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41 条记录 (耗时 0.029 秒)

    In vivo method of determining leucocyte migratory activity levels
    22.
    发明授权
    In vivo method of determining leucocyte migratory activity levels 失效
    体内测定白细胞迁移活性水平的方法

    公开(公告)号：US4366144A

    公开(公告)日：1982-12-28

    申请号：US117353

    申请日：1980-01-31

    申请人： Lorne M. Golub ,  Ralph S. Kaslick

    发明人： Lorne M. Golub ,  Ralph S. Kaslick

    IPC分类号： A61K49/00 ,  G01N33/48 ,  G01N33/50

    CPC分类号： A61K49/0004 ,  Y10S436/811

    摘要： Pharmacologically acceptable chemotactic agents when applied to gingival crevices cause the migration of crevicular fluid containing crevicular leucocytes into the said gingival crevice.A quantitative correlation has been found between the amount of crevicular fluid migrating into the crevice and the crevicular fluid migrating into the crevice and the crevicular leucocytes contained therein after chemotactic challenge.It has further been shown that the amount of fluid and leucocytes migrating into said crevice gave a predictable relationship to the migratory activity of leucocytes obtained from the same subject when measured by conventional in vitro means.A rapid, convenient and simple method is thus provided for detecting certain diseases involving leucocyte migratory activity abnormalities for example diabetes mellitus and periodontosis.

    摘要翻译： 药理学上可接受的趋化剂在应用于牙龈缝隙时会引起含有角质层白细胞的缝合液向所述牙龈缝隙的迁移。 已经发现，在趋化性攻击之后，迁移到缝隙中的缝隙液的量和迁移到缝隙中的缝合液和其中包含的缝合白细胞之间的定量相关性。 进一步表明，当通过常规体外方法测量时，迁移到所述缝隙中的流体和白细胞的量与从相同受试者获得的白细胞的迁移活性呈现可预测的关系。 因此，提供了用于检测涉及白细胞迁移活动异常（例如糖尿病和牙周病）的某些疾病的快速，方便和简单的方法。

    Method for decreasing low density lipoprotein
    24.
    发明授权
    Method for decreasing low density lipoprotein 失效
    降低低密度脂蛋白的方法

    公开(公告)号：US06841547B2

    公开(公告)日：2005-01-11

    申请号：US10377088

    申请日：2003-02-28

    申请人： David Brown ,  Lorne M. Golub ,  Hsi-Ming Lee ,  Robert Greenwald ,  Maria Ryan ,  Kavita Desai

    发明人： David Brown ,  Lorne M. Golub ,  Hsi-Ming Lee ,  Robert Greenwald ,  Maria Ryan ,  Kavita Desai

    IPC分类号： A61K31/65

    CPC分类号： A61K31/65

    摘要： The present invention relates to a method for decreasing elevated serum/plasma LDL-cholesterol levels or LDL-cholesterol levels and CRP levels in a mammal in need thereof. The methods comprises administering an effective amount of a tetracycline formulation. In one embodiment, the tetracycline formulation is a non-antibacterial tetracycline. In another embodiment, the tetracycline formulation is an antibacterial tetracycline at a sub-antibacterial amount.

    摘要翻译： 本发明涉及降低有需要的哺乳动物中升高的血清/血浆LDL-胆固醇水平或LDL-胆固醇水平和CRP水平的方法。 所述方法包括施用有效量的四环素制剂。 在一个实施方案中，四环素制剂是非抗菌四环素。 在另一个实施方案中，四环素制剂是亚抗菌量的抗菌四环素。

    Diagnostic method for detection of periodontitis or peri-implantitis
    29.
    发明授权
    Diagnostic method for detection of periodontitis or peri-implantitis 有权
    用于检测牙周炎或植入周围炎的诊断方法

    公开(公告)号：US6143506A

    公开(公告)日：2000-11-07

    申请号：US133887

    申请日：1998-08-13

    申请人： Lorne M. Golub ,  Timo Sorsa ,  Olli Teronen ,  Sari Hannele Tikanoja

    发明人： Lorne M. Golub ,  Timo Sorsa ,  Olli Teronen ,  Sari Hannele Tikanoja

    IPC分类号： G01N33/573 ,  G01N33/53

    CPC分类号： G01N33/573 ,  G01N2333/96486 ,  Y10S435/975

    摘要： The invention relates to methods and test kits for diagnosis of periodontal disease activity in mammals, especially in human. The methods of the invention provide for rapid chair-side diagnosis of periodontitis, peri-implantitis and HIV (+)-infection/AIDS-disease related periodontal diseases. Especially, the methods of the invention provide for rapid chair-side diagnosis of the loss of bone density associated with periodontal diseases.

    摘要翻译： 本发明涉及用于诊断哺乳动物，特别是人类中牙周病活动的方法和测试试剂盒。 本发明的方法提供牙周炎，植入周围炎和HIV（+） - 感染/ AIDS相关牙周病的快速椅子诊断。 特别地，本发明的方法提供了与牙周疾病相关的骨密度损失的快速的椅子侧诊断。

    Treatment of aortic and vascular aneurysms with tetracycline compounds
    30.
    发明授权
    Treatment of aortic and vascular aneurysms with tetracycline compounds 失效
    用四环素化合物治疗主动脉和血管动脉瘤

    公开(公告)号：US5834449A

    公开(公告)日：1998-11-10

    申请号：US662482

    申请日：1996-06-13

    申请人： Robert W. Thompson ,  Lorne M. Golub

    发明人： Robert W. Thompson ,  Lorne M. Golub

    IPC分类号： A61K31/65

    CPC分类号： A61K31/65

    摘要： A method for inhibiting the formation and progression of abnormal vascular dilatation and/or aneurysms. The method includes administering a tetracycline compound to a mammal in an amount which is effective against the formation or progression of aneurysm, or which is effective to induce regression of an established abnormal dilatation or aneurysm. The method is of particular advantage in the treatment of mammals having an abdominal aortic aneurysm, a relatively common, and life-threatening, condition. Further, there is provided a method for inhibiting elastolytic activity in vascular tissue, to diminish excessive proteolytic degradation of vascular elastic tissues, wherein such degradation is associated with abnormal vascular dilatation or aneurysm. Also provided is an apparatus for treating mammals suffering from an abnormal vascular dilatation and/or aneurysm.

    摘要翻译： 一种抑制异常血管扩张和/或动脉瘤形成和进展的方法。 所述方法包括以对抗动脉瘤形成或进展有效的量给哺乳动物施用四环素化合物，或有效诱导建立的异常扩张或动脉瘤的消退。 该方法在治疗具有相对常见和危及生命的腹主动脉瘤的哺乳动物中具有特别的优点。 此外，提供了抑制血管组织中的弹性分解活性的方法，以减少血管弹性组织的过度的蛋白水解降解，其中这种降解与异常的血管扩张或动脉瘤相关。 还提供了一种用于治疗患有血管扩张异常和/或动脉瘤的哺乳动物的装置。