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公开(公告)号:US10767198B2
公开(公告)日:2020-09-08
申请号:US15779214
申请日:2015-11-28
Applicant: SYMRISE AG
Inventor: Marco A. Fraatz , Holger Zorn , Johanna Rost , Michael Goldmann , Egon Gross , Jakob Ley , Katrin Geissler , Torsten Geissler , Michael Backes , Fabia Hentschel , Jens-Michael Hilmer
Abstract: A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes having the same number of carbon atoms compared to the free and/or bound carboxylic acids or into the corresponding aldehydes having a reduced number of carbon atoms by one compared to the free and/or bound carboxylic acids and producing the biologically produced second intermediate containing these aldehydes; (f) treating the chemically produced second intermediate with an oxidizing agent of a chemical nature to convert the free and/or bound alcohols into the corresponding aldehydes; and optionally (g) removing interfering by-components from the fractions obtainable after step(s) (d) and/or (e) and/or (f).
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公开(公告)号:US10702484B2
公开(公告)日:2020-07-07
申请号:US16071295
申请日:2016-04-28
Applicant: SYMRISE AG
Inventor: Gerhard Krammer , Jakob Ley , Fabia Hentschel , Susanne Paetz , Thomas Riess , Michael Backes
IPC: A61K31/12 , A23L27/00 , A23L27/26 , A23L27/30 , A23L27/60 , A23L27/20 , A23G3/38 , A23G4/06 , A23L2/56 , A23L2/60
Abstract: The present invention concerns the use of 3-(3-Hydroxy-4-methoxy-phenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one for masking, reducing or suppressing an unpleasant taste impression, preferably bitter, sour and/or astringent taste impression of unpleasant-tasting substances or mixture of substances, preferably bitter-, sour-, and/or astringent-tasting substances or mixtures of substances, and in particular the bitter taste impression of bitter-tasting substances, and/or modulating the taste impressions selected from the group consisting of cooling, umami, fruity and spicy notes of cooling-, umami-, fruity- or spicy-tasting substances or mixture of substances, and simultaneously intensifying the sweet-taste impression of sweet-tasting substances or mixtures of substances or both sweet- and bitter-tasting tasting substances or mixture of substances.
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公开(公告)号:US09894921B2
公开(公告)日:2018-02-20
申请号:US14436599
申请日:2013-12-02
Applicant: SYMRISE AG
Inventor: Michael Backes , Jakob Peter Ley , Susanne Paetz , Katharina Reichelt
CPC classification number: A23L27/204 , A23L27/23 , A23L27/26 , A23L27/88
Abstract: Proposed is the use of cinnamic acid amide derivatives of formula (I) in which R1, R2, R3 and R4, independently of one another, stand for hydrogen or a methoxy group, as a flavouring.
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24.
公开(公告)号:US09718839B2
公开(公告)日:2017-08-01
申请号:US14533345
申请日:2014-11-05
Applicant: SYMRISE AG , BASF SE
Inventor: Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC: C07D495/20 , A23L1/30 , A24B13/00 , A24D1/00 , A61K31/4375 , A61K31/438 , A61K31/506 , A61K31/5377 , A61K8/49 , A61Q11/00 , C07D401/04 , C07D491/147 , A23G3/36 , A23G4/06 , A23L2/52 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/513 , A61Q19/00 , C07C233/11 , C07C235/36 , C07C235/38 , C07D213/75 , C07D317/60 , C07D405/12 , C07D495/22 , C09D5/16 , D06M15/03 , D06M15/07 , D06M16/00 , A23L27/20 , A23L33/10 , A61Q17/04
CPC classification number: C07D495/20 , A23G3/36 , A23G4/06 , A23L2/52 , A23L27/2054 , A23L33/10 , A23V2002/00 , A24B13/00 , A24D1/002 , A61K8/49 , A61K8/4953 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4375 , A61K31/438 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K2800/10 , A61K2800/244 , A61K2800/78 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , C07C233/11 , C07C235/36 , C07C235/38 , C07C2601/14 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/1625 , D06M15/03 , D06M15/07 , D06M16/00
Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
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