公开(公告)号：US20050202478A1

公开(公告)日：2005-09-15

申请号：US11048068

申请日：2005-02-02

Applicant: Michael Thornton ,  Li Ding ,  Chandra Arvizu ,  Monique Yao ,  Catherine Tribouley ,  Preeti Lal ,  April Hafalia ,  Mariah Baughn ,  Jayalaxmi Ramkumar ,  Yan Lu ,  Narinder Chawla

Inventor： Michael Thornton ,  Li Ding ,  Chandra Arvizu ,  Monique Yao ,  Catherine Tribouley ,  Preeti Lal ,  April Hafalia ,  Mariah Baughn ,  Jayalaxmi Ramkumar ,  Yan Lu ,  Narinder Chawla

IPC: A61K38/00 ,  C12N9/16 ,  C12Q1/68 ,  A01K67/00 ,  C07H21/04

CPC classification number: C12N9/16 ,  A61K38/00

Abstract: The invention provides human phosphodiesterases (HPDE) and polynucleotides which identify and encode HPDE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of HPDE.

Abstract translation: 本发明提供了人类磷酸二酯酶（HPDE）和识别和编码HPDE的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HPDE异常表达相关的疾病的方法。

公开(公告)号：US20050048479A1

公开(公告)日：2005-03-03

申请号：US10311625

申请日：2001-06-26

Applicant: Ameena Gandhi ,  Catherine Tribouley ,  Li Ding ,  Dyung Lu ,  Ernestine Lee ,  Henry Yue ,  Junming Yang ,  Mariah Baughn ,  Michael Thornton ,  Monique Yao ,  Narinder Chawla ,  Y Tang ,  Vicki Elliott ,  Yan Lu

Inventor： Ameena Gandhi ,  Catherine Tribouley ,  Li Ding ,  Dyung Lu ,  Ernestine Lee ,  Henry Yue ,  Junming Yang ,  Mariah Baughn ,  Michael Thornton ,  Monique Yao ,  Narinder Chawla ,  Y Tang ,  Vicki Elliott ,  Yan Lu

IPC: G01N33/50 ,  A61K38/00 ,  A61K38/51 ,  A61K45/00 ,  A61P9/00 ,  A61P15/00 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P27/00 ,  A61P43/00 ,  C07K16/40 ,  C07K16/46 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/88 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/573 ,  A01K67/00 ,  C07H21/04 ,  C12N9/22

CPC classification number: C12N9/88 ,  A01K2217/05 ,  A61K38/00 ,  C12Y406/01001 ,  C12Y406/01002

Abstract: The invention provides human adenylyl and guanylyl cyclases (ADGUC) and polynucleotides which identify and encode ADGUC. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ADGUC.

Abstract translation: 本发明提供鉴定和编码ADGUC的人腺苷酰和鸟苷酸环化酶（ADGUC）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与ADGUC的异常表达相关的紊乱的方法。

公开(公告)号：US06483244B1

公开(公告)日：2002-11-19

申请号：US09868751

申请日：2001-07-31

Applicant: Eizo Kawato ,  Li Ding

Inventor： Eizo Kawato ,  Li Ding

IPC: H03B512

CPC classification number: H01J49/022 ,  H01J49/42 ,  H03B11/10

Abstract: A method of fast start and/or fast termination of a radio frequency resonator, which has a coil, a capacitor and two switches with internal resistance wherein one end of the switches is connected to a junction of the coil and the capacitor where a RF voltage is provided, and another end of each switch is connected to high voltage power supplies with opposite polarities, a fast start being achieved by closing one of the switches for a short period of time for fast start, and a fast termination being obtained by closing both switches for a while.

