公告)号：US06897031B1

公开(公告)日：2005-05-24

申请号：US09062330

申请日：1998-04-17

申请人： Joseph Fisher ,  James Lorens ,  Donald Payan ,  Alexander Rossi

发明人： Joseph Fisher ,  James Lorens ,  Donald Payan ,  Alexander Rossi

IPC分类号： G01N33/50 ,  G01N33/569 ,  G01N33/567

CPC分类号： G01N33/5011 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5047 ,  G01N33/56966 ,  G01N2333/43595 ,  G01N2333/4718

摘要： Described is a method for screening for alterations in exocytosis of a population of cells. The cells are sorted by a FACS machine by assaying for alterations in at least three of the properties selected from the group consisting of light scattering, fluorescent dye uptake, fluorescent dye release, annexin granule binding, surface granule enzyme activity, and the quantity of granule specific proteins. Methods for screening for bioactive agents capable of modulating exocytosis in a cell are also described. The methods provide for reduced background and increased specificity without increasing the time or steps involved in assaying for exocytosis.

摘要翻译： 描述了筛选细胞群的胞吐作用的方法。 细胞由FACS机通过测定至少三种选自光散射，荧光染料摄取，荧光染料释放，膜联蛋白颗粒结合，表面颗粒酶活性和颗粒数量的性质的变化进行分选 特异性蛋白质。 还描述了筛选能够调节细胞中胞吐作用的生物活性剂的方法。 所述方法提供降低的背景和增加的特异性，而不增加测定胞吐的时间或步骤。