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公开(公告)号：US20120156765A1
公开(公告)日：2012-06-21
申请号：US13393097
申请日：2010-08-25
CPC分类号： B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , Y10T29/4998
摘要： The invention relates to a fluid filtering device comprising a filter (2) for filtering a fluid and a substrate (3) comprising a collecting structure (4) for collecting the filtered fluid from the filter (2). An adhesive (5) holds the filter (2) in place with respect to the collecting structure (4). The filter (2), the substrate (3) with the collecting structure (4) and the adhesive (5) are arranged such that the collecting structure (4) contacts the filter (2) and the filter (2) is attached to the substrate (3) by the adhesive (5). The collecting structure is very close to the filter and the adhesive ensures that the collecting structure remains very close to the filter. The filtered fluid can therefore be collected very efficiently and very fast. The fluid filtering device is preferentially used for filtering blood in a biosensing device.
摘要翻译： 本发明涉及一种流体过滤装置，其包括用于过滤流体的过滤器（2）和包括用于从过滤器（2）收集过滤流体的收集结构（4）的基底（3）。 粘合剂（5）将过滤器（2）相对于收集结构（4）保持在适当的位置。 过滤器（2），具有收集结构（4）的基板（3）和粘合剂（5）被布置成使得收集结构（4）接触过滤器（2），并且过滤器（2）附接到 基材（3）由粘合剂（5）。 收集结构非常接近过滤器，并且粘合剂确保收集结构保持非常接近过滤器。 因此，可以非常有效和非常快地收集过滤的流体。 流体过滤装置优选用于过滤生物传感装置中的血液。
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公开(公告)号：US20120115246A1
公开(公告)日：2012-05-10
申请号：US13262942
申请日：2010-04-09
CPC分类号： B01L3/50273 , B01L3/5027 , B01L3/502746 , B01L2300/0627 , B01L2300/0825 , B01L2300/0877 , B01L2300/0887 , B01L2400/0406
摘要： The invention relates to a microfluidic device for performing detection of a substance in a liquid sample, wherein a cavity (24) is formed above a sensor surface area (22) of a sensor (18), said cavity (24) extending at the first side of a base plate (10) from a first area (32), where the cavity overlaps a first lateral channel part (30), to a second area (34), where the cavity overlaps a second lateral channel part (36); the second lateral channel part (36) comprising a lateral channel part formed by a porous capillary suction structure (13). The cavity (24) forms a flow path (42) from the first lateral channel part (30) along the sensor surface area (22) to the second lateral channel part (36); further, the invention relates to a method of detecting a target molecule in a liquid sample.
摘要翻译： 本发明涉及一种用于执行液体样品中物质检测的微流体装置，其中在传感器（18）的传感器表面区域（22）的上方形成空腔（24），所述空腔（24）在第一 来自第一区域（32）的基板（10）的侧面，其中空腔与第一横向通道部分（30）重叠，到第二区域（34），其中空腔与第二横向通道部分（36）重叠; 所述第二横向通道部分（36）包括由多孔毛细管抽吸结构（13）形成的侧向通道部分。 空腔（24）沿着传感器表面区域（22）从第一横向通道部分（30）形成到第二横向通道部分（36）的流动路径（42）。 此外，本发明涉及一种检测液体样品中的靶分子的方法。
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公开(公告)号：US20120100630A1
公开(公告)日：2012-04-26
申请号：US13265569
申请日：2010-04-16
CPC分类号： B01F13/0059 , B01F5/0683 , B01F5/0688 , B01F11/0071 , Y10T436/25 , Y10T436/2575
摘要： The invention relates to a micro fluidics system (1) comprising: a closed, expandable volume (35) for mixing a fluid; a flexible membrane (40) for allowing mixing in the closed, expandable volume (35), characterized in that the micro fluidics system (1) further comprises: a surface (5) comprising at least one channel (20, 20a, 20b, 20c, 20d) for fluidically coupling a first side (10) of the surface (5) to the closed, expandable volume (35) on a second side (15) of the surface (5), the channel (20, 20a, 20b, 20c, 20d) comprising a first channel opening (25) fluidically coupling the first side (10) of the surface (5) to the channel (20, 20a, 20b, 20c, 20d) and a second channel opening (30) fluidically coupling the channel (20, 20a, 20b, 20c, 20d) to the closed, expandable volume (35), the expandable volume (35) being defined by the flexible membrane (40) closing the second channel opening (30) when there is no fluid in the expandable volume (35). The invention further relates to a method for using such a microfluidics system (1).
