公开(公告)号：US07912525B2

公开(公告)日：2011-03-22

申请号：US11606837

申请日：2006-11-30

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

公开(公告)号：US07833157B2

公开(公告)日：2010-11-16

申请号：US12121647

申请日：2008-05-15

申请人： Rebecca Gottlieb ,  Rajiv Shah ,  Mary M. Morris ,  Victor Giron ,  Michael E. Miller ,  Bradley J. Enegren

发明人： Rebecca Gottlieb ,  Rajiv Shah ,  Mary M. Morris ,  Victor Giron ,  Michael E. Miller ,  Bradley J. Enegren

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61M25/0032 ,  A61B5/028 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/415 ,  A61M5/14244 ,  A61M5/1723 ,  A61M25/0017 ,  A61M25/0023 ,  A61M2025/0003 ,  A61M2025/0046 ,  A61M2230/201 ,  Y10T29/49826

摘要： A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.

摘要翻译： 一种多管导管，其具有延伸到导管内腔内的管道。 流明可用于血液，药物或其他药物。 流明也可用于传感器。 患者外部的连接元件将管道连接到管腔。 也在患者外部的管连接到输注构件，一个或多个输注系统可以连接到输注构件，以向患者输送血液，药物和其他药剂。 具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。 传感器的外部部分可以连接到相关联的电子设备，以提供对生理参数的自动监测以及对输入的自动传送和控制。 另外，一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管，其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。 第一个内腔在传感器的下游传送流体，以防止流体输送和传感器读数之间的任何干扰。 在其他版本中，中心线导管可以具有另外的流明用于其他目的。 此外，中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。

公开(公告)号：US07552522B2

公开(公告)日：2009-06-30

申请号：US10928863

申请日：2004-08-26

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： G01R3/00

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

公开(公告)号：US20070073129A1

公开(公告)日：2007-03-29

申请号：US11234722

申请日：2005-09-23

申请人： Rajiv Shah ,  Rebecca Gottlieb ,  Eric Larson

发明人： Rajiv Shah ,  Rebecca Gottlieb ,  Eric Larson

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/6849 ,  A61B2017/3407 ,  A61B2562/164

摘要： A flexible mounting base to hold a sensor at an infusion site, the sensor being a removable in vivo sensor for monitoring analyte concentration level in a patient, such as blood glucose (BG) level. The mounting base comprises a flexible adhesive that anchors the flexible sensor set at an infusion site to provide stability for the sensor set in a convenient and comfortable manner. Placement of the mounting base onto the patient's skin causes the insertion needle to pierce the skin for transcutaneous placement of the cannula with the sensor therein. The insertion needle can then be withdrawn to leave the cannula and sensor at the selected insertion position, with the distal segment of the sensor being exposed to patient extracellular fluid via apertures formed in the cannula.

摘要翻译： 用于将传感器保持在输注位置的柔性安装基座，所述传感器是可移动的体内传感器，用于监测患者中的分析物浓度水平，例如血糖（BG）水平。 安装基座包括柔性粘合剂，其将柔性传感器组固定在输注位置处，以便于和舒适地为传感器组提供稳定性。 将安装基座放置在患者皮肤上使得插入针刺穿皮肤，以便将套管与传感器经皮放置在其中。 然后可以将插入针抽出以将套管和传感器留在所选择的插入位置，传感器的远端部分通过形成在插管中的孔暴露于患者细胞外液。

公开(公告)号：US20060247603A1

公开(公告)日：2006-11-02

申请号：US11477744

申请日：2006-06-28

申请人： Rebecca Gottlieb ,  Bradley Enegren ,  Rajiv Shah

发明人： Rebecca Gottlieb ,  Bradley Enegren ,  Rajiv Shah

IPC分类号： A61M25/00 ,  A61B5/00

CPC分类号： A61F2/90 ,  A61F2230/0054 ,  A61M2025/105

摘要： A system and method for restenosis mitigation at a trauma site within the vasculature. The system may include a catheter capable of delivering a restenosis mitigating drug and a sensor extending through a lumen in the catheter. The catheter may be positioned adjacent the trauma site and the restenosis mitigating drug may be delivered to the trauma site through the catheter. The restenosis mitigating drug or some other parameter may be sensed by the sensor.

