-
21.发明申请Expandable Member Formed Of A Fibrous Matrix For Intraluminal Drug Delivery 有权用于腔内药物递送的纤维基质形成的可膨胀构件公开(公告)号：US20100081992A1
公开(公告)日：2010-04-01
申请号：US12238627
申请日：2008-09-26
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61L29/16 , A61L2300/606 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , D01D5/0076
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.
摘要翻译： 一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。 治疗剂可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治疗部位。 一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。
-
公开(公告)号：US20130005218A1
公开(公告)日：2013-01-03
申请号：US13173353
申请日：2011-06-30
IPC分类号： B24C1/00
CPC分类号： B24C1/083 , A61F2/915 , A61F2002/068 , A61F2002/91566 , A61F2230/0004
摘要： A device and method is disclosed for reducing turbulent blood flow over stent struts of an intravascular stent implanted in, for example, a coronary artery. An abrasive slurry is passed over the struts of an intravascular stent in order to remove a portion of the stent struts to form an airfoil shape. When the stent having airfoil-shaped struts is implanted in an artery, the flow of blood over the airfoil shape will reduce the likelihood of turbulent blood flow and thereby will reduce the likelihood of turbulent blood flow and thereby reduce the likelihood of a buildup in plaque or injury to the vessel wall.
摘要翻译： 公开了一种用于减少植入在例如冠状动脉中的血管内支架的支架支柱上的湍流血流的装置和方法。 研磨浆料通过血管内支架的支柱，以便去除支架支架的一部分以形成翼型形状。 当具有翼型支柱的支架植入动脉时，血液在翼型上的流动将降低湍流血流的可能性，从而降低湍流血流的可能性，从而降低斑块积聚的可能性 或损伤血管壁。
-
23.发明申请Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery 有权具有用于腔内药物递送的水凝胶聚合物的纤维基质的可膨胀构件公开(公告)号：US20100076377A1
公开(公告)日：2010-03-25
申请号：US12238026
申请日：2008-09-25
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/606 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1088
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site.
摘要翻译： 一种管腔内导管装置，其具有由纤维元件基质形成的可膨胀构件，所述可扩张构件包括其中结合有治疗剂的水凝胶聚合物。 水凝胶聚合物可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕水凝胶聚合物的保护性物质的第二涂层，其中具有治疗剂。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件包括其中分散有治疗剂的水凝胶聚合物，并将导管装置推进到 所需治疗部位。 一旦在期望的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并且将治疗剂从水凝胶聚合物释放并递送到所需的治疗部位。
-
公开(公告)号：US08524132B2
公开(公告)日：2013-09-03
申请号：US13087343
申请日：2011-04-14
IPC分类号： B29C55/22
CPC分类号： A61F2/915 , A61F2/2475 , A61F2/88 , A61F2/958 , A61F2002/825 , A61F2002/8483 , A61F2002/91558 , A61F2002/91566 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078
摘要： Devices and methods for treating veins and venous conditions, such as chronic cerebrospinal venous insufficiency, are provided. In one aspect, the disclosed subject matter provides an intraluminal scaffold having a generally tubular body with a lumen defined therethrough, the tubular body having a compressed condition for delivery and an expanded condition for implant within a vessel having a distended portion, at least a length of the tubular body configured to form an enlarged portion in the expanded condition to engage a wall of the distended portion of the vessel. Methods for fabricating and using the scaffold, methods for remodeling a vein, and methods of deploying a medical device in a vessel without negatively impacting the function of a valve of the vessel, are also provided.
