公开(公告)号：US5785968A

公开(公告)日：1998-07-28

申请号：US24253

申请日：1993-03-01

申请人： Kazuhiko Kimachi ,  Hiroaki Maeda ,  Kiyoto Nishiyama ,  Sachio Tokiyoshi ,  Yukinobu Tohya ,  Takeshi Mikami

发明人： Kazuhiko Kimachi ,  Hiroaki Maeda ,  Kiyoto Nishiyama ,  Sachio Tokiyoshi ,  Yukinobu Tohya ,  Takeshi Mikami

IPC分类号： A61K38/00 ,  C07K16/10 ,  C12N15/13 ,  C12P21/08 ,  C07H21/04 ,  A61K39/395 ,  C07H16/00

CPC分类号： C07K16/1045 ,  A61K38/00

摘要： Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line 1D7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.

摘要翻译： 提供了有效治疗，预防和诊断FCV感染的抗FCV（猫杯状病毒）猫科动物重组抗体和用于制备所述抗体的基因片段。 构建能够产生具有优异的FCV中和活性的小鼠单克隆抗体的细胞系1D7，得到编码负责所述抗体的FCV特异性结合的V区的基因片段。 使用该基因片段和编码猫抗体恒定区的基因得到嵌合抗FCV重组抗体。 获得的重组抗体是一种新的抗体，可用于诊断，治疗和预防猫病毒感染，特别是猫杯状病毒感染，对猫的施用具有高度的安全性。

公开(公告)号：US4281021A

公开(公告)日：1981-07-28

申请号：US66837

申请日：1979-08-15

申请人： Chiyokichi Iizuka ,  Hiroaki Maeda

发明人： Chiyokichi Iizuka ,  Hiroaki Maeda

IPC分类号： A01G7/06 ,  A01N63/04 ,  A01N65/00 ,  A23L1/23 ,  A23L1/275 ,  A23L1/272

CPC分类号： A01N63/04 ,  A23L27/24 ,  A23L5/46

摘要： This is a method in which a liquid extract containing effective ingredients is obtained from water solutions of Mycelium nutrient medium and tissue-medium from edible fungus belonging to the genus Basidiomycetes and is diluted with water and sprayed over the surface of the leaves to accelerate coloring and improve sweetness of citrus fruits.

摘要翻译： 这是一种含有有效成分的液体提取物的方法，其是从菌丝体营养培养基和来自担子菌属的食用真菌的组织培养基的水溶液中获得的，并且用水稀释并喷洒在叶子的表面上以加速着色和 提高柑橘类水果的甜度。

公开(公告)号：US08909112B2

公开(公告)日：2014-12-09

申请号：US12879585

申请日：2010-09-10

申请人： Tomoko Takahashi ,  Naoyuki Ozaki ,  Ryuji Yoshida ,  Nobuyuki Koinuma ,  Hiroaki Maeda ,  Shunichi Hashimoto ,  Mugijirou Uno ,  Yoshinori Nakagawa ,  Mikio Ishibashi ,  Hideki Zemba

发明人： Tomoko Takahashi ,  Naoyuki Ozaki ,  Ryuji Yoshida ,  Nobuyuki Koinuma ,  Hiroaki Maeda ,  Shunichi Hashimoto ,  Mugijirou Uno ,  Yoshinori Nakagawa ,  Mikio Ishibashi ,  Hideki Zemba

IPC分类号： G03G15/01 ,  G03G15/20 ,  G03G15/16

CPC分类号： G03G15/0131 ,  G03G15/1605 ,  G03G15/161

摘要： An image forming apparatus including a conveyance unit to convey a transfer medium, a first image forming unit to form a monochrome image transferred at a first transfer position onto the transfer medium, and a second image forming unit disposed downstream from the first image forming unit in a direction of conveyance of the transfer medium, including an intermediate transfer body to form a multi-colored toner image on the intermediate transfer body. The multi-colored toner image is transferred onto the transfer medium at a second transfer position. The conveyance unit is separated from the intermediate transfer body at the second transfer position in a monochrome mode to form the monochrome image using only the first image forming unit, and contacts the intermediate transfer body at the second transfer position in a full-color mode to form a full-color image using both the first and second image forming units.

