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    Crystallized P38 complexes
    24.
    发明授权
    Crystallized P38 complexes 有权
    结晶P38复合物

    公开(公告)号：US06387641B1

    公开(公告)日：2002-05-14

    申请号：US09457040

    申请日：1999-12-08

    Applicant: Steven Bellon ,  Guy Bemis ,  Keith Wilson ,  Matthew Fitzgibbon

    Inventor： Steven Bellon ,  Guy Bemis ,  Keith Wilson ,  Matthew Fitzgibbon

    IPC: C12Q148

    CPC classification number: C12N9/1205

    Abstract: This invention provides certain crystallized, protein kinase-ligand complexes, in particular P38-ligand complexes, and their structure coordinates. The structure coordinates are based on the structure of a phosphorylated P38&ggr; complex which has now been solved and which reveals new structural information useful for understanding the activated states of other, related kinase proteins as described herein. The key structural features of the proteins, particularly the shape of the substrate binding site, are useful in methods for designing or identifying selective inhibitors of the protein kinases, particularly P38&ggr; and in solving the structures of other proteins with similar features. The structure coordinates may be encoded in a data storage medium for use with a computer for graphical three-dimensional representation of the structure and for computer-aided molecular design of new inhibitors.

    Abstract translation: 本发明提供某些结晶的蛋白激酶 - 配体复合物，特别是P38-配体复合物及其结构坐标。 结构坐标是基于已经被解决的磷酸化P38γ复合物的结构，并且揭示了可用于理解本文所述其它相关激酶蛋白的活化状态的新结构信息。 蛋白质的关键结构特征，特别是底物结合位点的形状，可用于设计或鉴定蛋白激酶，特别是P38gamma的选择性抑制剂和解决具有相似特征的其它蛋白质的结构的方法。 结构坐标可以编码在用于计算机的数据存储介质中用于结构的图形三维表示和用于新型抑制剂的计算机辅助分子设计。

    Manifold spacer
    25.
    发明授权
    Manifold spacer 失效
    歧管间隔

    公开(公告)号：US06269805B1

    公开(公告)日：2001-08-07

    申请号：US09504423

    申请日：2000-02-15

    Applicant: Keith Wilson

    Inventor： Keith Wilson

    IPC: F02M2510

    CPC classification number: F02M35/10222 ,  F02M25/00 ,  F02M35/10032 ,  F02M35/10085 ,  F02M35/10236 ,  F02M35/10275 ,  F02M35/10301

    Abstract: An insert adapted to be placed between a carburetor or a throttle body and an intake manifold of an internal combustion engine is provided with a fuel manifold, a nitrous oxide manifold, and one or more burst diaphragms in a wall of said insert. Said manifolds are arranged one over the other and across an opening in said insert. A plurality of orifices extend along the length of each manifold, and are arranged to direct flow outward, downward, and radially relative to the axial flow of the fuel-oxidizer mixture through the insert.

    Abstract translation: 适于放置在化油器或节气门体和内燃机的进气歧管之间的插入件在所述插入件的壁中设置有燃料歧管，一氧化二氮歧管和一个或多个爆裂隔膜。 所述歧管彼此排列并跨越所述插入件中的开口。 多个孔沿着每个歧管的长度延伸，并且被布置成相对于燃料 - 氧化剂混合物的轴向流动通过插入件向外，向下和径向地引导流动。

    PORTABLE VANITY TRAY
    28.
    发明申请
    PORTABLE VANITY TRAY 审中-公开
    便携式透明托盘

    公开(公告)号：US20150374179A1

    公开(公告)日：2015-12-31

    申请号：US14318539

    申请日：2014-06-27

    Applicant: Keith Wilson ,  Brandon Kelly

    Inventor： Keith Wilson ,  Brandon Kelly

    IPC: A47K1/09

    CPC classification number: A47K1/09

    Abstract: A portable vanity tray rests on a sink and provides a work surface that can hold personal care items, cosmetics, etc. when counter space is insufficient. The portable vanity tray can have a workspace, one or more accessory hollows, a hot tool tray, and a faucet indent. Additional components can include one or more handles and a non-slip backing surface. The accessory hollows provide locations for items to be placed and retained. The hot tool tray is designed to hold beauty tools, especially those that become hot. Heat-dissipation ribbing can be incorporated therein. A faucet indent allows the tray to fit on sinks which have a protruding faucet. Handles provide for easy gripping locations in order manipulate the tray and allow it to be hung up. A non-slip bottom surface retains the tray in place once positioned on a sink or other location.

    Abstract translation: 便携式梳妆台搁置在水槽上，并提供了当柜台空间不足时可以容纳个人护理用品，化妆品等的工作表面。 便携式梳妆台可以具有工作空间，一个或多个附件中空，热工具托盘和水龙头缩进。 附加部件可以包括一个或多个手柄和防滑背衬表面。 附件凹槽提供要放置和保留的物品的位置。 热工具托盘设计用于容纳美容工具，特别是那些变热的美容工具。 散热肋可以并入其中。 水龙头缩进允许托盘适合具有突出水龙头的水槽。 手柄提供易于抓握位置，以便操纵托盘并允许其挂起。 位于水槽或其他位置后，防滑底面将托盘保持在原位。

    MAGNETIC BUTTON PHONE CASE
    29.
    发明申请
    MAGNETIC BUTTON PHONE CASE 审中-公开
    磁性钮扣电话机

    公开(公告)号：US20150207535A1

    公开(公告)日：2015-07-23

    申请号：US14674187

    申请日：2015-03-31

    Applicant: Keith Wilson

    Inventor： Keith Wilson

    IPC: H04B1/3888 ,  H01F7/02

    CPC classification number: H01F7/02 ,  H01F7/0252 ,  H04B1/3877

    Abstract: The various embodiments of the present invention disclose a mobile phone holder with magnetic adherence enhancement comprises a ruggedized case, a primary magnetic strip and a mating magnetic strip. The ruggedized case comprises an adjustable chamber on an internal surface. The primary magnetic strip is adhered to a back surface of the mobile phone holder using an adhesive. The mating magnetic strip comprises a rear surface applied with an adhesive. The mating magnetic strip is fixed to a non-metallic surface. The primary magnetic strip is magnetically locked to the mating magnetic strip.

    Abstract translation: 本发明的各种实施例公开了具有磁性附着力增强的移动电话保持器，包括坚固的外壳，主磁条和配合磁条。 坚固的外壳包括内表面上的可调节室。 使用粘合剂将主磁条粘附到移动电话机支架的后表面。 配合磁条包括涂有粘合剂的后表面。 配合磁条固定在非金属表面。 主磁条被磁性地锁定到配合的磁条上。

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