公开(公告)号：US20140291486A1

公开(公告)日：2014-10-02

申请号：US14350647

申请日：2012-08-02

申请人： Terumasa Nagano ,  Noburo Hosokawa ,  Tomofumi Suzuki ,  Takashi Baba

发明人： Terumasa Nagano ,  Noburo Hosokawa ,  Tomofumi Suzuki ,  Takashi Baba

IPC分类号： H01L27/144

CPC分类号： H01L27/14643 ,  H01L27/1446 ,  H01L27/14618 ,  H01L27/14636 ,  H01L27/14658 ,  H01L31/107

摘要： A light detection device 1 has a semiconductor light detection element having a semiconductor substrate, and a mounting substrate arranged as opposed to the semiconductor light detection element. The semiconductor light detection element includes a plurality of avalanche photodiodes operating in Geiger mode and formed in the semiconductor substrate, and electrodes electrically connected to the respective avalanche photodiodes and arranged on a second principal surface side of the semiconductor substrate. The mounting substrate includes a plurality of electrodes arranged corresponding to the respective electrodes on a third principal surface side, and quenching resistors electrically connected to the respective electrodes and arranged on the third principal surface side. The electrodes and the electrodes are connected through bump electrodes.

摘要翻译： 光检测装置1具有半导体光检测元件，该半导体光检测元件具有半导体衬底和与半导体光检测元件相对布置的安装衬底。 半导体光检测元件包括以Geiger模式操作并形成在半导体衬底中的多个雪崩光电二极管，以及电连接到各个雪崩光电二极管并且布置在半导体衬底的第二主表面侧上的电极。 安装基板包括在第三主面侧对应于各个电极布置的多个电极，并且电连接到各个电极并且布置在第三主表面侧上的淬火电阻。 电极和电极通过凸块电极连接。

公开(公告)号：US07951782B2

公开(公告)日：2011-05-31

申请号：US12065984

申请日：2006-09-28

申请人： Itsuki Murota ,  Tadakazu Tamai ,  Takashi Baba ,  Kenji Sato

发明人： Itsuki Murota ,  Tadakazu Tamai ,  Takashi Baba ,  Kenji Sato

IPC分类号： A61K38/08 ,  A61K38/06 ,  A61K38/07

CPC分类号： A61K35/60 ,  A61K38/07 ,  A61K38/1706

摘要： Disclosed is a composition comprising, as an active ingredient, an enzyme digest that is produced by digesting a basic fraction of an animal-derived cartilage extract with an enzyme. Also disclosed is a polypeptide composition comprising, as an active ingredient, at least one polypeptide selected from specific polypeptides including a polypeptide comprising an amino acid sequence depicted in any one of SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10.

摘要翻译： 公开了一种组合物，其包含通过用酶消化动物来源的软骨提取物的碱性部分而产生的酶消化物作为活性成分。 还公开了一种多肽组合物，其包含作为活性成分的至少一种选自特定多肽的多肽，所述多肽包括多肽，所述多肽包含SEQ ID NO：1,2,3,4,5,6， 7,8,9和10。

公开(公告)号：US07829845B2

公开(公告)日：2010-11-09

申请号：US11878241

申请日：2007-07-23

申请人： Kisaburo Deguchi ,  Atsumu Hirabayashi ,  Hiroki Ito ,  Takashi Baba

发明人： Kisaburo Deguchi ,  Atsumu Hirabayashi ,  Hiroki Ito ,  Takashi Baba

IPC分类号： H01J49/42 ,  H01J49/04

CPC分类号： G01N33/6848 ,  H01J49/004

摘要： To analyze glycans and peptide sequences without liberating glycans from glycosylated peptides, a glycan structure is analyzed through negative-ion CID, in which sialic acid and fucose are resistant to elimination, and a peptide sequence is analyzed through positive-ion ECD.

摘要翻译： 为了分析聚糖和肽序列而不从糖基化肽释放聚糖，通过负离子CID分析聚糖结构，其中唾液酸和岩藻糖对消除具有抗性，并且通过正离子ECD分析肽序列。

公开(公告)号：US07608819B2

公开(公告)日：2009-10-27

申请号：US12078523

申请日：2008-04-01

申请人： Takashi Baba ,  Yuichiro Hashimoto

发明人： Takashi Baba ,  Yuichiro Hashimoto

IPC分类号： H01J49/00

CPC分类号： H01J49/4225 ,  H01J49/0054 ,  H01J49/422

摘要： The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.