摘要翻译： 一种图像形成装置，包括：传送单元，用于传送转印介质;第一图像形成单元，形成在第一转印位置转印到转印介质上的单色图像;以及第二图像形成单元，设置在第一图像形成单元的下游 转印介质的输送方向，包括中间转印体，以在中间转印体上形成多色调色剂图像。 多色调色剂图像在第二转印位置转印到转印介质上。 输送单元在单色模式下在第二转印位置处与中间转印体分离，以仅使用第一图像形成单元形成单色图像，并且以全色模式在第二转印位置处接触中间转印体， 使用第一和第二图像形成单元形成全色图像。

公开(公告)号：US20140255050A1

公开(公告)日：2014-09-11

申请号：US14173044

申请日：2014-02-05

申请人： Ryuji YOSHIDA ,  Hideki Zemba ,  Yusuke Mitani ,  Shotaro Hoshi ,  Masahiko Shakuto ,  Hiroaki Maeda

发明人： Ryuji YOSHIDA ,  Hideki Zemba ,  Yusuke Mitani ,  Shotaro Hoshi ,  Masahiko Shakuto ,  Hiroaki Maeda

IPC分类号： G03G15/00 ,  G03G15/16 ,  G03G15/02

CPC分类号： G03G15/1675 ,  G03G15/0266 ,  G03G15/065

摘要： An image forming apparatus includes a charging bias output device, a developing bias output device, a transfer bias output device, and a controller. The controller controls the transfer bias output device to supply a transfer bias from a time at which a first position of a photosensitive member arrives at a transfer position after the charging bias output device starts supplying a charging bias. An initial value of the transfer bias is controlled to be smaller than a normal set value for a predetermined time period (Tc) which is a time after the transfer bias starts to be supplied and within a time corresponding to a rise time (Ta) during which a surface potential of the photosensitive member reaches a predetermined potential after the charging bias starts to be output. The first position of the photosensitive member is a position at which the charging device start charging the photosensitive member.

摘要翻译： 图像形成装置包括充电偏压输出装置，显影偏压输出装置，转印偏压输出装置和控​​制器。 控制器控制转印偏压输出装置，以在充电偏压输出装置开始提供充电偏压之后从感光元件的第一位置到达转印位置的时间提供转印偏压。 转移偏压的初始值被控制为小于正常设定值，该预定时间周期（Tc）是在转印偏压开始被提供之后的时间内，并且在对应于上升时间（Ta）的时间内 在充电偏压开始输出之后感光构件的表面电位达到预定电位。 感光构件的第一位置是充电装置开始对感光构件充电的位置。

公开(公告)号：US08680921B2

公开(公告)日：2014-03-25

申请号：US13426187

申请日：2012-03-21

申请人： Hirotake Honda ,  Hiroaki Maeda ,  Yousuke Okazaki ,  Yoshinobu Shizawa

发明人： Hirotake Honda ,  Hiroaki Maeda ,  Yousuke Okazaki ,  Yoshinobu Shizawa

IPC分类号： H03G3/20

CPC分类号： H03F1/0272 ,  H03F1/30 ,  H03F3/245 ,  H03F2200/18 ,  H03F2200/462 ,  H03G3/3042

摘要： A power amplifying apparatus has a GaN device for RF amplification, a GaN device for monitoring, an Idq detecting circuit, and a gate bias control (GBC) circuit. The GaN device for RF amplification amplifies an input signal to output the resultant. The GaN device for monitoring is an amplification device for monitoring an input/output signal of the GaN device for RF amplification. The Idq detecting circuit detects an output signal output by the GaN device for monitoring, corresponding to an input signal, which is diverged from the input signal to be input to the GaN device for RF amplification, and is input to the GaN device for monitoring. The gate bias control circuit controls a gate voltage to be applied to the GaN device for RF amplification in accordance with the output signal detected by the Idq detecting circuit.

摘要翻译： 功率放大装置具有用于RF放大的GaN器件，用于监视的GaN器件，Idq检测电路和栅极偏置控制（GBC）电路。 用于RF放大的GaN器件放大输入信号以输出结果。 用于监视的GaN器件是用于监视用于RF放大的GaN器件的输入/输出信号的放大器件。 Idq检测电路检测由GaN器件输出的输出信号，对应于从要输入到GaN器件的输入信号发散的输入信号进行监控，并输入到GaN器件进行监控。 栅极偏置控制电路根据由Idq检测电路检测的输出信号控制施加到GaN器件的RF放大的栅极电压。

公开(公告)号：US20110262998A1

公开(公告)日：2011-10-27

申请号：US13125328

申请日：2009-10-21

申请人： Hiroshi Nakatake ,  Akihiro Meta ,  Kiyotaka Suenaga ,  Masaki Hirashima ,  Hiroaki Maeda