摘要翻译： 在脉管系统内的创伤部位减轻再狭窄的系统和方法。 该系统可以包括能够递送再狭窄缓解药物的导管和延伸穿过导管内腔的传感器。 导管可以定位在创伤部位附近，并且再狭窄缓解药物可以通过导管输送到创伤部位。 再狭窄缓解药物或某些其他参数可由传感器检测。

公开(公告)号：US20050065556A1

公开(公告)日：2005-03-24

申请号：US10669426

申请日：2003-09-23

申请人： Bahar Reghabi ,  Rebecca Gottlieb ,  Rajiv Shah ,  Bradley Enegren

发明人： Bahar Reghabi ,  Rebecca Gottlieb ,  Rajiv Shah ,  Bradley Enegren

IPC分类号： A61B5/00 ,  A61B5/0205 ,  A61B5/0215 ,  A61N1/39

CPC分类号： A61B5/6852 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/412 ,  A61B5/7275

摘要： A system and method of sensing multiple parameters. The method may include implanting an implantable sensor in a patient and reading an output from at least one of the implantable sensing elements. The implantable sensor may have a housing within which are disposed a plurality of implantable sensing elements. At least one of the implantable sensing elements may respond to lactate. In addition, a medical professional may administer to the patient for myocardial ischemia, myocardial infarction angina, sepsis based on the output read. A medical professional may also administer to the patient having an implantable cardiovascular defibrillator or who is receiving extracorporeal membrane oxygenation. The method may be used in a surgical or intensive care environment.

摘要翻译： 一种感测多个参数的系统和方法。 该方法可以包括将可植入传感器植入患者体内并读取至少一个可植入感测元件的输出。 可植入传感器可以具有壳体，其中设置有多个可植入感测元件。 植入式感测元件中的至少一个可以响应于乳酸盐。 此外，医疗专业人员可以根据输出读取对患者进行心肌缺血，心肌梗塞心绞痛，败血症。 医疗专业人员还可以向具有可植入的心血管除颤器或正在接受体外膜氧合的患者施用。 该方法可用于外科或重症监护环境。

公开(公告)号：US20080289300A1

公开(公告)日：2008-11-27

申请号：US12189077

申请日：2008-08-08

申请人： Rebecca Gottlieb ,  Aaron Swanson ,  Bahar Reghabi ,  Kevin Branch

发明人： Rebecca Gottlieb ,  Aaron Swanson ,  Bahar Reghabi ,  Kevin Branch

IPC分类号： B65B55/02

CPC分类号： A61L2/18 ,  A61B50/30 ,  A61B2050/0065 ,  A61B2050/3005 ,  A61L2/08 ,  A61L2/206 ,  A61L2/26 ,  A61L2202/122 ,  A61L2202/24 ,  A61M25/002 ,  B65B55/22

摘要： A packaging system for hydrating sterile devices without comprising the integrity of the sterilization. The packaging system may include an enclosure for enclosing a device requiring hydration, a container containing a hydrate, a base located within the interior of the enclosure and an activating member located within the interior of the enclosure. The container and the device may be located within a receptacle. The receptacle may rest on the base and the activating member may be affixed on top of the receptacle. A force may be exerted on an exterior portion of the enclosure such that the activating member pushes on the receptacle and crushes or ruptures the container. The hydrate located within the container is then released to the device, thereby hydrating the device without breaking the seal of the enclosure. The sterilized environment is therefore maintained and the device is hydrated.

摘要翻译： 用于水合无菌装置的包装系统，不包括灭菌的完整性。 包装系统可以包括用于封闭需要水合的装置的外壳，容纳水合物的容器，位于外壳内部的基座和位于外壳内部的启动件。 容器和装置可以位于容器内。 容器可以搁置在基座上，并且致动构件可以固定在容器的顶部上。 力可以施加在外壳的外部部分上，使得致动构件推动容器并破碎或破裂容器。 然后将位于容器内的水合物释放到装置中，从而水合装置而不破坏外壳的密封。 因此，消毒的环境被保持并且装置是水合的。

公开(公告)号：US07634893B2

公开(公告)日：2009-12-22

申请号：US12189077

申请日：2008-08-08

申请人： Rebecca Gottlieb ,  Aaron Swanson ,  Bahar Reghabi ,  Kevin Branch

发明人： Rebecca Gottlieb ,  Aaron Swanson ,  Bahar Reghabi ,  Kevin Branch

IPC分类号： B65B55/18

CPC分类号： A61L2/18 ,  A61B50/30 ,  A61B2050/0065 ,  A61B2050/3005 ,  A61L2/08 ,  A61L2/206 ,  A61L2/26 ,  A61L2202/122 ,  A61L2202/24 ,  A61M25/002 ,  B65B55/22

摘要： A packaging system for hydrating sterile devices without comprising the integrity of the sterilization. The packaging system may include an enclosure for enclosing a device requiring hydration, a container containing a hydrate, a base located within the interior of the enclosure and an activating member located within the interior of the enclosure. The container and the device may be located within a receptacle. The receptacle may rest on the base and the activating member may be affixed on top of the receptacle. A force may be exerted on an exterior portion of the enclosure such that the activating member pushes on the receptacle and crushes or ruptures the container. The hydrate located within the container is then released to the device, thereby hydrating the device without breaking the seal of the enclosure. The sterilized environment is therefore maintained and the device is hydrated.

