公开(公告)号：US20080217673A1

公开(公告)日：2008-09-11

申请号：US12026421

申请日：2008-02-05

申请人： Takayuki Maruyama ,  Yukio Hayakawa ,  Hiroyuki Nansei

发明人： Takayuki Maruyama ,  Yukio Hayakawa ,  Hiroyuki Nansei

IPC分类号： H01L29/94 ,  H01L21/02 ,  H01L21/336

CPC分类号： H01L29/7923 ,  G11C16/0475 ,  H01L27/115 ,  H01L27/11568 ,  H01L27/11582 ,  H01L29/40117 ,  H01L29/7926

摘要： A semiconductor device includes a stack structure in which multiple channel layers are stacked on a substrate so as to be sandwiched between bit line layers, a gate electrode that is provided to the side of the lateral surface of an interior of a groove portion formed within the stack structure, and a charge storage layer that is provided between the gate electrode and the channel layer.

摘要翻译： 半导体器件包括堆叠结构，其中多个沟道层堆叠在衬底上以被夹在位线层之间，栅电极设置在形成在衬底内的沟槽部分的内部的侧表面侧 堆叠结构，以及设置在栅电极和沟道层之间的电荷存储层。

公开(公告)号：US20080033033A1

公开(公告)日：2008-02-07

申请号：US11749531

申请日：2007-05-16

申请人： Tohru Kambe ,  Toru Maruyama ,  Kaoru Kobayashi ,  Kousuke Tani ,  Yoshihiko Nakai ,  Toshihiko Nagase ,  Takayuki Maruyama ,  Kiyoto Sakata ,  Hideyuki Yoshida ,  Shinsei Fujimura ,  Akio Nishiura ,  Nobutaka Abe

发明人： Tohru Kambe ,  Toru Maruyama ,  Kaoru Kobayashi ,  Kousuke Tani ,  Yoshihiko Nakai ,  Toshihiko Nagase ,  Takayuki Maruyama ,  Kiyoto Sakata ,  Hideyuki Yoshida ,  Shinsei Fujimura ,  Akio Nishiura ,  Nobutaka Abe

IPC分类号： A61K31/41 ,  A61K31/4015 ,  C07D207/18 ,  C07D257/04

CPC分类号： C07D417/12 ,  C07D417/14

摘要： The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification.) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and/or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and/or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.

摘要翻译： 包含本发明化合物的盐，其盐，其溶剂合物或环糊精包合物，其具有由式（I）表示的8-氮杂前列腺素骨架（其中所有符号具有与说明书相同的含义） 或其前药，并且它们作为活性成分具有EP 4激动作用，因此被认为可用于预防和/或治疗免疫疾病，哮喘，神经元细胞死亡，关节炎，肺衰竭，肺纤维化 ，肺气肿，支气管炎，慢性阻塞性肺疾病，肝损伤，急性肝炎，肾炎，肾功能不全，高血压，心肌缺血，全身炎症反应综合征，败血症，血液综合征，巨噬细胞活化综合征，静脉炎，川崎病，烧伤，系统性 肉芽肿病，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭，休克和青光眼等。 此外，化合物还具有促进骨形成的作用，因此预期可用于预防和/或治疗与骨量丧失相关的疾病，例如原发性骨质疏松症，继发性骨质疏松症，癌症的骨转移， 高钙血症，佩吉特氏病，骨丢失，骨坏死，骨手术后的骨形成，骨移植的替代治疗。

公开(公告)号：US20080032880A1

公开(公告)日：2008-02-07

申请号：US11597568

申请日：2005-05-25

申请人： Takayuki Maruyama ,  Toshimi Chiba

发明人： Takayuki Maruyama ,  Toshimi Chiba

IPC分类号： C30B29/38

CPC分类号： H01L21/0262 ,  C30B25/02 ,  C30B25/18 ,  C30B29/36 ,  H01L21/02378 ,  H01L21/02433 ,  H01L21/02529

摘要： A process for manufacturing a wafer of a silicon carbide single crystal having: cutting a wafer from an α (hexagonal)-silicon carbide single crystal so that the off-angle is totally in the range from 0.4 to 2° to a plane obtained in perpendicular to the [0001]c axis of the silicon carbide single crystal; disposing the wafer in a reaction vessel; feeding a silicon source gas and carbon source gas in the reaction vessel; and epitaxially growing the α (hexagonal) silicon carbide single crystal on the wafer by allowing the silicon source gas and carbon source gas to react.

