公开(公告)号：US6013284A

公开(公告)日：2000-01-11

申请号：US513853

申请日：1996-05-01

Applicant: Daniel Samain ,  Pascal Delrieu ,  Joelle Gibilaro ,  Roselyne Dirson ,  Monique Cervilla ,  Ignacio De Miguel ,  Li Ding ,  Frederique Nguyen ,  Nadine Soulet ,  Corinne Soler

Inventor： Daniel Samain ,  Pascal Delrieu ,  Joelle Gibilaro ,  Roselyne Dirson ,  Monique Cervilla ,  Ignacio De Miguel ,  Li Ding ,  Frederique Nguyen ,  Nadine Soulet ,  Corinne Soler

IPC: A23L27/00 ,  A61K8/00 ,  A61K8/11 ,  A61K8/14 ,  A61K8/36 ,  A61K8/42 ,  A61K8/64 ,  A61K8/66 ,  A61K8/68 ,  A61K8/73 ,  A61K8/92 ,  A61K8/97 ,  A61K8/99 ,  A61K9/16 ,  A61K9/50 ,  A61K9/51 ,  A61Q19/00 ,  A61Q90/00

CPC classification number: A61K9/5123 ,  A23L27/70 ,  A23L27/72 ,  A61K8/11 ,  A61K8/14 ,  A61K8/66 ,  A61K8/97 ,  A61K9/1652 ,  A61K9/5015 ,  A61K9/5161 ,  A61Q19/00 ,  B82Y5/00 ,  A61K2800/412 ,  A61K2800/413 ,  Y10S514/951 ,  Y10S514/952 ,  Y10T428/2991

Abstract: A synthetic particulate vector comprising a non-liquid hydrophilic nucleus and an outer layer at least partially consisting of amphiphilic compounds, which is combined with the nucleus by hydrophobic interactions and/or ionic bonds. A process for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtained according to such a process, and pharmaceutical, cosmeticological and food compositions comprising such vectors are also disclosed.

Abstract translation: PCT No.PCT / FR94 / 00228 Sec。 371日期：1996年5月1日 102（e）日期1996年5月1日PCT 1994年3月1日PCT公布。 WO94 / 20078 PCT公开号 日期1994年9月15日一种包含非液体亲水核和至少部分由两亲化合物组成的外层的合成颗粒载体，其通过疏水相互作用和/或离子键与核结合。 还公开了通过包封可离子化活性成分，根据这种方法获得的载体以及包含这种载体的药物，美容和食用组合物来制备颗粒载体的方法。

公开(公告)号：US5534501A

公开(公告)日：1996-07-09

申请号：US479539

申请日：1995-06-07

Applicant: Daniel Samain ,  Joelle Gibilaro

Inventor： Daniel Samain ,  Joelle Gibilaro

IPC: A23L1/00 ,  A23L1/0522 ,  A23L1/0532 ,  A23L1/0534 ,  A23L1/054 ,  A23L1/30 ,  A23L1/308 ,  A01N43/04 ,  A01N25/34 ,  A61K9/127 ,  B01J13/02

CPC classification number: A23L33/21 ,  A23L29/219 ,  A23L29/256 ,  A23L29/262 ,  A23L29/269 ,  A23L33/115 ,  A23P10/35 ,  Y10T428/2989

Abstract: Particle for use especially as a fat substitute, characterized in that it includes an insoluble hydrophile matrix, surrounded by a hydrophobic layer of fatty acids bound to the matrix by covalent bonds and capable of interacting with lipidic or amphiphilic compounds. The invention also concerns a composition for use as a fat substitute and a process for the preparation of such particles.

Abstract translation: 用于特别用作脂肪替代物的颗粒，其特征在于其包括不溶性亲水基质，被疏水层包围，所述疏水层通过共价键与基质结合并能够与脂质或两亲性化合物相互作用。 本发明还涉及用作脂肪替代物的组合物和制备这种颗粒的方法。

公开(公告)号：US5206156A

公开(公告)日：1993-04-27

申请号：US521977

申请日：1990-05-11

Applicant: Daniel Samain ,  Frederique Nguyen ,  Michel Degre

Inventor： Daniel Samain ,  Frederique Nguyen ,  Michel Degre

IPC: C12N11/10 ,  A01N25/12 ,  A01N59/00 ,  A01N63/00 ,  A23L3/3571 ,  A61K8/66 ,  A61K9/16 ,  A61K9/50 ,  A61K9/51 ,  A61K38/44 ,  A61K47/48 ,  A61Q11/00 ,  C12N11/02

