公开(公告)号：US20110207935A1

公开(公告)日：2011-08-25

申请号：US13124345

申请日：2009-10-14

申请人： Kazuo Shimizu ,  Masato Iizuka ,  Hideki Fujikura ,  Yasushi Takigawa ,  Masahiro Hiratochi

发明人： Kazuo Shimizu ,  Masato Iizuka ,  Hideki Fujikura ,  Yasushi Takigawa ,  Masahiro Hiratochi

IPC分类号： C07D215/52 ,  C07D277/56 ,  C07D263/34 ,  C07D275/03 ,  C07D285/08 ,  C07D271/06 ,  C07C255/57 ,  C07D231/14 ,  C07D213/79

CPC分类号： C07C255/57 ,  A61K31/192 ,  A61K31/415 ,  A61K31/426 ,  A61K31/44 ,  A61K31/47 ,  C07C255/54 ,  C07D213/79 ,  C07D215/50 ,  C07D231/14 ,  C07D277/20 ,  C07D277/56

摘要： The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal plasma uric acid level and the like. The present invention relates to fused ring derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of plasma uric acid level, prodrugs thereof, salts thereof or the like. In the formula (I), X1 and X2 represent CH or N; ring U represents aryl or heteroaryl; m represents integral number from 0 to 2; n represents integral number from 0 to 3; R1 represents a hydroxy group, amino or C1-6 alkyl; R2 represents C1-6 alkyl, C1-6 alkoxy C1-6 alkyl or the like.

摘要翻译： 本发明提供了可用作预防或治疗与异常血浆尿酸水平等相关的疾病的药剂的化合物。 本发明涉及具有黄嘌呤氧化酶抑制活性的由下式（I）表示的稠环衍生物，可用作预防或治疗与血浆尿酸水平异常有关的疾病，其前药，其盐或类似物 。 在式（I）中，X 1和X 2表示CH或N; 环U表示芳基或杂芳基; m表示0〜2的整数; n表示0〜3的整数; R1表示羟基，氨基或C1-6烷基; R 2表示C 1-6烷基，C 1-6烷氧基C 1-6烷基等。

公开(公告)号：US08003160B2

公开(公告)日：2011-08-23

申请号：US11707091

申请日：2007-02-16

申请人： Hiroshi Sasaki ,  Makoto Kurosawa ,  Kazuo Shimizu

发明人： Hiroshi Sasaki ,  Makoto Kurosawa ,  Kazuo Shimizu

IPC分类号： B05D5/12

CPC分类号： H05K3/1208 ,  H05K3/125 ,  H05K3/386 ,  H05K2201/015 ,  H05K2201/0209 ,  H05K2203/013 ,  H05K2203/1173 ,  Y10T428/24917

摘要： A substrate is provided on which wires can be formed satisfactorily using a dispersion liquid of metal microparticles without causing disconnection or short circuit. The wiring substrate comprises a substrate, an organic membrane formed on the substrate, and a metal wire formed on the organic membrane. An arithmetic mean deviation Ra of the profile of the surface of the organic membrane where the metal wire is formed is not less than 60 nm and not more than 5×10−2D, where D is the width of the metal wire. The contact angle with respect to water on the surface of the organic membrane where the metal wire is formed is not less than 110°.

摘要翻译： 提供一种基板，其上可以令人满意地使用金属微粒的分散液形成导线，而不会导致断开或短路。 布线基板包括基板，形成在基板上的有机膜和形成在有机膜上的金属线。 形成金属线的有机膜的表面的轮廓的算术平均偏差Ra为60nm以上且5×10-2D以下，D为金属线的宽度。 形成金属线的有机膜表面上的水的接触角不小于110°。

公开(公告)号：US20100215215A1

公开(公告)日：2010-08-26

申请号：US12638884

申请日：2009-12-15

申请人： Hiromu UESHIMA ,  Kazuo Shimizu

发明人： Hiromu UESHIMA ,  Kazuo Shimizu

IPC分类号： G06K9/00

CPC分类号： A63F13/213 ,  A63F13/06 ,  A63F13/214 ,  A63F13/26 ,  A63F2300/1068 ,  A63F2300/1087 ,  A63F2300/301 ,  A63F2300/6045 ,  A63F2300/8011 ,  A63F2300/8064

