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51 条记录 (耗时 0.036 秒)

    Method for down-regulating GDF-8 activity
    21.
    发明授权
    Method for down-regulating GDF-8 activity 失效
    降低GDF-8活性的方法

    公开(公告)号：US07056512B1

    公开(公告)日：2006-06-06

    申请号：US09620586

    申请日：2000-07-20

    申请人： Steen Klysner ,  Soren Mouritsen ,  Torben Halkier

    发明人： Steen Klysner ,  Soren Mouritsen ,  Torben Halkier

    IPC分类号： A61K39/00 ,  A61K39/38

    CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0005 ,  A61K48/00 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55522 ,  C07K2319/00

    摘要： Disclosed are novel methods for increasing muscle mass by means of immunization against Growth Differentiation Factor 8 (GDF-8, myostatin). Immunization is preferably effected by administration of analogues of GDF-8 which are capable of inducing antibody production against homologous GDF-8. Especially preferred as an immunogen is homologous GDF-8 which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes while substantially preserving the tertiary structure of the homologous GDF-8. Also disclosed are nucleic acid vaccination against GDF-8 and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for identification of useful immunogenic GDF-8 analogues, methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.

    摘要翻译： 公开了通过免疫接种生长分化因子8（GDF-8，肌生成抑制素）来增加肌肉质量的新方法。 免疫优选通过施用能够诱导针对同源GDF-8的抗体产生的GDF-8的类似物来实现。 特别优选的是作为免疫原的同源GDF-8，其通过引入一个或多个外来的免疫显性和混杂的T细胞表位而被修饰，同时基本上保留了同源的GDF-8的三级结构。 还公开了针对GDF-8的核酸疫苗接种和使用活疫苗的疫苗接种以及用于疫苗接种的方法和装置。 这些方法和手段包括鉴定有用的免疫原性GDF-8类似物的方法，制备类似物和药物制剂的方法，以及核酸片段，载体，转化细胞，多肽和药物制剂。

    Enzyme with &bgr;-1,3-glucanase activity
    26.
    发明授权
    Enzyme with &bgr;-1,3-glucanase activity 失效
    具有β-1,3-葡聚糖酶活性的酶

    公开(公告)号：US06284509B1

    公开(公告)日：2001-09-04

    申请号：US09159106

    申请日：1998-09-23

    申请人： Pau Ferrer ,  Ivan Diers ,  Torben Halkier ,  Lisbeth Hedegaard

    发明人： Pau Ferrer ,  Ivan Diers ,  Torben Halkier ,  Lisbeth Hedegaard

    IPC分类号： C12N924

    CPC分类号： C12Y302/01039 ,  A61K38/00 ,  C07K2319/02 ,  C12N9/244 ,  C12Y302/01006 ,  Y02A50/473

    摘要： The present invention relates to a DNA construct exhibiting &bgr;-1,3-glucanase activity, which DNA sequence comprises: a) the DNA sequence shown in SEQ ID No. 1 or SEQ ID No. 12, or b) an analogue of the DNA sequence defined in a), which i) is homologous with the DNA sequence defined in a), or ii) hybridizes with the same oligonucleotide probe as the DNA sequence defined in a), or iii) encodes a polypeptide which is homologous with the polypeptide encoded by a DNA sequence comprising the DNA sequence defined in a), or iv) encodes a polypeptide which is immunologically reactive with an antibody raised against the purified &bgr;-1,3-glucanase derived from Oerksovia xanthineolytica LLG109 encoded by the DNA sequence defined in a). The DNA construct may further encode a mannose binding domain. The invention also relates to a DNA construct encoding a mannose binding domain. Further the invention relates to an expression vector comprising said DNA constructs, a cell harbouring said DNA constructs or expression vectors, a method of producing the novel enzyme, a novel enzyme preparation containing said novel enzyme, the use of the enzyme for degrading or modification of &bgr;-glucan containing material.

    摘要翻译： 本发明涉及显示β-1,3-葡聚糖酶活性的DNA构建体，该DNA序列包含：a）SEQ ID No.1或SEQ ID No.12所示的DNA序列，或b）DNA的类似物 a）中定义的序列，其i）与a）中定义的DNA序列同源，或ii）与与a）中定义的DNA序列相同的寡核苷酸探针杂交，或iii）编码与多肽同源的多肽 由包含a）中定义的DNA序列的DNA序列编码，或iv）编码与针对衍生自由Okssovia xanthineolytica LLG109纯化的β-1,3-葡聚糖酶产生的抗体免疫反应性的多肽，其由 一个）。 DNA构建体可以进一步编码甘露糖结合结构域。 本发明还涉及编码甘露糖结合结构域的DNA构建体。 此外，本发明涉及包含所述DNA构建体，含有所述DNA构建体或表达载体的细胞的表达载体，产生所述新酶的方法，含有所述新酶的新型酶制剂，所述酶用于降解或修饰 含β-葡聚糖的材料。

    Alkaline lipolytic enzyme
    29.
    发明授权
    Alkaline lipolytic enzyme 失效
    碱性脂解酶

    公开(公告)号：US5919746A

    公开(公告)日：1999-07-06

    申请号：US919724

    申请日：1997-08-28

    申请人： Satoshi Hirayama ,  Torben Halkier

    发明人： Satoshi Hirayama ,  Torben Halkier

    IPC分类号： C11D3/386 ,  C12N9/20 ,  C11D3/00 ,  C11D7/42

    CPC分类号： C11D3/38627 ,  C12N9/20

    摘要： The present invention relates to an alkaline lipolytic enzyme derivable from a strain of Botryosphaeria or Guignardia, to a lipolytic enzyme-producing microbial strain, to methods for the production of lipolytic enzyme and to a detergent composition comprising the lipolytic enzyme.

    摘要翻译： 本发明涉及可从Botryosphaeria或Guignardia菌株衍生的碱性脂肪分解酶，产生脂肪分解酶的微生物菌株，生产脂肪分解酶的方法和包含该脂肪分解酶的洗涤剂组合物。