发明人： Hiroshi Nakatake ,  Akihiro Meta ,  Kiyotaka Suenaga ,  Masaki Hirashima ,  Hiroaki Maeda

IPC分类号： C12N9/52 ,  C12N15/63 ,  C12N1/21 ,  C12N15/57

CPC分类号： C12N9/6491 ,  C07K2319/02 ,  C12P21/02

摘要： A process for preparing an inclusion body-forming protein is provided. A nucleic acid fragment consisting of a nucleotide sequence coding for a modified alkaline phosphatase signal peptide (modified APSP) where leucine at the 13th position in the amino acid sequence shown in SEQ ID NO: 1 is substituted with proline and/or alanine at the 21st position is substituted with the other amino acid, downstream of which nucleotide sequence is bound a nucleotide sequence of a gene of a protein of interest, and a process for preparing an inclusion body-forming protein consisting of the following steps: (1) preparing an expression vector in which a nucleic acid fragment is incorporated consisting of a nucleotide sequence coding for a modified signal peptide downstream of which is bound a nucleotide sequence of a gene of a protein of interest, (2) preparing a host cell transformed with the expression vector that produces an inclusion body-forming protein, and (3) purifying the inclusion body-forming protein from culture obtained by culturing the host cell that produces the inclusion body-forming protein. The above other amino acid is selected from the group consisting of aspartic acid, glutamic acid, lysine, histidine, phenylalanine and tyrosine.

摘要翻译： 提供了一种制备包涵体形成蛋白的方法。 由编码改变的碱性磷酸酶信号肽（修饰的APSP）的核苷酸序列组成的核酸片段，其中在第21位被脯氨酸和/或丙氨酸取代在SEQ ID NO：1所示的氨基酸序列中的第13位的亮氨酸 位置被其他氨基酸取代，其中核苷酸序列的下游与感兴趣蛋白质的基因的核苷酸序列结合，以及由以下步骤组成的包涵体形成蛋白的方法：（1）制备 表达载体，其中掺入核酸片段由编码下游的修饰信号肽的核苷酸序列组成，所述核苷酸序列与感兴趣蛋白质的基因的核苷酸序列结合，（2）制备用表达载体转化的宿主细胞 产生包涵体形成蛋白质，（3）通过培养生成的宿主细胞获得的培养物纯化包涵体形成蛋白质 是包涵体形成蛋白。 上述其它氨基酸选自天冬氨酸，谷氨酸，赖氨酸，组氨酸，苯丙氨酸和酪氨酸。

公开(公告)号：US08022763B2

公开(公告)日：2011-09-20

申请号：US11790384

申请日：2007-04-25

申请人： Hiroaki Maeda ,  Takashi Ono ,  Yousuke Okazaki ,  Hirotake Honda ,  Hiroyuki Ezuka

发明人： Hiroaki Maeda ,  Takashi Ono ,  Yousuke Okazaki ,  Hirotake Honda ,  Hiroyuki Ezuka

IPC分类号： H03F21/00

CPC分类号： H03F1/3247 ,  H03F2201/3233 ,  H04B1/0466 ,  H04B2001/0416

摘要： An amplifier failure detection apparatus for a radio transmitter that has a function for compensating for amplifier distortion of the radio transmitter and a function for determining amplifier failure has occurred by detecting that the gain of an amplifier has dropped a set level or more, in which: a gain-detection unit detects the gain of the amplifier; an alarm-detection-level-generation unit, which has a table for storing alarm-detection levels that correspond to input-amplitude levels, generates an alarm-detection level that corresponds to an input-amplitude level; and a comparison unit compares the gain detected by the gain-detection unit with the alarm-detection level, and generates an alarm based on the comparison results.

摘要翻译： 通过检测放大器的增益已经下降了设定值以上，已经发生了具有补偿无线电发射机的放大器失真的功能的放大器故障检测装置和用于确定放大器故障的功能，其中： 增益检测单元检测放大器的增益; 具有用于存储对应于输入幅度电平的报警检测电平的表的报警检测电平生成单元生成与输入幅度电平对应的报警检测电平; 并且比较单元将由增益检测单元检测到的增益与报警检测水平进行比较，并且基于比较结果生成报警。

公开(公告)号：US07829306B2

公开(公告)日：2010-11-09

申请号：US10576978

申请日：2004-10-21

申请人： Reiko Matsuyama ,  Hiroaki Maeda ,  Hitomi Shirahama ,  Takayuki Imamura ,  Yasuharu Kamachi

