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公开(公告)号：US5853702A
公开(公告)日：1998-12-29
申请号：US797366
申请日：1997-02-07
IPC分类号： C12N15/09 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/24 , C12N15/00 , C12N15/55 , C12R1/07 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/785 , C12R1/80 , C12R1/84 , C12R1/85 , A61K7/28 , C07H21/04 , C07K1/00
CPC分类号： C12Y302/01084 , C12N9/2402 , Y10S435/933 , Y10S435/935
摘要： The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
摘要翻译： 本发明涉及具有衍生葡聚糖酶活性的多肽和分离的编码多肽的核酸序列。 本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。 本发明还涉及口腔组合物和降解变应原的方法。
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公开(公告)号：US5874275A
公开(公告)日：1999-02-23
申请号：US956268
申请日：1997-10-22
IPC分类号： C12N15/09 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/24 , C12N15/00 , C12N15/55 , C12R1/07 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/785 , C12R1/80 , C12R1/84 , C12R1/85 , C07H21/04 , C12N1/20
CPC分类号： C12Y302/01084 , C12N9/2402 , Y10S435/933 , Y10S435/935
摘要： The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
摘要翻译： 本发明涉及具有衍生葡聚糖酶活性的多肽和分离的编码多肽的核酸序列。 本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。 本发明还涉及口腔组合物和降解变应原的方法。
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公开(公告)号：US6037161A
公开(公告)日：2000-03-14
申请号：US185111
申请日：1998-11-03
申请人： Stephan Christgau , Thomas Sandal , Markus Sakari Kauppinen , Torben Halkier , Henrik Dalb.o slashed.ge
发明人： Stephan Christgau , Thomas Sandal , Markus Sakari Kauppinen , Torben Halkier , Henrik Dalb.o slashed.ge
CPC分类号： C12N9/18
摘要： The present invention provides an enzyme with acetyl esterase activity comprising the amino acid sequence IxFGDxYYT(SEQ ID NO: 1), in which x designates any amino acid residue. The enzyme exhibits activity towards acetylated xylan and acetylated mannan and may be used for modifying or degrading plant containing materials.
摘要翻译： 本发明提供了含有氨基酸序列IxFGDxYYT（SEQ ID NO：1）的乙酰酯酶活性的酶，其中x表示任何氨基酸残基。 该酶显示出对乙酰化木聚糖和乙酰化甘露聚糖的活性，并可用于修饰或降解含植物材料。
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公开(公告)号：US06159718A
公开(公告)日：2000-12-12
申请号：US087194
申请日：1998-05-29
申请人： Henrik Dalboege , Lene Nonboe Andersen , Lene Venke Kofoed , Markus Sakari Kauppinen , Stephan Christgau , Hans Peter Heldt-Hansen , Torben Halkier
发明人： Henrik Dalboege , Lene Nonboe Andersen , Lene Venke Kofoed , Markus Sakari Kauppinen , Stephan Christgau , Hans Peter Heldt-Hansen , Torben Halkier
CPC分类号： C12G1/0203 , C12N9/2402 , C12Y302/01015
摘要： An enzyme exhibiting polygalacturonase activity, which enzyme is immunologically reactive with an antibody raised against a purified polygalacturonase derived from Aspergillus aculeatus, CBS 101.43. The enzyme may be produced by recombinant DNA techniques and may be used for degradation of plant cell walls, for instance in the wine and juice production.
摘要翻译： 显示多聚半乳糖醛酸酶活性的酶，该酶与针对源自Aspergillus aculeatus的纯化多聚半乳糖醛酸酶CBS 101.43产生的抗体具有免疫反应性。 该酶可以通过重组DNA技术产生并且可以用于植物细胞壁的降解，例如在葡萄酒和果汁生产中。
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公开(公告)号：US20120010389A1
公开(公告)日：2012-01-12
申请号：US13221014
申请日：2011-08-30
IPC分类号： C07K16/00
CPC分类号： G01N33/6803 , C07K16/18 , G01N33/564 , G01N33/6887 , G01N33/6893 , G01N33/6896 , Y10S530/84 , Y10T436/173076
摘要： Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
摘要翻译： 描述了用于改善发生氧化性NO-修饰的疾病的诊断可能性的方法，例如炎性病症，癌症，帕金森病或阿尔茨海默病，并提供监测对这些疾病采取的治疗措施的效果的方法。 本发明能够利用包含针对特异性蛋白特征性的硝化和非硝化表位的抗体的免疫测定来检测与氧化性NO修饰相关的疾病特异性分解代谢标志物。
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6.发明申请WATER-SOLUBLE STRONTIUM SALTS FOR USE IN TREATMENT OF CARTILAGE AND/OR BONE CONDITIONS 失效用于治疗骨质疏松症和/或骨质疏松症的水溶性UM条公开(公告)号：US20100048697A1
公开(公告)日：2010-02-25
申请号：US12535053
申请日：2009-08-04
IPC分类号： A61K31/28
CPC分类号： A61K33/24 , C07C55/08 , C07C55/10 , C07C57/145 , C07C59/08 , C07C59/19 , C07C59/347
摘要： Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1 g/l to about 100 g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.