CPC classification number: A61K9/5123 ,  A23L3/3571 ,  A61K38/443 ,  A61K47/4823 ,  A61K8/66 ,  A61K9/1676 ,  A61K9/5078 ,  A61K9/5161 ,  A61Q11/00 ,  C12N11/02

Abstract: The invention relates to a process for the preparation of a particulate antimicrobial product from the LP system of the lactoperoxidase enzyme/oxygen donor/oxidizable substrate (if needed). The process comprises bonding the lactoperoxidase enzyme to a particulate carrier comprising a polysaccharide nucleus, a first lipidic layer and a second phospholipidic layer in such a manner that the enzyme molecules are inserted into this second layer and/or into the first layer. The product according to the invention is obtained by then conditioning in a non-aqueous medium the aforesaid particulate vector and the molecules of the LP system not integrated into said vector. The process of the invention permits adjusting the diffusability of the product and its mobility as a function of the intended applications, without destruction of the LP system.

Abstract translation: 本发明涉及从乳过氧化物酶/氧供体/可氧化底物（如果需要）的LP系统制备颗粒抗微生物产品的方法。 该方法包括将乳过氧化物酶结合到包含多糖核，第一脂质层和第二磷脂层的颗粒载体上，使得酶分子插入该第二层和/或第一层中。 通过在非水介质中调节上述颗粒载体和未整合到所述载体中的LP系统的分子，获得本发明的产品。 本发明的方法允许根据预期应用调整产品的扩散性及其迁移率，而不破坏LP系统。

公开(公告)号：US20110014458A1

公开(公告)日：2011-01-20

申请号：US12810718

申请日：2008-12-22

Applicant: Nicoleta Camelia Stinga ,  Daniel Samain ,  David Guerin

Inventor： Nicoleta Camelia Stinga ,  Daniel Samain ,  David Guerin

IPC: B32B27/06 ,  B32B27/30 ,  B05D3/00

CPC classification number: C08J7/14 ,  B05D7/52 ,  C08J5/18 ,  C08J2329/04 ,  D21H19/20 ,  D21H19/32 ,  Y10T428/265 ,  Y10T428/31855 ,  Y10T428/3188

Abstract: Film having liquid-water, grease, gas and water-vapour barrier properties, comprising a PVA film grafted on the surface with a fatty acid.

Abstract translation: 具有液态水，油脂，气体和水蒸气阻隔性的膜，其包含在表面上与脂肪酸接枝的PVA膜。

公开(公告)号：US20080194805A1

公开(公告)日：2008-08-14

申请号：US11658852

申请日：2005-07-29

Applicant: Michel Vignon ,  Suzelei Montanari ,  Daniel Samain ,  Jean-Stephane Condoret

Inventor： Michel Vignon ,  Suzelei Montanari ,  Daniel Samain ,  Jean-Stephane Condoret

IPC: C08B1/00 ,  C08B37/00 ,  C08B31/18 ,  C07H3/06

CPC classification number: C08B15/04 ,  C08B31/08 ,  C08B33/08 ,  C08B35/08 ,  C08B37/00 ,  D06M15/03 ,  D21H17/24 ,  D21H19/54

Abstract: The invention relates to a method for the controlled oxidation of oligo- and/or polysaccharides containing free —CH2OH primary hydroxyl groups, using an oxidising agent. The invention is characterised in that the oxidation reaction is performed in a densified fluid which is inert in relation to the oxidising agents employed. The invention is suitable for use, for example, in the food, paint, paper, textile, agricultural and pharmaceutical industries, in the medical, biomedical or paramedical fields, in the surgical field, in the cosmetic industry and as agents for the complexing or sequestering of metal ions, heavy metals and radioactive elements in the nuclear industry.