摘要翻译： 本发明涉及一种微流体系统（1），其包括：用于混合流体的封闭的可膨胀体积（35） 柔性膜（40），用于允许在封闭的可膨胀体积（35）中进行混合，其特征在于，微流体系统（1）还包括：表面（5），包括至少一个通道（20,20a，20b，20c ，20d），用于将所述表面（5）的第一侧（10）与所述表面（5）的第二侧（15）上的所述封闭的可膨胀体积（35）流体耦合，所述通道（20,20a，20b， 包括将表面（5）的第一侧（10）流体耦合到通道（20,20a，20b，20c，20d）的第一通道开口（25）和与流体连接的第二通道开口（30） 所述通道（20,20a，20b，20c，20d）到所述封闭的可膨胀容积（35），所述可膨胀容积（35）由所述柔性膜（40）限定，当不存在时，所述柔性膜（40）封闭所述第二通道开口 可膨胀体积（35）中的流体。 本发明还涉及一种使用这种微流体系统（1）的方法。
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24.发明授权Multi-color biosensor for detecting luminescence sites on a substrate having a refractive optical element for adjusting and focusing at least two incident irradiation beams of different wavelengths 失效用于检测具有折射光学元件的基板上的发光位置的多色生物传感器，用于调节和聚焦至少两个不同波长的入射照射光束公开(公告)号：US08120002B2
公开(公告)日：2012-02-21
申请号：US12374006
申请日：2007-07-05
IPC分类号： G01N21/86
CPC分类号： G01N21/6428 , G01J3/02 , G01J3/021 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6463
摘要： A detection system for detecting luminescence sites on a substrate and including an irradiation unit for generating at least one excitation irradiation beam for exciting luminescence sites on the substrate; a first optical element, e.g. refractive element adapted for receiving at least two irradiation beams of different wavelengths or wavelength ranges, the at least two irradiation beams being excitation irradiation beam(s) to be focused on a substrate and/or luminescence irradiation beam(s) to be collected from the excited luminescence sites on the substrate; and an optical compensator for adjusting at least one of the at least two irradiation beams of different wavelengths or wavelength ranges so as to reduce or compensate for optical aberrations.
摘要翻译： 一种用于检测衬底上发光部位的检测系统，包括用于产生用于激发衬底上的发光部位的至少一个激发照射束的照射单元; 第一光学元件，例如。 用于接收不同波长或波长范围的至少两个照射光束的折射元件，所述至少两个照射光束是要聚焦在基底上的激发照射光束和/或从所述至少两个照射光束收集的发光照射光束 基底上激发的发光位点; 以及用于调整不同波长或波长范围的至少两个照射束中的至少一个的光学补偿器，以便减少或补偿光学像差。
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公开(公告)号：US20110101243A1
公开(公告)日：2011-05-05
申请号：US12999639
申请日：2009-06-23
申请人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
发明人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , B01L3/5027 , G02B21/0028
摘要： A system and method is described for detecting a plurality of analytes in a sample. The characterization system (100) comprises an aperture array (108) and a lens array (110) for generating and focusing a plurality of excitation sub-beams on different sub-regions of a substrate. These sub-regions can be provided with different binding sites for binding different analytes in the sample. By detecting the different luminescent responses in a detector, the presence or amount of different analytes can be determined simultaneously. Alternatively or in addition thereto collection of the luminescence radiation can be performed using the lens array for directly collecting the luminescence response and for guiding the collected luminescence response to corresponding apertures. In a preferred embodiment, the excitation sub-beams are focused at the side of the substrate opposite of the lens array and an immersion fluid is provided between the lens array and the substrate to increase the collection efficiency of the luminescence radiation.
