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1.发明授权公开(公告)号：US11434220B2
公开(公告)日：2022-09-06
申请号：US16642954
申请日：2018-08-31
Applicant: BASF SE , SYMRISE AG
Inventor： Benoît Join , Jekaterina Ongouta , Michael Backes , Rahim Brodhage , Arnold Machinek , Hubert Loges , Susanne Mundt , Tom Somers , Thomas Subkowski , Jens Wittenberg , Martin Weisel , Wolfgang Siegel , Claus Bollschweiler , Ralf Pelzer
IPC: C07D317/46 , C07C323/41 , C07D405/12 , C07D213/75 , C07D231/40 , C07D407/12 , C07D307/14 , C07D409/12 , C07D409/14 , C07D405/14 , A61K8/49 , A61K8/46 , A61Q11/00 , A23L29/00 , A23L27/00 , A23G3/36
Abstract: The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.
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2.发明授权公开(公告)号：US10584134B2
公开(公告)日：2020-03-10
申请号：US15629015
申请日：2017-06-21
Applicant: SYMRISE AG , BASF SE
Inventor： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC: C07D495/20 , A23L27/20 , A23L33/10 , A24B13/00 , A24D1/00 , A61K31/4375 , A61K31/438 , A61K31/5377 , A61Q11/00 , C07C233/11 , C07C235/36 , C07C235/38 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/16 , D06M15/03 , D06M15/07 , D06M16/00 , A23G3/36 , A23G4/06 , A23L2/52 , A61K8/49 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61Q19/00 , A61Q17/04
Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
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3.发明申请公开(公告)号：US20180093997A1
公开(公告)日：2018-04-05
申请号：US15629015
申请日：2017-06-21
Applicant: SYMRISE AG , BASF SE
Inventor： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC: C07D495/20 , C07D491/147 , A24B13/00 , A24D1/00 , A61K31/4375 , A61K31/438 , A61K31/5377 , A61Q11/00 , A23L33/10 , A23L27/20 , D06M16/00 , D06M15/07 , D06M15/03 , C09D5/16 , C07D495/22 , C07D405/12 , C07D401/04 , C07D317/60 , C07D213/75 , C07C235/38 , C07C235/36 , C07C233/11
Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
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4.发明申请USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS 审中-公开使用生理冷却活性成分，以及含有此类活性成分的试剂公开(公告)号：US20150086491A1
公开(公告)日：2015-03-26
申请号：US14533345
申请日：2014-11-05
Applicant: SYMRISE AG , BASF SE
Inventor： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC: C07D495/20 , A61K31/4375 , C07D491/147 , A61K31/506 , A23L1/30 , A61K31/5377 , A61K8/49 , A61Q11/00 , A24B13/00 , A24D1/00 , A61K31/438 , C07D401/04
CPC classification number: C07D495/20 , A23G3/36 , A23G4/06 , A23L2/52 , A23L27/2054 , A23L33/10 , A23V2002/00 , A24B13/00 , A24D1/002 , A61K8/49 , A61K8/4953 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4375 , A61K31/438 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K2800/10 , A61K2800/244 , A61K2800/78 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , C07C233/11 , C07C235/36 , C07C235/38 , C07C2601/14 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/1625 , D06M15/03 , D06M15/07 , D06M16/00
Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
Abstract translation: 本发明涉及一种用于实现对皮肤或粘膜的冷却作用的TRPM8调节剂。
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5.发明授权公开(公告)号：US09718839B2
公开(公告)日：2017-08-01
申请号：US14533345
申请日：2014-11-05
Applicant: SYMRISE AG , BASF SE
Inventor： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC: C07D495/20 , A23L1/30 , A24B13/00 , A24D1/00 , A61K31/4375 , A61K31/438 , A61K31/506 , A61K31/5377 , A61K8/49 , A61Q11/00 , C07D401/04 , C07D491/147 , A23G3/36 , A23G4/06 , A23L2/52 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/513 , A61Q19/00 , C07C233/11 , C07C235/36 , C07C235/38 , C07D213/75 , C07D317/60 , C07D405/12 , C07D495/22 , C09D5/16 , D06M15/03 , D06M15/07 , D06M16/00 , A23L27/20 , A23L33/10 , A61Q17/04
