公开(公告)号：US5757888A

公开(公告)日：1998-05-26

申请号：US887630

申请日：1997-07-03

申请人： Tadashi Fujii

发明人： Tadashi Fujii

IPC分类号： G03B42/02 ,  G03B42/04

CPC分类号： G03B42/045

摘要： In an X-ray apparatus, an X-ray film is placed in an closed space formed by front and rear sensitizer screen supports and a closing member fixed to one of the sensitizer screen supports so that a part of the X-ray film projects outside the closed space. The closed space is evacuated so that the sensitizer screens are brought into close contact with opposite sides of the X-ray film under vacuum. The front and rear sensitizer screen supports are movable between the X-raying position and a retracted position shifted from the X-raying position and are movable relative to each other in the retracted position between a closing position where the supports form the closed space together with the closing member and an open position where the supports form therebetween a wedge-shaped space flaring upward to permit insertion and removal of the X-ray film into and from the space. A transfer rollers hold the part of the X-ray film projected outside the closed space and insert and remove the X-ray film into and from the wedge-shaped space from above when the sensitizer screen supports are in the open position. Evacuation of the closed space is started as soon as the sensitizer screen supports are moved to the closing position in the retracted position.

摘要翻译： 在X射线装置中，将X射线胶片放置在由前后敏感剂筛网支撑体和固定在一个敏化筛网支撑体上的封​​闭部件形成的封闭空间中，使得X射线胶片的一部分突出到外部 封闭的空间。 将封闭空间抽真空，使得敏化剂筛在真空下与X射线胶片的相对侧紧密接触。 前部和后部敏化剂屏幕支撑件可以在X射线位置和从X射线位置偏移的缩回位置之间移动，并且能够在缩回位置相对于彼此移动，在关闭位置，其中支撑件形成封闭空间与 关闭构件和打开位置，其中支撑件形成在其间向上扩张的楔形空间，以允许将X射线胶片插入和移出空间。 转印辊将X射线胶片的一部分保持在封闭空间外部，并且当敏化剂屏幕支撑件处于打开位置时，将X射线胶片从上方插入和从楔形空间中取出。 一旦敏化剂筛网支撑件移动到缩回位置的关闭位置，就开始封闭空间的疏散。

公开(公告)号：US5272737A

公开(公告)日：1993-12-21

申请号：US760968

申请日：1991-09-17

申请人： Tadashi Fujii ,  Yoshiyuki Kataoka ,  Tohru Fukui ,  Masataka Hidaka ,  Toshitsugu Nakao ,  Shigeo Hatamiya ,  Hiroaki Suzuki ,  Masanori Naitoh ,  Isao Sumida ,  Kenji Tominaga ,  Tsuyoshi Niino

发明人： Tadashi Fujii ,  Yoshiyuki Kataoka ,  Tohru Fukui ,  Masataka Hidaka ,  Toshitsugu Nakao ,  Shigeo Hatamiya ,  Hiroaki Suzuki ,  Masanori Naitoh ,  Isao Sumida ,  Kenji Tominaga ,  Tsuyoshi Niino

IPC分类号： G21C9/004 ,  G21C9/00 ,  G21C9/008 ,  G21C13/00 ,  G21C15/18 ,  G21D1/00

CPC分类号： G21C15/18 ,  G21C13/00 ,  G21C9/004 ,  G21Y2002/206 ,  G21Y2004/305 ,  G21Y2004/402 ,  Y02E30/40

摘要： There is disclosed a nuclear reactor installation. An accumulator-type emergency core cooling system, a gravity-driven core cooling system and an equalizing system for submerging a reactor core are provided within a primary containment vessel containing a reactor pressure vessel in which the reactor core is disposed. These cooling systems are automatically operated sequentially in accordance with the pressure in the reactor pressure vessel without the need for any particular powered source. The primary containment vessel is made of steel, and the interior of this containment vessel is divided into a space containing the reactor pressure vessel and a space containing an operation floor in such a manner that the two spaces are isolated from each other. An opening device is provided between the two spaces so as to communicate the two spaces with each other in the event of an accident, the upper portion of the primary containment vessel being air-cooled while the lower portion of this containment vessel being water-cooled.