摘要翻译： 描述了用于检测样品中多个分析物的系统和方法。 表征系统（100）包括孔径阵列（108）和透镜阵列（110），用于在衬底的不同子区域上产生和聚焦多个激励子束。 这些子区域可以具有不同的结合位点，用于结合样品中的不同分析物。 通过检测检测器中的不同发光响应，可以同时测定不同分析物的存在或量。 或者或另外，可以使用透镜阵列来进行发光辐射的收集，用于直接收集发光响应并且用于将所收集的发光响应引导到相应的孔。 在优选实施例中，激发子光束在与透镜阵列相对的一侧聚焦，并且在透镜阵列和基板之间提供浸没流体，以增加发光辐射的收集效率。
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公开(公告)号：US20100270478A1
公开(公告)日：2010-10-28
申请号：US12747522
申请日：2008-12-10
IPC分类号： G01J1/58
CPC分类号： G01N21/6456
摘要： A detection system, comprising: a radiation source (24) for providing input radiation; a radiation focusing arrangement (26) for providing the input radiation to an analysis region of a sample (20);—a radiation collection (26) arrangement for collecting output radiation from the analysis region of the sample resulting from interaction of the input radiation with the sample; a radiation detector (28) for detecting the collected output radiation; operating means (40,50,60) for operating the detection device in a first detection mode and a second detection mode, wherein in the first detection mode the analysis has a first size and/or shape and wherein in the second detection mode the analysis region has a second size and/or shape that is different from the first size and/or shape.
摘要翻译： 一种检测系统，包括：用于提供输入辐射的辐射源（24）; 用于将输入辐射提供给样品（20）的分析区域的辐射聚焦装置（26）; - 辐射收集（26）装置，用于收集来自所述样品的分析区域的输出辐射，所述分析区域由所述输入辐射与 例子; 用于检测所收集的输出辐射的辐射检测器（28）; 用于在第一检测模式和第二检测模式下操作所述检测装置的操作装置（40,50,60），其中在所述第一检测模式中，所述分析具有第一尺寸和/或形状，并且其中在所述第二检测模式中，所述分析 区域具有与第一尺寸和/或形状不同的第二尺寸和/或形状。
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公开(公告)号：US20080271799A1
公开(公告)日：2008-11-06
申请号：US12067302
申请日：2006-09-19
申请人： Reinhold Wimberger-Friedl , Rifat Ata Mustafa Hikmet , Ties Van Bommel , Jacob Marinus Jan Den Toomder , Melike Yavuz
发明人： Reinhold Wimberger-Friedl , Rifat Ata Mustafa Hikmet , Ties Van Bommel , Jacob Marinus Jan Den Toomder , Melike Yavuz
CPC分类号： F15C3/04 , B01L3/502738 , B01L2200/12 , B01L2400/0487 , B01L2400/0633 , B01L2400/0638 , Y10T137/2191 , Y10T137/2202 , Y10T137/2213
摘要： The invention relates to a microfluidic regulating device, comprising a first layer having a first microfluidic channel defined therein, a second layer having a second microfluidic channel defined therein, a fluid flow regulating layer disposed between the first and the second microfluidic channel, which layer comprises a movable valve member which in open position allows fluid communication between the first and second channel and in closed position seals against a valve seat, whereby at least part of the valve member and of the valve seat is magnetic. The device is able to store small quantities of liquids at microfluidic cartridges and access these on demand in a well controlled and simple way.