摘要： This is provided with a plurality of retroreflective sheets each of which is attached to a screen and retroreflectively reflects received light, an imaging unit which photographs the retroreflective sheets, and an MCU which analyzes a differential picture obtained by photographing. The MCU detects, from the differential picture, a shade area corresponding to a part of the retroreflective sheet which is covered by a foot of a player. The detection of the shade area corresponds to the detection of the foot of the player. Because, in the case where the foot is placed on the retroreflective sheet, the part corresponding thereto is not captured in the differential picture, and is present as a shade area. It is possible to detect a foot without attaching and fixing a reflecting sheet to the foot.

摘要翻译： 设置有多个后向反射片，每个反光片附接到屏幕并且反射反射接收的光，拍摄逆反射片的成像单元和分析通过拍摄获得的差分图像的MCU。 MCU从差分图像检测对应于由播放器的脚覆盖的逆反射片的一部分的阴影区域。 阴影区域的检测对应于玩家脚的检测。 因为在脚放置在逆反射片上的情况下，与其对应的部分未被捕获在差分图像中，并且作为阴影区域存在。 可以检测脚而不将反射片固定到脚上。

公开(公告)号：US20080038242A1

公开(公告)日：2008-02-14

申请号：US11473957

申请日：2006-06-23

申请人： Norhiko Kikuchi ,  Yoshinori Nonaka ,  Kazuya Tatani ,  Masahiro Hiratochi ,  Yu Kuramochi ,  Masayuki Isaji ,  Kazuo Shimizu ,  Takashi Miyagi

发明人： Norhiko Kikuchi ,  Yoshinori Nonaka ,  Kazuya Tatani ,  Masahiro Hiratochi ,  Yu Kuramochi ,  Masayuki Isaji ,  Kazuo Shimizu ,  Takashi Miyagi

IPC分类号： A61K38/44 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4427 ,  A61P19/02 ,  A61P7/00 ,  C07D221/00 ,  C07D295/00 ,  C07D235/04 ,  C07D213/02 ,  A61P29/00 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K33/00

CPC分类号： C07H19/052

摘要： The present invention provides benzimidazole derivatives represented by the following formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an inhibitory activity on sodium-dependent nucleoside transporter 2 and are useful for a disease associated with an abnormality of plasma uric acid level. The compounds of the present invention are useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like. In the formula, n is 1 or 2; R1 and R2 are H, a halogen atom, cyano group, optionally substituted alkyl group, optionally substituted aryl group or the like; R3 is H, a halogen atom, optionally substituted alkyl group or the like; R4 and R5 are H, a halogen atom, OH or the like; and R6 and RX are H or OH: RY is F or OH.

摘要翻译： 本发明提供由下式（I）表示的苯并咪唑衍生物或其药学上可接受的盐或其前药，其对钠依赖性核苷转运蛋白2具有抑制活性，并且可用于与血浆尿酸异常有关的疾病 水平。 本发明的化合物可用于预防或治疗痛风，高尿酸血症，尿结石病，高尿酸性肾病等。 在该式中，n为1或2; R 1和R 2均为H，卤素原子，氰基，任选取代的烷基，任选取代的芳基等; R 3是H，卤素原子，任选取代的烷基等; R 4和R 5是H，卤素原子，OH等; R 6和R X是H或OH：R Y是F或OH。

公开(公告)号：US07222946B2

公开(公告)日：2007-05-29

申请号：US10824588

申请日：2004-04-15

申请人： Osamu Machida ,  Kunio Satou ,  Kazuo Shimizu ,  Yoshinari Suzuki

发明人： Osamu Machida ,  Kunio Satou ,  Kazuo Shimizu ,  Yoshinari Suzuki

IPC分类号： B41J2/045

CPC分类号： B41J2/14274

摘要： An ink jet head includes: a chamber plate having a plurality of pressuring chambers formed therein for storing an ink; a vibrating plate bonded to the chamber plate; a housing having an ink flow path through which an ink is supplied into the pressuring chambers; an orifice through which an ink is ejected from the pressuring chambers; and a longitudinal vibration mode piezoelectric element for generating pressure under which an ink droplet is ejected through the orifice. A thickness of the vibration plate is from 5 μm to 10 μm.