Abstract translation: 本发明涉及使用氧化剂来控制含有游离-CH 2 OH羟基的寡糖和/或多糖的氧化方法。 本发明的特征在于，氧化反应在致密流体中进行，该致密流体相对于所用的氧化剂是惰性的。 本发明适用于例如食品，油漆，纸张，纺织品，农业和制药工业，医疗，生物医学或辅助医疗领域，在外科领域，化妆品工业中，以及用于络合或 核工业中金属离子，重金属和放射性元素的螯合。

公开(公告)号：US20130199409A1

公开(公告)日：2013-08-08

申请号：US13809619

申请日：2011-07-08

Applicant: Daniel Samain ,  Camelia Stinga

Inventor： Daniel Samain ,  Camelia Stinga

IPC: C08L1/12

CPC classification number: C08L1/12 ,  C08J5/045 ,  C08J5/06 ,  C08J7/12 ,  C08J7/14 ,  C08J2301/00 ,  C08J2301/10 ,  C08J2301/12 ,  C08J2301/14 ,  C08J2397/02 ,  C08L1/10 ,  C08L1/14 ,  C08L97/02 ,  C08L2205/16 ,  D06M13/188 ,  D06M2101/06 ,  C08L2666/26

Abstract: New cellulose-based composites and production methods thereof, comprising partial peracetylation of cellulose fibers having a degree of crystallinity less than 80%.

Abstract translation: 新的纤维素基复合材料及其制备方法包括结晶度小于80％的纤维素纤维的部分过乙酰化。

公开(公告)号：US5968794A

公开(公告)日：1999-10-19

申请号：US12645

申请日：1998-01-23

Applicant: Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

Inventor： Daniel Samain ,  Ignacio De Miguel ,  Jaouad Meniali ,  Karim Ioualalen ,  Li Ding ,  Monique Cervilla ,  Valerie Rieumajou ,  Pascal Delrieu ,  Laurent Imbertie

IPC: A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  C12N11/12 ,  A61K38/43 ,  C07H1/02 ,  C07K1/04

CPC classification number: A61K9/5161 ,  A61K9/127 ,  A61K9/167 ,  A61K9/5192 ,  Y10S530/813 ,  Y10S530/814

Abstract: A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus formed of a cross-linked polysaccharide or oligosaccharide matrix having grafted ionic ligands, a layer of fatty acid compounds covalently bonded to the nucleus and a layer of phospholipids hydrophobically bonded to the layer of fatty acid compounds. Dextran, cellulose or starch may be cross-linked with epichlorohydrin to form a cross-linked polysaccharide matrix. Ionic ligands may be grafted using an acidic compound such as succinic acid, phosphoric acid or phosphorous oxychloride, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino) ethylamine fastened onto the grafted acidic compound. Phosphoric acid or phosphorous oxychloride in one step provide both cross-linking and ionic ligands. Co-cross-linking can be obtained using a protein such as keratin, collagen or elastase. The vector may be prepared by reacting succinic acid monochloride with a cross-linked polysaccharide matrix to graft succinic acid onto the matrix to form the nucleus having ionic ligands, grinding the nucleus to a size between 10 .mu.nm and 10 .mu.m, drying, coupling fatty acid compounds to the nucleus and hydrophobically bonding phospholipids to the fatty acid compounds. After coupling the fatty acid compounds and before bonding the phospholipids, a molecule having biological activity may be added. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.

Abstract translation: 制备用于输送生物活性分子的可生物降解的颗粒载体，其含有由具有接枝离子配体的交联多糖或寡糖基质形成的核，与核共价键合的脂肪酸化合物层和与层疏水结合的磷脂层 的脂肪酸化合物。 葡聚糖，纤维素或淀粉可以与表氯醇交联以形成交联的多糖基质。 离子配体可以使用酸性化合物如琥珀酸，磷酸或三氯氧磷，或碱性化合物如胆碱，羟基胆碱，2-（二甲基氨基）乙醇或2-（二甲基氨基）乙胺接枝在接枝的酸性化合物上。 磷酸或磷酰氯在一个步骤中提供交联和离子配体。 可以使用蛋白质如角蛋白，胶原或弹性蛋白酶获得共交联。 载体可以通过使琥珀酸一氯化物与交联的多糖基质反应来制备，以将琥珀酸接枝到基质上以形成具有离子配体的核，将细胞核研磨至10μm至10μm之间的大小，干燥，偶联 脂肪酸化合物到细胞核并将磷脂疏水性结合到脂肪酸化合物上。 偶联脂肪酸化合物之后，在磷脂结合之前，可以加入具有生物活性的分子。 琥珀酸一氯化物优选通过琥珀酸二氯化物与游离琥珀酸反应形成纯结晶琥珀酸一氯化物来制备。

公开(公告)号：US10207287B2

公开(公告)日：2019-02-19

申请号：US13885262

申请日：2011-11-16

Applicant: Daniel Samain ,  David Guerin ,  André Lemaitre ,  Laurent Lyannaz ,  Jean-Luc Guillouty