摘要翻译： 本发明涉及一种微流体调节装置，其包括具有限定在其中的第一微流体通道的第一层，其中限定有第二微流体通道的第二层，设置在第一和第二微流体通道之间的流体流动调节层，该层包括 处于打开位置的可移动阀构件允许第一和第二通道之间的流体连通并且在关闭位置中密封抵靠阀座，由此阀构件和阀座的至少一部分是磁性的。 该设备能够在微流控盒中储存少量液体，并以良好控制和简单的方式随时访问。
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公开(公告)号：US20080227188A1
公开(公告)日：2008-09-18
申请号：US12088941
申请日：2006-09-25
IPC分类号： G01N21/05
CPC分类号： G01N21/05 , G01N21/645 , G01N33/543 , G01N33/54366 , G01N2021/0346
摘要： The matching of refractive index of a nanoporous membrane with an analyte solution used with the membrane for use in a sensor is described. Scattering of the excitation and/or emitted light is reduced by matching the refractive indices. This improves efficiency when the porous translucent membrane is used in flow-through or flow-over sensors such as biosensors.
摘要翻译： 描述了纳米多孔膜的折射率与用于传感器的膜使用的分析物溶液的匹配。 通过匹配折射率来减少激发和/或发射光的散射。 当多孔半透膜用于流过或流过传感器（例如生物传感器）时，这提高了效率。
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公开(公告)号：US20080191688A1
公开(公告)日：2008-08-14
申请号：US11814826
申请日：2006-01-30
申请人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
发明人： Josephus Arnoldus Henricus Maria Kahlman , Rachel Estelle Thilwind , Menno Willem Jose Prins , Mischa Megens , Reinhold Wimberger-Friedl
IPC分类号： G01N33/543
CPC分类号： G01N27/745 , G01N33/54333 , G01N33/553
摘要： A sensor device (15) for detecting magnetic particles (13) has a binding surface (40) with binding sites thereon and comprises: at least one sensor element (23) for detecting the presence of magnetic particles (13), means for attracting magnetic structures comprising at least one magnetic particle (13) toward and onto the binding surface (40) of the sensor device (15), and means for re-arranging and randomizing the position of individual magnetic particles (13) with respect to the binding sites on the binding surface (40) to give binding sites on all individual particles (13) a substantial probability to have a contact time with binding sites on the binding surface (40). With such sensor device (15), the speed of detection of target molecules in a fluid is enhanced.
摘要翻译： 用于检测磁性颗粒（13）的传感器装置（15）具有在其上具有结合位置的结合表面（40），并包括：用于检测磁性颗粒（13）的存在的至少一个传感器元件（23），用于吸引磁性颗粒 包括朝向和传递到传感器装置（15）的结合表面（40）上的至少一个磁性颗粒（13）的结构，以及用于重新排列和随机化各个磁性颗粒（13）相对于结合位点 在结合表面（40）上以在所有单独的颗粒（13）上产生与结合表面（40）上的结合位点具有接触时间的可能性。 利用这种传感器装置（15），提高了流体中目标分子的检测速度。
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公开(公告)号：US09174182B2
公开(公告)日：2015-11-03
申请号：US13265569
申请日：2010-04-16
CPC分类号： B01F13/0059 , B01F5/0683 , B01F5/0688 , B01F11/0071 , Y10T436/25 , Y10T436/2575
摘要： A micro fluidics system includes a closed, expandable volume for mixing a fluid, and a flexible membrane for allowing mixing in the closed, expandable volume. The system further includes a surface having at least one channel for fluidically coupling a first side of the surface to the closed, expandable volume on a second side of the surface. The channel includes a first channel opening fluidically coupling the first side of the surface to the channel and a second channel opening fluidically coupling the channel to the closed, expandable volume. The expandable volume is defined by the flexible membrane closing the second channel opening when there is no fluid in the expandable volume.
摘要翻译： 微流体系统包括用于混合流体的封闭的可膨胀体积和用于允许在封闭的可膨胀体积中混合的柔性膜。 该系统还包括具有至少一个通道的表面，用于将表面的第一侧流体耦合到表面的第二侧上的封闭的可膨胀体积。 通道包括将表面的第一侧与通道流体连接的第一通道开口以及将通道流体连接到封闭的可膨胀体积的第二通道开口。 当可膨胀体积中没有流体时，可膨胀体积由柔性膜封闭第二通道开口限定。
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