摘要:
The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
摘要:
A closure mechanism particularly useful in a brewing device includes a cover member rotatably disposed above the brewing device. A slider member is slidably disposed within an interior cavity of the cover member and has one or more tabs which may extend outside of the interior cavity. The brewing device has one or more receptacles for receiving the tabs when the cover member is closed. A lid member on top of the cover member may push the tabs into the receptacles through a link member. A release arm is disposed within the brewing device and has at least one blocker which releasably holds a tab of the slider member within a receptacle when the cover member is closed.
摘要:
The present invention relates in part to compounds of formulas (I) and (III): and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.
摘要:
A container assembly for retaining a moisture-sensitive material has a selectively resealable outer container defining a chamber, where a bond portion of an inner surface of the outer container is formed of ultrasonically weldable material. The container assembly also has an inner container having a humidity-control substance, where the inner container is disposed within the chamber. The humidity-control substance is in humidity transferable communication with the chamber. A bond portion of an outer surface of the inner container is formed of ultrasonically weldable material. The bond portions of the outer and inner containers are ultrasonically welded to each other to fix the position of the inner container within the chamber of the outer container.
摘要:
A cell adhesion inhibitor of the general formula: R3-L-L′-R1 is disclosed. An inhibitor of the present invention interacts with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. Also disclosed are methods for preparing and using such a cell adhesion inhibitor, as well as pharmaceutical compositions containing the same.
摘要:
Methods of manufacturing hardenable dental articles, packaged hardenable dental articles, and methods of packaging hardenable dental articles are disclosed. In various embodiments, the manufacturing may involve molding a hardenable dental material in a mold cavity that may be lined with a mold liner. The mold body may also form the package of the hardenable dental article formed within the mold cavity. In other embodiments, the hardenable dental articles may be provided in mold cavities located in sacrificial mold bodies that may be torn, stretched, softened, dissolved, etc. to release the hardenable dental articles in the mold cavities.
摘要:
An apparatus for securely joining ropes for rope suspension or payload tie down. The apparatus includes a two substantially identical channel assemblies configured having a first bend to form a rope groove on one end and a second bend to form a cam channel on the other end, the cam channel having a rivet hole and a pin therethrough to enable a cam to rotate therein, and an attachment mechanism to secure the channel assemblies back-to-back thereto. By opening the cam of either assembly, a rope may be threaded through the rope grove, then again on the opposite assembly. The rope can be pulled from its end away from the assemblies to tighten prior to closing the cam(s) upon the ropes. The rope can further be secured by continuing to pull after the cam has been closed, or by using an optional tightening mechanism and method. A method of tying down cargo or rope suspension using the apparatus of the disclosure for uses such as general-purpose camping, hiking, and other general-purpose tie-down and/or suspension uses of ropes. A method of tightening one or more ropes using the tie-down apparatus disclosed.