摘要:
In one general aspect, an LED-based illumination source is disclosed that includes a screw-in household base with an outer thread centered about an insertion axis. A directional-type illumination housing is mechanically connected to the base and has a round light delivery end centered around the insertion axis and has a diameter that is larger than the base. One or more LED illumination elements occupy a portion of the round light delivery end of the directional-type illumination housing and each has an optical axis at least generally parallel with the insertion axis and face away from the base. One or more at least generally coplanar lenses have at least generally parallel optical axes each being aligned with one of the elements and being positioned opposite from the base with respect to the elements. A planar light-spreading element is positioned at least generally perpendicular to the optical axes and spans a portion of the round light delivery end of the directional-type illumination housing different from the portion of the round light delivery end of the directional-type illumination housing occupied by the illumination elements. The planar light-spreading element is optically coupled to the illumination elements, with the planar light-spreading element including an at least generally planar light-transmitting surface facing toward the base and with the planar light-transmitting surface defining lens elements each having an optical axis that is generally perpendicular to the light-transmitting surface.
摘要:
The present invention broadly comprises an automated pill crusher comprising a container operatively arranged to hold at least one pill, means for producing a linear force in a first direction upon at least one pill in the container, and, means for producing a spring force in a second direction upon at least one pill in the container. The pill crusher further comprises means for pulverizing at least one pill in the container.
摘要:
A system for drying fuel feedstocks, comprising a heat exchanger to heat an initial nitrogen gas and a combustion turbine engine for producing a combustion turbine exhaust. An apparatus for forming a pulverized fuel receives the heated nitrogen gas and combustion turbine exhaust, forming a steam and nitrogen mixture with the pulverized fuel source. A filter receives the mixture for filtering the dried fuel feedstock from the steam and nitrogen. The system further comprises a blower for applying a vacuum to the filter to separate the steam and nitrogen mixture into a discharge stream for and a recycle stream for mixing with additional dry nitrogen gas prior to mixing with combustion turbine exhaust in a continuous process.
摘要:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要:
A multi-well assembly according to one embodiment comprises a multi-well block and a guide plate. The multi-well block defines a plurality of wells, with each well having a fluid-impermeable bottom surface. The guide plate defines a plurality of fluid passageways corresponding to the wells of the multi-well block. The guide plate is configured such that, whenever the guide plate is registered with the multi-well block, fluid communication is established between each well and an associated fluid passageway. The guide plate enables iterative chemical or biological processes using multiple multi-well blocks. A seal plate is configured to cut fluid communication conferred by the guide plate via registration with the guide plate, or via registration with the multi-well block (once the guide plate is removed). The seal plate allows iterative chemical or biological processes within a single multi-well block.