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37 条记录 (耗时 0.042 秒)

    Compound Ws727713
    24.
    发明申请
    Compound Ws727713 失效
    化合物Ws727713

    公开(公告)号：US20070254829A1

    公开(公告)日：2007-11-01

    申请号：US11547729

    申请日：2005-03-22

    申请人： Takanao Otsuka ,  Hirotsugu Ueda ,  Keiko Fujie ,  Hideyuki Muramatsu ,  Michizane Hashimoto ,  Shigehiro Takase

    发明人： Takanao Otsuka ,  Hirotsugu Ueda ,  Keiko Fujie ,  Hideyuki Muramatsu ,  Michizane Hashimoto ,  Shigehiro Takase

    IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N1/21 ,  C12P1/04

    CPC分类号： C12R1/01 ,  A61K8/99 ,  A61K35/74 ,  A61K2800/85 ,  A61Q5/065 ,  A61Q19/00 ,  C07G17/00 ,  C12P1/06

    摘要： The present invention relates to a new compound useful as a modulator of melanxocortin receptors. In particular, the present invention relates to a compound WS727713, a process for production of the compound by culturing, in a culture medium, a WS727713-producing strain belonging to Pseudonocardia and recovering the compound from a culture broth, a pharmaceutical composition containing the compound, a use of the compound for manufacture of a medicament or a cosmetic for melanocortin receptor modulation, a use of the compound for manufacture of a medicament or a cosmetic for treating or preventing ishemia/reperfusion injury, brain and renal inflammatory diseases, hepatitis, sepsis/septic shock, hypoxic shock, acute respiratory distress syndrome (ARDS), rheumatic arthritis (RA), gouty arthritis, aortic regurgitation (AR), juvenile chronic arthritis, osteoarthritis, nephritis, induction of tolerance, contact hypersensitivity, inflammatory bowel disease (IBD), sexual dysfunction, transplantation, pain, disease progression of HIV, postinflammatory hypopigmentation, tinea versicolor, idiopathic guttate hypomelanosis, fever, functional bowel disease, obesity, satiety effect, diabetes mellitus, modulation of dermal exocrine function, canities (canities circumscripta), gray hair, pancreatitis, fibrotic disorders (hypertrophic scars, keloids, localized scleroderma, systematic sclerosis, sclerodermic graft versus host disease of the skin, cirrhosis of the liver, idiopathic and bleomycin induced lung fibrosis, cyclosporin induced nephropathy), uveitis (especially in Behçet's syndrome and sarcoidosis), vasculitis, microbial infections, celiac disease, vulvar vestibulitis syndrome, melonoma invasion, anorexia or the like.

    摘要翻译： 本发明涉及可用作黑皮皮素受体调节剂的新化合物。 特别地，本发明涉及化合物WS727713，该化合物的生产方法是在培养基中培养属于假诺卡氏菌属的WS727713生产菌株并从培养液中回收该化合物，含有该化合物的药物组合物 ，该化合物用于制造用于黑皮质素受体调节的药物或化妆品的用途，该化合物用于制备用于治疗或预防缺血/再灌注损伤，脑和肾炎性疾病，肝炎，败血症的药物或化妆品的用途 /脓毒性休克，缺氧休克，急性呼吸窘迫综合征（ARDS），风湿性关节炎（RA），痛风性关节炎，主动脉瓣反流（AR），青少年慢性关节炎，骨关节炎，肾炎，耐受诱导，接触性超敏反应，炎性肠病 ），性功能障碍，移植，疼痛，艾滋病病毒进展，炎性色素沉着，花斑斑， 乳糜泻黄斑病，发热，功能性肠病，肥胖症，饱腹感，糖尿病，皮肤外分泌功能的调节，阴毛（canence circumscripta），灰白色头发，胰腺炎，纤维化疾病（肥大性瘢痕，瘢痕疙瘩，局部硬皮病，系统性硬化症，硬皮病 皮肤移植物抗宿主病，肝硬化，特发性和博来霉素引起的肺纤维化，环孢菌素诱导的肾病），葡萄膜炎（尤其是Behçet综合征和结节病），血管炎，微生物感染，乳糜泻，外阴前庭炎综合征，美黄酮侵袭， 厌食症等。