摘要翻译： 本发明提供能够实现高效率和高通量ECD的质谱。 使用其中施加沿着并且大致平行于中心轴的磁场的电子源和二维组合离子阱，从而实现上述目的。 首先，前体离子被捕获。 通过采用二维组合离子阱，可以在注入和捕获时获得高离子捕获效率。 随后，使电子以这样的方式入射，即沿着不通过使用磁场施加射频的中心轴缠绕。 因此，可以使能量控制的电子达到前体离子。 可以实现能够避免由于射频电场引起的加热并且实现高通量/高效率ECD的质谱仪。

公开(公告)号：US20080078930A1

公开(公告)日：2008-04-03

申请号：US11979219

申请日：2007-10-31

申请人： Takashi Baba ,  Hiroyuki Satake ,  Izumi Waki

发明人： Takashi Baba ,  Hiroyuki Satake ,  Izumi Waki

IPC分类号： H01J49/04

CPC分类号： H01J49/4225 ,  H01J49/005 ,  H01J49/0054

摘要： An electron capture dissociation device to implement a combination of electron capture dissociation and collision dissociation and a mass spectrometer with the use thereof are provided. This device includes a linear ion trap provided with linear multipole electrodes applied with a radio frequency electric field and wall electrodes that are arranged on both ends in the axis direction of the linear multipole electrodes, have holes on the central axis thereof, and generate a wall electric field by being applied with a direct-current voltage, a cylindrical magnetic field-generating unit that generates a magnetic field parallel to the central axis of the linear multipole electrodes and surrounds the linear ion trap, and an electron source arranged opposite to the linear multipole electrodes with sandwiching one of the wall electrodes. The electron generation site of the electron source is placed in the inside of the magnetic field generated by the magnetic field-generating unit.

摘要翻译： 提供了一种实现电子俘获解离和碰撞解离的组合的电子俘获解离装置和使用该质谱仪的电子俘获解离装置。 该装置包括线性离子阱，其设置有施加有射频电场的线性多极电极和布置在线性多极电极的轴向两端的壁电极，在其中心轴上具有孔，并产生壁 通过施加直流电压的电场，产生平行于线性多极电极的中心轴并且包围线性离子阱的磁场的圆柱形磁场产生单元，以及与线性相反的电子源 夹着一个壁电极的多极电极。 电子源的电子产生位置位于由磁场产生单元产生的磁场的内部。

公开(公告)号：US07329862B2

公开(公告)日：2008-02-12

申请号：US11495534

申请日：2006-07-31

申请人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

发明人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

IPC分类号： H01J49/00

CPC分类号： H01J49/4225 ,  H01J49/004 ,  H01J49/401

摘要： A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.

摘要翻译： 能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。 质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱，其具有设置在出射端处的终端电极，其排出离子，以相对于端电极的DC电位改变DC电位梯度，并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器，其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围 离子从第一线性捕集器喷射到第二线性阱。

公开(公告)号：US20070069124A1

公开(公告)日：2007-03-29

申请号：US11605437

申请日：2006-11-29

申请人： Takashi Baba ,  Yuichiro Hashimoto

发明人： Takashi Baba ,  Yuichiro Hashimoto

IPC分类号： H01J49/00

CPC分类号： H01J49/4225 ,  H01J49/0054 ,  H01J49/422

摘要： The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.

公开(公告)号：US20060012262A1

公开(公告)日：2006-01-19

申请号：US11181282

申请日：2005-07-13

申请人： Takashi Baba ,  Manabu Okamura ,  Sachio Nakayama

发明人： Takashi Baba ,  Manabu Okamura ,  Sachio Nakayama

IPC分类号： H02K1/04 ,  H02K15/12 ,  H02K1/06 ,  H02K15/00

CPC分类号： H02K1/185 ,  H02K5/08 ,  Y10T29/49009

摘要： The electric power steering apparatus includes a brushless motor as an electric motor. The motor has a rotor and a stator 34. The stator 34 includes: a back core BY; a plurality of teeth TS disposed along the circumference of the back core protruding from the back core BY toward its radial center and forming slots SL therebetween; and an exciting coil 38 wound around each of the teeth TS. Each of the slots SL is filled with a resin material. The back core BY is partially press-fitted into a yoke 21 so that the outer surface of the back core BY comes partially into contact with the inner surface of the yoke 21 along their circumferences.

