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公开(公告)号：US06278110B1
公开(公告)日：2001-08-21
申请号：US09030676
申请日：1998-02-25
IPC分类号： H01J4426
CPC分类号： H01J49/165 , G01N30/7253
摘要： A method and apparatus wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. The invention provides reduced noise and increased signal sensitivity in both API electrospray and APCI operating modes.
摘要翻译： 一种方法和装置，其中将多个电场和蒸发的分析物的正交喷雾构型如此组合以提高分析物检测和质量分析的效率。 本发明在API电喷雾和APCI操作模式中提供降低的噪声和增加的信号灵敏度。
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公开(公告)号：US4746068A
公开(公告)日：1988-05-24
申请号：US924709
申请日：1986-10-29
CPC分类号： H01J49/0018 , B05B7/0483 , G01N30/7246 , H01J49/045
摘要： A nebulizer assembly particularly well adapted as a liquid chromatograph/mass spectrometer interface including a pair of nebulizer plates, a base, and a cap for tightly holding the nebulizer plates against the base. A first nebulizer plate has a centrally located outlet orifice and a radially extending groove, and the second plate has a centrally located gas inlet orifice and a radially displaced liquid inlet orifice. The gas inlet orifice aligns with the outlet orifice and an aperture provided in the cap, and the liquid inlet orifice aligns with a section of the groove provided in the first nebulizer plate. When the gas inlet orifice is coupled to a pressurized gas source and the liquid inlet orifice is coupled to a pressurized liquid source, uniform droplets having a diameter of approximately 10 microns can be formed from an outlet orifice twice that diameter.
摘要翻译： 特别适合作为液相色谱仪/质谱仪界面的喷雾器组件，包括一对雾化器板，底座和盖子，用于将喷雾器板紧紧地固定在基座上。 第一雾化器板具有位于中心的出口孔和径向延伸的槽，并且第二板具有位于中心的气体入口孔和径向移位的液体入口孔。 气体入口孔与出口孔和设置在盖中的孔对准，并且液体入口孔与设置在第一雾化器板中的槽的一部分对准。 当气体入口孔连接到加压气体源并且液体入口孔连接到加压液体源时，可以从两个直径的出口孔形成具有约10微米直径的均匀液滴。
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公开(公告)号：US08502162B2
公开(公告)日：2013-08-06
申请号：US13164386
申请日：2011-06-20
CPC分类号： H01J49/044 , H01J49/10
摘要： An atmospheric pressure ionization apparatus includes a chamber, an ion inlet structure, an electrode, a sample emitter, and a gas passage. The ion inlet structure includes a sampling orifice. The electrode includes an electrode bore. An ionization region is defined between the ion inlet structure and the electrode. The flared structure is coaxially disposed about the ion inlet structure, and extends along an outward direction that includes a radial component relative to the sampling axis. The sample emitter is oriented at an angle to the sampling axis for directing a sample stream toward the ionization region. The gas passage directs a stream of gas from a gas source to the chamber. The flared structure and the wall cooperatively form an outward-directed portion of the gas passage that extends annularly about the sampling axis and along the outward direction. The gas flows through the outward-directed portion, around the flared structure, and toward the ionization region and the electrode bore.
摘要翻译： 大气压离子化装置包括室，离子入口结构，电极，样品发射体和气体通道。 离子入口结构包括采样孔。 电极包括电极孔。 在离子入口结构和电极之间限定电离区域。 扩口结构围绕离子入口结构同轴设置，并且沿着包括相对于采样轴线的径向分量的向外方向延伸。 样品发射器与采样轴成一角度定向，以将样品流引向电离区。 气体通道将气流从燃气源引导到腔室。 扩口结构和壁协同地形成气体通道的向外的部分，其环绕取样轴线并沿着向外方向延伸。 气体在扩张结构周围流过外向部分，并朝向电离区域和电极孔流动。
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24.发明申请公开(公告)号：US20100230589A1
公开(公告)日：2010-09-16
申请号：US12753786
申请日：2010-04-02
申请人： Jean-Luc Truche , Paul C. Goodley , Gregor Overney
发明人： Jean-Luc Truche , Paul C. Goodley , Gregor Overney
CPC分类号： H01J49/142
摘要： An apparatus and method for generating analyte ions from a sample. An ion generating device is provided having a chamber with an outlet and a surface having a material and means for applying a high velocity gas flow through the chamber toward the outlet such that charged particles are produced by physical interaction between the high velocity gas and the material. The charged particles then induce the generation of primary ions by interaction with molecules of the high velocity gas. The primary ions are emitted from the outlet of the ion generating device toward a sample-bearing surface and analyte ions are generated by impact of the primary ions on the analyte sample on the surface.
摘要翻译： 一种用于从样品中产生分析物离子的装置和方法。 提供一种离子产生装置，其具有具有出口的腔室和具有材料的表面，以及用于将高速气流经由腔室朝向出口施加的装置，使得通过高速气体和材料之间的物理相互作用产生带电粒子 。 带电粒子然后通过与高速气体分子的相互作用诱导产生初级离子。 主要离子从离子产生装置的出口朝向样品承载表面发射，分析物离子通过主离子冲击表面上的分析物样品而产生。
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公开(公告)号：US07385189B2
公开(公告)日：2008-06-10
申请号：US11171976
申请日：2005-06-29
IPC分类号： H01J49/10
CPC分类号： H01J49/165 , H01J49/0468
摘要： The present invention provides an apparatus and method for use with a mass spectrometry system. The invention provides an ion source for providing radiative heating to an ionization region. The ion source includes a nanospray ionization device for producing ions and a conduit adjacent to the ionization device for receiving ions from the ionization device. The conduit includes a conductive material for providing indirect radiative heating to the ionization region. Direct radiative heating may also be provided using a heater in the conduit. The ion source may be used separately or in conjunction with the mass spectrometry system. When used in conjunction with a mass spectrometry system a detector may also be employed down stream from the device. A method for desolvating an analyte using the device is also disclosed.
