摘要:
The present invention relates to a process for producing etoposide by reacting a 4'-halogenoacetyl-4'-demethylepipodophyllotoxin-.beta.-D-2,3-di-O-halogenoacetyl-4,6-O-ethylideneglucoside represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, represent each --COCHX.sub.2 or --COCX.sub.3, wherein X represents a halogen atom, with an alcohol, an amine, and/or ammonia to remove the halogenoacetyl groups.
摘要:
The present invention provides novel dihydrate crystals of etoposide-2-dimethylamino compound hydrochloride [4'-demethylepipodophillotoxin 9-(4,6-O-ethylidene-2-dimethylamino-2-deoxy-.beta.-D-glucopyranoside hydrochloride] used as a carcinostatic agent and a process for production thereof.
摘要:
Disclosed is a means for improving the poor conversion efficiency in a conventional bioconversion system using a transformant which is given by introducing a gene originated from xerogenic organisms. A transformant is prepared by using a host which is defective in a gene encoding a multidrug efflux protein and introducing a gene originated from xerogenic organisms. Use of the transformant results in much effective microbial conversion of a hydrophobic or amphipathic substrate compound into a desired compound. In case, an Escherichia coli is used as the host, the gene encoding a multidrug efflux protein to be defective may be tolC, acrA, acrB and the like.
摘要:
A process by which many kinds of unstretched films comprising a thermoplastic resin are produced each in a small amount and high yield. A thermoplastic resin (A) to be formed into an unstretched film and another thermoplastic resin (B) are separately melted by heating. The thermoplastic resin (B) is introduced to each edge part of a T-die (2) for extrusion. The two resins are ejected and extruded on a casting roll so that the thermoplastic rosin (B) is disposed on the side of each edge of the thermally melted thermoplastic resin (A). Thus, an unstretched film (20) is formed which comprises the thermoplastic resin (A) and the thermoplastic resin (B) disposed on the side of each edge of the resin (A). Thereafter, the parts constituted of the thermoplastic resin (B) are removed y cutting to form a target unstretched film (20) consisting only of the thermoplastic resin (A).
摘要:
The present invention provides an excellent radiation curable aqueous coating composition, which is highly safe and can make the adhesion to a metal surface and the corrosion resistance compatible which have been considered to conflict with each other, particularly adhesion after severe working and solvent resistance, and particularly durability to alcohols having high polarity. The composition of the present invention contains (1) a phosphoric acid ester compound having an ethylenically unsaturated double bond, (2) an aqueous polyurethane resin having both an ethylenically unsaturated double bond and a group capable of forming a salt, and (3) colloidal silica.
摘要:
Provided are an isolated gene capable of participating in the production of L-homoglutamic acid, and a production system of L-homoglutamic acid by using this gene. The gene is derived from the genome of Flavobacterium lutescens.
摘要:
In an indirect cycle nuclear reactor, a size of the reactor containment vessel is decreased by removing decay heat inside the reactor pressure vessel without using any active component to improve the economic feasibility. A main steam pipe communicating with a heat exchanger of the indirect cycle nuclear reactor is branched in a position upstream of a main steam isolation valve to connect the branched pipe to a heat exchanger in a pressure suppression pool through an isolation valve. A feed water pipe is also branched in a position upstream of an isolation valve to connect the branched pipe to the heat exchanger through the isolation valve. Decay heat is dissipated from the heat exchanger into the pressure suppression pool, and condensed water condensed by heat dissipation is returned to the heat exchanger to cool the inside of the pressure vessel. Heat in the pressure suppression pool is transferred from a condensing type heat exchanger to a heat dissipater outside a containment vessel to be dissipated to the outside of the containment vessel.
摘要:
In a plant equipment comprising apparatus of a plurality of systems and control means for switching the systems and changing capacities of the apparatus, an apparatus of each system bas a rated capacity which is 1/N of a capacity of the whole equipment, and the plant equipment is constituted of (N+1) systems. In conditions of normal operation, all the (N+1) systems are operated at capacities less than the rated capacity through the control means. During normal operation, when one system is inspected, or when an abnormality occurs in one system, this system is stopped by the control means. Capacities of apparatus in N of the systems which are operated are increased to the rated 1/N capacity through the control means, and operation is continued with a structure of 1/N capacity.times.N systems. When the maintenance of apparatus in the stopped system is finished, the stopped system is restarted, so as to operate all of the (N+1) systems at capacities less than the rated capacity again.
摘要:
A sheet supply apparatus supplies a sheet such as an X-ray sheet film from a cassette to a recording device. The sheet supply apparatus has at least a pair of rollers for gripping and feeding a sheet, a feeding mechanism for feeding a sheet from a storage cassette and supplying the sheet along a feed path to the pair of rollers, a tilt correcting mechanism having for correcting the sheet out of a tilted condition with respect to a direction transverse to the feed path, and a position correcting mechanism for displacing the pair of rollers in the direction while the pair of rollers is gripping the sheet, to correct the sheet positionally with respect to the direction. The feeding mechanism has suction devices movable into the feed path for attracting the sheet under vacuum, and the tilt correcting mechanism has at least a pair of stoppers movable into the feed path for engaging a leading end of the sheet to correct the sheet out of the tilted condition. The sheet supply apparatus also has a drive mechanism for displacing the suction devices and the stoppers between the feed path and respective positions outside of the feed path.
摘要:
The drawing device inserts a warp into a heald hole of a heald and between reed dents of a reed. The device comprises an air guide including an air passage having an entrance and an exit, an air stream generating mechanism operationally connected with the air passage for generating an air stream running from the entrance toward the exit in the air passage, a heald feeding and moving mechanism for feeding one heald just in front of the entrance of the air passage and for arranging the heald so that the heald hold of the heald may be opposite to the entrance, and a warp feeding mechanism for feeding and arranging a warp just in front of the heald hole of the heald arranged just in front of the entrance of the air passage.