摘要翻译： 用于治疗和/或预防软骨和/或骨骼状况的化合物和药物组合物以及治疗这种病症的方法。 化合物是在室温下具有约1g / l至约100g / l水溶性的锶盐，特别是锶的锶或二羧酸盐的氨基酸盐。 新的水溶性锶盐的实例是例如。 谷氨酸锶和α-酮戊二酸锶。 本发明还涉及一种制备谷氨酸锶盐的改进方法。
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7.发明授权Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions 失效用于治疗软骨和/或骨骼状况的水溶性锶盐公开(公告)号：US07595342B2
公开(公告)日：2009-09-29
申请号：US11269289
申请日：2005-11-07
IPC分类号： A61K31/19
CPC分类号： A61K33/24 , C07C55/08 , C07C55/10 , C07C57/145 , C07C59/08 , C07C59/19 , C07C59/347
摘要： Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1 g/l to about 100 g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.
摘要翻译： 用于治疗和/或预防软骨和/或骨骼状况的化合物和药物组合物以及治疗这种病症的方法。 化合物是在室温下具有约1g / l至约100g / l水溶性的锶盐，特别是锶的锶或二羧酸盐的氨基酸盐。 新的水溶性锶盐的实例是例如。 谷氨酸锶和α-酮戊二酸锶。 本发明还涉及一种制备谷氨酸锶盐的改进方法。
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8.发明申请Assay of isomerised and/or optically inverted proteins and protein fragments 有权异构化和/或光学倒置的蛋白质和蛋白质片段的测定公开(公告)号：US20050054014A1
公开(公告)日：2005-03-10
申请号：US10154424
申请日：2002-05-23
申请人： Stephan Christgau , Dennis Henriksen , Paul Cloos
发明人： Stephan Christgau , Dennis Henriksen , Paul Cloos
CPC分类号： G01N33/6887 , Y10S530/84
摘要： Disclosed are compositions and methods for performing an immuno-assay that includes measuring the amount of an isomerised or optically inverted non-collagen protein derived from cartilage.
摘要翻译： 公开了用于进行免疫测定的组合物和方法，其包括测量衍生自软骨的异构化或光学倒置的非胶原蛋白的量。
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公开(公告)号：US5858760A
公开(公告)日：1999-01-12
申请号：US887365
申请日：1997-07-02
申请人： Henrik Dalb.o slashed.ge , Lene Venke Kofod , Markus Sakari Kauppinen , Lene Nonboe Andersen , Stephan Christgau , Hans Peter Heldt-Hansen
发明人： Henrik Dalb.o slashed.ge , Lene Venke Kofod , Markus Sakari Kauppinen , Lene Nonboe Andersen , Stephan Christgau , Hans Peter Heldt-Hansen
摘要： The nucleic acid sequence encoding a pectin lyase from Aspergillus aculeatus, CBS 101.43 and the corresponding amino acid sequence are disclosed. The nucleic acid is used to transform a host cell which is utilized in a method to make the pectin lyase. The catalytic properties and stability characteristics of the enzyme are reported. The enzyme is useful for the degradation of plant cell wall components.
摘要翻译： PCT No.PCT / DK94 / 00105 Sec。 371日期：1995年9月26日 102（e）日期1995年9月26日PCT 1994年3月11日PCT公布。 公开号WO94 / 21786 1994年9月29日，公开了从棘孢曲霉CBS 101.43和相应的氨基酸序列编码果胶裂解酶的核酸序列。 核酸用于转化用于制备果胶裂解酶的方法中的宿主细胞。 报道了酶的催化性质和稳定性。 该酶可用于植物细胞壁组分的降解。
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公开(公告)号：US5854050A
公开(公告)日：1998-12-29
申请号：US578551
申请日：1996-02-01
申请人： Henrik Dalb.o slashed.ge , Stephan Christgau , Lene Nonboe Andersen , Lene Venke Kofod , Markus Sakari Kauppinen , Jack Bech Nielsen , Claus Dambmann
发明人： Henrik Dalb.o slashed.ge , Stephan Christgau , Lene Nonboe Andersen , Lene Venke Kofod , Markus Sakari Kauppinen , Jack Bech Nielsen , Claus Dambmann
IPC分类号： C12N1/21 , A21D2/26 , A21D8/04 , A23K20/189 , C11D3/00 , C11D3/386 , C11D3/39 , C12N1/15 , C12N5/04 , C12N9/62 , C12N9/82 , C12N15/09 , C12N15/57 , C12P21/06 , C12R1/685 , C12R1/69 , C07H21/04
CPC分类号： C11D3/3947 , A21D8/042 , A23K20/189 , C11D3/0078 , C11D3/386 , C11D3/38618 , C11D3/38636 , C12N9/62 , C12N9/82
摘要： A DNA construct comprising a DNA sequence encoding an enzyme exhibiting protease activity, which DNA sequence comprises the DNA sequence shown in SEQ ID No. 1 or 2 or an analog of any of these sequences being at least 80% homologous to the DNA sequence shown in SEQ ID No. 1 or 2. The proteases encoded by the DNA sequences have an acid pH optimum.
摘要翻译： PCT No.PCT / DK94 / 00274 Sec。 371日期：1996年2月1日 102（e）日期1996年2月1日PCT提交1994年7月5日PCT公布。 WO95 / 02044 PCT公开号 日期1995年1月19日一种包含编码表现出蛋白酶活性的酶的DNA序列的DNA构建体，该DNA序列包含SEQ ID No.1或2所示的DNA序列或这些序列中的任一个的类似物与 DNA序列如SEQ ID No.1或2所示。由DNA序列编码的蛋白酶具有酸性pH最佳值。
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