摘要翻译： 本发明提供了一种与质谱系统一起使用的装置和方法。 本发明提供了一种用于向电离区域提供辐射加热的离子源。 离子源包括用于产生离子的纳米喷雾离子化装置和与电离装置相邻的导管，用于从离子化装置接收离子。 导管包括用于向电离区提供间接辐射加热的导电材料。 也可以使用导管中的加热器来提供直接辐射加热。 离子源可以单独使用或与质谱系统结合使用。 当与质谱系统结合使用时，也可以从装置下游使用检测器。 还公开了使用该装置对分析物进行脱溶剂的方法。
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公开(公告)号：US20080067356A1
公开(公告)日：2008-03-20
申请号：US11523963
申请日：2006-09-20
IPC分类号： H01J49/04
CPC分类号： H01J49/02 , H01J49/0009
摘要： An apparatus for ionizing an analyte sample with a mass calibrant is provided. The apparatus includes an ionization chamber defining an ionization region, a first passageway coupled to the ionization region for delivering the analyte sample to the ionization region, a second passageway leading to a mass analyzer having an orifice arranged adjacent to the ionization region to receive ions from the ionization region, a third passageway coupled to the ionization chamber at a first end and having a second end with an orifice arranged to receive gaseous neutral mass calibrant molecules, and an ionization device arranged within the ionization chamber. The ionization device generates primary ions from the analyte sample, and the primary ions ionize a portion of the gaseous neutral mass calibrant molecules received into the ionization region via the third passageway.
摘要翻译： 提供了一种用质量校准物离子化分析物样品的装置。 该装置包括限定电离区域的电离室，耦合到离子化区域的用于将分析物样品输送到电离区域的第一通道，通向质量分析器的第二通道，该质量分析器具有邻近离子化区域布置的孔口， 电离区域，第三通道，其在第一端处耦合到电离室，并且具有布置成接收气态中性质量校准物分子的孔的第二端，以及布置在电离室内的电离装置。 离子化装置从分析物样品产生初级离子，并且初级离子通过第三通道将接收到电离区的气态中性质量校准物分子的一部分电离。
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公开(公告)号：US07205536B2
公开(公告)日：2007-04-17
申请号：US11064545
申请日：2005-02-23
申请人： Paul C. Goodley , Jean-Luc Truche
发明人： Paul C. Goodley , Jean-Luc Truche
CPC分类号： H01J49/167 , H01J49/0018 , H01J49/04
摘要： A source of ions for an analyzer includes a reservoir for containing a liquid, a manifold having a plurality of nozzles, a conduit connecting the reservoir to the manifold and a counter electrode having a potential different between the counter electrode and the nozzles to enable liquid to be ejected from the nozzles in droplets and to enable ions to be ejected from the droplets.
摘要翻译： 用于分析器的离子源包括用于容纳液体的储存器，具有多个喷嘴的歧管，将储存器连接到歧管的导管和在对电极和喷嘴之间具有不同电位的对电极， 从喷嘴喷出液滴，并使离子从液滴中喷出。
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公开(公告)号：US07204431B2
公开(公告)日：2007-04-17
申请号：US10699448
申请日：2003-10-31
申请人： Ganggiang Li , Paul C. Goodley , Hongfeng Yin
发明人： Ganggiang Li , Paul C. Goodley , Hongfeng Yin
IPC分类号： A01G23/10
CPC分类号： H01J49/167
摘要： The invention provides an electrospray apparatus with an auxiliary electrode, and a method of using.
摘要翻译： 本发明提供一种具有辅助电极的电喷射装置及其使用方法。
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公开(公告)号：US06627880B2
公开(公告)日：2003-09-30
申请号：US09505910
申请日：2000-02-17
申请人： Paul C. Goodley , Jean-Luc Truche
发明人： Paul C. Goodley , Jean-Luc Truche
IPC分类号： B01D5944
CPC分类号： H01J49/167 , H01J49/0018
摘要： A source of ions for an analyzer includes a reservoir for containing a liquid and a channel having a first end opening into the reservoir. A nozzle element adjacent a second end of the channel includes a plurality of tips for producing individual droplets from the liquid. The plurality of tips reduces the likelihood that individual droplets will coalesce, increases the overall flow of material or analyte to the mass spectrometer and provides a level of redundancy in the delivery of liquid for producing droplets. The tips also may produce a higher current output and greater signal from the system, as well. With micro-miniaturization, the individual droplets are relatively small, thereby increasing the likelihood that ions would be ejected from the droplet surfaces under the influence of an electric field. Multiple nozzle elements can be used to more selectively deliver fluid droplets to the analyzer, or to increase the overall flow rate of droplets from the reservoir. The tips may have a volcano or truncated cone shape for the desired fluid delivery, electrostatic effects and manufacture ability.
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