Abstract translation: 一种具有线圈，电容器和具有内部电阻的两个开关的射频谐振器的快速启动和/或快速终止的方法，其中开关的一端连接到线圈和电容器的结，RF电压 并且每个开关的另一端连接到具有相反极性的高压电源，快速启动是通过闭合其中一个开关短时间来快速启动的，并且通过闭合两者来获得快速终止 切换一会儿

公开(公告)号：US5968794A

公开(公告)日：1999-10-19

申请号：US12645

申请日：1998-01-23

Applicant: Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

Inventor： Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

IPC: A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  C12N11/12 ,  A61K38/43 ,  C07H1/02 ,  C07K1/04

CPC classification number: A61K9/5161 ,  A61K9/127 ,  A61K9/167 ,  A61K9/5192 ,  Y10S530/813 ,  Y10S530/814

Abstract: A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus formed of a cross-linked polysaccharide or oligosaccharide matrix having grafted ionic ligands, a layer of fatty acid compounds covalently bonded to the nucleus and a layer of phospholipids hydrophobically bonded to the layer of fatty acid compounds. Dextran, cellulose or starch may be cross-linked with epichlorohydrin to form a cross-linked polysaccharide matrix. Ionic ligands may be grafted using an acidic compound such as succinic acid, phosphoric acid or phosphorous oxychloride, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino) ethylamine fastened onto the grafted acidic compound. Phosphoric acid or phosphorous oxychloride in one step provide both cross-linking and ionic ligands. Co-cross-linking can be obtained using a protein such as keratin, collagen or elastase. The vector may be prepared by reacting succinic acid monochloride with a cross-linked polysaccharide matrix to graft succinic acid onto the matrix to form the nucleus having ionic ligands, grinding the nucleus to a size between 10 .mu.nm and 10 .mu.m, drying, coupling fatty acid compounds to the nucleus and hydrophobically bonding phospholipids to the fatty acid compounds. After coupling the fatty acid compounds and before bonding the phospholipids, a molecule having biological activity may be added. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.

Abstract translation: 制备用于输送生物活性分子的可生物降解的颗粒载体，其含有由具有接枝离子配体的交联多糖或寡糖基质形成的核，与核共价键合的脂肪酸化合物层和与层疏水结合的磷脂层 的脂肪酸化合物。 葡聚糖，纤维素或淀粉可以与表氯醇交联以形成交联的多糖基质。 离子配体可以使用酸性化合物如琥珀酸，磷酸或三氯氧磷，或碱性化合物如胆碱，羟基胆碱，2-（二甲基氨基）乙醇或2-（二甲基氨基）乙胺接枝在接枝的酸性化合物上。 磷酸或磷酰氯在一个步骤中提供交联和离子配体。 可以使用蛋白质如角蛋白，胶原或弹性蛋白酶获得共交联。 载体可以通过使琥珀酸一氯化物与交联的多糖基质反应来制备，以将琥珀酸接枝到基质上以形成具有离子配体的核，将细胞核研磨至10μm至10μm之间的大小，干燥，偶联 脂肪酸化合物到细胞核并将磷脂疏水性结合到脂肪酸化合物上。 偶联脂肪酸化合物之后，在磷脂结合之前，可以加入具有生物活性的分子。 琥珀酸一氯化物优选通过琥珀酸二氯化物与游离琥珀酸反应形成纯结晶琥珀酸一氯化物来制备。

公开(公告)号：US09159544B2

公开(公告)日：2015-10-13

申请号：US14001747

申请日：2011-09-28

Applicant: Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

Inventor： Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

IPC: H01J49/42 ,  H01J49/02 ,  H01J49/00 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

Abstract translation: 用于质量分析的静电离子阱包括第一电极阵列和与第一电极阵列间隔开的第二电极阵列。 第一和第二电极阵列可以是由平行条形电极或同心圆形或部分圆形导电环形成的平面阵列。 阵列的电极被提供有基本上相同的电压模式，由此阵列之间的空间中的电位分布使得在飞行方向上等离子地反射离子，使得它们在空间中经历周期性的振荡运动 基本上位于阵列之间。 放大器电路用于检测具有与经历周期性振荡运动的离子的质荷比相关的频率分量的图像电流。

