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21.发明申请公开(公告)号：US20110288005A1
公开(公告)日：2011-11-24
申请号：US13078499
申请日：2011-04-01
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to compositions comprising alpha 1-antitrypsin linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of alpha 1-antitrypsin-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的α1-抗胰蛋白酶的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用这些组合物治疗α1- 抗胰蛋白酶相关疾病，病症和病症。
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公开(公告)号：US07968681B2
公开(公告)日：2011-06-28
申请号：US12761346
申请日：2010-04-15
申请人： Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Lui , Joshua Silverman , Richard Smith , Candace Swimmer
发明人： Willem P. C. Stemmer , D. Victor Perlroth , Sanjeev Satyal , Benjamin M. Alba , Alice Bakker , Amy N. Duguay , Qiang Lui , Joshua Silverman , Richard Smith , Candace Swimmer
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , G01N33/566 , G01N33/574 , G01N2333/4753 , G01N2333/82 , G01N2500/00
摘要： Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.
摘要翻译： 提供了包含与c-MET结合的单体结构域的多肽或其部分。
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公开(公告)号：US20110077199A1
公开(公告)日：2011-03-31
申请号：US12796640
申请日：2010-06-08
CPC分类号： A61K47/48246 , A61K38/00 , A61K47/64 , C07K14/001 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/75
摘要： The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of growth hormone-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生长激素的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗生长激素相关疾病的方法， 疾病和病症。
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公开(公告)号：US20100239554A1
公开(公告)日：2010-09-23
申请号：US12699761
申请日：2010-02-03
申请人： Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
发明人： Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
IPC分类号： A61K38/48 , C07K14/46 , C12N9/64 , C07K14/61 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , A61P3/10 , A61P3/04 , A61P3/08 , A61P3/06 , A61P7/04 , A61P9/12 , A61P9/10 , A61P5/06 , A61P1/04 , A61P19/02 , A61K38/27 , A61K38/16 , A61K38/26 , A61K38/23 , A61K38/31 , A61P5/22 , A61K38/22 , A61K38/18 , A61K38/36
CPC分类号： C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生物活性蛋白质的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及使用这些组合物治疗葡萄糖相关疾病，代谢疾病 ，凝血障碍和生长激素相关的疾病和病症。
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公开(公告)号：US07786262B2
公开(公告)日：2010-08-31
申请号：US11486246
申请日：2006-07-12
申请人： Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
发明人： Alice Bakker , Amy N. Duguay , Qiang Liu , Joshua Silverman , Kevin Moore
CPC分类号： C07K14/715
摘要： Polypeptides comprising monomer domains that bind to IL-6, or portions thereof, are provided.
摘要翻译： 提供了包含与IL-6结合的单体结构域的多肽或其部分。
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公开(公告)号：US20130017997A1
公开(公告)日：2013-01-17
申请号：US13365166
申请日：2012-02-02
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US20110172146A1
公开(公告)日：2011-07-14
申请号：US12848984
申请日：2010-08-02
CPC分类号： C07K14/001 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/75
摘要： The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in administration to animals.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生长激素，编码组合物的分离的核酸和载体的组合物和含有其的宿主细胞的组合物，以及在给予动物时制备和使用这些组合物的方法。
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28.发明申请公开(公告)号：US20110046061A1
公开(公告)日：2011-02-24
申请号：US12806005
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20100323956A1
公开(公告)日：2010-12-23
申请号：US12796650
申请日：2010-06-08
IPC分类号： A61K38/26 , C07K19/00 , C07K14/605 , A61K38/16 , C12P21/02 , C07H21/00 , C12N15/63 , C12N1/00 , A61P3/10 , A61P3/08 , A61P11/00 , A61P13/12 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/28 , A61P9/04 , A61P1/16 , A61P1/00 , A61P13/00 , A61P9/00 , A61P43/00
CPC分类号： C07K14/605 , A23V2200/328 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N15/70 , C12P21/02 , Y10S514/866
摘要： The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of glucose regulating peptide-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的葡萄糖调节肽的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用该组合物治疗葡萄糖调节肽相关的方法 疾病，病症和状况。
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公开(公告)号：US07507806B2
公开(公告)日：2009-03-24
申请号：US11203806
申请日：2005-08-15
申请人： Titia de Lange , Joshua Silverman
发明人： Titia de Lange , Joshua Silverman
CPC分类号： C12Q1/485 , G01N2500/10 , G01N2800/2835
摘要： The present invention relates to human Rif1 (hRif1) nucleic acid sequences and human Rif1 amino acid sequences encoded therefrom. The invention also encompasses antibodies that are immunologically specific for human Rif1 polypeptides. Also included in the present invention are methods directed to detecting Rif1 foci formed in response to various treatments that induce DNA damage. The formation of foci comprising Rif1 in response to DNA damage serves as a positive indicator of the presence of wild type ATM kinase activity in a cell, whereas the absence of detectable Rif1 foci under such circumstances serves to identify a cell with reduced ATM kinase activity. Modulators of ATM kinase activity and/or Rif1 activity and methods for identifying such modulators are also included in the present invention.
摘要翻译： 本发明涉及人Rif1（hRif1）核酸序列和由其编码的人Rif1氨基酸序列。 本发明还包括对人Rif1多肽具有免疫学特异性的抗体。 本发明还包括用于检测响应诱导DNA损伤的各种治疗形成的Rif1病灶的方法。 包含Rif1响应于DNA损伤的病灶的形成作为细胞中存在野生型ATM激酶活性的阳性指标，而在这种情况下不存在可检测的Rif1病灶用于鉴定具有降低的ATM激酶活性的细胞。 ATM激酶活性和/或Rif1活性的调节剂和鉴定这种调节剂的方法也包括在本发明中。
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