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    System and Method for Extending Dynamic Range for a Detector
    24.
    发明申请
    System and Method for Extending Dynamic Range for a Detector 审中-公开
    用于扩展检测器动态范围的系统和方法

    公开(公告)号：US20120214246A1

    公开(公告)日：2012-08-23

    申请号：US13361875

    申请日：2012-01-30

    申请人： Mark F. Oldham ,  Austin B. Tomaney

    发明人： Mark F. Oldham ,  Austin B. Tomaney

    IPC分类号： G01N21/75

    CPC分类号： G01J1/42 ,  G01J2001/4406 ,  Y10T436/143333

    摘要： A system and method for measuring signals having a wide range of intensity components using detectors adapted for use in biological analysis devices. In certain biological analysis applications, signals emitted by a sample may have intensity components that vary over several orders of magnitude. Measurement of such a signal may yield an acceptable quality for one intensity component at the expense of another component. For example, a detector configured to measure a relatively weak intensity component may cause it to overflow when subjected to a relatively strong intensity component. The detector can be adapted to be operated at different configurations to allow measurements of different components of the signal, and the results can be combined to yield an accurate representation of the signal.

    摘要翻译： 一种用于使用适用于生物分析装置的检测器来测量具有宽范围的强度分量的信号的系统和方法。 在某些生物分析应用中，由样品发射的信号可以具有在几个数量级上变化的强度分量。 这种信号的测量可以以另一个组件为代价产生一个强度分量的可接受的质量。 例如，被配置为测量相对弱的强度分量的检测器可以在经受相对强的强度分量时使其溢出。 检测器可以适于以不同的配置操作，以允许对信号的不同部件进行测量，并且可以将结果组合以产生信号的精确表示。

    System for detecting markers
    26.
    发明授权
    System for detecting markers 有权
    检测标记系统

    公开(公告)号：US07636160B2

    公开(公告)日：2009-12-22

    申请号：US12321781

    申请日：2009-01-26

    申请人： Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  John S. Shigeura ,  Janice G. Shigeura, legal representative

    发明人： Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  John S. Shigeura

    IPC分类号： G01N21/00

    CPC分类号： G01N27/44721 ,  B82Y10/00 ,  B82Y20/00 ,  G01N2015/149 ,  G01N2015/1497

    摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

    摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

    Array imaging system
    29.
    发明授权
    Array imaging system 失效
    阵列成像系统

    公开(公告)号：US07135667B2

    公开(公告)日：2006-11-14

    申请号：US11188243

    申请日：2005-07-22

    申请人： Mark F. Oldham ,  Howard G. King ,  Douwe D. Haga ,  Tracy L. Ferea

    发明人： Mark F. Oldham ,  Howard G. King ,  Douwe D. Haga ,  Tracy L. Ferea

    IPC分类号： H01L27/00 ,  G01T1/20 ,  G01N21/86 ,  G01V8/00

    CPC分类号： G01N21/76 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0633 ,  G01N2201/0634

    摘要： An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus can comprise a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light can illuminate the illumination region. Additionally, the apparatus can comprise an image collecting device adapted to selectively collect images of either a first signal when the illumination source is illuminating the illumination region, or a second signal absent illumination of the illumination region. The first signal can have wavelengths effectively different from the wavelengths of the portion of the light emitted by the LEDs that illuminates the illumination region.

    摘要翻译： 一种用于对与样本瓦片相关联的多个特征的阵列进行成像的装置。 该装置可以包括在照明区域中支撑样品瓦的台，以及具有适于发光的多个LED的照明源。 光的至少一部分可以照亮照明区域。 另外，该装置可以包括图像采集装置，适于当照明源照射照明区域时选择性地收集第一信号的图像，或者不存在照明区域的照明的第二信号。 第一信号可以具有与照亮照明区域的LED发射的光的部分的波长有效地不同的波长。

    Shaped illumination geometry and intensity using a diffractive optical element
    30.
    发明授权
    Shaped illumination geometry and intensity using a diffractive optical element 失效
    使用衍射光学元件形成照明几何形状和强度

    公开(公告)号：US06744502B2

    公开(公告)日：2004-06-01

    申请号：US09964778

    申请日：2001-09-28

    申请人： Louis B. Hoff ,  Mark F. Oldham

    发明人： Louis B. Hoff ,  Mark F. Oldham

    IPC分类号： G01J330

    CPC分类号： G02B27/0944 ,  G01J1/20 ,  G01J3/10 ,  G02B19/0014 ,  G02B19/0052 ,  G02B27/0927

    摘要： A method and apparatus to illuminate a target. The apparatus can comprise a first lens configured to receive light from the light source, a diffractive optical element configured to receive the light from the first lens and to regulate the light into regulated light, and second lens configured to receive the regulated light and to direct the regulated light to a selected area of the target.

    摘要翻译： 照明目标的方法和装置。 该装置可以包括被配置为从光源接收光的第一透镜，被配置为接收来自第一透镜的光并将光调节为调节光的衍射光学元件，以及被配置为接收调节光并引导 调节光到目标的选定区域。