公开(公告)号：US4757138A

公开(公告)日：1988-07-12

申请号：US904372

申请日：1986-09-08

申请人： Tadashi Fujii ,  Yukio Chikui

发明人： Tadashi Fujii ,  Yukio Chikui

IPC分类号： C07D493/04 ,  C07H17/04 ,  C07H15/24

CPC分类号： C07D493/04 ,  C07H17/04

摘要： The present invention relates to a process for producing etoposide by reacting a 4'-halogenoacetyl-4'-demethylepipodophyllotoxin-.beta.-D-2,3-di-O-halogenoacetyl-4,6-O-ethylideneglucoside represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, represent each --COCHX.sub.2 or --COCX.sub.3, wherein X represents a halogen atom, with an alcohol, an amine, and/or ammonia to remove the halogenoacetyl groups.

摘要翻译： 本发明涉及通过使由以下通式表示的4'-卤代乙酰基-4'-去甲基表鬼臼毒素-β-D-2,3-二-O-卤代乙酰基-4,6-O-亚乙基葡萄糖苷与制备依托泊苷的方法： 其中R 1和R 2可以相同或不同，表示每个-COCHX 2或-COCX 3，其中X表示卤素原子，与醇，胺和/或氨反应以除去卤代乙酰基。

公开(公告)号：US4730076A

公开(公告)日：1988-03-08

申请号：US942146

申请日：1986-12-16

申请人： Tadashi Fujii ,  Hiroshi Yagiuchi ,  Akikazu Mitsunobu ,  Shigeru Aoki ,  Makoto Tsuda

发明人： Tadashi Fujii ,  Hiroshi Yagiuchi ,  Akikazu Mitsunobu ,  Shigeru Aoki ,  Makoto Tsuda

IPC分类号： C07K5/075 ,  C07C101/02

CPC分类号： C07K5/0613

摘要： The present invention relates to a process for producing .alpha.-aspartyl-phenylalanine ester represented by the general formula ##STR1## wherein R' represents an alkyl group having 1 to 4 carbon atoms, by reducing an N-protected-N-hydroxymethyl-.alpha.-aspartyl-phenylalanine ester represented by the general formula ##STR2## wherein R represents an organic mioety which can be substituted reductively by hydrogen, and R' is as defined above, with hydrogen gas or formic acid, in the presence of a reduction catalyst and an aromatic primary amine. According to the present invention, there can be obtained a high purity .alpha.-aspartyl-phenylalanine ester with a high yield.

摘要翻译： 本发明涉及通过还原N-保护的N-羟甲基-α-谷氨酰胺来制备由通式“IMAGE”表示的α-天门冬酰胺 - 苯丙氨酸酯的方法，其中R'代表具有1至4个碳原子的烷基， 由通式表示的天冬氨酰基 - 苯丙氨酸酯，其中R表示可在氢还原催化剂和还原催化剂存在下用氢气或甲酸还原的氢被还原反应的R'和R'定义的有机二氧化物， 芳族伯胺。 根据本发明，可以高产率地得到高纯度的α-天冬氨酰基苯丙氨酸酯。

公开(公告)号：US4597292A

公开(公告)日：1986-07-01

申请号：US725797

申请日：1985-04-22

申请人： Tadashi Fujii ,  Yoshinori Hayakawa

发明人： Tadashi Fujii ,  Yoshinori Hayakawa

IPC分类号： G01N29/44 ,  G01N29/34 ,  G01S7/52 ,  G01S15/89 ,  G01N29/04

CPC分类号： G01S15/8952 ,  G01N29/0645 ,  G01N29/069 ,  G01N29/245 ,  G01N29/348 ,  G01S15/8997 ,  G01S7/52036

摘要： An ultrasonic transducer is adapted to transmit spherical ultrasonic waves which have a plurality of frequencies into an object under examination while being scanned in a direction at right angles to the direction of transmission. By repeating this operation, echo signals are obtained, on the basis of which a B-scan distribution image of the echo signals is obtained through use of a synthetic aperture method. Using the distribution image, there is determined position information relating to positions of interest in the object as indicated in the distribution image, as well as scanning positions of the ultrasonic transducer situated on extensions of straight lines connecting the positions of interest. The attenuation coefficient of the object is measured based on echo signals at the scanning positions.