摘要翻译： 提供了用于治疗静脉和静脉疾病如慢性脑脊髓静脉功能不全的装置和方法。 在一个方面，所公开的主题提供了一种管腔内支架，其具有通过其限定的内腔的大体管状体，所述管状体具有用于输送的压缩状态和用于植入物的扩张状态，所述容器具有扩张部分，至少长度 所述管体被构造成在膨胀状态下形成扩大部分以接合容器的扩张部分的壁。 还提供了制造和使用支架的方法，用于重建静脉的方法，以及在容器中部署医疗装置的方法，而不会不利地影响容器的阀的功能。
-
公开(公告)号：US20120259399A1
公开(公告)日：2012-10-11
申请号：US13350515
申请日：2012-01-13
CPC分类号： A61F2/2475 , A61F2/86 , A61F2210/009 , A61F2230/0058 , A61F2230/0076
摘要： Intraluminal scaffold assembly implantable in a body lumen of a patient to manipulate a valve of the lumen is provided. The intraluminal scaffold assembly includes an intraluminal scaffold, an elongated core member coupled with the intraluminal scaffold having a length sufficient to traverse a valve in a body lumen with the intraluminal scaffold positioned proximate the valve. The intraluminal scaffold assembly can further include one or more additional intraluminal scaffolds, a weighted element or an active element that is coupled with the elongated core member. A system including a delivery system and the intraluminal scaffold assembly, as well as methods of delivering the intraluminal scaffold assembly and using the intraluminal scaffold assembly to manipulate a valve in a body lumen, is also provided.
摘要翻译： 提供可植入患者的体腔中以操纵管腔的瓣膜的腔内支架组件。 管腔内支架组件包括管腔内支架，与管腔内支架连接的细长芯构件，其长度足以横穿体腔内的瓣膜，腔内支架位于瓣膜附近。 管腔内支架组件还可以包括一个或多个额外的管腔内支架，加权元件或与细长芯构件联接的有源元件。 还提供了包括递送系统和管腔内支架组件的系统，以及递送管腔内支架组件和使用管腔内支架组件来操纵体腔中的瓣膜的方法。
-
26.发明授权Expandable member formed of a fibrous matrix for intraluminal drug delivery 有权由用于管腔内药物递送的纤维基质形成的可膨胀构件公开(公告)号：US08076529B2
公开(公告)日：2011-12-13
申请号：US12238627
申请日：2008-09-26
CPC分类号： A61M25/104 , A61L29/16 , A61L2300/606 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , D01D5/0076
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.
摘要翻译： 一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。 治疗剂可以以同轴构型涂覆在纤维元件上。 纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。 纤维元素的基质可以通过静电纺丝形成。 将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治疗部位。 一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。
-
公开(公告)号：US20100249702A1
公开(公告)日：2010-09-30
申请号：US12409785
申请日：2009-03-24
申请人： Jesus Magana , Randolf von Oepen , William E. Webler, Jr. , Allan Bradshaw , Kevin J. Ehrenreich
发明人： Jesus Magana , Randolf von Oepen , William E. Webler, Jr. , Allan Bradshaw , Kevin J. Ehrenreich
CPC分类号： A61M25/1027 , A61M25/007 , A61M25/1006 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , A61M2025/1061 , A61M2025/1086 , B23K26/382 , B23K2101/04 , B23K2103/42 , B23K2103/50 , B24C1/045 , B26F1/31 , B29C49/00 , B29C49/08 , B29C67/0018 , B29C2049/0089 , B29C2793/0045 , B29K2027/06 , B29K2067/00 , B29K2105/258 , B29L2031/7542
摘要： A porous balloon or other catheter structure is formed by creating specific size pores for delivering an agent to a body lumen. The pores can be created by passing matter or energy through the surface of the catheter structure, as by a laser or a projectile. In the case of a laser, the catheter structure can be reversed so that the inner surface becomes the outer surface to convert diverging pores into converging pores. In the case of projectiles, a pore size can be achieved by selecting an appropriate size and shaped projectile to obtain the desired characteristic. Alternatively, a material to make the catheter structure can include impurities that can be removed once the catheter structure is set, leaving pores where the material formed around the impurities.