摘要翻译： 一种喷墨头包括：一个室板，其中形成有多个压力室，用于储存油墨; 结合到室板的振动板; 具有油墨流动通道的壳体，通过所述油墨流路将油墨供应到所述加压室中; 从所述加压室喷射墨水的孔口; 以及用于产生压力的纵向振动模式压电元件，在该压力下通过孔口喷射墨滴。 振动板的厚度为5um〜10um。

公开(公告)号：US07163279B2

公开(公告)日：2007-01-16

申请号：US10874283

申请日：2004-06-24

申请人： Kazuo Shimizu ,  Osamu Machida ,  Tomohiko Koda

发明人： Kazuo Shimizu ,  Osamu Machida ,  Tomohiko Koda

IPC分类号： B41J2/045

CPC分类号： B41J2/1629 ,  B41J2/14274 ,  B41J2/1612 ,  B41J2/1628 ,  B41J2202/11

摘要： A piezoelectric element is attached to a diaphragm via a relay member. A length of the relay member is shorter than the length of the piezoelectric element and longer than an active section in the piezoelectric element with respect to a direction orthogonal to a direction in which a plurality of nozzles are aligned. Also, a surface of the relay member that attached to the diaphragm has a width that is shorter than the piezoelectric element with respect to the direction in which the nozzles are aligned.

摘要翻译： 压电元件经由继电器构件附接到隔膜。 继电器构件的长度比压电元件的长度短，并且比压电元件中与多个喷嘴对准的方向正交的方向的有效部分长。 此外，附接到隔膜的中继构件的表面相对于喷嘴对准的方向具有比压电元件短的宽度。

公开(公告)号：US20060166899A1

公开(公告)日：2006-07-27

申请号：US10523820

申请日：2003-08-07

申请人： Hirotaka Teranishi ,  Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Kazuo Shimizu ,  Toshihide Shibazaki ,  Masayuki Isaji

发明人： Hirotaka Teranishi ,  Nobuhiko Fushimi ,  Shigeru Yonekubo ,  Kazuo Shimizu ,  Toshihide Shibazaki ,  Masayuki Isaji

IPC分类号： A61K31/7056 ,  C07H17/02

CPC分类号： C07H17/02

摘要： The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C1-6 alkylene group etc.; Z represents CO or SO2; R4 and R5 represent H, an optionally substituted C1-6 alkyl group etc.; and R3, R6 and R7 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.

摘要翻译： 本发明提供由以下通式表示的吡唑衍生物：其中R 1表示H，任选取代的C 1-6烷基等; Q和T之一表示由通式表示的基团或由通式表示的基团：而另一个表示任选取代的C 1-6烷基等; R 2表示H，卤素原子，OH，任选取代的C 1-6烷基等; X表示单键，O或S; Y表示单键，C 1-6亚烷基等; Z表示CO或SO 2; R 4和R 5表示H，任选取代的C 1-6烷基等; R 3，R 6和R 7表示H，卤素原子等，其药学上可接受的盐或其前药，其表现出 在人SGLT1中具有优异的抑制活性，并且可用作预防或治疗与糖尿病，糖尿病并发症或肥胖症等高血糖相关的疾病的药剂，以及含有该疾病的药物组合物，其药学用途及其生产用中间体。

公开(公告)号：US20050158528A1

公开(公告)日：2005-07-21

申请号：US11019984

申请日：2004-12-23

申请人： Hiroshi Sasaki ,  Makoto Kurosawa ,  Kazuo Shimizu

发明人： Hiroshi Sasaki ,  Makoto Kurosawa ,  Kazuo Shimizu

IPC分类号： H05K1/09 ,  B32B1/00 ,  B32B9/00 ,  C08J7/12 ,  C09K3/18 ,  H05K1/02 ,  H05K3/10 ,  H05K3/12 ,  H05K3/38

CPC分类号： H05K3/1208 ,  H05K3/125 ,  H05K3/386 ,  H05K2201/015 ,  H05K2201/0209 ,  H05K2203/013 ,  H05K2203/1173 ,  Y10T428/24917

摘要： A substrate is provided on which wires can be formed satisfactorily using a dispersion liquid of metal microparticles without causing disconnection or short circuit. The wiring substrate comprises a substrate, an organic membrane formed on the substrate, and a metal wire formed on the organic membrane. An arithmetic mean deviation Ra of the profile of the surface of the organic membrane where the metal wire is formed is not less than 60 nm and not more than 5×10−2 D, where D is the width of the metal wire. The contact angle with respect to water on the surface of the organic membrane where the metal wire is formed is not less than 110°.