摘要翻译： 超声波换能器适于将具有多个频率的球面超声波在与传播方向成直角的方向扫描的同时将被检测物体发送到被检查物体中。 通过重复该操作，获得回波信号，基于此，通过使用合成孔径法获得回波信号的B扫描分布图像。 使用分布图像，确定与分布图像中指示的对象中感兴趣的位置相关的位置信息，以及位于连接感兴趣的位置的直线的延伸部上的超声波换能器的扫描位置。 基于扫描位置处的回波信号测量物体的衰减系数。

公开(公告)号：US4594895A

公开(公告)日：1986-06-17

申请号：US651963

申请日：1984-09-18

申请人： Tadashi Fujii

发明人： Tadashi Fujii

IPC分类号： A61B8/14 ,  A61B8/00 ,  G01N29/00 ,  G01N29/04 ,  G01N29/11 ,  G01N29/27 ,  G01N29/44 ,  G01S15/88

CPC分类号： G01N29/27 ,  G01N29/11 ,  G01N2291/048

摘要： A method and apparatus wherein two probes are arranged to oppose each other on either side of an object under investigation and each of two probes emits ultrasonic waves to measure the acoustic characteristics of the object respectively.Mean attenuation coefficients for small intervals can be calculated solely from the received echo signals by processing signals indicative of echos of the ultrasonic waves from the two probes. Reflection coefficients can be calculated from the mean attenuation coefficients obtained. In addition, a distribution image of either of the mean attenuation coefficient and reflection coefficient distributions are obtained from these mean attenuation coefficients and reflection coefficients for the small intervals.

摘要翻译： 一种方法和装置，其中两个探针被布置为在被研究物体的任一侧彼此相对，并且两个探针中的每一个分别发射超声波以分别测量物体的声学特性。 通过处理表示来自两个探针的超声波的回波的信号，可以仅从接收的回波信号计算小间隔的平均衰减系数。 可以从获得的平均衰减系数计算反射系数。 此外，从这些平均衰减系数和小间隔的反射系数中获得平均衰减系数和反射系数分布中的任一个的分布图像。

公开(公告)号：US4592000A

公开(公告)日：1986-05-27

申请号：US504235

申请日：1983-06-14

申请人： Hideo Ishizaka ,  Tadashi Fujii

发明人： Hideo Ishizaka ,  Tadashi Fujii

IPC分类号： G01K7/24 ,  G01K7/42

CPC分类号： G01K7/245 ,  G01K7/42

摘要： An electronic clinical thermometer having a store of plural temperature prediction functions in which elapsed measurement time is a variable, each function prescribing a temperature change up to a final, stable temperature. Temperature at a specific point in time is predicted in accordance with a selected temperature prediction function based on a temperature at a specific sampling instant and elapsed measurement time up to the past sampling instant. The predicted value and a value actually measured at the specific point in time are compared to obtain a difference between them. When the difference falls outside prescribed limits, another temperature prediction function is selected, a subsequent predicted value is obtained based thereon, and the foregoing process is repeated until a difference is found which lies within the prescribed limits. When this occurs, a predicted value of the final, stable temperature corresponding to the prediction function is obtained and delivered as an output.

摘要翻译： 一种具有多个温度预测功能的电子体温计，其中经过的测量时间是可变的，每个功能规定温度变化直到最终的稳定的温度。 根据特定采样时间的温度和直到过去采样时刻的经过的测量时间，根据所选择的温度预测函数预测特定时间点的温度。 将预测值和在特定时间点实际测量的值进行比较以获得它们之间的差异。 当差异超出规定限度时，选择另一温度预测函数，基于此获得随后的预测值，并且重复上述处理，直到发现位于规定限度内的差异。 当发生这种情况时，获得与预测函数相对应的最终稳定温度的预测值并将其输出作为输出。

公开(公告)号：US09006412B2

公开(公告)日：2015-04-14

申请号：US13122675

申请日：2009-10-05

申请人： Yoshikazu Fujii ,  Tadashi Fujii ,  Akira Arisawa ,  Tomohiro Tamura

发明人： Yoshikazu Fujii ,  Tadashi Fujii ,  Akira Arisawa ,  Tomohiro Tamura

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N15/64 ,  C12P21/06 ,  C12P21/02 ,  C12N9/02 ,  C12N15/74 ,  C12P7/02 ,  C12P7/62 ,  C12P17/06

CPC分类号： C12P21/02 ,  C12N9/0071 ,  C12N9/0073 ,  C12N15/74 ,  C12P7/02 ,  C12P7/62 ,  C12P17/06 ,  C12Y114/13013

摘要： An expression vector capable of expressing a foreign gene in Pseudonocardia autotrophica; a transformant of Pseudonocardia autotrophica produced by using the expression vector; a method for producing a protein by using the transformant; a method for producing an active form of vitamin D3 from vitamin D3, which comprises highly expressing a gene encoding an enzyme involved in the synthesis of the active form of vitamin D3 in a transformant by using the expression vector or the transformant; a method for producing 25-hydroxyvitamin D2 from vitamin D2; and a method for producing pravastatin from compactin, which comprises highly expressing a compactin hydroxylase gene in a transformant by using the expression vector or the transformant.