摘要翻译： 一种用于制造碳化硅单晶晶片的方法，具有：从α（六方晶） - 碳化硅单晶切割晶片，使得所述偏角完全在垂直方向获得的平面的0.4至2° 到碳化硅单晶的[c]轴; 将晶片设置在反应容器中; 在反应容器内供给硅源气体和碳源气体; 并通过允许硅源气体和碳源气体反应在晶片上外延生长α（六方晶）碳化硅单晶。

公开(公告)号：US07196198B2

公开(公告)日：2007-03-27

申请号：US10737901

申请日：2003-12-18

申请人： Kousuke Tani ,  Kaoru Kobayashi ,  Takayuki Maruyama

发明人： Kousuke Tani ,  Kaoru Kobayashi ,  Takayuki Maruyama

IPC分类号： C07D211/72 ,  C07D211/84

CPC分类号： C07D213/30 ,  C07B2200/07 ,  C07C233/55 ,  C07C235/38 ,  C07C235/84 ,  C07C255/60 ,  C07C323/62 ,  C07C2601/02 ,  C07C2603/18 ,  C07D213/75 ,  C07D213/80 ,  C07D215/06 ,  C07D215/12 ,  C07D215/14 ,  C07D263/34 ,  C07D307/68 ,  C07D333/38

摘要： An agent comprising the benzoic acid of formula (I) wherein A, B, R6, R7 are carbocyclic ring, heterocyclic ring, etc.; R1 is hydroxy etc.; R2, R3, R4 are alkyl etc.; R5, D, E are alkylene, etc.; G is oxygen etc., as active ingredient. The compound of formula (I) is considered to be useful for the treatment and/or prophylaxis of bone diseases, cancer, systemic granuloma, immunological diseases, allergy, atopy, asthma, gumboil, gingivitis, periodontitis, neurocyte death, Alzheimer's diseases, lungs injury, pulmopathy, acute hepatitis, nephritis, myocardial ischemia, Kawasaki disease, ambustion, ulcerative colitis, Crohn's disease, multiple organ failure, sleeping disorder, platelet aggregation, etc.

摘要翻译： 包含式（I）的苯甲酸的试剂

公开(公告)号：US20070034145A1

公开(公告)日：2007-02-15

申请号：US10558369

申请日：2004-05-28

申请人： Takayuki Maruyama ,  Yoshinori Kobayashi ,  Takuya Monbara

发明人： Takayuki Maruyama ,  Yoshinori Kobayashi ,  Takuya Monbara

IPC分类号： C30B23/00 ,  C30B28/12 ,  C30B25/00 ,  C30B28/14

CPC分类号： C30B29/36 ,  C01B32/956 ,  C30B23/00 ,  Y02P20/149

摘要： A method of producing a silicon carbide single crystal has storing a sublimation law material on a first end portion in a reaction container; disposing a seed crystal of a silicon carbide single crystal on a second end portion substantially facing the sublimation law material in the reaction container; and re-crystallizing the sublimated sublimation law material on the seed crystal to grow a silicon carbide single crystal, wherein a sealing portion is provided in the reaction container to grow a silicon carbide single crystal on the seed crystal provided in the sealing portion while preventing the leak of the sublimated sublimation law material from the atmosphere for sublimation.

摘要翻译： 碳化硅单晶的制造方法在反应容器的第一端部存储升华规律材料， 在基本面向反应容器中的升华规律材料的第二端部上设置碳化硅单晶晶种; 并将升华的升华定律材料再结晶在晶种上以生长碳化硅单晶，其中在反应容器中设置密封部分以在设置在密封部分中的晶种上生长碳化硅单晶，同时防止 泄漏的升华升华法物质从大气升华。

公开(公告)号：US07048798B2

公开(公告)日：2006-05-23

申请号：US10450151

申请日：2001-12-21

申请人： Takayuki Maruyama ,  Shigeki Endo

发明人： Takayuki Maruyama ,  Shigeki Endo

IPC分类号： C30B23/02 ,  C30B29/36

CPC分类号： C30B23/00 ,  C30B29/36

摘要： A method of producing a silicon carbide single crystal in which a sublimation raw material 40 is accommodated at the side of vessel body 12 in a graphite crucible 10, placing a seed crystal of a silicon carbide single crystal at the side of cover body 11 of the graphite crucible 10, the sublimation raw material 40 is sublimated by a first induction heating coil 21 placed at the side of sublimation raw material 40, a re-crystallization atmosphere is form by a second induction heating coil 20 placed at the side of cover body 11 so that the sublimation raw material 40 sublimated by the first induction heating coil 21 is re-crystallizable only in the vicinity of the seed crystal of a silicon carbide single crystal, and the sublimation raw material 40 is re-crystallized on the seed crystal of a silicon carbide single crystal, and a silicon carbide single crystal 60 is grown while keeping the whole surface of its growth surface in convex shape through the all growth processes.A high quality silicon carbide single crystal with large diameter excellent in dielectric breakdown property, heat resistance, radiation resistance and the like, suitable for electronic and optical devices and the like, and showing no contamination of polycrystals and polymorphs, no defect of micropipes and the like can be produced efficiently without cracking and the like.