摘要翻译： 电动助力转向装置包括作为电动机的无刷电动机。 电动机具有转子和定子34.定子34包括：背芯BY; 沿着背芯的圆周设置的多个齿TS，其从后芯BY向其径向中心突出并在其间形成狭槽SL; 以及缠绕在每个齿TS上的励磁线圈38。 每个槽SL填充有树脂材料。 背芯BY被部分地压配合到轭21中，使得后芯BY的外表面沿其圆周部分地与轭21的内表面接触。

公开(公告)号：US06967323B2

公开(公告)日：2005-11-22

申请号：US10868933

申请日：2004-06-17

申请人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

发明人： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

IPC分类号： G01N27/62 ,  G01N27/64 ,  H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/063 ,  H01J49/004 ,  H01J49/0481

摘要： An ion mass spectrometer comprising an ionization source for generating ions, a linear trap region for accumulation and dissociation of ions, and a time-of-flight mass spectrometer for mass spectroscopy of ions based on the flying time, and having a collision damping region introduced with a buffer gas for reducing the kinetic energy of ions ejected from the linear trap region and converting the ion packet into continuous beam and provided with plural electrodes for generating multipole electric fields in the inside between the linear trap region and the time-of-flight mass spectrometer, and having an ion transmission control mechanism for allowing or inhibiting incidence of ion from the linear trap region to the collision damping region between the linear trap region and the collision damping region.

摘要翻译： 一种离子质谱仪，包括用于产生离子的电离源，用于离子的聚集和离解的线性捕获区域，以及用于基于飞行时间的离子质谱的飞行时间质谱仪，并且具有引入的碰撞阻尼区域 使用缓冲气体，用于降低从线性捕获区域排出的离子的动能，并将离子包转换为连续光束，并设置有多个电极，用于在线性捕获区域和飞行时间之间的内部产生多极电场 并且具有用于允许或抑制从线性捕获区域到线性捕获区域和碰撞阻尼区域之间的碰撞阻尼区域的入射的离子传输控制机构。

公开(公告)号：US06566651B2

公开(公告)日：2003-05-20

申请号：US10215014

申请日：2002-08-12

申请人： Takashi Baba ,  Izumi Waki ,  Dongbing Wang

发明人： Takashi Baba ,  Izumi Waki ,  Dongbing Wang

IPC分类号： H01J4942

CPC分类号： G01N21/6404 ,  H01J49/42

摘要： A laser-cooled fluorescence mass spectrometry apparatus includes an ion trap for trapping sample ions, laser-cooled ions, and probe ions therein; a first irradiating device for irradiating the sample ions, the laser-cooled ions, and the probe ions in the ion trap with a first laser beam for cooling the ions; a second irradiating device for irradiating the sample ions, the laser-cooled ions, and the probe ions in the ion trap with a second laser beam for detecting temperature changes in the ions; a detecting device for detecting the temperature changes in the ions; a first ion source for the sample ions; a second ion source for the laser-cooled ions; and a third ion source for the probe ions. The probe ions may be different ions than the laser-cooled ions, or the probe ions may be the same ions as the laser-cooled ions.

摘要翻译： 激光冷却荧光质谱仪包括用于捕获样品离子，激光冷却离子和探针离子的离子阱; 第一照射装置，用于用用于冷却离子的第一激光束照射离子阱中的样品离子，激光冷却离子和探针离子; 第二照射装置，用于用用于检测离子温度变化的第二激光束照射离子阱中的样品离子，激光冷却离子和探针离子; 用于检测离子温度变化的检测装置; 用于样品离子的第一离子源; 用于激光冷却离子的第二离子源; 和用于探针离子的第三离子源。 探针离子可能是与激光冷却离子不同的离子，或探针离子可能与激光冷却离子相同的离子。