摘要翻译： 能够在自养假诺卡氏菌中表达外源基因的表达载体; 通过使用表达载体产生的假心内膜自养基因的转化体; 通过使用该转化体生产蛋白质的方法; 从维生素D3生产活性形式的维生素D3的方法，其包括通过使用表达载体或转化体高度表达编码参与转化体中活性形式的维生素D3的活性形式的酶的基因; 从维生素D2生产25-羟基维生素D 2的方法; 以及通过使用表达载体或转化体高效表达转化体中的致密蛋白羟化酶基因的来自美伐他汀的普伐他汀的制造方法。

公开(公告)号：US08460915B2

公开(公告)日：2013-06-11

申请号：US12449876

申请日：2008-02-28

申请人： Tadashi Fujii ,  Yoshikazu Fujii ,  Atsushi Ochiai ,  Masashi Ito ,  Kazuhiro Machida

发明人： Tadashi Fujii ,  Yoshikazu Fujii ,  Atsushi Ochiai ,  Masashi Ito ,  Kazuhiro Machida

IPC分类号： C12N9/00 ,  C12N9/02 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC分类号： C12P7/18 ,  C12N9/0077

摘要： Disclosed is a means for improving the poor conversion efficiency in a bioconversion system using an Escherichia coli cell having a bacterium-originated cytochrome P-450 gene integrated therein. A recombinant Escherichia coli cell is produced by introducing aciB and aciC which encode a gene for the electron transport system originated from the Acinetobacter sp. OC4 strain into an Escherichia coli cell, and adding a polynucleotide encoding an N-terminal sequence composed of 48 amino acid residues of AciA and the like to the 5′-terminus of a bacterium-originated cytochrome P-450 gene, wherein AciA is an alkane-oxidative cytochrome P-450 originated from the Acinetobacter sp. OC4 strain. Use of the recombinant Escherichia coli cell results in much effective microbial conversion of a hydrophobic or amphipathic substrate compound into a desired compound.

摘要翻译： 公开了一种用于提高生物转化系统中转化效率差的方法，该系统使用其中整合有细菌色素细胞色素P-450基因的大肠杆菌细胞。 通过引入编码源自不动杆菌属的电子传递系统的基因的aciB和aciC来产生重组大肠杆菌细胞。 OC4菌株加入到大肠杆菌细胞中，并将编码由AciA等的48个氨基酸残基组成的N末端序列的多核苷酸加入到细菌来源的细胞色素P-450基因的5'末端，其中AciA为 链烷氧化细胞色素P-450源自不动杆菌属。 OC4菌株。 重组大肠杆菌细胞的使用导致疏水性或两亲性底物化合物成为所需化合物的有效微生物转化。

公开(公告)号：US20070026170A1

公开(公告)日：2007-02-01

申请号：US11489621

申请日：2006-07-20

申请人： Kenichi Kawano ,  Tadashi Fujii ,  Tatsuo Hiyoshi

发明人： Kenichi Kawano ,  Tadashi Fujii ,  Tatsuo Hiyoshi

IPC分类号： B41M5/40

CPC分类号： B41M5/506

摘要： A recording medium has an ink-receiving layer provided on at least one surface of a substrate, wherein the substrate comprises a base material, and a resin layer having ink absorbency and/or ink permeability formed at least on the side of the base material on which the ink-receiving layer is provided, and wherein the resin layer has a contact angle with respect to water of 60° or smaller, a water vapor transmission rate of 100 g/m2/24 hr or larger according to JIS-Z-0208 and the thickness of 10 to 100 μm.

摘要翻译： 记录介质具有设置在基板的至少一个表面上的油墨接收层，其中所述基板包括基材，以及至少在所述基材的侧面上形成油墨吸收性和/或油墨渗透性的树脂层， 其中设置有油墨接收层，并且其中树脂层相对于水的接触角为60°或更小，水蒸汽透过率为100g / m 2 / 24hr或 根据JIS-Z-0208较大，厚度为10〜100μm。