公开(公告)号：US20080274529A1

公开(公告)日：2008-11-06

申请号：US11720488

申请日：2005-11-29

Applicant: Kishan Dholakia ,  Christian Thomas Alcuin Brown ,  Lynn Paterson

Inventor： Kishan Dholakia ,  Christian Thomas Alcuin Brown ,  Lynn Paterson

IPC: C12N13/00

CPC classification number: C12N15/87 ,  C12M35/02

Abstract: An opening is formed in a cell using laser radiation. A Bessel beam is formed using the laser radiation and the Bessel beam is directed onto the cell to form an opening. The guiding of material towards the opening may be involved using optical trapping/manipulation. The material may change cellular function or analyse cell behaviour. Both pulsed laser radiation and continuous wave radiation may be formed using the same laser.

Abstract translation: 在使用激光辐射的电池中形成开口。 使用激光辐射形成贝塞尔光束，并且贝塞尔光束被引导到细胞上以形成开口。 材料向开口的引导可能涉及使用光学捕获/操纵。 该物质可能改变细胞功能或分析细胞行为。 可以使用相同的激光器来形成脉冲激光辐射和连续波辐射。

公开(公告)号：US20080017808A1

公开(公告)日：2008-01-24

申请号：US11596490

申请日：2005-05-10

Applicant: Kishan Dholakia ,  Thomas Krauss ,  Simon Cran-McGreehin

Inventor： Kishan Dholakia ,  Thomas Krauss ,  Simon Cran-McGreehin

IPC: G01N21/01

CPC classification number: G21K1/006 ,  B01L3/5027

Abstract: An on-chip micro-fluidic device (10) fabricated using a semiconductor material. The device has a micro-fluidic channel or chamber (14) defined within the material and one or more monolithically integrated semiconductor lasers (12) operate to form an optical trap in the channel or chamber (14).

Abstract translation: 使用半导体材料制造的片上微流体装置（10）。 所述装置具有限定在所述材料内的微流体通道或室（14），并且一个或多个单片集成半导体激光器（12）操作以在所述通道或室（14）中形成光阱。

公开(公告)号：US09176313B2

公开(公告)日：2015-11-03

申请号：US13057706

申请日：2009-08-28

Applicant: Kishan Dholakia ,  Michael Mazilu ,  Jorg Baumgartl

Inventor： Kishan Dholakia ,  Michael Mazilu ,  Jorg Baumgartl

IPC: H01S3/00 ,  G02B21/32

CPC classification number: G02B21/32

Abstract: A method for manipulating one or more particles comprising exposing the particle(s) to a beam of radiation that is able to lift and or impart an acceleration to the particle(s) to cause it to move in a curved trajectory.

Abstract translation: 一种用于操纵一个或多个颗粒的方法，包括将颗粒暴露于辐射束，所述辐射束能够提升和/或赋予颗粒以使其在弯曲轨迹中移动的加速度。

公开(公告)号：US08962235B2

公开(公告)日：2015-02-24

申请号：US12442327

申请日：2007-09-20

Applicant: Michael MacDonald ,  Kishan Dholakia ,  Igor Andreev

Inventor： Michael MacDonald ,  Kishan Dholakia ,  Igor Andreev

IPC: C12N5/078 ,  C12M1/00 ,  G01N15/14

CPC classification number: C12M47/04 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2400/0454 ,  G01N15/1484 ,  G01N2015/149

Abstract: A method for sorting particles, in particular cells A and B. The method uses a single channel with only one input and only one output. A particle mix A and B in a fluid is introduced into the channel and particles within the channel are sorted.

Abstract translation: 一种用于排序粒子的方法，特别是单元A和B.该方法使用单个通道，只有一个输入，只有一个输出。 将流体中的颗粒混合物A和B引入通道中，并且分配通道内的颗粒。

公开(公告)号：US08816234B2

公开(公告)日：2014-08-26

申请号：US12442325

申请日：2007-09-20

Applicant: Michael MacDonald ,  Kishan Dholakia ,  Daniel Rhodes ,  Graham Milne

Inventor： Michael MacDonald ,  Kishan Dholakia ,  Daniel Rhodes ,  Graham Milne

IPC: B03C7/00 ,  G01N15/02 ,  G01N15/14

CPC classification number: G01N15/0205 ,  G01N1/40 ,  G01N2015/149 ,  G02B21/32

Abstract: A method for sorting particles in a fluid. The method involves generating an optical landscape using an acousto-optic device. Preferably, the optical landscape is arranged to sort particles based on size or refractive index or shape.