公开(公告)号：US08890058B2

公开(公告)日：2014-11-18

申请号：US12093862

申请日：2005-11-16

Applicant: Sadao Takeuchi ,  Hiroaki Waki ,  Li Ding ,  Roger Giles

Inventor： Sadao Takeuchi ,  Hiroaki Waki ,  Li Ding ,  Roger Giles

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/067 ,  H01J49/066

Abstract: The present invention provides a mass spectrometer having an ion lens capable of transporting an ion having a large mass to charge ratio with a high level of ion-passing efficiency even under a low-vacuum atmosphere. In conventional atmospheric pressure ionization mass spectrometers or similar mass spectrometers, applying an excessively high voltage to the ion lens undesirably causes an electric discharge. Therefore, the passing efficiency for an ion having a large mass to charge ratio cannot be adequately improved, which leads to a poor detection sensitivity. To solve this problem, the mass spectrometer according to the present invention includes a voltage controller 21 that controls a variable radiofrequency (RF) voltage generator 24 so that both the amplitude and the frequency of the RF voltage applied to the lens electrodes of an ion lens 5 are changed according to the mass to charge ratio of an ion to be analyzed. This control enables the ion lens 5 to focus an ion and transport it to the subsequent stage with a high level of passing efficiency even in the case of analyzing an ion having a large mass to charge ratio. Thus, the detection sensitivity is improved. The aforementioned control is conducted on the basis of the control data stored in a voltage control data storage 22. These data are obtained in advance by a measurement of a sample containing a substance having a known mass to charge ratio, in which the intensity of the signal of an ion detector is maintained while the analysis conditions are changed.

Abstract translation: 本发明提供一种质谱仪，其具有能够即使在低真空气氛下也能以高水平的离子通过效率将具有大质荷比的离子输送的离子透镜。 在传统的大气压电离质谱仪或类似的质谱仪中，对离子透镜施加过高的电压会导致放电。 因此，不能充分提高质荷比大的离子的通过效率，导致检测灵敏度差。 为了解决这个问题，根据本发明的质谱仪包括控制可变射频（RF）电压发生器24的电压控制器21，使得施加到离子透镜的透镜电极的RF电压的幅度和频率 5根据待分析的离子的质荷比而改变。 这种控制使得离子透镜5能够聚焦离子并且即使在分析具有大的质荷比的离子的情况下，也可以将其输送到具有高水平的通过效率的后续阶段。 因此，提高了检测灵敏度。 上述控制是根据存储在电压控制数据存储器22中的控制数据进行的。这些数据是通过测量包含具有已知质荷比的物质的样品预先获得的，其中， 在分析条件改变的同时保持离子检测器的信号。

公开(公告)号：US20140217275A1

公开(公告)日：2014-08-07

申请号：US14001747

申请日：2011-09-28

Applicant: Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

Inventor： Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

Abstract translation: 用于质量分析的静电离子阱包括第一电极阵列和与第一电极阵列间隔开的第二电极阵列。 第一和第二电极阵列可以是由平行条形电极或同心圆形或部分圆形导电环形成的平面阵列。 阵列的电极被提供有基本上相同的电压模式，由此阵列之间的空间中的电位分布使得在飞行方向上等离子地反射离子，使得它们在空间中经历周期性的振荡运动 基本上位于阵列之间。 放大器电路用于检测具有与经历周期性振荡运动的离子的质荷比相关的频率分量的图像电流。

公开(公告)号：US08486055B2

公开(公告)日：2013-07-16

申请号：US12146976

申请日：2008-06-26

Applicant: Wayne H. Knox ,  Li Ding ,  Krystel R. Huxlin ,  Jay F. Kunzler

Inventor： Wayne H. Knox ,  Li Ding ,  Krystel R. Huxlin ,  Jay F. Kunzler

IPC: A61B18/18

CPC classification number: A61F9/00804 ,  A61F9/008 ,  A61F9/00829 ,  A61F2009/00842 ,  A61F2009/00848 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/0088

Abstract: A method for modifying the refractive index of ocular tissues. The method comprises irradiating select regions of ocular tissue with a visible or near-IR laser. The irradiation results in the formation of structures in the ocular tissue, characterized by a change in refractive index, and which exhibit little or no scattering loss.