摘要翻译： 通过产生用于将药剂递送到体腔的特定尺寸的孔来形成多孔气球或其它导管结构。 可以通过将物质或能量通过导管结构的表面，如通过激光或射弹来产生孔。 在激光的情况下，可以将导管结构反转，使得内表面成为外表面，以将发散的孔转化成会聚的孔。 在弹丸的情况下，可以通过选择适当的尺寸和成形的抛射体来获得孔径，以获得所需的特性。 或者，用于制造导管结构的材料可以包括一旦导管结构被设置就可以去除的杂质，留下在杂质周围形成材料的孔。
-
28.发明授权Stent delivery system having a fibrous matrix covering with improved stent retention 失效支架输送系统具有纤维基质覆盖，具有改善的支架保留公开(公告)号：US08500687B2
公开(公告)日：2013-08-06
申请号：US13069020
申请日：2011-03-22
CPC分类号： A61F2/95 , A61F2/958 , A61F2002/9583 , A61L29/16 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： The present invention provides an intraluminal stent delivery catheter device having improved stent retention. Particularly, the present invention is directed to a catheter having an expandable member and a fibrous matrix positioned over the expandable member and a stent mounted on the outer surface of the fibrous matrix. The fibrous matrix provides mechanical interface for improved stent retention, delivery and deployment.
摘要翻译： 本发明提供了具有改善的支架保留的管腔内支架输送导管装置。 特别地，本发明涉及一种导管，其具有位于可扩张部件上方的可扩张部件和纤维矩阵，以及安装在纤维基质外表面上的支架。 纤维基质提供机械界面，用于改进支架保留，递送和部署。
-
公开(公告)号：US20120043703A1
公开(公告)日：2012-02-23
申请号：US13087343
申请日：2011-04-14
CPC分类号： A61F2/915 , A61F2/2475 , A61F2/88 , A61F2/958 , A61F2002/825 , A61F2002/8483 , A61F2002/91558 , A61F2002/91566 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078
摘要： Devices and methods for treating veins and venous conditions, such as chronic cerebrospinal venous insufficiency, are provided. In one aspect, the disclosed subject matter provides an intraluminal scaffold having a generally tubular body with a lumen defined therethrough, the tubular body having a compressed condition for delivery and an expanded condition for implant within a vessel having a distended portion, at least a length of the tubular body configured to form an enlarged portion in the expanded condition to engage a wall of the distended portion of the vessel. Methods for fabricating and using the scaffold, methods for remodeling a vein, and methods of deploying a medical device in a vessel without negatively impacting the function of a valve of the vessel, are also provided.
摘要翻译： 提供了用于治疗静脉和静脉疾病如慢性脑脊髓静脉功能不全的装置和方法。 在一个方面，所公开的主题提供了一种管腔内支架，其具有通过其限定的内腔的大体管状体，该管状体具有用于输送的压缩状态和用于植入物的膨胀状态，该容器具有扩张部分，至少长度 所述管体被构造成在膨胀状态下形成扩大部分以接合容器的扩张部分的壁。 还提供了制造和使用支架的方法，用于重建静脉的方法，以及在容器中部署医疗装置的方法，而不会不利地影响容器的阀的功能。
-
公开(公告)号：US20120259400A1
公开(公告)日：2012-10-11
申请号：US13350529
申请日：2012-01-13
CPC分类号： A61F2/86 , A61F2/966 , A61F2002/9505 , A61F2002/9665 , A61F2210/0076 , A61F2220/0016 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0058 , A61F2230/0076 , A61F2230/0093
摘要： Expandable intraluminal scaffold defining a longitudinal axis is provided, wherein the scaffold includes at least two filaments extending from a head portion disposed along the longitudinal axis at a first longitudinal end, each of the at least two filaments including a free end portion at a second longitudinal end opposite the head portion. The at least two filaments converge toward each other at a juncture disposed proximate the longitudinal axis between the first longitudinal end and the second longitudinal end. A system including a delivery system and the intraluminal scaffold, as well as a method of delivering the scaffold, is also provided.
摘要翻译： 提供了限定纵向轴线的可展开的管腔内支架，其中所述支架包括至少两根从沿所述纵向轴线设置的头部部分延伸的细丝，所述头部沿第一纵向端部延伸，所述至少两根细丝中的每一个包括在第二纵向 在头部相对的端部。 所述至少两根细丝在第一纵向端和第二纵向端之间的纵向轴线附近的接合部处朝向彼此会聚。 还提供了包括递送系统和管腔内支架的系统以及递送支架的方法。
-
-
-
-
-
-
-
-
-
搜索结果
58 条记录 (耗时 0.026 秒)