Abstract translation: 用于分选流体中的颗粒的方法。 该方法涉及使用声光装置产生光学景观。 优选地，光学景观布置成基于尺寸或折射率或形状对颗粒进行分类。

公开(公告)号：US20120075627A1

公开(公告)日：2012-03-29

申请号：US12892640

申请日：2010-09-28

Applicant: Praveen Cheriyan Ashok ,  Gajendra Pratap Singh ,  Kishan Dholakia ,  Khay Tan

Inventor： Praveen Cheriyan Ashok ,  Gajendra Pratap Singh ,  Kishan Dholakia ,  Khay Tan

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2201/08

Abstract: A microfluidic device comprising at least one microfluidic channel with an input and an output for allowing fluid flow; and at least one Raman fiber based probe having an excitation fiber probe and/or a collection fiber probe positioned so that one end of the probe is in the microfluidic channel.

Abstract translation: 一种微流体装置，包括至少一个具有输入的微流体通道和用于允许流体流动的输出; 以及至少一个具有激发纤维探针和/或收集纤维探针的拉曼光纤探针，其定位使得探针的一端在微流体通道中。

公开(公告)号：US20100328657A1

公开(公告)日：2010-12-30

申请号：US12532723

申请日：2008-03-10

Applicant: Kishan Dholakia ,  Iain Cormack ,  Michael Mazilu

Inventor： Kishan Dholakia ,  Iain Cormack ,  Michael Mazilu

IPC: G01J3/10 ,  G01J3/44

CPC classification number: G01J3/44 ,  G01J3/10 ,  G01J2003/4424

Abstract: A Raman spectrometer comprising means for illuminating a sample with a shaped laser beam and a detector that is operable to detect light that is reflected from or transmitted through a sample. Preferably, the shaped laser beam has a dark spot at its centre.

Abstract translation: 拉曼光谱仪，其包括用成形激光束照射样品的装置和可操作以检测从样品反射或透过样品的光的检测器。 优选地，成形激光束在其中心处具有黑点。

公开(公告)号：US07732758B2

公开(公告)日：2010-06-08

申请号：US11596490

申请日：2005-05-10

Applicant: Kishan Dholakia ,  Thomas F. Krauss ,  Simon John Cran-McGreehin

Inventor： Kishan Dholakia ,  Thomas F. Krauss ,  Simon John Cran-McGreehin

IPC: G21K5/00 ,  H01S5/026

CPC classification number: G21K1/006 ,  B01L3/5027

Abstract: An on-chip micro-fluidic device (10) fabricated using a semiconductor material. The device has a micro-fluidic channel or chamber (14) defined within the material and one or more monolithically integrated semiconductor lasers (12) operate to form an optical trap in the channel or chamber (14).

Abstract translation: 使用半导体材料制造的片上微流体装置（10）。 所述装置具有限定在所述材料内的微流体通道或室（14），并且一个或多个单片集成半导体激光器（12）操作以在所述通道或室（14）中形成光阱。

公开(公告)号：US20070091442A1

公开(公告)日：2007-04-26

申请号：US10554937

申请日：2004-05-07

Applicant: Michael MacDonald ,  Kishan Dholakia ,  Steven Neale ,  Gabriel Spalding

Inventor： Michael MacDonald ,  Kishan Dholakia ,  Steven Neale ,  Gabriel Spalding

IPC: G02B27/00

CPC classification number: B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0864 ,  B01L2400/0454 ,  G01N15/1434 ,  G01N15/1459 ,  G01N2015/145 ,  G01N2015/149 ,  G01N30/02 ,  B01D2015/3895

Abstract: A fractionation system comprising means for forming a three dimensional optical lattice that is operable to separate particles that have different physical characteristics. Preferably, the wells of the optical lattice are interlinked. For example, the wells may be linked in such a manner as to provide deflection greater than or equal to 15 degrees.

Abstract translation: 分级系统包括用于形成三维光学晶格的装置，其可操作以分离具有不同物理特性的颗粒。 优选地，光栅的阱是相互连接的。 例如，孔可以以提供大于或等于15度的偏转的方式连接。

公开(公告)号：US09417457B2

公开(公告)日：2016-08-16

申请号：US13640453

申请日：2011-04-13

Applicant: Kishan Dholakia ,  Jorg Baumgartl ,  Michael Mazilu ,  Anna Chiara De Luca

Inventor： Kishan Dholakia ,  Jorg Baumgartl ,  Michael Mazilu ,  Anna Chiara De Luca

IPC: G06F17/11 ,  G02B27/58

Abstract: A method of optimising at least one measure that is a quadratic function of a wavefunction, such as the spot size of a laser, the method comprising: superimposing a plurality of wavefunctions; determining a relationship between the superimposed wavefunctions and the quadratic measure, and using the determined relationship to identify the superimposed wavefunctions that provide a desired or optimised quadratic measure.