发明人： Reiko Matsuyama ,  Hiroaki Maeda ,  Hitomi Shirahama ,  Takayuki Imamura ,  Yasuharu Kamachi

IPC分类号： C12P21/06 ,  C12N15/70 ,  C12N15/00

CPC分类号： C12P21/02 ,  C12N2510/02

摘要： A gene encoding a production amount-potentiating factor is introduced into an animal cell to transform the cell. Alternatively, a protein production gene and the gene encoding the production amount-potentiating factor are introduced into the animal cell to transform the cell. Herein, as the production amount potentiating factor, there is used a factor having caspase activity inhibiting activity and/or protein biosynthesis activity potentiating action, for example, baculovirus P35. Further, the animal cell is cultured by a culturing method under a condition that apoptosis is not induced, so that a protein is mass-produced.

摘要翻译： 将编码产生量增加因子的基因导入动物细胞以转化细胞。 或者，将蛋白质生产基因和编码产生量增强因子的基因导入动物细胞以转化细胞。 这里，作为生产量增强因子，使用具有半胱天冬酶活性抑制活性和/或蛋白质生物合成活性增强作用的因子，例如杆状病毒P35。 此外，通过培养方法在不诱导细胞凋亡的条件下培养动物细胞，从而大量生产蛋白质。

公开(公告)号：US20100240329A1

公开(公告)日：2010-09-23

申请号：US12721064

申请日：2010-03-10

申请人： Yoshinobu Shizawa ,  Hiroaki Maeda ,  Yousuke Okazaki ,  Hirotake Honda

发明人： Yoshinobu Shizawa ,  Hiroaki Maeda ,  Yousuke Okazaki ,  Hirotake Honda

IPC分类号： H04B1/04 ,  H03F3/68

CPC分类号： H03F1/0288 ,  H03F1/0222 ,  H03F1/3247 ,  H03F2201/3233

摘要： An amplifying device includes an amplifier including a first amplifying element with a drain voltage thereof being controlled, and a second amplifying element, the amplifier amplifying a transmission signal with the first and second amplifying elements, synthesizing the transmission signals amplified by the first and second amplifying elements, and outputting the synthesized transmission signal; a distortion compensator part which performs distortion compensation on the input signal in accordance with a compensation coefficient derived from a difference between a input signal and a feedback signal generated from a portion of a signal output from the amplifier; and a controller part which controls the drain voltage of the first amplifying element in response to a result of a comparison between a power level of the input signal prior to the distortion compensation operation by the distortion compensator part and a threshold value.

摘要翻译： 一种放大装置，包括：放大器，包括其漏极电压被控制的第一放大元件;以及第二放大元件，放大器利用第一和第二放大元件放大发送信号，合成由第一和第二放大器放大的发送信号 并输出合成的发送信号; 失真补偿部，其根据从输入信号和从放大器输出的信号的一部分产生的反馈信号之间的差导出的补偿系数，对输入信号进行失真补偿; 以及控制器部分，其响应于在失真补偿器部分的失真补偿操作之前的输入信号的功率电平与阈值之间的比较的结果来控制第一放大元件的漏极电压。

公开(公告)号：US20100151522A1

公开(公告)日：2010-06-17

申请号：US10566266

申请日：2004-07-28

申请人： Reiko Matsuyama ,  Hiroaki Maeda

发明人： Reiko Matsuyama ,  Hiroaki Maeda

IPC分类号： C12P21/04 ,  C12N15/87 ,  C12N5/06 ,  C07K14/00

CPC分类号： C07K14/75

摘要： When genes encoding three kinds of proteins constituting fibrinogen, an α chain (or variant of α chain), a β chain and a γ chain (or variant of γ chain) are incorporated into an animal cell, a constitutional ratio of respective genes is such that a γ chain (and/or variant of γ chain) gene is an equal amount to a 1000-fold amount relative to an α chain (and/or variant of α chain) gene and a β chain gene and, further, by using a baculovirus P35 gene, a recombinant fibrinogen highly producing cell is prepared.

摘要翻译： 当编码构成纤维蛋白原的三种蛋白质的基因，α链（或α链的变体），a＆bgr; 链和γ链（或γ链的变体）并入动物细胞中，各基因的构成比例使得γ链（和/或γ链的变体）基因等于1000倍 相对于α链（和/或α链的变体）基因和bgr的量; 链基因，并且通过使用杆状病毒P35基因，制备重组纤维蛋白原高产细胞。