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18 条记录 (耗时 0.034 秒)

    WF14573 or its salt, production thereof and use thereof
    4.
    发明授权
    WF14573 or its salt, production thereof and use thereof 失效
    WF14573或其盐，其制备及其用途

    公开(公告)号：US06730776B1

    公开(公告)日：2004-05-04

    申请号：US09646342

    申请日：2000-09-18

    申请人： Yasuhiro Hori ,  Shigehiro Takase ,  Yasuhisa Tsurumi ,  Michizane Hashimoto ,  Motohiro Hino

    发明人： Yasuhiro Hori ,  Shigehiro Takase ,  Yasuhisa Tsurumi ,  Michizane Hashimoto ,  Motohiro Hino

    IPC分类号： C07K750

    CPC分类号： C07K7/56 ,  A61K38/00

    摘要： The present invention provides a new antimicrobial compound WF14573, and a process for producing WF14573 by (a) culturing a WF14573A and/or B-producing microorganism in a nutrient medium and recovering WF14573A and/or B from the resultant cultured broth or (b) deacylating WF14573A and/or B in the presence of a microbial substance which is capable of deacylating WF14573A and/or B. Also provided are an antimicrobial agent comprising WF14573 and carrier(s), a pharmaceutical composition comprising an effective amount of WF14573 and pharmaceutically acceptable carrier(s), a method for killing microorganisms by applying WF14573 to the microorganisms, and use of WF14573 for the treatment of infectious diseases caused by pathogenic microorganisms.

    摘要翻译： 本发明提供了一种新的抗微生物化合物WF14573，以及（a）在营养培养基中培养WF14573A和/或产生B生物的微生物并从所得培养液中回收WF14573A和/或B或（b）生产WF14573的方法， 在能够脱酰基WF14573A和/或B的微生物物质存在下脱酰基WF14573A和/或B。还提供了包含WF14573和载体的抗微生物剂，包含有效量的WF14573和药学上可接受的药物组合物 载体，通过向微生物施用WF14573杀死微生物的方法，以及使用WF14573来治疗由病原微生物引起的感染性疾病。

    Cyclic tetrapeptide compound and use thereof
    6.
    发明授权
    Cyclic tetrapeptide compound and use thereof 失效
    环状四肽化合物及其用途

    公开(公告)号：US06656905B1

    公开(公告)日：2003-12-02

    申请号：US09806500

    申请日：2001-05-04

    申请人： Hiroaki Mori ,  Kazutoshi Sakamoto ,  Yasuhisa Tsurumi ,  Shigehiro Takase ,  Motohiro Hino

    发明人： Hiroaki Mori ,  Kazutoshi Sakamoto ,  Yasuhisa Tsurumi ,  Shigehiro Takase ,  Motohiro Hino

    IPC分类号： A61K3807

    CPC分类号： A61K38/12 ,  C07K5/126

    摘要： A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to Acremonium and recovering the compound from a culture broth, a pharmaceutical composition containing the compound as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound for use as a medicament, a use of the compound for manufacture of a medicament for inhibiting histone deacetylase, a use of the compound for manufacture of a medicament for treating or preventing inflammatory disorders, diabetes, diabetic complications, homozygous thalassemia, fibrosis, cirrhosis, acute promyelocytic leukaemia (APL), protozoal infections, organ transplant rejections, autoimmune diseases, or tumors, a use of histone deacetylase inhibitors as an immunosuppressant or an antitumor agent, and a use of histone deacetylase inhibitors for manufacture of a medicament for treating or preventing organ transplant rejections, autoimmune diseases or tumors are described.

    摘要翻译： 一种环状四肽化合物及其用途。 特别地，化合物WF27082是通过在营养培养基中培养属于顶孢菌属的WF27082产生菌株并从培养液中回收化合物，将含有该化合物作为活性成分的药物组合物生产化合物的方法， 与药学上可接受的，基本上无毒的载体或赋形剂的相关联，用作药物的化合物，该化合物用于制备用于抑制组蛋白脱乙酰酶的药物的用途，该化合物用于制备用于治疗或 预防炎性疾病，糖尿病，糖尿病并发症，纯合地中海贫血，纤维化，肝硬化，急性早幼粒细胞白血病（APL），原生动物感染，器官移植排斥，自身免疫疾病或肿瘤，组蛋白脱乙酰酶抑制剂作为免疫抑制剂或抗肿瘤剂的用途， 以及使用组蛋白脱乙酰酶抑制剂来制造用于治疗或预防的药物 描述器官移植排斥，自身免疫性疾病或肿瘤。

    Process for preparing FR900482 and compounds analogous thereto
    9.
    发明授权
    Process for preparing FR900482 and compounds analogous thereto 失效
    制备FR900482及其类似物的方法

    公开(公告)号：US06423530B1

    公开(公告)日：2002-07-23

    申请号：US09705898

    申请日：2000-11-06

    申请人： Masaru Tsuboi ,  Shiho Shimizu ,  Michio Yamashita ,  Yasuhisa Tsurumi ,  Seiji Hashimoto

    发明人： Masaru Tsuboi ,  Shiho Shimizu ,  Michio Yamashita ,  Yasuhisa Tsurumi ,  Seiji Hashimoto

    IPC分类号： C12N114

    CPC分类号： C12P17/188 ,  Y10S435/929

    摘要： A process for producing a compound of the general formula (I): (wherein R1 represents hydrogen, a lower alkanoyl group or a lower alkyl group; R2 and R3 each represents hydrogen or a lower alkanoyl group) characterized in that a compound of the general formula (II): (wherein R1, R2 and R3 are respectively as defined above) is reacted with a culture of a strain of microorganism belonging to the genus Fusarium or its cells harvested by filtering the broth.

    摘要翻译： 一种制备通式（I）的化合物的方法（其中R 1表示氢，低级烷酰基或低级烷基; R 2和R 3各自表示氢或低级烷酰基），其特征在于通式 式（II）:(其中R1，R2和R3分别如上定义）与属于镰刀菌属的微生物菌株或通过过滤肉汤收获的细胞的培养物反应。