Abstract translation: 一种改变眼组织折射率的方法。 该方法包括用可见光或近红外激光照射眼组织的选择区域。 照射导致眼组织中的结构的形成，其特征在于折射率的变化，并且表现出很少或没有散射损失。

公开(公告)号：US20120248307A1

公开(公告)日：2012-10-04

申请号：US13079740

申请日：2011-04-04

Applicant: Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

Inventor： Li Ding ,  Tao Lin ,  Gongyu Jiang ,  Hui Mu

IPC: H01J49/34

CPC classification number: H01J49/423

Abstract: The present invention relates generally to the field of ion storage and analysis, in particular to a linear ion trap mass analyzer comprised by multiple columnar electrodes. High frequency voltages are applied on at least one of the columnar electrodes to form ion confining space, which mainly consists of two-dimensional quadrupole electric radial trapping field, and there is at least one through slot for ion ejection in at least one direction perpendicular to the axis of the ion trap, wherein an AC electric field superposition is applied to invoke dipole excitation. Opposite to the through slot, there is an elongated electrode for field adjusting between two columnar electrodes or inside the slit of one of the columnar electrodes mentioned above. The potential on the elongated electrode for field adjusting is set as the sum of a portion of the high frequency voltage which applied on one adjacent columnar electrode and a DC offset, which can be adjusted freely. Through adjusting the portion of the high frequency potential and DC potential on this electrode, one or more objectives, including field optimization inside the ion trap as well as ion motion characteristics of resonant ejection, can be realized.

Abstract translation: 本发明一般涉及离子存储和分析领域，特别涉及由多个柱状电极组成的线性离子阱质量分析仪。 在至少一个柱状电极上施加高频电压以形成主要由二维四极电子径向捕获场组成的离子限制空间，并且至少有一个通孔用于在至少一个垂直于 离子阱的轴线，其中施加AC电场叠加以调用偶极子激发。 与通孔相对，有一个用于在两个柱状电极之间进行现场调节的细长电极或者在上述一个柱状电极的狭缝内部。 用于场调整的细长电极上的电位被设置为施加在一个相邻柱状电极上的高频电压的一部分和可以自由调节的DC偏移之和。 通过调节该电极上的高频电位和直流电位的一部分，可以实现一个或多个目标，包括离子阱内的场优化以及共振喷射的离子运动特性。

公开(公告)号：US20110270038A1

公开(公告)日：2011-11-03

申请号：US13138112

申请日：2009-12-31

Applicant: Wenqiang Jiang ,  Li Ding

Inventor： Wenqiang Jiang ,  Li Ding

IPC: A61B1/267

CPC classification number: A61B1/267 ,  A61B1/00052 ,  A61B1/00073 ,  A61B1/06

Abstract: A video laryngoscope has a handle and a groove on one side of the handle. The groove is used for guiding a guide wire when the larynogoscope is placed in a patient's mouth. A video camera located near the end of the handle is used to view the area around the glottis. When the guide wire is properly positioned near the glottis, the upper part of the guide wire is disengaged from the groove so as to allow an endotracheal tube to be slipped over the guide wire and to be inserted into part of the trachea through the glottis. When the tube is properly inserted for intubation, the guide wire is removed from the tube. An illuminating light source such as an LED lamp can be installed at the end of the handle to provide illumination for the video camera.

Abstract translation: 视频喉镜在手柄的一侧具有手柄和凹槽。 当喉镜放置在患者口中时，该凹槽用于引导导丝。 位于手柄末端附近的摄像机用于查看声门周围的区域。 当引导线适当地定位在声门附近时，导丝的上部与凹槽脱离，以允许气管内导管滑过导丝并通过声门插入到气管的一部分中。 当管正确插入插管时，导丝从管中取出。 诸如LED灯的照明光源可以安装在手柄的端部以为摄像机提供照明。