摘要翻译： 一种生产碳化硅单晶的方法，其中升华原料40容纳在石墨坩埚10中的容器本体12侧，将碳化硅单晶的晶种放置在盖体11的侧面 石墨坩埚10中，升华原料40通过位于升华原料40一侧的第一感应加热线圈21而升华，通过设置在盖体11侧的第二感应加热线圈20形成再结晶气氛 使得由第一感应加热线圈21升华的升华原料40仅在碳化硅单晶的晶种附近再结晶，升华原料40在晶种上再结晶 碳化硅单晶和碳化硅单晶60生长，同时通过全部生长工艺将其生长表面的整个表面保持凸形。 具有优异的绝缘击穿性，耐热性，耐辐射性等优异的高质量碳化硅单晶，适用于电子和光学器件等，并且不显示多晶体和多晶型物的污染，无微孔缺陷和 可以有效地生产，而不会破裂等。

公开(公告)号：US20050020686A1

公开(公告)日：2005-01-27

申请号：US10484500

申请日：2002-07-22

申请人： Toru Maruyama ,  Kaoru Kobayashi ,  Tohru Kambe ,  Takayuki Maruyama ,  Hideyuki Yoshida ,  Akio Nishiura ,  Nobutaka Abe

发明人： Toru Maruyama ,  Kaoru Kobayashi ,  Tohru Kambe ,  Takayuki Maruyama ,  Hideyuki Yoshida ,  Akio Nishiura ,  Nobutaka Abe

IPC分类号： A61K45/00 ,  A61K31/559 ,  A61P19/08 ,  A61P19/10 ,  C07C405/00 ,  A61K31/557

CPC分类号： C07C405/0033 ,  A61K9/0019 ,  A61K9/1647 ,  A61K9/19 ,  A61K9/2054 ,  A61K31/4015 ,  A61K31/41 ,  A61K31/5575 ,  A61K31/559

摘要： A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

摘要翻译： 用于预防和/或治疗与包含EP4激动剂作为活性成分的骨量减少相关的疾病的局部施用的药物组合物。 包含具有前列腺素骨架的化合物作为代表的EP4激动剂具有促进骨形成的作用，因此可用于预防和/或治疗与骨质量减少有关的疾病（骨疾病如原发性骨质疏松症，继发性骨质疏松症 骨质疏松症，癌症的骨转移，高钙血症，佩吉特氏病，骨丢失和骨坏死，术后成骨，骨移植的替代疗法）。

公开(公告)号：US06277306B1

公开(公告)日：2001-08-21

申请号：US09200457

申请日：1998-11-27

申请人： Shigeki Endo ,  Takayuki Maruyama ,  Hiroaki Wada ,  Tasuku Saito

发明人： Shigeki Endo ,  Takayuki Maruyama ,  Hiroaki Wada ,  Tasuku Saito

IPC分类号： H01B320

CPC分类号： C10M171/001

摘要： An electro-rheological fluid made from an oil medium and fine particulates by mixing, is highly reliable and in which dielectric breakdown, such as generation of electrical discharge, is very low even when a high voltage is applied. A method of manufacturing the electro-rheological fluid and a method of storing the fluid are also provided. The electro-rheolological fluid includes fine particulates dispersed in an oil medium having an electric insulation property, and has a dielectric breakdown strength of 4 kV/mm or more. When the electro-rheological fluid is placed under a reduced pressure of 10 Pa, foaming does not occur. Alternatively, the electro-reheoleological fluid can contain 20% by volume or more of a gas contained in the oil medium that has a dielectric breakdown strength of 4 kV/mm or more.

摘要翻译： 由油介质和细粒子通过混合制成的电流变流体是高度可靠的，即使施加高电压，诸如放电产生的介质击穿也非常低。 还提供了制造电流变流体的方法和储存流体的方法。 电流变流体包括分散在具有电绝缘性的油介质中的细小颗粒，并且具有4kV / mm以上的介电击穿强度。 当电流变流体放置在10Pa的减压下时，不会发生起泡。 或者，电致液化流体可以含有介质击穿强度为4kV / mm以上的油介质中所含的20体积％以上的气体。

公开(公告)号：US6013673A

公开(公告)日：2000-01-11

申请号：US12448

申请日：1998-01-23

申请人： Yuuki Nagao ,  Kazuhiko Torisu ,  Takayuki Maruyama

发明人： Yuuki Nagao ,  Kazuhiko Torisu ,  Takayuki Maruyama

IPC分类号： A61K31/16 ,  A61K31/41 ,  A61K31/44 ,  C07C233/22 ,  C07C235/20 ,  C07C235/34 ,  C07C235/66 ,  C07C243/28 ,  C07C255/16 ,  C07D213/40 ,  C07D257/04

