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公开(公告)号：US20090082264A1
公开(公告)日：2009-03-26
申请号：US11735351
申请日：2007-04-13
申请人： Carrie L. Fischer , Craig A. Rosen , Daniel R. Soppet , Steven M. Ruben , Hla Kyaw , Yi Li , Zhizhen Zeng , David W. LaFleur , Paul A. Moore , Yanggu Shi , Henrik Olsen , Reinhard Ebner , Charles E. Birse
发明人： Carrie L. Fischer , Craig A. Rosen , Daniel R. Soppet , Steven M. Ruben , Hla Kyaw , Yi Li , Zhizhen Zeng , David W. LaFleur , Paul A. Moore , Yanggu Shi , Henrik Olsen , Reinhard Ebner , Charles E. Birse
IPC分类号： A61K38/00 , C12N15/11 , C12N15/00 , C12N15/87 , C12N5/06 , C12Q1/68 , G01N33/566 , A61P43/00 , C12Q1/02 , A61K31/70 , C07K14/00 , C07K16/18 , C12P21/04
CPC分类号： A01C23/024 , A61K38/00 , C07K14/47 , C12N9/00 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/5091 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20090203635A1
公开(公告)日：2009-08-13
申请号：US11968925
申请日：2008-01-03
申请人： Craig A. Rosen , George A. Komatsoulis , Kevin P. Baker , Michele Fiscella , Paul A. Moore , Ping Wei , D. Roxanne Duan , Yanggu Shi , Ram Gupta
发明人： Craig A. Rosen , George A. Komatsoulis , Kevin P. Baker , Michele Fiscella , Paul A. Moore , Ping Wei , D. Roxanne Duan , Yanggu Shi , Ram Gupta
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20090088555A1
公开(公告)日：2009-04-02
申请号：US12274626
申请日：2008-11-20
申请人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
发明人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
CPC分类号： C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06569992B1
公开(公告)日：2003-05-27
申请号：US09369247
申请日：1999-08-05
申请人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
发明人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC分类号： A61K3800
CPC分类号： C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06919433B2
公开(公告)日：2005-07-19
申请号：US09853161
申请日：2001-05-11
申请人： Steven M. Ruben , Craig A. Rosen , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie L. Fischer , Haodong Li , Daniel R. Soppet , Reiner L. Gentz , Ying-Fei Wei , Paul A. Moore , Paul E. Young , John M. Greene , Ann M. Ferrie , Gregg A. Hastings
发明人： Steven M. Ruben , Craig A. Rosen , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie L. Fischer , Haodong Li , Daniel R. Soppet , Reiner L. Gentz , Ying-Fei Wei , Paul A. Moore , Paul E. Young , John M. Greene , Ann M. Ferrie , Gregg A. Hastings
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20100291033A1
公开(公告)日：2010-11-18
申请号：US12793652
申请日：2010-06-03
申请人： Craig A. ROSEN , Adam Bell , Paul A. Moore , Yanggu Shi , David W. LaFleur , Jason B. Bock , Michael W. Laird , William A. Haseltine , Douglas B. Woods , Mani Subramanian
发明人： Craig A. ROSEN , Adam Bell , Paul A. Moore , Yanggu Shi , David W. LaFleur , Jason B. Bock , Michael W. Laird , William A. Haseltine , Douglas B. Woods , Mani Subramanian
IPC分类号： A61K38/38 , C07K14/76 , A61K38/21 , C07H21/04 , A61P31/18 , A61P35/00 , A61P31/12 , A61P9/12 , A61P9/04 , A61P35/02 , A61P31/04 , A61P3/10 , C12N5/10 , C12N1/19 , C12N1/21
CPC分类号： C07K14/765 , A61K38/38 , A61K47/643 , C07K2319/31
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。
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公开(公告)号：US20090311256A1
公开(公告)日：2009-12-17
申请号：US12264040
申请日：2008-11-03
申请人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
发明人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C07K14/00 , C07K16/00 , C12P21/02 , A61K31/7088 , A61K38/16 , C12Q1/68 , G01N33/53 , A61P9/00 , A61P3/00
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及12种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US08372948B2
公开(公告)日：2013-02-12
申请号：US12264040
申请日：2008-11-03
申请人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
发明人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
IPC分类号： C07K5/00
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：US06903072B2
公开(公告)日：2005-06-07
申请号：US09345373
申请日：1999-07-01
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07K14/50 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
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公开(公告)号：US06916786B2
公开(公告)日：2005-07-12
申请号：US10075446
申请日：2002-02-15
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N1/20 , C12N5/10
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07K14/50 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
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