公开(公告)号：US10920099B2

公开(公告)日：2021-02-16

申请号：US16036988

申请日：2018-07-17

Applicant: Novartis AG

Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

IPC: C09D133/26 ,  C08L33/26 ,  C08L79/02 ,  C09D179/02 ,  C08F220/28 ,  C08F220/38 ,  C08F220/56 ,  C09D5/02 ,  C09D133/14 ,  C09D179/08 ,  G02B1/04

Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

公开(公告)号：US10823983B2

公开(公告)日：2020-11-03

申请号：US16280084

申请日：2019-02-20

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Troy Vernon Holland ,  John Dallas Pruitt ,  Jared Nelson

IPC: G02C7/10 ,  C07D249/20 ,  C08F230/08 ,  G02B1/04 ,  G02C7/04 ,  B29D11/00 ,  C08F20/36 ,  G02B5/20 ,  G02B5/22 ,  C07C233/38 ,  C08F220/60 ,  C08F220/70 ,  B29K105/00

Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.

公开(公告)号：US10472319B2

公开(公告)日：2019-11-12

申请号：US16401193

申请日：2019-05-02

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Troy Vernon Holland ,  Walter R. Laredo

IPC: G02B1/04 ,  C07C225/22 ,  B29D11/00 ,  G02C7/10 ,  C07C225/10 ,  C08F116/06 ,  C07D249/20 ,  G02C7/04

Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.

公开(公告)号：US20190235277A1

公开(公告)日：2019-08-01

申请号：US16260544

申请日：2019-01-29

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Richard Charles Breitkopf ,  Weihong Lang ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Frank Chang ,  Thomas M. Moy ,  Troy Vernon Holland

IPC: G02C7/04 ,  C09D143/00 ,  C08J7/04 ,  C08F230/00

CPC classification number: G02C7/049 ,  C08F230/00 ,  C08J7/047 ,  C08J2329/14 ,  C08J2443/00 ,  C09D143/00 ,  G02B1/043

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.

公开(公告)号：US10268053B2

公开(公告)日：2019-04-23

申请号：US15434098

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Troy Vernon Holland ,  Frank Chang ,  Walter R. Laredo ,  Xuwei Jiang ,  Ryan DeSousa

IPC: C07C233/23 ,  G02C7/10 ,  C07C233/33 ,  C08F283/12 ,  G02B1/04 ,  G02C7/04 ,  C07C225/22 ,  C07C237/32 ,  C07C237/34

Abstract: Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.

公开(公告)号：US20190062485A1

公开(公告)日：2019-02-28

申请号：US16175904

申请日：2018-10-31

Applicant: Novartis AG

Inventor： Frank Chang ,  Jinyu Huang ,  Troy Vernon Holland

IPC: C08F290/06 ,  G02B1/04 ,  C08F283/12 ,  C08G77/20 ,  C08F222/10 ,  C08F220/40 ,  C08F222/38

Abstract: The invention provides a class of amphiphilic branched macromers and the uses thereof. An amphiphilic branched polydiorganosiloxane macromer of the invention is produced from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator by ATRP polymerization of one or more hydrophilic vinylic monomers. It comprises at least two polydiorganosiloxane polymer chains each having at most two terminal methacryloxy groups, dangling hydrophilic polymer chains each having a polymerizable or non-polymerizable terminal group, and one or more hydrophilic polymer chains as linkages between two polydiorganosiloxane chains. The present invention is also related to a silicone hydrogel contact lens, which comprises units derived from a polydiorganosiloxane-containing amphiphilic branched macromer of the invention.

公开(公告)号：US20190023891A1

公开(公告)日：2019-01-24

申请号：US16036983

申请日：2018-07-17

Applicant: Novartis AG

Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

IPC: C08L33/26 ,  C08K5/523

Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

公开(公告)号：US20180354214A1

公开(公告)日：2018-12-13

申请号：US16000928

申请日：2018-06-06

Applicant: Novartis AG

Inventor： Daqing Wu ,  Steve Yun Zhang ,  Xinming Qian ,  Zach Munoz ,  Frank Chang ,  Wei Liang ,  Ying Zheng ,  Richard Charles Breitkopf ,  Matthew D. Nelson ,  Augustine Twum Kumi

IPC: B29D11/00 ,  G02B1/04

CPC classification number: B29D11/00134 ,  B29D11/00067 ,  B29D11/00076 ,  C08G77/442 ,  C08L83/04 ,  G02B1/043

Abstract: The present invention generally relates to a method for producing inherently wettable silicone hydrogel contact lenses with a robusteness of lens shape and having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus.

公开(公告)号：US10082604B2

公开(公告)日：2018-09-25

申请号：US15598652

申请日：2017-05-18

Applicant: Novartis AG

Inventor： Jinyu Huang ,  Frank Chang

IPC: G02B1/04 ,  C08F283/12 ,  C08G77/20 ,  C07F7/18 ,  C08G77/392 ,  C08G77/388 ,  C08G77/38 ,  C08F230/08 ,  C07F9/09 ,  C08G77/50 ,  C08G77/395

Abstract: The invention provides a hydrophilized carbosiloxane vinylic monomer which comprises (1) a poly(carbosiloxane) segment, (2) one sole ethylenically unsaturated group, and (3) at least one terminal or pendant group which is a hydrophilic group or hydrophilic polymer chain. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a hydrophilized carbosiloxane vinylic monomer of the invention.

公开(公告)号：US20180100038A1

公开(公告)日：2018-04-12

申请号：US15727674

申请日：2017-10-09

Applicant: Novartis AG

Inventor： Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/38 ,  C08F299/08 ,  C08F26/10 ,  C08F20/06 ,  G02C7/04

CPC classification number: C08G77/442 ,  C08F20/06 ,  C08F26/10 ,  C08F299/08 ,  C08F2800/20 ,  C08G77/20 ,  C08G77/38 ,  C08G77/46 ,  C08G2210/00 ,  G02C7/049

Abstract: The invention provides a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer which comprises (1) a linear polymer chain comprising at least two polydimethylsiloxane segments, one hydrophilic polyoxyalkylene segment between each pair of polydimethylsiloxane segments, and one amide-rich linker between each pair of one polydimethylsiloxane segment and one hydrophilic polyoxyalkylene segment, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a weight average molecular weight of at least 3000 Daltons. The invention is also related to a silicone hydrogel contact lens produced from a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer of the invention.