CPC分类号： C07D213/40 ,  C07C233/22 ,  C07C235/20 ,  C07C235/34 ,  C07C235/66 ,  C07C243/28 ,  C07C255/16 ,  C07D257/04

摘要： A naphthyloxyacetic acid derivative of the formula (I) ##STR1## wherein R.sup.1 is H, alkyl, alkylene-(--COOR.sup.10, --OH, --CONR.sup.4 R.sup.5, --CONR.sup.6 -alkylene-OH, --NR.sup.4 R.sup.5, -cyano or -tetrazolyl); A is single bond, alkylene, alkenylene, --S-alkylene, --O-alkylene; B is NR.sup.3 CO, CONR.sup.3 ; R.sup.2 is (1) alkyl (2) alkenyl, (3) alkyl or alkenyl substituted by 1-3 of phenyl, cycloalkyl, naphthyl and heterocyclic ring containing nitrogen atom (the said ring may be substituted by 1-3 of alkyl, alkoxy and halogen etc.), (4) NR.sup.7 R.sup.8 or (5) alkylene-NR.sup.7 R.sup.8 ; non-toxic salt thereof, non-toxic acid addition salt thereof and hydrate thereof can bind the PGE.sub.2 receptor and exhibits the activity to antagonize or agonize for PGE.sub.2., therefore, they are useful as PGE.sub.2 antagonist or PGE.sub.2 agonist.

摘要翻译： 其中R 1为H，烷基，亚烷基 - （ - COOR 10，-OH，-CONR 4 R 5，-CONR 6 - 亚烷基-OH，-NR 4 R 5 - 氰基或四唑基）的式（I）的萘氧基乙酸衍生物; A是单键，亚烷基，亚烯基，-S-亚烷基，-O-亚烷基; B为NR3CO，CONR3; R2是（1）烷基（2）烯基，（3）被1-3个含氮原子的苯基，环烷基，萘基和杂环取代的烷基或链烯基（所述环可以被1-3个烷基，烷氧基和 卤素等），（4）NR7R8或（5）亚烷基-NR7R8; 其无毒盐，无毒性酸加成盐和其水合物可结合PGE2受体并表现出拮抗或激动PGE2的活性，因此它们可用作PGE2拮抗剂或PGE2激动剂。

公开(公告)号：US5624959A

公开(公告)日：1997-04-29

申请号：US355187

申请日：1994-12-08

申请人： Yuuki Nagao ,  Takayuki Maruyama ,  Nobuyuki Hamanaka

发明人： Yuuki Nagao ,  Takayuki Maruyama ,  Nobuyuki Hamanaka

IPC分类号： C07C311/08 ,  C07C311/13 ,  C07C311/20 ,  C07C311/27 ,  C07C311/28 ,  C07C311/29 ,  A61K31/195

CPC分类号： C07C311/13 ,  C07C311/08 ,  C07C311/20 ,  C07C311/27 ,  C07C311/28 ,  C07C311/29

摘要： (1) Naphthyloxyaetic acid represented by the compound of the formula (I): ##STR1## and non-toxic salts thereof, (2) process for the preparation of the compounds represented by the compound of the formula (I) described hereinbefore,(3) PGE.sub.2 antagonist or agonist containing the compound represented by the compound of the formula (I) as the active ingredient.The compounds represented by the compounds of the formula (I) can be adapted to medicines which possess an inhibitory effect of uterine contraction, an analgesic action, an inhibitory effect of digestive peristalsis, a sleep-inducing effect as PGE.sub.2 antagonists, and an uterine contractile activity, a promoting effect of digestive peristalsis, a suppressive effect of gastric acid secretion, hypotensive activity as PGE.sub.2 agonists. The compounds bind to PGE.sub.2 receptor and have an activity of antagonist or agonist against the action thereof.

摘要翻译： （1）由式（I）的化合物代表的萘乙酸：其中，（I）化合物及其无毒盐，（2）由上述式（I）的化合物表示的化合物的制备方法， （3）PGE2拮抗剂或含有式（I）化合物所代表的化合物作为活性成分的激动剂。 由式（I）化合物表示的化合物可以适用于具有子宫收缩抑制作用，止痛作用，消化性蠕动抑制作用，睡眠诱导作用PGE2拮抗剂和子宫收缩的药物 活动，消化性蠕动的促进作用，胃酸分泌的抑制作用，作为PGE2激动剂的降血压活性。 该化合物与PGE2受体结合，并具有拮抗剂或激动剂抵抗其作用的活性。