Inventor： Daniel Samain ,  David Guerin ,  André Lemaitre ,  Laurent Lyannaz ,  Jean-Luc Guillouty

IPC: B05D3/00 ,  B05C9/12 ,  C08J7/14 ,  D21H17/06 ,  D21H17/11 ,  D21H17/14 ,  D21H21/16 ,  D21H25/02 ,  D21H25/04

Abstract: The invention relates to a machine for chromatogenous grafting treatment of a scrolling substrate (S) having a hydroxylated face (Fh), comprising: an application device (3) of a grafting reagent on the hydroxylated face (Fh) of the substrate, a heating roller (4) for the development of the grafting reaction on the hydroxylated face (Fh) of the substrate, said roller (4) being provided with a bar-end system (5a, 5b) for applying a face of the substrate (S) against said heating roller (4), an extraction device (6) of the hydrochloric acid produced during the grafting reaction, an application device (7) of an air knife on the treated face of the substrate for eliminating the residual grafting reagent. The invention also relates to a chromatogenous grafting process used in said machine.

公开(公告)号：US09193851B2

公开(公告)日：2015-11-24

申请号：US13809619

申请日：2011-07-08

Applicant: Daniel Samain ,  Camelia Stinga

Inventor： Daniel Samain ,  Camelia Stinga

IPC: C08L97/02 ,  C08L1/12 ,  C08J7/12 ,  C08J5/06 ,  C08J7/14 ,  C08J5/04 ,  C08L1/10 ,  C08L1/14 ,  D06M13/188 ,  D06M101/06

CPC classification number: C08L1/12 ,  C08J5/045 ,  C08J5/06 ,  C08J7/12 ,  C08J7/14 ,  C08J2301/00 ,  C08J2301/10 ,  C08J2301/12 ,  C08J2301/14 ,  C08J2397/02 ,  C08L1/10 ,  C08L1/14 ,  C08L97/02 ,  C08L2205/16 ,  D06M13/188 ,  D06M2101/06 ,  C08L2666/26

Abstract: New cellulose-based composites and production methods thereof, comprising partial peracetylation of cellulose fibers having a degree of crystallinity less than 80%.

Abstract translation: 新的纤维素基复合材料及其制备方法包括结晶度小于80％的纤维素纤维的部分过乙酰化。

公开(公告)号：US20130236647A1

公开(公告)日：2013-09-12

申请号：US13885262

申请日：2011-11-16

Applicant: Daniel Samain ,  David Guerin ,  André Lemaitre ,  Laurent Lyannaz ,  Jean-Luc Guillouty

Inventor： Daniel Samain ,  David Guerin ,  André Lemaitre ,  Laurent Lyannaz ,  Jean-Luc Guillouty

IPC: B05C9/12 ,  B05D3/00

CPC classification number: B05C9/12 ,  B05D3/007 ,  C08J7/14 ,  C08J2301/02 ,  D21H17/06 ,  D21H17/11 ,  D21H17/14 ,  D21H21/16 ,  D21H25/02 ,  D21H25/04

Abstract: The invention relates to a machine for chromatogenous grafting treatment of a scrolling substrate (S) having a hydroxylated face (Fh), comprising: an application device (3) of a grafting reagent on the hydroxylated face (Fh) of the substrate, a heating roller (4) for the development of the grafting reaction on the hydroxylated face (Fh) of the substrate, said roller (4) being provided with a bar-end system (5a, 5b) for applying a face of the substrate (S) against said heating roller (4), an extraction device (6) of the hydrochloric acid produced during the grafting reaction, an application device (7) of an air knife on the treated face of the substrate for eliminating the residual grafting reagent. The invention also relates to a chromatogenous grafting process used in said machine.

Abstract translation: 本发明涉及一种用于对具有羟基化面（Fh）的滚动衬底（S）进行染色体接枝处理的机器，包括：在所述衬底的羟基化面（Fh）上的接枝剂的施加装置（3），加热 用于在基材的羟基化面（Fh）上开发接枝反应的辊（4），所述辊（4）设置有用于施加基材（S）的表面的棒端系统（5a，5b） 在接枝反应过程中产生的盐酸的提取装置（6），用于消除残余接枝试剂的基板处理面上的气刀施加装置（7）的加热辊（4）。 本发明还涉及用于所述机器中的染色体接枝方法。