CPC classification number: C07D495/20 , A23G3/36 , A23G4/06 , A23L2/52 , A23L27/2054 , A23L33/10 , A23V2002/00 , A24B13/00 , A24D1/002 , A61K8/49 , A61K8/4953 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4375 , A61K31/438 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K2800/10 , A61K2800/244 , A61K2800/78 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , C07C233/11 , C07C235/36 , C07C235/38 , C07C2601/14 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/1625 , D06M15/03 , D06M15/07 , D06M16/00
Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
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Patent Agency Ranking
公开(公告)号：US11234450B2
公开(公告)日：2022-02-01
申请号：US15804026
申请日：2017-11-06
Applicant: Symrise AG , Sven Siegel
Inventor： Torsten Kulke , Sven Siegel , Michael Backes , Benoit Join , Hubert Loges , Günter Kindel
IPC: A23G4/06 , A61K8/02 , A61K8/69 , A61K8/34 , A61K8/37 , A61K8/42 , A61K8/49 , A61K31/045 , A61K31/216 , A61K31/343 , A61K31/357 , A61K31/381 , A61K31/4155 , A61K31/42 , A61K31/426 , A61K31/4436 , A61K31/497 , A61Q5/00 , A23L27/20 , A23L29/00 , A61Q19/10 , A61Q11/00 , A61Q19/00 , A61Q17/04
Abstract: Proposed are preparations, comprising special amides and menthol or menthol compounds or aromatic substances, characterized in that they have improved flavor and scent properties, and also that they allow the production of preparations, particularly emulsions with improved shelf life.
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7.发明申请公开(公告)号：US20150272185A1
公开(公告)日：2015-10-01
申请号：US14436599
申请日：2013-12-02
Applicant: SYMRISE AG
Inventor： Michael Backes , Jakob Peter Ley , Susanne Paetz , Katharina Reichelt
CPC classification number: A23L27/204 , A23L27/23 , A23L27/26 , A23L27/88
Abstract: Proposed is the use of cinnamic acid amide derivatives of formula (I) in which R1, R2, R3 and R4, independently of one another, stand for hydrogen or a methoxy group, as a flavouring.
Abstract translation: 建议使用式（I）的肉桂酸酰胺衍生物，其中R 1，R 2，R 3和R 4彼此独立地代表氢或甲氧基，作为调味剂。
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公开(公告)号：US12262725B2
公开(公告)日：2025-04-01
申请号：US15771944
申请日：2015-11-14
Applicant: SYMRISE AG
Inventor： Johannes Kiefl , Susanne Paetz , Jakob Ley , Michael Backes , Joachim Hans
Abstract: The present invention describes a food product comprising (a) juice, marrow, flesh or peels or other components of at least one citrus fruit, (b) at least one neoflavonoid as well as optionally (c) further flavoring agents or flavor preparations, providing that the component (b) is present in a sufficient amount to improve the sour and/or bitter taste of the component (a).
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公开(公告)号：US11485930B2
公开(公告)日：2022-11-01
申请号：US16615863
申请日：2017-06-01
Applicant: SYMRISE AG
Inventor： Michael Backes , Jekaterina Ongouta , Jakob Ley , Tobias Vössing , Volkmar Koppe , Jens Koch
Abstract: The present invention primarily relates to a method for producing an aromatic blend comprising unsaturated dienals. The invention further relates to aromatic blends obtained or obtainable by a method according to the invention and compositions or semi-finished products for producing said compositions, comprising aromatic blends according to the invention. A further aspect of the present invention relates to the use of an aromatic blend according to the invention for aromatizing a composition, preferably a composition serving for food or pleasure, or a semi-finished product for producing such a composition.
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公开(公告)号：US20210040028A1
公开(公告)日：2021-02-11
申请号：US17077133
申请日：2020-10-22
Applicant: SYMRISE AG
Inventor： Michael Backes , Jakob Peter Ley , Andreas Degenhardt , Susanne Paetz , Katharina Reichelt , Thomas Riess , Bettina Klose , Fabia Hentschel
IPC: C07C69/734 , A23L27/20 , A23L27/00 , A61K47/14 , C07C69/708 , C07C69/757 , A23B4/06
Abstract: Compounds of formula (I) and novel uses of compounds of formula (I), such as for flavour compositions. New preparations and new methods using compounds of formula (I).
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