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公开(公告)号：US10435658B2
公开(公告)日：2019-10-08
申请号：US13659616
申请日：2012-10-24
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael E. Goodwin , Nephi D. Jones
IPC: B01F13/00 , B01F15/00 , C12N1/00 , C12N5/07 , C12Q3/00 , C12M3/02 , C12M1/00 , B01F7/00 , C12M3/00 , C12M1/06 , B01F7/02 , B01F15/02
Abstract: A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.
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公开(公告)号：US10350554B2
公开(公告)日：2019-07-16
申请号：US15473148
申请日：2017-03-29
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael E. Goodwin , Nephi D. Jones , Derik R. West
Abstract: A container assembly includes a flexible bag having an interior surface bounding a chamber and an opposing exterior surface, the bag having a bottom end wall being comprised of a first sheet overlying a second sheet, the first sheet and the second sheet of the bottom end wall being welded together so as to form a first sparging area and a separated second sparging area that are both bounded between the first sheet and the second sheet, at least a portion of the first sheet overlying the first and second sparging areas being gas permeable.
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公开(公告)号：US10308378B2
公开(公告)日：2019-06-04
申请号：US14728717
申请日：2015-06-02
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael E. Goodwin , Jeremy K. Larsen , Patrick L. Draper , Brandon M. Knudsen
Abstract: A fluid manifold system includes a manifold having at least portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. A plurality of receiving containers are in fluid communication with the fluid flow path of the manifold, each receiving container bounding a compartment. The receiving containers can be formed integral with the manifold by welding together a second portion of the opposing flexible sheets or can comprise separate containers that are coupled to the manifold.
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公开(公告)号：US20190125906A1
公开(公告)日：2019-05-02
申请号：US16233403
申请日：2018-12-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael E. Goodwin , Nephi D. Jones , Bradley H. Buchanan
Abstract: A container includes a first wall and an opposing second wall that extend between a first end and an opposing second end, a first fluid flow path being bounded between the first wall and the second wall. An inlet is formed at the first end and communicates with the first fluid flow path. An outlet is formed at the second end and communicates with the first fluid flow path. The first wall includes a primary wall portion having a first opening extending therethrough in alignment with the first fluid flow path. A secondary wall portion extends over the first opening and is secured to the primary wall portion so as to seal the first opening closed, the secondary wall portion being comprised of a film having a thickness that is less than a thickness of the primary wall portion.
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公开(公告)号：US20190083947A1
公开(公告)日：2019-03-21
申请号：US16196882
申请日：2018-11-20
Applicant: Life Technologies Corporation
Inventor： Michael E. Goodwin , Wade A. Cornia , Jacob D. Lee
Abstract: A bioreactor system includes a support housing having an interior surface bounding a compartment. A rack is secured to the support housing in alignment with the opening. An elongated first shaft has a first end and an opposing second end, the first end of the first shaft being secured to the rack. A structure is secured to the first shaft at or towards the second end of the first shaft, the structure outwardly projecting away from the first shaft. A collapsible bag bounds a chamber and is at least partially disposed within the compartment of the support housing. A member projects from the collapsible bag and passes through the opening on the support housing, the structure supporting or restraining movement of the member.
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Patent Agency Ranking
公开(公告)号：US20170197185A1
公开(公告)日：2017-07-13
申请号：US15473148
申请日：2017-03-29
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael E. Goodwin , Nephi D. Jones , Derik R. West
CPC classification number: B01F3/04269 , B01F15/0085 , B01F2003/04148 , B01F2003/04191 , B01F2003/04297 , B01F2003/04326 , B01F2003/04347 , B01F2003/04361 , B01F2215/0073 , C12M23/14 , C12M23/26 , C12M23/40 , C12M29/06
Abstract: A container assembly includes a flexible bag having an interior surface bounding a chamber and an opposing exterior surface, the bag having a bottom end wall being comprised of a first sheet overlying a second sheet, the first sheet and the second sheet of the bottom end wall being welded together so as to form a first sparging area and a separated second sparging area that are both bounded between the first sheet and the second sheet, at least a portion of the first sheet overlying the first and second sparging areas being gas permeable.
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公开(公告)号：US20170088805A1
公开(公告)日：2017-03-30
申请号：US15374689
申请日：2016-12-09
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Clinton C. Staheli , Nephi D. Jones , Michael E. Goodwin
IPC: C12M1/00 , B01D5/00 , B01F3/04 , B01F7/16 , F28F3/12 , B01F7/00 , B01F15/00 , B01F15/06 , F28B1/02 , F28F21/06 , C12M1/02 , B01F7/22
Abstract: A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.