摘要翻译： 用于水合无菌装置的包装系统，不包括灭菌的完整性。 包装系统可以包括用于封闭需要水合的装置的外壳，容纳水合物的容器，位于外壳内部的基座和位于外壳内部的启动件。 容器和装置可以位于容器内。 容器可以搁置在基座上，并且致动构件可以固定在容器的顶部上。 力可以施加在外壳的外部部分上，使得致动构件推动容器并破碎或破裂容器。 然后将位于容器内的水合物释放到装置中，从而水合装置而不破坏外壳的密封。 因此，消毒的环境被保持并且装置是水合的。

公开(公告)号：US07415811B2

公开(公告)日：2008-08-26

申请号：US11149760

申请日：2005-06-10

申请人： Rebecca Gottlieb ,  Aaron Swanson ,  Bahar Reghabi ,  Kevin Branch

发明人： Rebecca Gottlieb ,  Aaron Swanson ,  Bahar Reghabi ,  Kevin Branch

IPC分类号： B65B55/02

CPC分类号： A61L2/18 ,  A61B50/30 ,  A61B2050/0065 ,  A61B2050/3005 ,  A61L2/08 ,  A61L2/206 ,  A61L2/26 ,  A61L2202/122 ,  A61L2202/24 ,  A61M25/002 ,  B65B55/22

摘要： A packaging system for hydrating sterile devices without comprising the integrity of the sterilization. The packaging system may include an enclosure for enclosing a device requiring hydration, a container containing a hydrate, a base located within the interior of the enclosure and an activating member located within the interior of the enclosure. The container and the device may be located within a receptacle. The receptacle may rest on the base and the activating member may be affixed on top of the receptacle. A force may be exerted on an exterior portion of the enclosure such that the activating member pushes on the receptacle and crushes or ruptures the container. The hydrate located within the container is then released to the device, thereby hydrating the device without breaking the seal of the enclosure. The sterilized environment is therefore maintained and the device is hydrated.

摘要翻译： 用于水合无菌装置的包装系统，不包括灭菌的完整性。 包装系统可以包括用于封闭需要水合的装置的外壳，容纳水合物的容器，位于外壳内部的基座和位于外壳内部的启动件。 容器和装置可以位于容器内。 容器可以搁置在基座上，并且激活构件可以固定在容器的顶部上。 力可以施加在外壳的外部部分上，使得致动构件推动容器并破碎或破裂容器。 然后将位于容器内的水合物释放到装置中，从而水合装置而不破坏外壳的密封。 因此，消毒的环境被保持并且装置是水合的。

公开(公告)号：US06991096B2

公开(公告)日：2006-01-31

申请号：US10331136

申请日：2002-12-27

申请人： Rebecca Gottlieb ,  Aaron Swanson ,  Bahar Reghabi ,  Kevin Branch

发明人： Rebecca Gottlieb ,  Aaron Swanson ,  Bahar Reghabi ,  Kevin Branch

IPC分类号： A61M25/00 ,  B65D81/32

CPC分类号： A61L2/18 ,  A61B50/30 ,  A61B2050/0065 ,  A61B2050/3005 ,  A61L2/08 ,  A61L2/206 ,  A61L2/26 ,  A61L2202/122 ,  A61L2202/24 ,  A61M25/002 ,  B65B55/22

摘要： A packaging system for hydrating sterile devices without comprising the integrity of the sterilization. The packaging system may include an enclosure for enclosing a device requiring hydration, a container containing a hydrate, a base located within the interior of the enclosure and an activating member located within the interior of the enclosure. The container and the device may be located within a receptacle. The receptacle may rest on the base and the activating member may be affixed on top of the receptacle. A force may be exerted on an exterior portion of the enclosure such that the activating member pushes on the receptacle and crushes or ruptures the container. The hydrate located within the container is then released to the device, thereby hydrating the device without breaking the seal of the enclosure. The sterilized environment is therefore maintained and the device is hydrated.