摘要翻译： 提供一种基板，其上可以令人满意地使用金属微粒的分散液形成导线，而不会导致断开或短路。 布线基板包括基板，形成在基板上的有机膜和形成在有机膜上的金属线。 形成金属线的有机膜表面的轮廓的算术平均偏差Ra不小于60nm且不大于5×10 -2 D，其中D是 金属丝。 形成金属线的有机膜表面上的水的接触角不小于110°。

公开(公告)号：US06764381B2

公开(公告)日：2004-07-20

申请号：US10388508

申请日：2003-03-17

申请人： Norio Kimura ,  Hideji Isobe ,  Kazuo Shimizu ,  Hiroyuki Osawa

发明人： Norio Kimura ,  Hideji Isobe ,  Kazuo Shimizu ,  Hiroyuki Osawa

IPC分类号： B24B4910

CPC分类号： B24B37/013 ,  B24B49/04 ,  B24B49/10 ,  H01L21/30625

摘要： A polishing apparatus is used for polishing a substrate such as a semiconductor wafer, and has a sensor capable of continuously detecting the thickness of an electrically conductive layer. The polishing apparatus includes a polishing table having a polishing surface, and a top ring for holding and pressing the substrate against the polishing surface to polish the surface of the substrate. A sensor such as an eddy-current sensor is disposed below the polishing surface of the polishing table for measuring the thickness of a conductive layer formed on the surface of the substrate.

摘要翻译： 抛光装置用于抛光诸如半导体晶片的基板，并且具有能够连续地检测导电层的厚度的传感器。 抛光装置包括具有抛光表面的抛光台和用于将基板保持并压靠在抛光表面上以抛光基板的表面的顶环。 诸如涡电流传感器的传感器设置在抛光台的抛光表面下方，用于测量在基板表面上形成的导电层的厚度。

公开(公告)号：US06561629B2

公开(公告)日：2003-05-13

申请号：US10095468

申请日：2002-03-13

申请人： Takahiro Yamada ,  Kunio Satou ,  Shinya Kobayashi ,  Hitoshi Kida ,  Kazuo Shimizu ,  Toshitaka Ogawa ,  Yoshikane Matsumoto ,  Lee Chahn

发明人： Takahiro Yamada ,  Kunio Satou ,  Shinya Kobayashi ,  Hitoshi Kida ,  Kazuo Shimizu ,  Toshitaka Ogawa ,  Yoshikane Matsumoto ,  Lee Chahn

IPC分类号： B41J206

CPC分类号： B41J2/06

摘要： A back electrode 30 is provided at a rear surface side of a recording sheet 60. An orifice electrode 11 is attached to an orifice plate 15 of a head module 10. The orifice electrode 11, the orifice plate 15, and ink filling in a nozzle element 2 are electrically connected to the ground. The back electrode 30 has the potential corresponding to that of a charging/deflecting signal. With this configuration, the orifice electrode 11, a pressure chamber 13, and the back electrode 30 together generates an inclined electric field 85 at a position a close to a center trajectory 90. A charged ink droplet is deflected greatly by the inclined electric field 85, at an early stage of the ink flight, and even greater deflection can be achieved as the flight proceeds.

摘要翻译： 背面电极30设置在记录片材60的后表面侧。孔电极11附着到头模块10的孔板15上。孔电极11，孔板15和填充在喷嘴中的墨 元件2电连接到地面。 背面电极30具有与充电/偏转信号相对应的电位。 利用这种构造，孔电极11，压力室13和背电极30一起在接近中心轨迹90的位置处产生倾斜电场85.带电墨滴被倾斜电场85大大偏转 在油墨飞行的早期阶段，随着飞行的进行，可以实现更大的偏转。