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公开(公告)号：US09388375B2
公开(公告)日：2016-07-12
申请号：US14395728
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Christopher D. Brau , Nephi D. Jones , Benjamin R. Madsen , Michael E. Goodwin
IPC: C12M1/04 , C12M1/00 , B01F13/02 , B01F3/04 , C12M1/02 , C12M1/34 , B01F7/22 , B01F15/00 , B01F11/00
CPC classification number: C12M29/06 , B01F3/04439 , B01F3/0446 , B01F3/04531 , B01F7/22 , B01F11/0002 , B01F11/0082 , B01F13/0205 , B01F13/0211 , B01F13/0272 , B01F15/0085 , B01F2003/04879 , B01F2003/04943 , B01F2215/0073 , C12M23/00 , C12M23/14 , C12M23/26 , C12M27/00 , C12M27/02 , C12M29/14 , C12M41/34
Abstract: A method and system for achieving a gas-liquid mass transfer includes delivering into a compartment of a container a liquid, the liquid having an exposed top surface disposed within the compartment. A stream of a gas is passed over the top surface of the liquid so that the stream of gas produces turbulence on the top surface that is sufficient to achieve the gas-liquid mass transfer. In one embodiment the liquid is a culture that includes cells or microorganisms and the mass transfer functions to oxygenate the culture sufficient to sustain the cells or microorganisms.
Abstract translation: 用于实现气 - 液传质的方法和系统包括将液体输送到容器的隔室中，液体具有设置在隔室内的暴露的顶表面。 气体流通过液体的顶表面，使得气流在顶表面上产生足以实现气 - 液传质的湍流。 在一个实施方案中，液体是包含细胞或微生物的培养物，并且传质功能使培养物充氧足以维持细胞或微生物。
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公开(公告)号：US20150118753A1
公开(公告)日：2015-04-30
申请号：US14395728
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Christopher D. Brau , Nephi D. Jones , Benjamin R. Madsen , Michael E. Goodwin
CPC classification number: C12M29/06 , B01F3/04439 , B01F3/0446 , B01F3/04531 , B01F7/22 , B01F11/0002 , B01F11/0082 , B01F13/0205 , B01F13/0211 , B01F13/0272 , B01F15/0085 , B01F2003/04879 , B01F2003/04943 , B01F2215/0073 , C12M23/00 , C12M23/14 , C12M23/26 , C12M27/00 , C12M27/02 , C12M29/14 , C12M41/34
Abstract: A method and system for achieving a gas-liquid mass transfer includes delivering into a compartment of a container a liquid, the liquid having an exposed top surface disposed within the compartment. A stream of a gas is passed over the top surface of the liquid so that the stream of gas produces turbulence on the top surface that is sufficient to achieve the gas-liquid mass transfer. In one embodiment the liquid is a culture that includes cells or microorganisms and the mass transfer functions to oxygenate the culture sufficient to sustain the cells or microorganisms.
Abstract translation: 用于实现气 - 液传质的方法和系统包括将液体输送到容器的隔室中，液体具有设置在隔室内的暴露的顶表面。 气体流通过液体的顶表面，使得气流在顶表面上产生足以实现气 - 液传质的湍流。 在一个实施方案中，液体是包含细胞或微生物的培养物，并且传质功能使培养物充氧足以维持细胞或微生物。
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公开(公告)号：US11999930B2
公开(公告)日：2024-06-04
申请号：US18336338
申请日：2023-06-16
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael E. Goodwin , Nephi D. Jones
IPC: C12M1/06 , B01F27/07 , B01F27/113 , B01F27/2121 , B01F27/213 , B01F27/231 , B01F27/61 , B01F33/00 , B01F35/22 , B01F35/513 , C12M1/00 , C12M1/34 , C12M3/00 , B01F35/71
CPC classification number: C12M23/14 , B01F27/071 , B01F27/113 , B01F27/2121 , B01F27/213 , B01F27/2312 , B01F27/61 , B01F33/86 , B01F35/2209 , B01F35/513 , C12M23/26 , C12M23/48 , C12M23/52 , C12M27/02 , C12M27/06 , C12M41/00 , B01F35/715
Abstract: A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.
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