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    Emulsions for in-situ delivery systems
    21.
    发明授权
    Emulsions for in-situ delivery systems 失效
    用于原位输送系统的乳液

    公开(公告)号：US07128927B1

    公开(公告)日：2006-10-31

    申请号：US09060047

    申请日：1998-04-14

    申请人： Richard L. Dunn

    发明人： Richard L. Dunn

    IPC分类号： A61K9/107 ,  A61K47/32 ,  A61K47/34

    CPC分类号： A61K9/0024 ,  Y02A50/465

    摘要： The invention is provides a composition for sustained delivery of a biologically active agent comprising a biologically active mixture and a controlled release formulation. The composition protects the biologically active agent from being destroyed by the controlled release composition. The biologically active mixture includes the biologically active agent and a pharmaceutically acceptable protective carrier. The controlled release formulation includes a pharmaceutically acceptable, biodegradable, matrix forming material that is substantially insoluble in aqueous or body fluids and a pharmaceutically acceptable organic solvent. The biologically active mixture is combined with the controlled release formulation to form an emulsion, the delivery composition, which is then administered to a patient. The protective carrier can be an aqueous substance, a non-aqueous substance or a combination of both. The matrix forming material can be a polymeric material, a non-polymeric material or a combination of both. The organic solvent can have a solubility ranging from a high water solubility to a low water solubility.

    摘要翻译： 本发明提供了用于持续递送包含生物活性混合物和控释制剂的生物活性剂的组合物。 组合物保护生物活性剂免受控释组合物的破坏。 生物活性混合物包括生物活性剂和药学上可接受的保护载体。 控制释放制剂包括药学上可接受的，可生物降解的基质形成材料，其基本上不溶于水性或体液和药学上可接受的有机溶剂。 将生物活性混合物与控制释放制剂组合以形成乳剂，然后将其输送给患者。 保护载体可以是水性物质，非水性物质或两者的组合。 基体形成材料可以是聚合材料，非聚合材料或两者的组合。 有机溶剂可以具有从高水溶性到低水溶性的溶解度。

    Method for making a biodegradable adhesive for soft living tissue
    29.
    发明授权
    Method for making a biodegradable adhesive for soft living tissue 失效
    制造软生物体组织的生物降解性粘合剂的方法

    公开(公告)号：US4804691A

    公开(公告)日：1989-02-14

    申请号：US90861

    申请日：1987-08-28

    申请人： James P. English ,  Gerald W. McNeely ,  Richard L. Dunn

    发明人： James P. English ,  Gerald W. McNeely ,  Richard L. Dunn

    IPC分类号： A61L24/04 ,  C08G18/42 ,  C09J175/06 ,  C08G18/30

    CPC分类号： C09J175/06 ,  A61L24/046 ,  C08G18/4277 ,  C08G18/428 ,  C08G2230/00 ,  Y10S528/905

    摘要： A method for making an adhesive for use in joining soft living tissue including the steps of preparing a hydroxyl-terminated polyester by reacting a biodegradable monomer with a polyhydroxy polymerization initiator in the presence of an amount up to about 2.0 weight percent of a catalyst, and then preparing a diisocyanate-terminated prepolymer adhesive by reacting about 24 to 92 weight percent of the hydroxy-terminated polyester with about 8 to 76 weight percent excess aromatic diisocyante. The polyester and the diisocyanate are preferably dissolved in an organic solvent prior to the mixture thereof in a ratio of solids to solvent of about 60:40. The polyester is a polymer or copolymer of lactide, glycolide or .epsilon.-caprolactone. The initiator is ethylene glycol, diethylene glycol, pentaerythritol or 1,1,1-tris (hydroxymethyl) ethane. The catalyst is stannous octoate, a zinc compound, an aliphatic tertiary amine, dibutyltin diacetate or 1,4-diazabicyclo [2,2,2] octane.

    摘要翻译： 一种制造用于连接软性生物体组织的粘合剂的方法，其包括通过使可生物降解的单体与多羟基聚合引发剂在至多约2.0重量％的催化剂的量存在下反应制备羟基封​​端的聚酯的步骤，以及 然后通过使约24至92重量％的羟基封端的聚酯与约8至7​​6重量％的过量芳族二异氰酸酯反应制备二异氰酸酯封端的预聚物粘合剂。 聚酯和二异氰酸酯优选在固体与溶剂的比例为约60:40的混合物之前溶解在有机溶剂中。 聚酯是丙交酯，乙交酯或ε-己内酯的聚合物或共聚物。 引发剂是乙二醇，二甘醇，季戊四醇或1,1,1-三（羟甲基）乙烷。 催化剂为辛酸亚锡，锌化合物，脂族叔胺，二乙酸二丁基锡或1,4-二氮杂双环[2,2,2]辛烷。