    CYCLIC COMPOUND AND SALT THEREOF
    27.
    发明申请
    CYCLIC COMPOUND AND SALT THEREOF 有权
    环状化合物及其盐

    公开(公告)号：US20110015121A1

    公开(公告)日：2011-01-20

    申请号：US12922337

    申请日：2009-03-13

    申请人： Ikuko Nakamura ,  Koji Yoshikawa ,  Keisuke Ohsumi ,  Ryuichi Kanasaki ,  Shigehiro Takase

    发明人： Ikuko Nakamura ,  Koji Yoshikawa ,  Keisuke Ohsumi ,  Ryuichi Kanasaki ,  Shigehiro Takase

    IPC分类号： A61K38/12 ,  C07K7/64 ,  A61P31/00 ,  C12P21/04

    CPC分类号： A61K36/06 ,  C07K7/64 ,  C12N1/14 ,  C12P21/02 ,  C12R1/645

    摘要： A compound useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, is provided. A fungus Acremonium persicinum was collected, and cyclic compounds were isolated from culture liquids thereof. The present inventors confirmed that the cyclic compounds or salts thereof have a potent antifungal activity and are useful as medicaments, particularly an antifungal agent, and thus the present invention was completed. The cyclic compound and the salt thereof according to the present invention can be used as an agent for preventing or treating mycoses, particularly deep-seated mycoses.

    摘要翻译： 提供了可用作抗真菌剂的化合物，特别是用于深层真菌病的治疗剂。 收集真菌Acremonium persicinum，从其培养液中分离出环状化合物。 本发明人证实，环状化合物或其盐具有有效的抗真菌活性，可用作药物，特别是抗真菌剂，因此完成了本发明。 根据本发明的环状化合物及其盐可用作预防或治疗真菌病，特别是深层真菌病的药剂。

    Method of treating tumors using tetracyclo compounds
    29.
    发明授权
    Method of treating tumors using tetracyclo compounds 失效
    使用四环化合物治疗肿瘤的方法

    公开(公告)号：US4861774A

    公开(公告)日：1989-08-29

    申请号：US947759

    申请日：1986-12-30

    申请人： Masanobu Kohsaka ,  Hiroshi Terano ,  Tadaaki Komori ,  Morita Iwami ,  Michio Yamashita ,  Masashi Hashimoto ,  Itsuo Uchida ,  Shigehiro Takase

    发明人： Masanobu Kohsaka ,  Hiroshi Terano ,  Tadaaki Komori ,  Morita Iwami ,  Michio Yamashita ,  Masashi Hashimoto ,  Itsuo Uchida ,  Shigehiro Takase

    IPC分类号： A61K31/535 ,  A61P31/04 ,  A61P35/00 ,  C07D498/18 ,  C12P17/18 ,  C12R1/465

    CPC分类号： C07D498/18 ,  C12P17/188 ,  C12R1/465 ,  Y02P20/55

    摘要： The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl,R.sup.2 is hydroxy, alkoxy, or protected hydroxy,R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, orR.sup.3 and R.sup.4 are combined together to form methylene or oxo,R.sup.5 is hydroxy, alkoxy or protected hydroxy, andR.sup.6 is hydrogen, imino-protective group or alkyl,and pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及一种治疗哺乳动物癌或肉瘤肿瘤的方法，包括向所述哺乳动物施用有效量的下式的四环化合物：其中R 1为甲酰基，被保护的甲酰基，羟甲基，保护的羟甲基，芳基氨基甲基 羧基，保护的羧基，芳基亚氨基甲基，羟基亚氨基甲基，烷氧基亚氨基甲基，酰氧基亚氨基甲基，氨基甲酰基甲基或芳基氨基丙基甲基，R2是羟基，烷氧基或被保护的羟基，R3是氢，R4是甲基，羟甲基或保护的羟甲基，或R3和R4组合在一起形成 亚甲基或氧代，R 5为羟基，烷氧基或保护的羟基，R 6为氢，亚氨基保护基或烷基，及其药学上可接受的盐。